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Volumn 43, Issue , 2010, Pages 273-295

In vitro safety pharmacology profiling: An important tool to decrease attrition

Author keywords

In vitro safety pharmacology profiling; Lead optimization; Secondary pharmacology profile

Indexed keywords

IN-VITRO; LEAD OPTIMIZATION; SAFETY PHARMACOLOGY; SECONDARY PHARMACOLOGY PROFILE;

EID: 85018193727     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527627448.ch12     Document Type: Chapter
Times cited : (2)

References (61)
  • 1
    • 0027933948 scopus 로고
    • Status of safety pharmacology in the pharmaceutical industry, 1993
    • Kinter, L.B., Gossett, K.A. and Kerns,W.D. (1993) Status of safety pharmacology in the pharmaceutical industry, 1993. Drug Development Research, 32. (4), 208-216.
    • (1993) Drug Development Research , vol.32 , Issue.4 , pp. 208-216
    • Kinter, L.B.1    Gossett, K.A.2    Kerns, W.D.3
  • 2
    • 0029113895 scopus 로고
    • Safety pharmacology program for pharmaceuticals
    • Kinter, L.D. and Dixon, L.W. (1995) Safety pharmacology program for pharmaceuticals. Drug Development Research, 35. (3), 179-182.
    • (1995) Drug Development Research , vol.35 , Issue.3 , pp. 179-182
    • Kinter, L.D.1    Dixon, L.W.2
  • 3
    • 0029080005 scopus 로고
    • Status of safety pharmacology in the pharmaceutical industry-1995
    • Sullivan, A.T. and Kinter, L.B. (1995) Status of safety pharmacology in the pharmaceutical industry-1995. Drug Development Research, 35. (3), 166-172.
    • (1995) Drug Development Research , vol.35 , Issue.3 , pp. 166-172
    • Sullivan, A.T.1    Kinter, L.B.2
  • 4
    • 0025597019 scopus 로고
    • The role of pharmacology profiling in safety assessment
    • Williams, P.D. (1990) The role of pharmacology profiling in safety assessment. Regulatory Toxicology and Pharmacology, 12. (3), 238-252.
    • (1990) Regulatory Toxicology and Pharmacology , vol.12 , Issue.3 , pp. 238-252
    • Williams, P.D.1
  • 6
    • 26944446576 scopus 로고    scopus 로고
    • In vitro safety pharmacology profiling: an essential tool for successful drug development
    • Whitebread, S., Hamon, J., Bojanic, D. and Urban, L. (2005) In vitro safety pharmacology profiling: an essential tool for successful drug development. Drug Discovery Today, 10. (21), 1421-1433.
    • (2005) Drug Discovery Today , vol.10 , Issue.21 , pp. 1421-1433
    • Whitebread, S.1    Hamon, J.2    Bojanic, D.3    Urban, L.4
  • 10
    • 24944547571 scopus 로고    scopus 로고
    • Why drugs fail -A study on side effects in new chemical entities
    • Schuster, D., Laggner, C. and Langer, T. (2005) Why drugs fail -A study on side effects in new chemical entities. Current Pharmaceutical Design, 11, 3545-3559.
    • (2005) Current Pharmaceutical Design , vol.11 , pp. 3545-3559
    • Schuster, D.1    Laggner, C.2    Langer, T.3
  • 16
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates? Nature Reviews
    • Kola, I. and Landis, J. (2004) Can the pharmaceutical industry reduce attrition rates? Nature Reviews. Drug Discovery, 3, 711-715.
    • (2004) Drug Discovery , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 19
    • 39049161143 scopus 로고    scopus 로고
    • FDA drug approvals: a year of flux
    • Hughes, B. (2008) FDA drug approvals: a year of flux. Nature Reviews. Drug Discovery, 7. (2), 107-109, http://dx.doi.org/ 10.1038/nrd2514.
    • (2008) Nature Reviews. Drug Discovery , vol.7 , Issue.2 , pp. 107-109
    • Hughes, B.1
  • 23
    • 45549091674 scopus 로고    scopus 로고
    • Retinoic acid in development: Towards an integrated view
    • Niederreither, K. and Dolle, P. (2008) Retinoic acid in development: Towards an integrated view. Nature Reviews. Genetics, 9, 541-553.
    • (2008) Nature Reviews. Genetics , vol.9 , pp. 541-553
    • Niederreither, K.1    Dolle, P.2
  • 25
    • 85018575862 scopus 로고    scopus 로고
    • Consolidated list of products whose consumption and/or sale have been banned withdrawn, severely restricted or not approved by governments
