-
1
-
-
26944446576
-
In vitro safety pharmacology profiling: An essential tool for drug development
-
Whitebread, S.; Hamon, J.; Bojanic, D.; Urban, L. (2005), In vitro safety pharmacology profiling: An essential tool for drug development, Drug Discov. Today 10, 1421-1433.
-
(2005)
Drug Discov. Today
, vol.10
, pp. 1421-1433
-
-
Whitebread, S.1
Hamon, J.2
Bojanic, D.3
Urban, L.4
-
2
-
-
70449461523
-
Exploratory safety pharmacology: A new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations
-
Cavero, I. (2009), Exploratory safety pharmacology: A new safety paradigm to de-risk drug candidates prior to selection for regulatory science investigations, Expert Opin. Drug Saf. 8, 627-647.
-
(2009)
Expert Opin. Drug Saf.
, vol.8
, pp. 627-647
-
-
Cavero, I.1
-
3
-
-
0037603310
-
Cilostazol: A review of its use in intermittent claudication
-
Chapman, T. M.; Goa, K L. (2003), Cilostazol: A review of its use in intermittent claudication, Am. J. Cardiovasc. Drugs 3, 117-138.
-
(2003)
Am. J. Cardiovasc. Drugs
, vol.3
, pp. 117-138
-
-
Chapman, T.M.1
Goa, K.L.2
-
4
-
-
44949226137
-
Cilostazol for peripheral arterial disease
-
Robless, P.; Mikhailidis, D. P.; Stansby, G. P. (2008), Cilostazol for peripheral arterial disease, Cochrane Diabetes Syst. Rev. 23, 1-23.
-
(2008)
Cochrane Diabetes Syst. Rev.
, vol.23
, pp. 1-23
-
-
Robless, P.1
Mikhailidis, D.P.2
Stansby, G.P.3
-
5
-
-
30444456367
-
Phosphodiesterase inhibitors
-
Boswell-Smith, V.; Spina, D.; Page, C. P. (2006), Phosphodiesterase inhibitors, Br. J. Pharmacol. 147, S252-S257.
-
(2006)
Br. J. Pharmacol.
, vol.147
-
-
Boswell-Smith, V.1
Spina, D.2
Page, C.P.3
-
6
-
-
33746156959
-
Global mapping of pharmacological space
-
Paolini, G. V.; Shapland, R. H. B.; van Hoorn, W. P.; et al. (2006), Global mapping of pharmacological space, Nature Biotechnol. 24, 805-815.
-
(2006)
Nature Biotechnol.
, vol.24
, pp. 805-815
-
-
Paolini, G.V.1
Shapland, R.H.B.2
van Hoorn, W.P.3
-
7
-
-
0043031339
-
Predicting ADME properties and side effects: The BioPrint approach
-
Krejsa, C. M. et al. (2003), Predicting ADME properties and side effects: The BioPrint approach, Curr. Opin. Drug Discov. Dev. 6, 470-480.
-
(2003)
Curr. Opin. Drug Discov. Dev.
, vol.6
, pp. 470-480
-
-
Krejsa, C.M.1
-
8
-
-
84885968343
-
Cancer and managed care in the 21st century
-
McGivney,W. T.; Mullen, J. (2005), Cancer and managed care in the 21st century, Am. J. Manage. Care S509 (Suppl. 12/1)11-13.
-
(2005)
Am. J. Manage. Care
, vol.S509
, Issue.1 SUPPL. 12
, pp. 11-13
-
-
McGivney, W.T.1
Mullen, J.2
-
9
-
-
0028131172
-
The effect of poor compliance and treatment side-effects on sample size requirements in randomized clinical trials
-
Schechtman, K. B.; Gordon, M. E. (1994), The effect of poor compliance and treatment side-effects on sample size requirements in randomized clinical trials, J. Biopharm. Stat. 4, 223-232.
