-
2
-
-
0013881809
-
La tachycardie ventriculaire à deux foyers opposés variables
-
Dessertenne, F. La tachycardie ventriculaire à deux foyers opposés variables. Arch Mal Coeur Vaiss. 1966, 59, 263-272
-
(1966)
Arch Mal Coeur Vaiss.
, vol.59
, pp. 263-272
-
-
Dessertenne, F.1
-
4
-
-
0030066573
-
Molecular genetic insights into cardiovascular disease
-
Keating, M. T.; Sanguinetti, M. C. Molecular genetic insights into cardiovascular disease. Science 1996, 272, 681-685.
-
(1996)
Science
, vol.272
, pp. 681-685
-
-
Keating, M.T.1
Sanguinetti, M.C.2
-
5
-
-
0036039326
-
The significance of QT interval in drug development
-
Shah, R. R. The significance of QT interval in drug development. Br. J. Clin. Pharmacol. 2002, 54, 188-202.
-
(2002)
Br. J. Clin. Pharmacol.
, vol.54
, pp. 188-202
-
-
Shah, R.R.1
-
7
-
-
0029002969
-
A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel
-
Sanguinetti, M. C.; Jiang, C.; Curran, M. E.; Keating, M. T. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell 1995, 81, 299-307.
-
(1995)
Cell
, vol.81
, pp. 299-307
-
-
Sanguinetti, M.C.1
Jiang, C.2
Curran, M.E.3
Keating, M.T.4
-
8
-
-
0034710933
-
A structural basis for drug-induced long QT syndrome
-
Mitcheson, J. S.; Chen, J.; Lin, M.; Culberson, C.; Sanguinetti, M. C. A structural basis for drug-induced long QT syndrome. Proc. Natl. Acad. Sci. U.S.A. 2000, 97, 12329-12333.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 12329-12333
-
-
Mitcheson, J.S.1
Chen, J.2
Lin, M.3
Culberson, C.4
Sanguinetti, M.C.5
-
9
-
-
0038743107
-
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches
-
Pearlstein, R. A.; Vaz, R. J.; Kang, J.; Chen, X.-L.; Preobrazhenskaya, M.; Shchekotikhin, A. E.; Korolev, A. M.; Lysenkova, L. N.; Miroshnikova, O. V.; Hendrix, J.; Rampe, D. Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. Bioorg. Med. Chem. Lett. 2003, 13, 1829-1835.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 1829-1835
-
-
Pearlstein, R.A.1
Vaz, R.J.2
Kang, J.3
Chen, X.-L.4
Preobrazhenskaya, M.5
Shchekotikhin, A.E.6
Korolev, A.M.7
Lysenkova, L.N.8
Miroshnikova, O.V.9
Hendrix, J.10
Rampe, D.11
-
10
-
-
0037194634
-
Toward a pharmacophore for drugs inducing the long QT syndrome: Insights from a CoMFA study of HERG K(+) channel blockers
-
Cavalli, A.; Poluzzi, E.; De Ponti, F.; Recanatini, M. Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. J. Med. Chem. 2002, 45, 3844-3853.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3844-3853
-
-
Cavalli, A.1
Poluzzi, E.2
De Ponti, F.3
Recanatini, M.4
-
11
-
-
0036229805
-
Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel
-
Ekins, S.; Crumb, W. J.; Sarazan, R. D.; Wikel, J. H.; Wrighton, S. A. Three-Dimensional Quantitative Structure-Activity Relationship for Inhibition of Human Ether-a-Go-Go-Related Gene Potassium Channel. J. Pharmacol. Exp. Ther. 2002, 301, 427-434.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, pp. 427-434
-
-
Ekins, S.1
Crumb, W.J.2
Sarazan, R.D.3
Wikel, J.H.4
Wrighton, S.A.5
-
12
-
-
4644299288
-
Physicochemical determinants for drug induced blockade of HERG potassium channels: Effect of charge and charge shielding
-
Zolotoy, A. B.; Plouvier, B. P.; Beatch, G. B.; Hayes, E. S.; Wall, R. A.; Walker, M. J. A. Physicochemical determinants for drug induced blockade of HERG potassium channels: Effect of charge and charge shielding. Curr. Med. Chem. Cardiovasc. Agents 2003, 1, 225-241.