    • United Nations (2005) Consolidated list of products whose consumption and/or sale have been banned, withdrawn, severely restricted or not approved by governments. 12th issue. UN Office for Economic and Social Council Support and Coordination, pp. 595.
    • (2005) UN Office for Economic and Social Council Support and Coordination , pp. 595
  • 26
    • 0037082324 scopus 로고    scopus 로고
    • Target validation of G-protein coupled receptors
    • Wise, A., Gearing, K. and Rees, S. (2002) Target validation of G-protein coupled receptors. Drug Discovery Today, 7. (4), 235-246.
    • (2002) Drug Discovery Today , vol.7 , Issue.4 , pp. 235-246
    • Wise, A.1    Gearing, K.2    Rees, S.3
  • 35
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia
    • Roth, B.L., Sheffler, D.J. and Kroeze, W.K. (2004) Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nature Reviews. Drug Discovery, 3, 353-359.
    • (2004) Nature Reviews. Drug Discovery , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 36
    • 33846076665 scopus 로고    scopus 로고
    • The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and M30
    • Youdim, M.B.H. (2006) The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and M30. Current Alzheimer Research, 3, 541-550.
    • (2006) Current Alzheimer Research , vol.3 , pp. 541-550
    • Youdim, M.B.H.1
  • 37
    • 14244255403 scopus 로고    scopus 로고
    • The promiscuous drug concept? with applications to Alzheimers disease
    • Stephenson, V.C., Heydingb, R.A. and Weaver, D.F. (2005) The promiscuous drug concept? with applications to Alzheimers disease. FEBS letters, 579. (6), 1338-1342.
    • (2005) FEBS letters , vol.579 , Issue.6 , pp. 1338-1342
    • Stephenson, V.C.1    Heydingb, R.A.2    Weaver, D.F.3
  • 38
    • 3242802116 scopus 로고    scopus 로고
    • Promiscuous? anticancer drugs that hit multiple targets may thwart resistance
    • Hampton, T. (2004) Promiscuous? anticancer drugs that hit multiple targets may thwart resistance. The Journal of the American Medical Association, 292. (4), 419-422.
    • (2004) The Journal of the American Medical Association , vol.292 , Issue.4 , pp. 419-422
    • Hampton, T.1
  • 42
    • 41649105837 scopus 로고    scopus 로고
    • Kinase-likeness and Kinase-Privileged Fragments: Toward Virtual Polypharmacology
    • Aronov, A.M., McClain, B., Moody, C.S. and Murcko, M.A. (2008) Kinase-likeness and Kinase-Privileged Fragments: Toward Virtual Polypharmacology. Journal of Medicinal Chemistry, 51, 1214-1222.
    • (2008) Journal of Medicinal Chemistry , vol.51 , pp. 1214-1222
    • Aronov, A.M.1    Mc Clain, B.2    Moody, C.S.3    Murcko, M.A.4
  • 43
    • 42949142178 scopus 로고    scopus 로고
    • Pyridylphenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
    • Whitlock, G.A., Fish, P.V., Fray, M.J., Stobie, A. andWakenhut, F. (2008) Pyridylphenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity. Bioorganic and Medicinal Chemistry Letters, 18, 2896-2899.
    • (2008) Bioorganic and Medicinal Chemistry Letters , vol.18 , pp. 2896-2899
    • Whitlock, G.A.1    Fish, P.V.2    Fray, M.J.3    Stobie A.andWakenhut, F.4
  • 44
    • 0029548199 scopus 로고
    • Combination therapy on murine arthritis -Salazosulfapyridine, bucillamine, and methotrexate
    • Abe, C., Kikukawa, T. and Komatsu, Y. (1995) Combination therapy on murine arthritis -Salazosulfapyridine, bucillamine, and methotrexate. International Journal of Immunotherapy, 11, 129-132.
    • (1995) International Journal of Immunotherapy , vol.11 , pp. 129-132
    • Abe, C.1    Kikukawa, T.2    Komatsu, Y.3
  • 45
    • 0036732005 scopus 로고    scopus 로고
    • Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator
    • Burcoglu-O?Ral, A., Erkan, D. and Asherson, R. (2002) Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator. Journal of Rheumatology, 29, 2006-2011.
    • (2002) Journal of Rheumatology , vol.29 , pp. 2006-2011
    • Burcoglu-Oral, A.1    Erkan, D.2    Asherson, R.3
  • 48
    • 35748934487 scopus 로고    scopus 로고
    • The influence of drug-like concepts on decision-making in medicinal chemistry
    • Leeson, P.D. and Springthorpe, B. (2007) The influence of drug-like concepts on decision-making in medicinal chemistry. Nature Reviews. Drug Discovery, 6, 881-890.