-
(1994)
J. Biopharm. Stat.
, vol.4
, pp. 223-232
-
-
Schechtman, K.B.1
Gordon, M.E.2
-
10
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
Kola, I.; Landis, J. (2004), Can the pharmaceutical industry reduce attrition rates? Nature Rev. 3, 711-715.
-
(2004)
Nature Rev
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
11
-
-
35248817286
-
Modeling promiscuity based on in vitro safety pharmacology profiling data
-
Azzaoui, K. J.; Faller, B.; Whitebread, S.; Jacoby, E.; Bender, A.; Jenkins, J.; Urban, L. (2007), Modeling promiscuity based on in vitro safety pharmacology profiling data, ChemMedChem 2, 874-880.
-
(2007)
ChemMedChem
, vol.2
, pp. 874-880
-
-
Azzaoui, K.J.1
Faller, B.2
Whitebread, S.3
Jacoby, E.4
Bender, A.5
Jenkins, J.6
Urban, L.7
-
12
-
-
84927082469
-
Integrated approaches to lead optimization: Improving the therapeutic index
-
Xu, L., J. J.; Urban, eds., Cambridge Univ. Press
-
Urban, L.; Wang, J.; Bojanic, D.; Ward, S. Integrated approaches to lead optimization: Improving the therapeutic index, in Xu, J. J.; Urban, L., eds., Predictive Toxicology in Drug Safety Evaluation, Cambridge Univ. Press, 2010.
-
(2010)
Predictive Toxicology in Drug Safety Evaluation
-
-
Urban, L.1
Wang, J.2
Bojanic, D.3
Ward, S.4
-
13
-
-
84885991733
-
Integrated risk assessment
-
Faller, B.; Urban, L., eds., Wiley-VCH, Weinheim
-
Faller, B.; Urban, L., Integrated risk assessment, in Faller, B.; Urban, L., eds., Hit and Lead Profiling, Wiley-VCH, Weinheim, 2009.
-
(2009)
Hit and Lead Profiling
-
-
Faller, B.1
Urban, L.2
-
14
-
-
0041528452
-
HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery
-
Netzer, R.; Bischoff, U.; Ebneth, A. (2003), HTS techniques to investigate the potential effects of compounds on cardiac ion channels at early-stages of drug discovery, Curr. Opin. Drug Discov. Dev. 6, 462-469.
-
(2003)
Curr. Opin. Drug Discov. Dev.
, vol.6
, pp. 462-469
-
-
Netzer, R.1
Bischoff, U.2
Ebneth, A.3
-
15
-
-
65649093070
-
Mapping adverse drug reactions in chemical space
-
Scheiber, J.; Jenkins, J.; Sukuru, S. C. K.; Bender, A.; Mikhailov, D.; Milik, M.; Azzaoui, K.; Whitebread, S.; Hamon, J.; Urban, L.; Glick, M.; Davies, J.W. (2009), Mapping adverse drug reactions in chemical space, J. Med. Chem. 52, 3103-3107.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 3103-3107
-
-
Scheiber, J.1
Jenkins, J.2
Sukuru, S.C.K.3
Bender, A.4
Mikhailov, D.5
Milik, M.6
Azzaoui, K.7
Whitebread, S.8
Hamon, J.9
Urban, L.10
Glick, M.11
Davies, J.W.12
-
16
-
-
65249092595
-
A comprehensive systems biology analysis gains insight into off-target mediated effects of drug candidates
-
Scheiber, J.; Chen, B.; Milik, M.; Sukuru, S. C. K.; Bender, A.;Mikhailov,D.; Whitebread, S.;Hamon, J.; Azzaoui, K.; Urban, L.; Glick, M.; Davies, J.; Jenkins, J. (2008), A comprehensive systems biology analysis gains insight into off-target mediated effects of drug candidates, J. Chem. Inform. Model. 49, 308-317.
