-
1
-
-
0027933948
-
Status of safety pharmacology in the pharmaceutical industry, 1993
-
Kinter, L.B., Gossett, K.A. and Kerns,W.D. (1993) Status of safety pharmacology in the pharmaceutical industry, 1993. Drug Development Research, 32. (4), 208-216.
-
(1993)
Drug Development Research
, vol.32
, Issue.4
, pp. 208-216
-
-
Kinter, L.B.1
Gossett, K.A.2
Kerns, W.D.3
-
2
-
-
0029113895
-
Safety pharmacology program for pharmaceuticals
-
Kinter, L.D. and Dixon, L.W. (1995) Safety pharmacology program for pharmaceuticals. Drug Development Research, 35. (3), 179-182.
-
(1995)
Drug Development Research
, vol.35
, Issue.3
, pp. 179-182
-
-
Kinter, L.D.1
Dixon, L.W.2
-
3
-
-
0029080005
-
Status of safety pharmacology in the pharmaceutical industry-1995
-
Sullivan, A.T. and Kinter, L.B. (1995) Status of safety pharmacology in the pharmaceutical industry-1995. Drug Development Research, 35. (3), 166-172.
-
(1995)
Drug Development Research
, vol.35
, Issue.3
, pp. 166-172
-
-
Sullivan, A.T.1
Kinter, L.B.2
-
4
-
-
0025597019
-
The role of pharmacology profiling in safety assessment
-
Williams, P.D. (1990) The role of pharmacology profiling in safety assessment. Regulatory Toxicology and Pharmacology, 12. (3), 238-252.
-
(1990)
Regulatory Toxicology and Pharmacology
, vol.12
, Issue.3
, pp. 238-252
-
-
Williams, P.D.1
-
6
-
-
26944446576
-
In vitro safety pharmacology profiling: an essential tool for successful drug development
-
Whitebread, S., Hamon, J., Bojanic, D. and Urban, L. (2005) In vitro safety pharmacology profiling: an essential tool for successful drug development. Drug Discovery Today, 10. (21), 1421-1433.
-
(2005)
Drug Discovery Today
, vol.10
, Issue.21
, pp. 1421-1433
-
-
Whitebread, S.1
Hamon, J.2
Bojanic, D.3
Urban, L.4
-
8
-
-
0036422569
-
The application of in vitro methods to safety pharmacology
-
Wakefield, I.D., Pollard, C., Redfern,W.S., Hammond, T.G. and Valentin, J.P. (2002) The application of in vitro methods to safety pharmacology. Fundamental and Clinical Pharmacology, 16, 209-218.
-
(2002)
Fundamental and Clinical Pharmacology
, vol.16
, pp. 209-218
-
-
Wakefield, I.D.1
Pollard, C.2
Redfern, W.S.3
Hammond, T.G.4
Valentin, J.P.5
-
10
-
-
24944547571
-
Why drugs fail -A study on side effects in new chemical entities
-
Schuster, D., Laggner, C. and Langer, T. (2005) Why drugs fail -A study on side effects in new chemical entities. Current Pharmaceutical Design, 11, 3545-3559.
-
(2005)
Current Pharmaceutical Design
, vol.11
, pp. 3545-3559
-
-
Schuster, D.1
Laggner, C.2
Langer, T.3
-
11
-
-
0344643494
-
A mechanism for rapacuronium-induced bronchospasm: M2
-
Jooste, E., Klafter, F., Hirshman, C.A. and Emala, C.W. (2003) A mechanism for rapacuronium-induced bronchospasm: M2. muscarinic receptor antagonism. Anesthesiology, 98. (4), 906-911.
-
(2003)
muscarinic receptor antagonism. Anesthesiology
, vol.98
, Issue.4
, pp. 906-911
-
-
Jooste, E.1
Klafter, F.2
Hirshman, C.A.3
Emala, C.W.4
-
12
-
-
12344326762
-
PCP: from pharmacology to modelling schizophrenia
-
Morris, B.J., Cochran, S.M. and Pratt, J.A. (2005) PCP: from pharmacology to modelling schizophrenia. Current Opinion in Pharmacology, 5. (1), 101-106.
