Aging epidermis is maintained by changes in transit-amplifying cell kinetics, not stem cell kinetics

Journal of Investigative Dermatology

Volumn 129, Issue 11, 2009, Pages 2541-2543

  Winter, Michael C ^a   Bickenbach, Jackie R ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN;

CASE REPORT; CELL; CELL AGING; CELL FUNCTION; CELL KINETICS; CELL POPULATION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CUTANEOUS PARAMETERS; EPIDERMIS; HUMAN; KERATINOCYTE; MICROENVIRONMENT; NONHUMAN; NOTE; PRIORITY JOURNAL; STEM CELL; TISSUE REGENERATION; TRANSIT AMPLIFYING CELL; WOUND HEALING IMPAIRMENT;

EID: 70350043754     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2009.236     Document Type: Note

References (18)

1. Bickenbach JR (1981) Identification and behavior of label-retaining cells in oral mucosa and skin. J Dent Res 122C:1611-1620
2. Charruyer A, Barland CO, Yu e L, Wessendorf HB, Lu Y, Lawrence HJ et al. (2009) Transit-amplifying cell frequency and cell cycle kinetics are altered in aged epidermis. J Invest Dermatol 129:2574-2583
3. Gallico GG, O'Connor NE, Compton CC, Kehinde O, Green H (1984) Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med 311:448-451
4. Ghazizadeh S, Taichman LB (2005) Organization of stem cells and their progeny in human epidermis. J Invest Dermatol 124:367-372
5. Giangreco A, Qin M, Pintar JE, Watt FW (2008) Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell 7:250-259
6. Halprin KM (1972) Epidermal turnover time-a re-examination. Br J Dermatol 86:14-19
7. Lavker RM, Sun T-T (2000) Epidermal stem cells: properties, markers, and location. Proc Natl Acad Sci USA 97:13473-13475
8. Liang L, Bickenbach JR (2002) Somatic epidermal stem cells can produce multiple cell lineages during development. Stem Cells 20:21-31
9. Liang L, Chinnathambi S, Stern M, Tomanek-Chalkley A, Manuel TD, Bickenbach JR (2004) As epidermal stem cells age they do not substantially change their characteristics. J Invest Dermatol Symp Proc 9:229-237
10. Mackenzie IC (1970) Relationship between mitosis and the ordered structure of the stratum corneum in mouse epidermis. Nature 226:653-655
11. Martin K, Kirkwood TB, Potten CS (1998) Age changes in stem cells of murine small intestinal crypts. Exp Cell Res 241:316-323
12. Muffler S, Star H-J, Amoro M, Falkowska-Hansen B, Buehning T, Marme A et al. (2008) A stable niche supports long-term maintenance of human epidermal stem cells in organotypic cultures. Stem Cells 26:2506-2515
13. Pellegrini G, Ranno R, Stracuzzi G, Bondanza S, Guerra L, Zambruno G et al. (1999) The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin. Transplantation 68:868-879
14. Potten CS (1974) The epidermal proliferative unit: the possible role of the central basal cell. Cell Tissue Kinet 7:77-88
15. Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ et al. (2005) Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 102:9194-9199
16. Schneider TE, Barland C, Alex AM, Mancianti ML, Lu Y, Cleaver JE et al. (2003) Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci USA 100:11412-11417
17. Stern MM, Bickenbach JR (2007) Epidermal stem cells are resistant to cellular aging. Aging Cell 6:439-452
18. Webb A, Kaur P (2006) Epidermal stem cells. Frontiers Biosci 11:1031-1041