    • (2007) Nature Reviews. Drug Discovery , vol.6 , pp. 881-890
    • Leeson, P.D.1    Springthorpe, B.2
  • 50
    • 0344492207 scopus 로고    scopus 로고
    • Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
    • Redfern, W.S., Carlsson, L., Davis, A.S., Lynch,W.G.,MacKenzie, I., Palethorpe, S., Siegl, P.K.S., Strang, I. et al. (2003) Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovascular Research, 58, 32-45.
    • (2003) Cardiovascular Research , vol.58 , pp. 32-45
    • Redfern, W.S.1    Carlsson, L.2    Davis, A.S.3    Lynch, W.G.4    MacKenzie, I.5    Palethorpe, S.6    Siegl, P.K.S.7    Strang, I.8
  • 51
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: identifying and developing new uses for existing drugs
    • Ashburn, T.T. and Thor, K.B. (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nature Reviews. Drug Discovery, 3, 673-683.
    • (2004) Nature Reviews. Drug Discovery , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 52
    • 33644668387 scopus 로고    scopus 로고
    • Finding new tricks for old drugs: An efficient route for public-sector drug discovery
    • O?Connor, K.A. and Roth, B.L. (2005) Finding new tricks for old drugs: An efficient route for public-sector drug discovery. Nature Reviews. Drug Discovery, 4, 1005-1014.
    • (2005) Nature Reviews. Drug Discovery , vol.4 , pp. 1005-1014
    • Oconnor, K.A.1    Roth, B.L.2
  • 55
    • 34547620338 scopus 로고    scopus 로고
    • Embryonic stem cells as a source of models for drug discovery
    • Pouton, C.W. and Haynes, J.M. (2007) Embryonic stem cells as a source of models for drug discovery. Nature Reviews. Drug Discovery, 6. (8), 605-616.
    • (2007) Nature Reviews. Drug Discovery , vol.6 , Issue.8 , pp. 605-616
    • Pouton, C.W.1    Haynes, J.M.2
  • 56
    • 39049168646 scopus 로고    scopus 로고
    • Understanding mechanisms of toxicity: insights from drug discovery research
    • Houck, K.A. and Kavlock, R.J. (2008) Understanding mechanisms of toxicity: insights from drug discovery research. Toxicology and Applied Pharmacology, 227. (2), 163-178.
    • (2008) Toxicology and Applied Pharmacology , vol.227 , Issue.2 , pp. 163-178
    • Houck, K.A.1    Kavlock, R.J.2
  • 57
    • 48149111146 scopus 로고    scopus 로고
    • Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery
    • Barros, T.P., Alderton, W.K., Reynolds, H.M., Roach, A.G. and Berghmans, S. (2008) Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery. British Journal of Pharmacology, 154, 1400-1413.
    • (2008) British Journal of Pharmacology , vol.154 , pp. 1400-1413
    • Barros, T.P.1    Alderton, W.K.2    Reynolds, H.M.3    Roach, A.G.4    Berghmans, S.5
  • 58
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming, P., Sinning, C. and Meyer, A. (2006) Drugs, their targets and the nature and number of drug targets. Nature Reviews. Drug Discovery, 5, 821-834.
    • (2006) Nature Reviews. Drug Discovery , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 60
    • 40049100210 scopus 로고    scopus 로고
    • Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
    • Bender, A., Scheiber, J., Glick, M., Davies, J.W., Azzaoui, K., Hamon, J., Urban, L., Whitebread, S. and Jenkins, J.L. (2007) Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. ChemMedChem, 2, 861-873.
    • (2007) ChemMedChem , vol.2 , pp. 861-873
    • Bender, A.1    Scheiber, J.2    Glick, M.3    Davies, J.W.4    Azzaoui, K.5    Hamon, J.6    Urban, L.7    Whitebread, S.8    Jenkins, J.L.9
  • 61
    • 33749335282 scopus 로고    scopus 로고
    • The Connectivity Map: Using Gene-Expression Signatures to connect small molecules, genes, and disease
    • Lamb, J., Crawford, E.D., Peck, D., Modell, J.W., Blat, I.C., Wrobel, M.J., Lerner, J., Brunet, J.-P. et al. (2006) The Connectivity Map: Using Gene-Expression Signatures to connect small molecules, genes, and disease. Science, 313, 1929-1935.
    • (2006) Science , vol.313 , pp. 1929-1935
    • Lamb, J.1    Crawford, E.D.2    Peck, D.3    Modell, J.W.4    Blat, I.C.5    Wrobel, M.J.6    Lerner, J.7    Brunet, J.-P.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.