-
(2003)
Curr. Med. Chem. Cardiovasc. Agents
, vol.1
, pp. 225-241
-
-
Zolotoy, A.B.1
Plouvier, B.P.2
Beatch, G.B.3
Hayes, E.S.4
Wall, R.A.5
Walker, M.J.A.6
-
13
-
-
0034728673
-
Prediction of properties from simulations: Free energies of solvation in hexadecane, octanol, and water
-
Duffy, E. M.; Jorgensen, W. L. Prediction of Properties from Simulations: Free Energies of Solvation in Hexadecane, Octanol, and Water. J. Am. Chem. Soc. 2000, 122, 2878-2888.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 2878-2888
-
-
Duffy, E.M.1
Jorgensen, W.L.2
-
14
-
-
0036904104
-
A virtual screening method for prediction of the HERG potassium channel liability of compound libraries
-
Roche, O.; Trube, G.; J., Z.; Pflimlin, P.; Alanine, A.; Schneider, G. A virtual screening method for prediction of the HERG potassium channel liability of compound libraries. ChemBioChem 2002, 3, 455-459.
-
(2002)
ChemBioChem
, vol.3
, pp. 455-459
-
-
Roche, O.1
Trube, G.2
J, Z.3
Pflimlin, P.4
Alanine, A.5
Schneider, G.6
-
15
-
-
0038487659
-
Prediction of hERG potassium channel affinity by traditional and hologram QSAR methods
-
Keseru, G. M. Prediction of hERG potassium channel affinity by traditional and hologram QSAR methods. Bioorg. Med. Chem. Lett. 2003, 13, 2773-2775.
-
(2003)
Bioorg. Med. Chem. Lett.
, vol.13
, pp. 2773-2775
-
-
Keseru, G.M.1
-
16
-
-
1842686775
-
A model for identifying HERG K+ channel blockers
-
Aronov, A. M.; Goldman, B. B. A model for identifying HERG K+ channel blockers. Bioorg. Med. Chem. 2004, 12, 2307-2315.
-
(2004)
Bioorg. Med. Chem.
, vol.12
, pp. 2307-2315
-
-
Aronov, A.M.1
Goldman, B.B.2
-
17
-
-
3543145510
-
HERG binding specificity and binding site structure: Evidence from a fragment-based evolutionary computing SAR study
-
Bains, W.; Basman, A.; White, C. hERG binding specificity and binding site structure: evidence from a fragment-based evolutionary computing SAR study. Prog. Biophys. Mol. Bio. 2004, 86, 205-233.
-
(2004)
Prog. Biophys. Mol. Bio.
, vol.86
, pp. 205-233
-
-
Bains, W.1
Basman, A.2
White, C.3
-
18
-
-
33244474244
-
Development and Evaluation of an in Silico Model for hERG Binding
-
Song, M.; Clark, M. Development and Evaluation of an in Silico Model for hERG Binding. J. Chem. Inf. Model. 2006, 46, 392-400.
-
(2006)
J. Chem. Inf. Model.
, vol.46
, pp. 392-400
-
-
Song, M.1
Clark, M.2
-
19
-
-
33645856496
-
A QSAR model of hERG binding using a large, diverse, and internally consistent training set
-
Seierstad, M.; Agrafiotis, D. K. A QSAR Model of hERG Binding Using a Large, Diverse, and Internally Consistent Training Set. Chem. Biol. Drug Des. 2006, 67, 284-296.
-
(2006)
Chem. Biol. Drug Des.
, vol.67
, pp. 284-296
-
-
Seierstad, M.1
Agrafiotis, D.K.2
-
20
-
-
72949111042
-
-
National Technical Information Center (NTIS): Alexandria: VA. Accessed June 1 2009. Pharmapendium; Elsevier B.V. New York, NY; http://www. pharmapendium.com. Accessed June 1
-
AERS Data; National Technical Information Center (NTIS): Alexandria: VA; http://www.ntis.gov. Accessed June 1, 2009. Pharmapendium; Elsevier B.V.: New York, NY; http://www.pharmapendium.com. Accessed June 1, 2009.