-
(2005)
Current Opinion in Pharmacology
, vol.5
, Issue.1
, pp. 101-106
-
-
Morris, B.J.1
Cochran, S.M.2
Pratt, J.A.3
-
13
-
-
33748549016
-
3-[5-(4,5-dihydro-1Himidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor
-
Gentili, F., Pizzinat, N., Ordener, C., Marchal-Victorion, S., Maurel, A., Hofmann, R., Renard, P., Delagrange, P. et al. (2006) 3-[5-(4,5-dihydro-1Himidazol-2-yl)-furan-2-yl]phenylamine (Amifuraline), a promising reversible and selective peripheral MAO-A inhibitor. Journal of Medicinal Chemistry, 49, 5578-5586.
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, pp. 5578-5586
-
-
Gentili, F.1
Pizzinat, N.2
Ordener, C.3
Marchal-Victorion, S.4
Maurel, A.5
Hofmann, R.6
Renard, P.7
Delagrange, P.8
-
14
-
-
0028817865
-
Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B
-
McKenzie, R., Fried, M.W., Sallie, R., Conjeevaram, H., Di Bisceglie, A.M., Park, Y., Savarese, B., Kleiner, D. et al. (1995) Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B. New England Journal of Medicine, 333, 1099-1105.
-
(1995)
New England Journal of Medicine
, vol.333
, pp. 1099-1105
-
-
Mc Kenzie, R.1
Fried, M.W.2
Sallie, R.3
Conjeevaram, H.4
Di Bisceglie, A.M.5
Park, Y.6
Savarese, B.7
Kleiner, D.8
-
15
-
-
33745198904
-
Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1
-
Lee, E.-W., Lai, Y., Zhang, H. and Unadkat, J.D. (2006) Identification of the mitochondrial targeting signal of the human equilibrative nucleoside transporter 1. (hENT1): Implications for interspecies differences in mitochondrial toxicity of fialuridine. The Journal of Biological Chemistry, 281. (24), 16700-16706.
-
(2006)
(hENT1): Implications for interspecies differences in mitochondrial toxicity of fialuridine. The Journal of Biological Chemistry
, vol.281
, Issue.24
, pp. 16700-16706
-
-
Lee, E.-W.1
Lai, Y.2
Zhang, H.3
Unadkat, J.D.4
-
16
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates? Nature Reviews
-
Kola, I. and Landis, J. (2004) Can the pharmaceutical industry reduce attrition rates? Nature Reviews. Drug Discovery, 3, 711-715.
-
(2004)
Drug Discovery
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
17
-
-
0036570099
-
Timing of new black box warnings and withdrawals for prescription medications
-
Lasser, K.E., Allen, P.D.,Woolhandler, S.J., Himmelstein, D.U., Wolfe, S.M. and Bor, D.H. (2002) Timing of new black box warnings and withdrawals for prescription medications. JAMA -Journal of the American Medical Association, 287. (17), 2215-2220.
-
(2002)
JAMA -Journal of the American Medical Association
, vol.287
, Issue.17
, pp. 2215-2220
-
-
Lasser, K.E.1
Allen, P.D.2
Woolhandler, S.J.3
Himmelstein, D.U.4
Wolfe, S.M.5
Bor, D.H.6
-
18
-
-
0032522873
-
Incidence of adverse drug reactions in hospitalized patients
-
Lazarou, J., Pomeranz, B.H. and Corey, P.N. (1998) Incidence of adverse drug reactions in hospitalized patients. JAMA -Journal of the AmericanMedical Association, 279, 1200-1205.
-
(1998)
JAMA -Journal of the AmericanMedical Association
, vol.279
, pp. 1200-1205
-
-
Lazarou, J.1
Pomeranz, B.H.2
Corey, P.N.3
-
19
-
-
39049161143
-
FDA drug approvals: a year of flux
-
Hughes, B. (2008) FDA drug approvals: a year of flux. Nature Reviews. Drug Discovery, 7. (2), 107-109, http://dx.doi.org/ 10.1038/nrd2514.