-
(2008)
J. Chem. Inform. Model.
, vol.49
, pp. 308-317
-
-
Scheiber, J.1
Chen, B.2
Milik, M.3
Sukuru, S.C.K.4
Bender, A.5
Mikhailov, D.6
Whitebread, S.7
Hamon, J.8
Azzaoui, K.9
Urban, L.10
Glick, M.11
Davies, J.12
Jenkins, J.13
-
17
-
-
84885974052
-
Process logistics, testing strategies and automation aspects
-
Faller, B.; Urban, L., eds., Wiley-VCH, Weinheim, 2009
-
Haas, H.; DeWitte, R. S.; Dunn-Dufault, R.; Stelzer, A. (2009), Process logistics, testing strategies and automation aspects, in Faller, B.; Urban, L., eds., Hit and Lead Profiling, Wiley-VCH, Weinheim, 2009.
-
(2009)
Hit and Lead Profiling
-
-
Haas, H.1
DeWitte, R.S.2
Dunn-Dufault, R.3
Stelzer, A.4
-
18
-
-
19444367740
-
Antimalarial drugs: QT prolongation and cardiac arrhythmias
-
Traebert, M.; Dumotier, B. (2005), Antimalarial drugs: QT prolongation and cardiac arrhythmias, Expert Opin. Drug Saf. 4, 421-431.
-
(2005)
Expert Opin. Drug Saf.
, vol.4
, pp. 421-431
-
-
Traebert, M.1
Dumotier, B.2
-
19
-
-
0037186909
-
Cardiotoxicity of new antihistamines and cisapride
-
Paakkari, I. (2002), Cardiotoxicity of new antihistamines and cisapride, Toxicol. Lett. 127, 279-284.
-
(2002)
Toxicol. Lett.
, vol.127
, pp. 279-284
-
-
Paakkari, I.1
-
20
-
-
36349007027
-
Comparative evaluation of hERG potassium channel blockade by antipsychotics
-
Silvestre, J. S.; Prous, J. R. (2007), Comparative evaluation of hERG potassium channel blockade by antipsychotics, Methods Find. Exp. Clin. Pharmacol. 29(7): 457-465.
-
(2007)
Methods Find. Exp. Clin. Pharmacol.
, vol.29
, Issue.7
, pp. 457-465
-
-
Silvestre, J.S.1
Prous, J.R.2
-
21
-
-
73449119314
-
Voltage-gated potassium channels as therapeutic targets
-
Wulff, H.; Castle, N. A.; Pardo, L. A. (2009), Voltage-gated potassium channels as therapeutic targets, Nature Rev. Drug Discov. 8, 982-1001.
-
(2009)
Nature Rev. Drug Discov.
, vol.8
, pp. 982-1001
-
-
Wulff, H.1
Castle, N.A.2
Pardo, L.A.3
-
22
-
-
11844264906
-
Role of the newer alpha-adrenergic-receptor antagonistsin [for] the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms
-
Lowe, F. C. (2004), Role of the newer alpha-adrenergic-receptor antagonistsin [for] the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms, Clin. Ther. 26, 1701-1713.
-
(2004)
Clin. Ther.
, vol.26
, pp. 1701-1713
-
-
Lowe, F.C.1
-
23
-
-
0034452038
-
α1-Adrenergic receptor regulation: Basic science and clinical implications
-
Michelotti, G. A.; Price, D. T.; Schwinn, D. A. (2000), α1-Adrenergic receptor regulation: Basic science and clinical implications, Pharmacol. Ther. 88(3), 281-309.
-
(2000)
Pharmacol. Ther.
, vol.88
, Issue.3
, pp. 281-309
-
-
Michelotti, G.A.1
Price, D.T.2
Schwinn, D.A.3
-
24
-
-
0025861680
-
High prevalence ofbenign prostatic hypertrophy in the community
-
Garraway, W. M.; Collins, G. N.; Lee, R. J. (1991), High prevalence ofbenign prostatic hypertrophy in the community, Lancet 338, 469-471.
-
(1991)
Lancet
, vol.338
, pp. 469-471
-
-
Garraway, W.M.1
Collins, G.N.2
Lee, R.J.3
-
25
-
-
0031857718
-
Controversies in the management of lower urinary tract symptoms: An overview
-
Coffey, D. S. (1998), Controversies in the management of lower urinary tract symptoms: An overview, Br. J. Urol. 81, 1-5.