-
(2009)
AERS Data
-
-
-
21
-
-
72949120454
-
-
Adverse Event Reporting System; U.S. Food and Drug Administration: Silver Springs MD. Accessed June 1
-
Adverse Event Reporting System; U.S. Food and Drug Administration: Silver Springs, MD; http://www.fda.gov/cder/aers. Accessed June 1, 2009.
-
(2009)
-
-
-
23
-
-
0038931405
-
Bayesian data mining in large frequency tables, with an application to the FDA spontaneous reporting system
-
DuMouchel, W. Bayesian data mining in large frequency tables, with an application to the FDA spontaneous reporting system. J. Am. Stat. Assoc. 1999, 53, 177-190.
-
(1999)
J. Am. Stat. Assoc.
, vol.53
, pp. 177-190
-
-
Dumouchel, W.1
-
24
-
-
0042413852
-
Disproportionality analysis using empirical Bayes data mining: A tool for the evaluation of drug interactions in the post-marketing setting
-
Almenoff, J. S.; DuMouchel, W.; Kindman, L. A.; Yang, X.; Fram, D. M. Disproportionality analysis using empirical Bayes data mining: a tool for the evaluation of drug interactions in the post-marketing setting. Pharmacoepidemiol. Drug Saf. 2003, 12, 517-521.
-
(2003)
Pharmacoepidemiol. Drug Saf.
, vol.12
, pp. 517-521
-
-
Almenoff, J.S.1
Dumouchel, W.2
Kindman, L.A.3
Yang, X.4
Fram, D.M.5
-
25
-
-
38449085273
-
Effect of consumer reporting on signal detection: Using disproportionality analysis
-
Hammond, I. W.; Rich, D. S.; Gibbs, T. G. Effect of consumer reporting on signal detection: using disproportionality analysis. Expert Opin. Drug Saf. 2007, 6, 705-712.
-
(2007)
Expert Opin. Drug Saf.
, vol.6
, pp. 705-712
-
-
Hammond, I.W.1
Rich, D.S.2
Gibbs, T.G.3
-
26
-
-
0034749428
-
Some FDA perspectives on data mining for pediatric safety assessment
-
O'Neill, R. T.; Szarfman, A. Some FDA perspectives on data mining for pediatric safety assessment. Curr. Ther. Res. Clin. Exp. 2001, 62, 650-663.
-
(2001)
Curr. Ther. Res. Clin. Exp.
, vol.62
, pp. 650-663
-
-
O'neill, R.T.1
Szarfman, A.2
-
27
-
-
0036300732
-
Use of screening algorithms and computer systems to efficiently signal higher-than-expected combinations of drugs and events in the US FDA's spontaneous reports database
-
Szarfman, A.; Machado, S. G.; O'Neill, R. T. Use of Screening Algorithms and Computer Systems to Efficiently Signal Higher-Than-Expected Combinations of Drugs and Events in the US FDA's Spontaneous Reports Database. Drug Saf. 2002, 6, 381-392.
-
(2002)
Drug Saf.
, vol.6
, pp. 381-392
-
-
Szarfman, A.1
MacHado, S.G.2
O'neill, R.T.3
-
28
-
-
0037256026
-
Application of quantitative signal detection in the dutch spontaneous reporting system for adverse drug reactions
-
van Puijenbroek, E. P.; Diemont, W. L.; van Grootheest, K. Application of Quantitative Signal Detection in the Dutch Spontaneous Reporting System for Adverse Drug Reactions. Drug Saf. 2003, 5, 293-301.
-
(2003)
Drug Saf.