-
(2008)
Nature Reviews. Drug Discovery
, vol.7
, Issue.2
, pp. 107-109
-
-
Hughes, B.1
-
20
-
-
0036417847
-
Safety pharmacology -a progressive approach
-
Redfern, W.S., Wakefield, I.D., Prior, H., Pollard, C.E., Hammond, T.G. and Valentin, J.-P. (2002) Safety pharmacology -a progressive approach. Fundamental and Clinical Pharmacology, 16, 161-173.
-
(2002)
Fundamental and Clinical Pharmacology
, vol.16
, pp. 161-173
-
-
Redfern, W.S.1
Wakefield, I.D.2
Prior, H.3
Pollard, C.E.4
Hammond, T.G.5
Valentin, J.-P.6
-
22
-
-
0033066150
-
Teratogenic effects of the endothelin receptor antagonist L-753,037
-
Spence, S., Anderson, C., Cukierski, M. and Patrick, D. (1999) Teratogenic effects of the endothelin receptor antagonist L-753,037. in the rat. Reproductive Toxicology, 13. (12), 15-29.
-
(1999)
in the rat. Reproductive Toxicology
, vol.13
, Issue.12
, pp. 15-29
-
-
Spence, S.1
Anderson, C.2
Cukierski, M.3
Patrick, D.4
-
23
-
-
45549091674
-
Retinoic acid in development: Towards an integrated view
-
Niederreither, K. and Dolle, P. (2008) Retinoic acid in development: Towards an integrated view. Nature Reviews. Genetics, 9, 541-553.
-
(2008)
Nature Reviews. Genetics
, vol.9
, pp. 541-553
-
-
Niederreither, K.1
Dolle, P.2
-
24
-
-
38549151817
-
DrugBank: a knowledgebase for drugs, drug actions and drug targets
-
Wishart, D.S., Knox, C., Guo, A.C., Cheng, D., Shrivastava, S., Tzur, D., Gautam, B. and Hassanali, M. (2008) DrugBank: a knowledgebase for drugs, drug actions and drug targets.NucleicAcids Research, 36, D901-D906.
-
(2008)
NucleicAcids Research
, vol.36
, pp. D901-D906
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastava, S.5
Tzur, D.6
Gautam, B.7
Hassanali, M.8
-
25
-
-
85018575862
-
Consolidated list of products whose consumption and/or sale have been banned withdrawn, severely restricted or not approved by governments
-
United Nations (2005) Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments. 12th issue. UN Office for Economic and Social Council Support and Coordination, pp. 595.
-
(2005)
UN Office for Economic and Social Council Support and Coordination
, pp. 595
-
-
-
26
-
-
0037082324
-
Target validation of G-protein coupled receptors
-
Wise, A., Gearing, K. and Rees, S. (2002) Target validation of G-protein coupled receptors. Drug Discovery Today, 7. (4), 235-246.
-
(2002)
Drug Discovery Today
, vol.7
, Issue.4
, pp. 235-246
-
-
Wise, A.1
Gearing, K.2
Rees, S.3
-
27
-
-
33749854572
-
High-throughput screening: update on practices and success
-
Fox, S., Farr-Jones, S., Sopchak, L., Boggs, A., Nicely, H.W., Khoury, R. and Biros, M. (2006) High-throughput screening: update on practices and success. Journal of Biomolecular Screening, 11. (7), 864-869.
-
(2006)
Journal of Biomolecular Screening
, vol.11
, Issue.7
, pp. 864-869
-
-
Fox, S.1
Farr-Jones, S.2
Sopchak, L.3
Boggs, A.4
Nicely, H.W.5
Khoury, R.6
Biros, M.7
-
28
-
-
0043031339
-
Predicting ADME properties and side effects: The BioPrint approach
-
Krejsa, C.M., Horvath, D., Rogalski, S.L., Penzotti, J.E., Mao, B., Barbosa, F. and Migeon, J.C. (2003) Predicting ADME properties and side effects: The BioPrint approach. Current Opinion in Drug Discovery and Development, 6. (4), 470-480.