-
(1998)
Br. J. Urol.
, vol.81
, pp. 1-5
-
-
Coffey, D.S.1
-
26
-
-
33749335282
-
The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease
-
Lamb, J.; Crawford, E. D.; Peck, D.; et al. (2006), The connectivity map: Using gene-expression signatures to connect small molecules, genes, and disease, Science 313,1929-1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
-
27
-
-
0036119338
-
Molecular
-
Hoyer, D.; Hannona, J. P.; Martin, G. R. (2002), Molecular, pharmacological and functional diversity of 5-HT receptors, Pharmacol. Biochem. Behav. 71, 533-554.
-
(2002)
Pharmacological and functional diversity of 5-HT receptors, Pharmacol. Biochem. Behav.
, vol.71
, pp. 533-554
-
-
Hoyer, D.1
Hannona, J.P.2
Martin, G.R.3
-
28
-
-
52949140574
-
5-HT1A receptor, an old target for new therapeutic agents
-
Lacivita, E.; Leopoldo, M.; Berardi, F.; Perrone, R. (2008), 5-HT1A receptor, an old target for new therapeutic agents, Curr. Top. Med. Chem. 8, 1024-1034.
-
(2008)
Curr. Top. Med. Chem.
, vol.8
, pp. 1024-1034
-
-
Lacivita, E.1
Leopoldo, M.2
Berardi, F.3
Perrone, R.4
-
29
-
-
54449095352
-
Drug-induced serotonin syndrome: A review
-
Sun-Edelstein, C. et al. (2008), Drug-induced serotonin syndrome: A review, Expert Opin. Drug Saf. 7, 587-596.
-
(2008)
Expert Opin. Drug Saf.
, vol.7
, pp. 587-596
-
-
Sun-Edelstein, C.1
-
30
-
-
70349310091
-
Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment
-
Huang, X. P.; Setola, V.; Yadav, P. N. et al. (2009), Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment, Mol. Pharmacol. 76, 710-722.
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 710-722
-
-
Huang, X.P.1
Setola, V.2
Yadav, P.N.3
-
31
-
-
33845986031
-
Dopamine agonists and the risk of cardiac-valve regurgitation
-
Schade, R.; Andersohn, F.; Suissa, S.; Haverkamp, W.; Garbe, E. (2007), Dopamine agonists and the risk of cardiac-valve regurgitation, New Engl. J. Med. 356, 29-38.
-
(2007)
New Engl. J. Med.
, vol.356
, pp. 29-38
-
-
Schade, R.1
Andersohn, F.2
Suissa, S.3
Haverkamp, W.4
Garbe, E.5
-
32
-
-
41549098689
-
Serotonin receptor modulators in the treatment of irritable bowel syndrome
-
Fayyaz, M.; Lackner, J. M. (2008), Serotonin receptor modulators in the treatment of irritable bowel syndrome, Ther. Clin. Risk Manage. 4, 41-48.
-
(2008)
Ther. Clin. Risk Manage.
, vol.4
, pp. 41-48
-
-
Fayyaz, M.1
Lackner, J.M.2
-
33
-
-
84886083462
-
Prediction of adverse drug reactions and off-target effects from chemical structure based on pharmacology data
-
Bender, A.; Jenkins, J. L.; Glick, M.; Davies, J. W.; Azzaoui, K.; Hamon, J.; Fekete, A.; Urban, L.; Whitebread, S. (2007), Prediction of adverse drug reactions and off-target effects from chemical structure based on pharmacology data, ChemMedChem. 2, 1-15.
-
(2007)
ChemMedChem.
, vol.2
, pp. 1-15
-
-
Bender, A.1
Jenkins, J.L.2
Glick, M.3
Davies, J.W.4
Azzaoui, K.5
Hamon, J.6
Fekete, A.7
Urban, L.8
Whitebread, S.9
-
34
-
-
42949150113
-
High-throughput kinase profiling as a platform for drug discovery
-
Goldstein, D. M. et al. (2008), High-throughput kinase profiling as a platform for drug discovery, Nature Rev. Drug Discov. 7, 391-397.