, vol.5
, pp. 293-301
-
-
Van Puijenbroek, E.P.1
Diemont, W.L.2
Van Grootheest, K.3
-
29
-
-
69549096044
-
Comparison of sensitivity and timing of early signal detection of four frequently used signal detection methods: An empirical study based on the us fda adverse event reporting system database
-
Chen, Y.; Guo, J.; Steinbuch, M.; Lin, X.; Buncher, C. R.; Patel, N. C. Comparison of Sensitivity and Timing of Early Signal Detection of Four Frequently Used Signal Detection Methods: An Empirical Study Based on the US FDA Adverse Event Reporting System Database. Pharm. Med. 2008, 6, 359-365.
-
(2008)
Pharm. Med.
, vol.6
, pp. 359-365
-
-
Chen, Y.1
Guo, J.2
Steinbuch, M.3
Lin, X.4
Buncher, C.R.5
Patel, N.C.6
-
30
-
-
34447117012
-
Bayesian confidence propagation neural network
-
Andrew, B. Bayesian confidence propagation neural network. Drug Saf. 2007, 7, 623-625.
-
(2007)
Drug Saf.
, vol.7
, pp. 623-625
-
-
Andrew, B.1
-
31
-
-
72949102508
-
The reporting odds ratio versus the proportional reporting ratio: 'deuce'
-
Waller, P.; van Puijenbroek, E.; Egberts, A.; Evans, S. The reporting odds ratio versus the proportional reporting ratio: 'deuce'. Pharmacoepidemiol. Drug Saf. 2003, 8, 52-526.
-
(2003)
Pharmacoepidemiol. Drug Saf.
, vol.8
, pp. 52-526
-
-
Waller, P.1
Van Puijenbroek, E.2
Egberts, A.3
Evans, S.4
-
32
-
-
66749083239
-
Hepatic effects of duloxetine-III: Analysis of hepatic events using external data sources
-
Strombom, I.; Wernicke, J. F.; Seeger, J.; D'Souza, D. N.; Acharya, N. Hepatic Effects of Duloxetine-III: Analysis of Hepatic Events Using External Data Sources. Curr. Drug Saf. 2008, 3, 154-162.
-
(2008)
Curr. Drug Saf.
, vol.3
, pp. 154-162
-
-
Strombom, I.1
Wernicke, J.F.2
Seeger, J.3
D'souza, D.N.4
Acharya, N.5
-
33
-
-
33645085895
-
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling
-
Matthews, E. J.; Kruhlak, N. L.; Weaver, J. L.; Benz, R. D.; Contrera, J. F. Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Curr. Drug Discov. Tech. 2004, 1, 243-254.
-
(2004)
Curr. Drug Discov. Tech.
, vol.1
, pp. 243-254
-
-
Matthews, E.J.1
Kruhlak, N.L.2
Weaver, J.L.3
Benz, R.D.4
Contrera, J.F.5
-
34
-
-
72949118374
-
QSAR modleing of human liver adverse effects database using kNN method
-
Presented at, Seattle Washington March; Abstract 244
-
Rodgers, A. D.; Zhu, H.; Rusyn, I.; Tropsha, A. QSAR Modleing of Human Liver Adverse Effects Database Using kNN Method. Presented at Society of Toxicology 47th Annual Meeting and ToxExpo, Seattle Washington, March 16-20, 2008; Abstract 244.
-
(2008)
Society of Toxicology 47th Annual Meeting and ToxExpo
, pp. 16-20
-
-
Rodgers, A.D.1
Zhu, H.2
Rusyn, I.3
Tropsha, A.4
-
35
-
-
72949111474
-
-
Version 8.2.1; University of California at Berkeley: Berkeley, CA
-
PostgreSQL relational database, Version 8.2.1; University of California at Berkeley: Berkeley, CA, 2008.
-
(2008)
PostgreSQL Relational Database
-
-
-
36
-
-
72949094302
-
-
U.S. Food and Drug Administration: Silver Springs, MD. Accessed June 1
-
Drugs@FDA Data Files; U.S. Food and Drug Administration: Silver Springs, MD; http://www.fda.gov/cder/drugsatfda/datafiles/. Accessed June 1, 2009.