-
(2003)
Current Opinion in Drug Discovery and Development
, vol.6
, Issue.4
, pp. 470-480
-
-
Krejsa, C.M.1
Horvath, D.2
Rogalski, S.L.3
Penzotti, J.E.4
Mao, B.5
Barbosa, F.6
Migeon, J.C.7
-
29
-
-
0037015067
-
Salvinorin A: A potent naturally occurring nonnitrogenous k opioid selective agonist
-
Roth, B.L., Baner, K., Westkaemper, R., Siebert, D., Rice, K.C., Steinberg, S., Ernsberger, P. and Rothman, R.B. (2002) Salvinorin A: A potent naturally occurring nonnitrogenous k opioid selective agonist. Proceedings of the National Academy of Sciences of the United States of America, 99, 11934-11939.
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 11934-11939
-
-
Roth, B.L.1
Baner, K.2
Westkaemper, R.3
Siebert, D.4
Rice, K.C.5
Steinberg, S.6
Ernsberger, P.7
Rothman, R.B.8
-
30
-
-
8844269161
-
The Human Polyomavirus, JCV Uses Serotonin Receptors to Infect Cells
-
Elphick, G.F., Querbes, W., Jordan, J.A., Gee, G.V., Eash, S.,Manley, K., Dugan, A., Stanifer, M. et al. (2004) The Human Polyomavirus, JCV Uses Serotonin Receptors to Infect Cells. Science, 306, 380-1383.
-
(2004)
Science
, vol.306
, pp. 380-1383
-
-
Elphick, G.F.1
Querbes, W.2
Jordan, J.A.3
Gee, G.V.4
Eash, S.5
Manley, K.6
Dugan, A.7
Stanifer, M.8
-
32
-
-
35148838537
-
Drug-target network
-
Yildirim, M.A., Goh, K.-I., Cusick, M.E., Barabasi, A.-L. and Vidal, M. (2007) Drug-target network. Nature Biotechnology, 25, 1119-1126.
-
(2007)
Nature Biotechnology
, vol.25
, pp. 1119-1126
-
-
Yildirim, M.A.1
Goh, K.-I.2
Cusick, M.E.3
Barabasi, A.-L.4
Vidal, M.5
-
33
-
-
33746156959
-
Global mapping of pharmacological space
-
Paolini, G.V., Shapland, R.H.B., Van Hoorn, W.P., Mason, J.S. and Hopkins, A.L. (2006) Global mapping of pharmacological space. Nature Biotechnology, 24, 805-815.
-
(2006)
Nature Biotechnology
, vol.24
, pp. 805-815
-
-
Paolini, G.V.1
Shapland, R.H.B.2
Van Hoorn, W.P.3
Mason, J.S.4
Hopkins, A.L.5
-
35
-
-
4644271084
-
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
-
Roth, B.L., Sheffler, D.J. and Kroeze, W.K. (2004) Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Reviews. Drug Discovery, 3, 353-359.
-
(2004)
Nature Reviews. Drug Discovery
, vol.3
, pp. 353-359
-
-
Roth, B.L.1
Sheffler, D.J.2
Kroeze, W.K.3
-
36
-
-
33846076665
-
The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and M30
-
Youdim, M.B.H. (2006) The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and M30. Current Alzheimer Research, 3, 541-550.
-
(2006)
Current Alzheimer Research
, vol.3
, pp. 541-550
-
-
Youdim, M.B.H.1
-
37
-
-
14244255403
-
The promiscuous drug concept? with applications to Alzheimers disease
-
Stephenson, V.C., Heydingb, R.A. and Weaver, D.F. (2005) The promiscuous drug concept? with applications to Alzheimers disease. FEBS letters, 579. (6), 1338-1342.
-
(2005)
FEBS letters
, vol.579
, Issue.6
, pp. 1338-1342
-
-
Stephenson, V.C.1
Heydingb, R.A.2
Weaver, D.F.3
-
38
-
-
3242802116
-
Promiscuous? anticancer drugs that hit multiple targets may thwart resistance
-
Hampton, T. (2004) Promiscuous? anticancer drugs that hit multiple targets may thwart resistance. The Journal of the American Medical Association, 292. (4), 419-422.