-
(2008)
Nature Rev. Drug Discov.
, vol.7
, pp. 391-397
-
-
Goldstein, D.M.1
-
35
-
-
4644266613
-
The role of the vanilloid receptor (TRPV1) in physiology and pathology
-
Nagy, I.; Santha, P.; Jancso, G.; Urban, L. (2004), The role of the vanilloid receptor (TRPV1) in physiology and pathology, Eur. J. Pharmacol. 500, 351-369.
-
(2004)
Eur. J. Pharmacol.
, vol.500
, pp. 351-369
-
-
Nagy, I.1
Santha, P.2
Jancso, G.3
Urban, L.4
-
36
-
-
34250378330
-
MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts
-
Luo, X. J.; Lin, X.; Zhang, H.; et al. (2007), MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts, J. Biol. Chem. 282, 12363-12367.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 12363-12367
-
-
Luo, X.J.1
Lin, X.2
Zhang, H.3
-
37
-
-
85047683939
-
Maximizing the use of in vitro ADMET tools to predict in vivo bioavailability and safety
-
Wang, J.; Urban, L.; Bojanic, D. (2007), Maximizing the use of in vitro ADMET tools to predict in vivo bioavailability and safety, Expert Opin. Drug Discov. 3, 641-665.
-
(2007)
Expert Opin. Drug Discov.
, vol.3
, pp. 641-665
-
-
Wang, J.1
Urban, L.2
Bojanic, D.3
-
38
-
-
33845479693
-
High-throughput in-vitro profiling assays: How useful for decision making?
-
Faller, B.;Wang, J.; Zimmerlin, A.; et al. (2006), High-throughput in-vitro profiling assays: How useful for decision making? Expert Opin. Drug Metab. Toxicol. 2, 823-833.
-
(2006)
Expert Opin. Drug Metab. Toxicol.
, vol.2
, pp. 823-833
-
-
Faller, B.1
Wang, J.2
Zimmerlin, A.3
-
39
-
-
77953409482
-
Prospective in in vitro safety pharmacology profiling: What else beyond hERG?
-
Hamon, J.; Whitebread, S.; Techer-Etienne, V.; et al. (2009), Prospective in in vitro safety pharmacology profiling: What else beyond hERG? Future Med. Chem. 1, 1-21.
-
(2009)
Future Med. Chem.
, vol.1
, pp. 1-21
-
-
Hamon, J.1
Whitebread, S.2
Techer-Etienne, V.3
-
40
-
-
33745381593
-
An empirical process for the design of high-throughput screening deck filters
-
Pearce, B. C.; Sofia, M. J.; Good, A. C.; Drexler, D. M.; Stock, D. A. (2006), An empirical process for the design of high-throughput screening deck filters, J. Chem. Inform. Model. 46, 1060-1068.
-
(2006)
J. Chem. Inform. Model.
, vol.46
, pp. 1060-1068
-
-
Pearce, B.C.1
Sofia, M.J.2
Good, A.C.3
Drexler, D.M.4
Stock, D.A.5
-
41
-
-
4644271084
-
Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
-
Roth, B. L.; Sheffler, D. J.; Kroeze, W. K. (2004), Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia, Nature Rev. Drug Discov. 3, 353-359.
-
(2004)
Nature Rev. Drug Discov.
, vol.3
, pp. 353-359
-
-
Roth, B.L.1
Sheffler, D.J.2
Kroeze, W.K.3
-
42
-
-
33746088604
-
In vitro safety pharmacology profiling
-
Hamon, J.; Azzaoui, K.; Whitebread, S.; et al. (2006), In vitro safety pharmacology profiling, Eur. Pharm. Rev. 1, 60-63.
-
(2006)
Eur. Pharm. Rev.