-
(2009)
Drugs@FDA Data Files
-
-
-
37
-
-
72949109194
-
Adverse effects of pharmaceuticals: A. construction of a relational databaes of adverse cardiological effects
-
Proceedings of the Society of Toxicology 47th Annual Meeting and ToxExpo, Seattle, Washington, March 16-20; Abstract 242
-
Frid, A. A.; Matthews, E. J.; Kruhlak, N. L.; Benz, R.; Contrera, J. F. Adverse Effects of Pharmaceuticals: A. Construction of a Relational Databaes of Adverse Cardiological Effects. Using FDA ArchiVes, Pharmapendium, and Public Sources. Proceedings of the Society of Toxicology 47th Annual Meeting and ToxExpo, Seattle, Washington, March 16-20, 2008; Abstract 242.
-
(2008)
Using FDA Archives, Pharmapendium, and Public Sources
-
-
Frid, A.A.1
Matthews, E.J.2
Kruhlak, N.L.3
Benz, R.4
Contrera, J.F.5
-
38
-
-
33845389394
-
Reye's syndrome: The case for a causal link with aspirin
-
Glasgow, J. F. Reye's syndrome: the case for a causal link with aspirin. Drug Saf. 2006, 12, 111-121.
-
(2006)
Drug Saf.
, vol.12
, pp. 111-121
-
-
Glasgow, J.F.1
-
39
-
-
17844369895
-
Generalized fragment-substructure based property prediction method
-
Clark, M. Generalized Fragment-Substructure Based Property Prediction Method. J. Chem. Inf. Model. 2005, 45, 30-38.
-
(2005)
J. Chem. Inf. Model.
, vol.45
, pp. 30-38
-
-
Clark, M.1
-
41
-
-
57549105281
-
Toward an improved clustering of large data sets using maximum common substructures and topological fingerprints
-
Bocker, A. Toward an Improved Clustering of Large Data Sets Using Maximum Common Substructures and Topological Fingerprints. J. Chem. Inf. Model. 2008, 48, 2097-2107.
-
(2008)
J. Chem. Inf. Model.
, vol.48
, pp. 2097-2107
-
-
Bocker, A.1
-
42
-
-
0034265657
-
Evaluation of descriptors and mini-fingerprints for the identification of molecules with similar activity
-
(a) Xue, L.; Godden, J. W.; Bajorath, J. Evaluation of descriptors and mini-fingerprints for the identification of molecules with similar activity. J. Chem. Inf. Comput. Sci. 2000, 5, 1227-1234.
-
(2000)
J. Chem. Inf. Comput. Sci.
, vol.5
, pp. 1227-1234
-
-
Xue, L.1
Godden, J.W.2
Bajorath, J.3
-
43
-
-
0036828938
-
Predicting plasma protein binding of drugs: A new approach
-
Kratochwil, N. A.; Huber, W.; Muller, F.; Kansy, M.; Gerber, P. R. Predicting plasma protein binding of drugs: a new approach. Biochem. Pharmacol. 2002, 64, 1355-1374.
-
(2002)
Biochem. Pharmacol.
, vol.64
, pp. 1355-1374
-
-
Kratochwil, N.A.1
Huber, W.2
Muller, F.3
Kansy, M.4
Gerber, P.R.5
-
45
-
-
0027209171
-
The probability of chance correlation using partial least squares (PLS)
-
Clark, M.; Cramer, R. D. The Probability of Chance Correlation Using Partial Least Squares (PLS). Quant. Struct.-Act. Relat. 1993, 12, 137-145.
-
(1993)
Quant. Struct.-Act. Relat.
, vol.12
, pp. 137-145
-
-
Clark, M.1
Cramer, R.D.2
-
46
-
-
72949105876
-
-
version 1.0; Leadscope, Inc.: Columbus OH
-
FDA Model Applier Leadscope, version 1.0; Leadscope, Inc.: Columbus OH, 2008.