-
(2004)
The Journal of the American Medical Association
, vol.292
, Issue.4
, pp. 419-422
-
-
Hampton, T.1
-
39
-
-
44349132828
-
Antipsychotic therapy and short-term serious events in older adults with dementia
-
Rochon, P.A., Normand, S.-L., Gomes, T., Gill, S.S., Anderson, G.M., Melo, M., Sykora, K., Lipscombe, L., et al. (2008) Antipsychotic therapy and short-term serious events in older adults with dementia. Archives of Internal Medicine, 168. (10), 1090-1096.
-
(2008)
Archives of Internal Medicine
, vol.168
, Issue.10
, pp. 1090-1096
-
-
Rochon, P.A.1
Normand, S.-L.2
Gomes, T.3
Gill, S.S.4
Anderson, G.M.5
Melo, M.6
Sykora, K.7
Lipscombe, L.8
-
40
-
-
77953375253
-
Broad-scale in vitro pharmacology profiling to predict clinical adverse effects
-
Whitebread, S., Hamon, J., Scheiber, J., Fekete, A., Azzaoui, K., Mikhailov, D., Lu, Q. and Urban, L. (2008) Broad-scale in vitro pharmacology profiling to predict clinical adverse effects. American Drug Discovery, 3. (2), 32-38.
-
(2008)
American Drug Discovery
, vol.3
, Issue.2
, pp. 32-38
-
-
Whitebread, S.1
Hamon, J.2
Scheiber, J.3
Fekete, A.4
Azzaoui, K.5
Mikhailov, D.6
Lu, Q.7
Urban, L.8
-
41
-
-
32344446028
-
Can we rationally design promiscuous drugs?
-
Hopkins, A.L.,Mason, J.S. and Overington, J.P. (2006) Can we rationally design promiscuous drugs? Current Opinion in Structural Biology, 16. (1), 127-136.
-
(2006)
Current Opinion in Structural Biology
, vol.16
, Issue.1
, pp. 127-136
-
-
Hopkins, A.L.1
Mason, J.S.2
Overington, J.P.3
-
42
-
-
41649105837
-
Kinase-likeness and Kinase-Privileged Fragments: Toward Virtual Polypharmacology
-
Aronov, A.M., McClain, B., Moody, C.S. and Murcko, M.A. (2008) Kinase-likeness and Kinase-Privileged Fragments: Toward Virtual Polypharmacology. Journal of Medicinal Chemistry, 51, 1214-1222.
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, pp. 1214-1222
-
-
Aronov, A.M.1
Mc Clain, B.2
Moody, C.S.3
Murcko, M.A.4
-
43
-
-
42949142178
-
Pyridylphenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
-
Whitlock, G.A., Fish, P.V., Fray, M.J., Stobie, A. andWakenhut, F. (2008) Pyridylphenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity. Bioorganic and Medicinal Chemistry Letters, 18, 2896-2899.
-
(2008)
Bioorganic and Medicinal Chemistry Letters
, vol.18
, pp. 2896-2899
-
-
Whitlock, G.A.1
Fish, P.V.2
Fray, M.J.3
Stobie A.andWakenhut, F.4
-
44
-
-
0029548199
-
Combination therapy on murine arthritis -Salazosulfapyridine, bucillamine, and methotrexate
-
Abe, C., Kikukawa, T. and Komatsu, Y. (1995) Combination therapy on murine arthritis -Salazosulfapyridine, bucillamine, and methotrexate. International Journal of Immunotherapy, 11, 129-132.
-
(1995)
International Journal of Immunotherapy
, vol.11
, pp. 129-132
-
-
Abe, C.1
Kikukawa, T.2
Komatsu, Y.3
-
45
-
-
0036732005
-
Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator
-
Burcoglu-O?Ral, A., Erkan, D. and Asherson, R. (2002) Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator. Journal of Rheumatology, 29, 2006-2011.