, vol.1
, pp. 60-63
-
-
Hamon, J.1
Azzaoui, K.2
Whitebread, S.3
-
43
-
-
49849094738
-
Physiochemical drug properties associated with in vivo toxicological outcomes
-
Hughes, J. D.; Blagg, J.; Price, D. A.; et al. (2008), Physiochemical drug properties associated with in vivo toxicological outcomes, Bioorg. Med. Chem. Lett. 18, 4872-4875.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, pp. 4872-4875
-
-
Hughes, J.D.1
Blagg, J.2
Price, D.A.3
-
44
-
-
35748934487
-
The influence of drug-like concepts on decisionmaking in medicinal chemistry
-
Leeson, P. D.; Springthorpe, B. (2007), The influence of drug-like concepts on decisionmaking in medicinal chemistry, Nature Rev. Drug Discov. 6, 881-890.
-
(2007)
Nature Rev. Drug Discov.
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
45
-
-
65549132575
-
Pharmacological promiscuity: Dependence on compound properties and target specificity in a set of recent Roche compounds
-
Peters, J.-U.; Schnider, P.; Mattei, P.; Kansy, M. (2009), Pharmacological promiscuity: Dependence on compound properties and target specificity in a set of recent Roche compounds, ChemMedChem 4, 680-686.
-
(2009)
ChemMedChem
, vol.4
, pp. 680-686
-
-
Peters, J.-U.1
Schnider, P.2
Mattei, P.3
Kansy, M.4
-
46
-
-
0037061628
-
Acommon mechanism underlying promiscuous inhibitors from virtual and high-throughput screening
-
McGovern, S. L.; Caselli, E.; Grigorieff, N.; Shoichet, B. K. (2002),Acommon mechanism underlying promiscuous inhibitors from virtual and high-throughput screening, J. Med. Chem. 45, 1712-1722.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
47
-
-
0043031339
-
Predicting ADME properties and side effects: The BioPrint approach
-
Krejsa, C. M.; Horvath, D.; Rogalski, S. L.; Penzotti, J. E.; et al. (2003), Predicting ADME properties and side effects: The BioPrint approach, Curr. Opin. Drug Discov. Dev. 6, 470-480.
-
(2003)
Curr. Opin. Drug Discov. Dev.
, vol.6
, pp. 470-480
-
-
Krejsa, C.M.1
Horvath, D.2
Rogalski, S.L.3
Penzotti, J.E.4
-
48
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology
-
Redfern, W. S.; Carlsson, L.; Davis, A. S.; Lynch, W. G.; et al. (2003), Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development, Cardiovasc. Res. 58, 32-45.
-
(2003)
Clinical QT interval prolongation and torsade de pointes for a broad range of drugs: Evidence for a provisional safety margin in drug development, Cardiovasc. Res.
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
-
49
-
-
77953422573
-
Use of broad biological profiling as a relevant descriptor to describe and differentiate compounds: Structure-in vitro (pharmacology-ADME)-in Vivo (safety) relationships
-
Vaz, R. J.; Klabunde, T., eds., Weinheim
-
Mason, J. S.; Migeon, J.; Dupuis, P.; Otto-Bruc, A., Use of broad biological profiling as a relevant descriptor to describe and differentiate compounds: Structure-in vitro (pharmacology-ADME)-in Vivo (safety) relationships, in Vaz, R. J.; Klabunde, T., eds., Antitargets: Prediction and Prevention of Drug Side EffectsWiley-VCH,Weinheim, 2008, pp. 23-52.
-
(2008)
Antitargets: Prediction and Prevention of Drug Side Effects Wiley-VCH
, pp. 23-52
-
-
Mason, J.S.1
Migeon, J.2
Dupuis, P.3
Otto-Bruc, A.4
-
50
-
-
85018193727
-
In vitro safety pharmacology profiling: An important tool to decrease attrition
-
Faller, B.; Urban, L., eds., Weinheim
-
Hamon, J.; Whitebread, S., In vitro safety pharmacology profiling: An important tool to decrease attrition, in Faller, B.; Urban, L., eds., Hit and Lead Profiling Wiley-VCH, Weinheim, 2009, pp. 273-295.