-
(2008)
FDA Model Applier Leadscope
-
-
-
47
-
-
33644782827
-
Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs
-
Katchman, A. N.; Koerner, J.; Tosaka, T.; Woosley, R. L.; Ebert, S. N. Comparative evaluation of HERG currents and QT intervals following challenge with suspected torsadogenic and nontorsadogenic drugs. J. Pharmacol. Exp. Ther. 2006, 316, 1098-1106.
-
(2006)
J. Pharmacol. Exp. Ther.
, vol.316
, pp. 1098-1106
-
-
Katchman, A.N.1
Koerner, J.2
Tosaka, T.3
Woosley, R.L.4
Ebert, S.N.5
-
48
-
-
44649155043
-
Temporal variability of QT interval and changes in T wave morphology in dogs as markers of the clinical risk of drug-induced proarrhythmia
-
Hanton, G.; Yvon, A.; Racaud, A. Temporal variability of QT interval and changes in T wave morphology in dogs as markers of the clinical risk of drug-induced proarrhythmia. J. Pharmacol. Toxicol. Methods 2008, 3, 194-201.
-
(2008)
J. Pharmacol. Toxicol. Methods
, vol.3
, pp. 194-201
-
-
Hanton, G.1
Yvon, A.2
Racaud, A.3
-
49
-
-
43049173726
-
Assessing QT prolongation in conscious dogs: Validation of a beat-to-beat method
-
Fossa, A. A. Assessing QT prolongation in conscious dogs: validation of a beat-to-beat method. Pharmacol. Therapeut. 2008, 2, 133-140.
-
(2008)
Pharmacol. Therapeut.
, vol.2
, pp. 133-140
-
-
Fossa, A.A.1
-
50
-
-
48949085884
-
The sertindole safety survey: A retrospective analysis under a named patient use programme in Europe
-
Lançon, C.; Toumi, M.; Sapin, C.; Hansen, K. The Sertindole Safety Survey: a retrospective analysis under a named patient use programme in Europe. BMC Psychiatry 2008, 8, 1-8.
-
(2008)
BMC Psychiatry
, vol.8
, pp. 1-8
-
-
Lançon, C.1
Toumi, M.2
Sapin, C.3
Hansen, K.4
-
51
-
-
0028868256
-
Terfenadine increases the QT interval in isolated guinea pig heart
-
Pinney, S. P.; Koller, B. S.; Franz, M. R.; Woolsey, R. L. Terfenadine increases the QT interval in isolated guinea pig heart. J. Cardiovasc. Pharmacol. 1995, 1, 30-34.
-
(1995)
J. Cardiovasc. Pharmacol.
, vol.1
, pp. 30-34
-
-
Pinney, S.P.1
Koller, B.S.2
Franz, M.R.3
Woolsey, R.L.4
-
52
-
-
34147138368
-
Illusions of objectivity and a recommendation for reporting data mining results
-
Hauben, M.; Reich, L.; Gerrits, C. M.; Younus, M. Illusions of objectivity and a recommendation for reporting data mining results. Eur. J. Clin. Pharmacol. 2007, 63, 517-521.
-
(2007)
Eur. J. Clin. Pharmacol.
, vol.63
, pp. 517-521
-
-
Hauben, M.1
Reich, L.2
Gerrits, C.M.3
Younus, M.4
-
53
-
-
45749129400
-
Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity
-
Hao, Z.; Rusyn, I.; Richard, A.; Tropsha, A. Use of Cell Viability Assay Data Improves the Prediction Accuracy of Conventional Quantitative Structure-Activity Relationship Models of Animal Carcinogenicity. Environ. Health Perspect. 2008, 116, 506-513.
-
(2008)
Environ. Health Perspect.
, vol.116
, pp. 506-513
-
-
Hao, Z.1
Rusyn, I.2
Richard, A.3
Tropsha, A.4
-
54
-
-
0034015298
-
Quinoline-induced QT interval prolongation: A not-sounexpected class effect
-
Ball, P. Quinoline-induced QT interval prolongation: a not-sounexpected class effect. J. Antimicrob. Chemother. 2000, 45, 557-559.
-
(2000)
J. Antimicrob. Chemother.
, vol.45
, pp. 557-559
-
-
Ball, P.1
|