-
(2002)
Journal of Rheumatology
, vol.29
, pp. 2006-2011
-
-
Burcoglu-Oral, A.1
Erkan, D.2
Asherson, R.3
-
46
-
-
33746088604
-
In vitro safety pharmacology profiling
-
Hamon, J., Azzaoui, K., Whitebread, S., Urban, L., Jacoby, E. and Faller, B. (2006) In vitro safety pharmacology profiling. European Pharmaceutical Review, 2006. (1), 60-63.
-
(2006)
European Pharmaceutical Review
, vol.2006
, Issue.1
, pp. 60-63
-
-
Hamon, J.1
Azzaoui, K.2
Whitebread, S.3
Urban, L.4
Jacoby, E.5
Faller, B.6
-
47
-
-
35248817286
-
Modeling promiscuity based on in vitro safety pharmacology profiling data
-
Azzaoui, K., Hamon, J., Faller, B., Whitebread, S., Jacoby, E., Bender, A., Jenkins, J.L. and Urban, L. (2007) Modeling promiscuity based on in vitro safety pharmacology profiling data. ChemMedChem, 2, 874-880.
-
(2007)
ChemMedChem
, vol.2
, pp. 874-880
-
-
Azzaoui, K.1
Hamon, J.2
Faller, B.3
Whitebread, S.4
Jacoby, E.5
Bender, A.6
Jenkins, J.L.7
Urban, L.8
-
48
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
Leeson, P.D. and Springthorpe, B. (2007) The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Reviews. Drug Discovery, 6, 881-890.
-
(2007)
Nature Reviews. Drug Discovery
, vol.6
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
49
-
-
35748961114
-
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges
-
Wilke, R.A., Lin, W., Roden, D.M., Watkins, P.B., Flockhart, D., Zineh, I., Giacomini, K.M. and Krauss, R.M. (2007) Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nature Reviews. Drug Discovery, 6, 904-916.
-
(2007)
Nature Reviews. Drug Discovery
, vol.6
, pp. 904-916
-
-
Wilke, R.A.1
Lin, W.2
Roden, D.M.3
Watkins, P.B.4
Flockhart, D.5
Zineh, I.6
Giacomini, K.M.7
Krauss, R.M.8
-
50
-
-
0344492207
-
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
-
Redfern, W.S., Carlsson, L., Davis, A.S., Lynch,W.G.,MacKenzie, I., Palethorpe, S., Siegl, P.K.S., Strang, I. et al. (2003) Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovascular Research, 58, 32-45.
-
(2003)
Cardiovascular Research
, vol.58
, pp. 32-45
-
-
Redfern, W.S.1
Carlsson, L.2
Davis, A.S.3
Lynch, W.G.4
MacKenzie, I.5
Palethorpe, S.6
Siegl, P.K.S.7
Strang, I.8
-
51
-
-
4344668661
-
Drug repositioning: identifying and developing new uses for existing drugs
-
Ashburn, T.T. and Thor, K.B. (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nature Reviews. Drug Discovery, 3, 673-683.
-
(2004)
Nature Reviews. Drug Discovery
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
52
-
-
33644668387
-
Finding new tricks for old drugs: An efficient route for public-sector drug discovery
-
O?Connor, K.A. and Roth, B.L. (2005) Finding new tricks for old drugs: An efficient route for public-sector drug discovery. Nature Reviews. Drug Discovery, 4, 1005-1014.
-
(2005)
Nature Reviews. Drug Discovery
, vol.4
, pp. 1005-1014
-
-
Oconnor, K.A.1
Roth, B.L.2
-
53
-
-
33845876624
-
Cellular dielectric spectroscopy: A label-free comprehensive platform for functional evaluation of endogenous receptors
-
Verdonk, E., Johnson, K., McGuinness, R., Leung, G., Chen, Y.W., Tang, H.R., Michelotti, J.M. and Liu, V.F. (2006) Cellular dielectric spectroscopy: A label-free comprehensive platform for functional evaluation of endogenous receptors. Assay and Drug Development Technologies, 4. (5), 609-619.
