An extract of Apium graveolens var. dulce leaves: Structure of the major constituent, apiin, and its anti-inflammatory properties

Journal of Pharmacy and Pharmacology

Volumn 59, Issue 6, 2007, Pages 891-897

  Mencherini, T ^a   Cau, A ^a   Bianco, G ^a   Della Loggia, R ^b   Aquino, R P ^a   Autore, G ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APIIN; APIUM GRAVEOLENS EXTRACT; CROTON OIL; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INDOMETACIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELERY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; DRUG STRUCTURE; EDEMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC 50; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN EXPRESSION; ULTRAVIOLET SPECTROPHOTOMETRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APIUM GRAVEOLENS; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; FLAVONOIDS; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHENOLS; PLANT EXTRACTS; PLANT LEAVES; PLANTS, EDIBLE;

EID: 34447300768     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.59.6.0016     Document Type: Article

References (32)

1. Agrawal, P. K. (1989) (ed.) Carbon-13 NMR of flavonoids. Elsevier, London
2. Al-Hindawi, M. K., Al-Deen, I. H., Nabi, M. H., Huang Ismail, M. A. (1989) Anti-inflammatory activity of some Iraqi plants using intact rats. J. Ethnopharmacol. 26: 163-168
3. Aquino, R., Morelli, S., Tomaino, A., Pellegrino, M., Saija, A., Grumetto, L., Puglia, C., Ventura, D., Bonina, F. (2002) Antioxidant and photoprotective activity of a crude extract of Culcitium reflexum H.B.K. leaves and their major flavonoids. J. Ethnopharmacol. 79: 183-191
4. Atta, A. H., Alkofahi, A. (1998) Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J. Ethnopharmacol. 60: 117-124
5. Ching, L. S., Mohamed, S. (2001) Alpha-tocopherol content in 62 edible tropical plants. J. Agric. Food Chem. 49: 3101-3105
6. Chu, Y.-F., Sun, J., Wu, X., Liu, R. H. (2002) Antioxidant and anti-proliferative activities of common vegetables. J. Agric. Food Chem. 50: 6910-6916
7. Comalada, M., Ballester, I., Bailon, E., Sierra, S., Xaus, J., Galvez, J., de Medina, F. S., Zarzuelo, A. (2006) Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure activity relationship. Biochem. Pharmacol. 72: 1010-1021
8. Cooks, N. C., Samman, S. (1996) Flavonoids - Chemistry, metabolism, cardioprotective effects and dietary sources. J. Nutr. Biochem. 7: 66
9. Crozier, A., Michael, E. J. L., McDonald, M. S., Black, C. (1997) Quantitative analysis of the flavonoid content of commercial tomatoes, onions, lettuce, and celery. J. Agric. Food Chem. 45: 590-595
10. Daunter, B. (1995) Butylphthalide, sedanolide, sedanenolide, and related compounds as therapeutic agents for treatment of inflammation. PCT Int. Appl. WO 9500157
11. Deng, C., Song, G., Zheng, X., Hu, Y., Zhang, X. (2003) Analysis of the volatile constituents of Apium graveolens L. and Oenanthe L. by gas chromatography - mass spectrometry, using headspace solid-phase microextraction. Chromatographia 57: 805-809
12. Galensa, R., Herrmann, K. (1979) Flavone glycosides of the leaves and tubers of celery (Apium graveolens L.). 9. Flavonols and flavones of vegetables. Zeitschrift fuer Lebensmittel-Untersuchung und -Forschung 169: 170-172
13. Gazzani, G., Papetti, A., Daglia, M., Bertè, F., Gregotti, C. (1998) Protective activity of water soluble components of some common diet vegetables on rat liver microsome and the effect of thermal treatment. J. Agric. Food Chem. 46: 4123-4127
14. 15N] nitrate in biological fluids. Anal. Biochem. 126: 131-138
15. Gryglewski, R. J., Korbut, R., Robak, J., Sueis, J. (1987) On the mechanism of antithrombotic action of flavonoid. Biochem. Pharmacol. 36: 317
16. Kim, H. K., Cheon, B. S., Kim, Y. H., Kim, S. Y., Kim, H. P. (1999) Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol. 58: 759-765
17. Horinaka, M., Yoshida, T., Shiraishi, T., Nakata, S., Wakada, M., Sakai, T. (2006) The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand. Mol. Cancer Ther. 5: 945-951
18. Lion Corp. Japan (1984) Dentifrices containing plant extracts, carvone and/or menthol. Jpn. Kokai Tokkyo Koho, JKXXAF JP 59013712
19. Middleton, E. J. R., Kandaswami, C. (1992) Effect of flavonoids on immune and inflammatory cell function. Biochem. Pharmacol. 43: 1167-1179
20. Miean, K. H., Mohamed, S. (2001) Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants. J. Agric. Food Chem. 49: 3106-3112
21. Momin, R. A., Nair, M. G. (2002) Antioxidant, cyclooxygenase and topoisomerase inhibitory compounds from Apium graveolens Linn, seeds. Phytomedicine 9: 312-318
22. Mosmann, T. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63
23. Ninfali, P., Bacchiocca, M. (2003) Polyphenols and antioxidant capacity of vegetables under fresh and frozen conditions. J. Agric. Food Chem. 51: 2222-2226
24. Picerno, P., Mencherini, T., Lauro, M. R., Barbato, F., Aquino, R. (2003) Phenolic constituents and antioxidant properties of Xanthosoma violaceum leaves. J. Agric. Food Chem. 51: 6423-6428
25. Picerno, P., Autore, G., Marzocco, S., Meloni, M., Sanogo, R., Aquino, R. (2005) Anti-inflammatory activity of Verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J. Nat. Prod. 68: 1610-1614
26. Rao, L. J. M., Nagalakshmi, S., Naik, J. P., Shankaracharya, N. B. (2000) Studies on chemical and technological aspects of celery (Apium graveolens. Linn) seed. J. Food Sci. Technol. 37: 631-635
27. Sakuma, K. (2002) Mass production of dried powders of plant leaves and their applications. Jpn. Kokai Tokkyo Koho, JKXXAF JP 2002205952
28. Totsuka, Y., Bandai, Y. (2001) Antiaging cosmetics containing plant extracts and metal ions. Jpn. Kokai Tokkyo Koho, JKXXAF JP 2001139484
29. Tubaro, A., Dri, P., Delbello, G., Zilli, G., Della Loggia, R. (1985) The croton oil test revised. Agents Actions 17: 347-349
30. Vargo, M. A., Voss, O. H., Poustka, F., Cardounel, A. J., Grotewold, E., Doseff, A. I. (2006) Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem. Pharmacol. 72: 681-692
31. Woods, J. A., Jewell, C., O'Brien, N. M. (2001) Sedanolide, a natural phthalide from celery seed oil: effect on hydrogen peroxide and tert-butyl hydroperoxide-induced toxicity in HepG2 and CaCo-2 human cell lines. In Vitro Mol. Toxicol. 14: 233-240
32. Wu, M.-C., Huang, C.-J. (2001) Inhibition of prostaglandin E2 production of a macrophage cell line by some phytochemicals. Food Sci. Agric. Chem. 3: 59-71