-
(2009)
Hit and Lead Profiling Wiley-VCH
, pp. 273-295
-
-
Hamon, J.1
Whitebread, S.2
-
51
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman, M. W.; Herrgard, S.; Treiber, D. K.; et al. (2008), A quantitative analysis of kinase inhibitor selectivity, Nature Biotechnol. 26 (1), 127-132.
-
(2008)
Nature Biotechnol.
, vol.26
, Issue.1
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
-
52
-
-
70449634957
-
Predicting new molecular targets forknown drugs
-
Keiser,M. J.; Setola, V.; Irwin, J. J.; Laggner, C.; Abbas, A. I.; et al. (2009), Predicting new molecular targets forknown drugs, Nature 462, 175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
-
53
-
-
33745391215
-
Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases
-
Glick, M.; Davies, J. W.; Jenkins, J. L. (2006), Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases, J. Chem. Inform. Model. 46, 1124-1133.
-
(2006)
J. Chem. Inform. Model.
, vol.46
, pp. 1124-1133
-
-
Glick, M.1
Davies, J.W.2
Jenkins, J.L.3
-
54
-
-
33846876695
-
Relating protein pharmacology by ligand chemistry
-
Keiser, M. J.; Roth, B. L.; Armbruster, B. N.; Ernsberger, P.; Irwin, J. J.; Shoichet, B. K. (2007), Relating protein pharmacology by ligand chemistry, Nature Biotechnol. 25, 197-206.
-
(2007)
Nature Biotechnol.
, vol.25
, pp. 197-206
-
-
Keiser, M.J.1
Roth, B.L.2
Armbruster, B.N.3
Ernsberger, P.4
Irwin, J.J.5
Shoichet, B.K.6
-
55
-
-
72949116422
-
Fragment-based prediction of the clinical occurrence of long QT syndrome and torsade de pointes
-
Clark, M.;Wiseman, J. S. (2009), Fragment-based prediction of the clinical occurrence of long QT syndrome and torsade de pointes, J. Chem. Inform. Model. 49, 2617-2626.
-
(2009)
J. Chem. Inform. Model.
, vol.49
, pp. 2617-2626
-
-
Clark, M.1
Wiseman, J.S.2
-
56
-
-
47249146126
-
Drug target identification using side-effect similarity
-
Campillos, M.; Kuhn, M.; Gavin, A. C.; Jensen, L. J.; Bork, P. (2008), Drug target identification using side-effect similarity, Science 321, 263-266.
-
(2008)
Science
, vol.321
, pp. 263-266
-
-
Campillos, M.1
Kuhn, M.2
Gavin, A.C.3
Jensen, L.J.4
Bork, P.5
-
57
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser,M. J.; Setola, V.; Irwin, J. J.; Laggner, C.; Abbas, A. I.; Hufeisen, S. J.; et al. (2009), Predicting new molecular targets for known drugs, Nature 462, 175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
-
58
-
-
74549126594
-
Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
-
Rihel, J.; Prober, D. A.; Arvanites, A.; Lam, K.; Zimmerman, S.; et al. (2010), Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation, Science 327, 348-351.
-
(2010)
Science
, vol.327
, pp. 348-351
-
-
Rihel, J.1
Prober, D.A.2
Arvanites, A.3
Lam, K.4
Zimmerman, S.5
-
59
-
-
77249135113
-
Rapid behavior-based identification of neuroactive small molecules in the zebrafish
-
Kokel, D.; Bryan, J.; Laggner, C.; White, R.; Cheung, C.Y.; Mateus, R.; et al. (2010), Rapid behavior-based identification of neuroactive small molecules in the zebrafish, Nature Chem. Biol. 6, 231-237.
-
(2010)
Nature Chem. Biol.
, vol.6
, pp. 231-237
-
-
Kokel, D.1
Bryan, J.2
Laggner, C.3
White, R.4
Cheung, C.Y.5
Mateus, R.6
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