-
(2006)
Assay and Drug Development Technologies
, vol.4
, Issue.5
, pp. 609-619
-
-
Verdonk, E.1
Johnson, K.2
McGuinness, R.3
Leung, G.4
Chen, Y.W.5
Tang, H.R.6
Michelotti, J.M.7
Liu, V.F.8
-
54
-
-
85047685425
-
New cell models and assays in cardiac safety profiling
-
Meyer, T., Sartipy, P., Blind, F., Leisgen, C. and Guenther, E. (2007) New cell models and assays in cardiac safety profiling. Expert Opinion on Drug Metabolism and Toxicology, 3. (4), 507-517.
-
(2007)
Expert Opinion on Drug Metabolism and Toxicology
, vol.3
, Issue.4
, pp. 507-517
-
-
Meyer, T.1
Sartipy, P.2
Blind, F.3
Leisgen, C.4
Guenther, E.5
-
55
-
-
34547620338
-
Embryonic stem cells as a source of models for drug discovery
-
Pouton, C.W. and Haynes, J.M. (2007) Embryonic stem cells as a source of models for drug discovery. Nature Reviews. Drug Discovery, 6. (8), 605-616.
-
(2007)
Nature Reviews. Drug Discovery
, vol.6
, Issue.8
, pp. 605-616
-
-
Pouton, C.W.1
Haynes, J.M.2
-
56
-
-
39049168646
-
Understanding mechanisms of toxicity: insights from drug discovery research
-
Houck, K.A. and Kavlock, R.J. (2008) Understanding mechanisms of toxicity: insights from drug discovery research. Toxicology and Applied Pharmacology, 227. (2), 163-178.
-
(2008)
Toxicology and Applied Pharmacology
, vol.227
, Issue.2
, pp. 163-178
-
-
Houck, K.A.1
Kavlock, R.J.2
-
57
-
-
48149111146
-
Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery
-
Barros, T.P., Alderton, W.K., Reynolds, H.M., Roach, A.G. and Berghmans, S. (2008) Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery. British Journal of Pharmacology, 154, 1400-1413.
-
(2008)
British Journal of Pharmacology
, vol.154
, pp. 1400-1413
-
-
Barros, T.P.1
Alderton, W.K.2
Reynolds, H.M.3
Roach, A.G.4
Berghmans, S.5
-
58
-
-
33749234216
-
Drugs, their targets and the nature and number of drug targets
-
Imming, P., Sinning, C. and Meyer, A. (2006) Drugs, their targets and the nature and number of drug targets. Nature Reviews. Drug Discovery, 5, 821-834.
-
(2006)
Nature Reviews. Drug Discovery
, vol.5
, pp. 821-834
-
-
Imming, P.1
Sinning, C.2
Meyer, A.3
-
59
-
-
33751547539
-
How many drug targets are there? Nature Reviews
-
Overington, J.P., Al-Lazikani, B. and Hopkins, A.L. (2006) How many drug targets are there? Nature Reviews. Drug Discovery, 5, 993-996.
-
(2006)
Drug Discovery
, vol.5
, pp. 993-996
-
-
Overington, J.P.1
Al-Lazikani, B.2
Hopkins, A.L.3
-
60
-
-
40049100210
-
Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
-
Bender, A., Scheiber, J., Glick, M., Davies, J.W., Azzaoui, K., Hamon, J., Urban, L., Whitebread, S. and Jenkins, J.L. (2007) Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. ChemMedChem, 2, 861-873.
-
(2007)
ChemMedChem
, vol.2
, pp. 861-873
-
-
Bender, A.1
Scheiber, J.2
Glick, M.3
Davies, J.W.4
Azzaoui, K.5
Hamon, J.6
Urban, L.7
Whitebread, S.8
Jenkins, J.L.9
-
61
-
-
33749335282
-
The Connectivity Map: Using Gene-Expression Signatures to connect small molecules, genes, and disease
-
Lamb, J., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.-P. et al. (2006) The Connectivity Map: Using Gene-Expression Signatures to connect small molecules, genes, and disease. Science, 313, 1929-1935.
-
(2006)
Science
, vol.313
, pp. 1929-1935
-
-
Lamb, J.1
Crawford, E.D.2
Peck, D.3
Modell, J.W.4
Blat, I.C.5
Wrobel, M.J.6
Lerner, J.7
Brunet, J.-P.8
|