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Volumn 147, Issue SUPPL. 1, 2006, Pages

Phosphodiesterase inhibitors

Author keywords

Asthma; Erectile dysfunction; Inflammation; PDE4; PDE5; Phosphodiesterase

Indexed keywords

2 METHYL 5 NITROBENZENESULFONIC ACID DIMETHYLAMIDE; 4 [2 [3 (CYCLOPENTYLOXY) 4 METHOXYPHENYL] 2 PHENYLETHYL]PYRIDINE; BAY 73 6691; BECLOMETASONE DIPROPIONATE; CILOMILAST; CILOSTAMIDE; CILOSTAZOL; DIPYRIDAMOLE; GLUCOCORTICOID; HT 0712; KS 505A; MILRINONE; OGLEMILAST; PAPAVERINE; PENTOXIFYLLINE; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; ROFLUMILAST; ROLIPRAM; SIGUAZODAN; SILDENAFIL; TADALAFIL; THEOPHYLLINE; UNCLASSIFIED DRUG; VARDENAFIL; ZAPRINAST;

EID: 30444456367     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706495     Document Type: Review
Times cited : (365)

References (53)
  • 1
    • 0025857568 scopus 로고
    • Pentoxifylline in the treatment of vascular impotence - Case reports
    • ALLENBY, K.S., BURRIS, J.F. & MROCZEK, W.J. (1991). Pentoxifylline in the treatment of vascular impotence - case reports. Angiology, 42, 418-420.
    • (1991) Angiology , vol.42 , pp. 418-420
    • Allenby, K.S.1    Burris, J.F.2    Mroczek, W.J.3
  • 2
    • 0000941242 scopus 로고
    • Isolation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate from rat urine
    • ASHMAN, D.F., LIPTON, R., MELICOW, M.M. & PRICE, T.D. (1963). Isolation of adenosine 3′,5′-monophosphate and guanosine 3′,5′-monophosphate from rat urine. Biochem. Biophys. Res. Commun., 11, 330-334.
    • (1963) Biochem. Biophys. Res. Commun. , vol.11 , pp. 330-334
    • Ashman, D.F.1    Lipton, R.2    Melicow, M.M.3    Price, T.D.4
  • 3
    • 0032445219 scopus 로고    scopus 로고
    • Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
    • BALLARD, S.A., GINGELL, C.J., TANG, K., TURNER, L.A., PRICE, M.E. & NAYLOR, A.M. (1998). Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J. Urol., 159, 2164-2171.
    • (1998) J. Urol. , vol.159 , pp. 2164-2171
    • Ballard, S.A.1    Gingell, C.J.2    Tang, K.3    Turner, L.A.4    Price, M.E.5    Naylor, A.M.6
  • 4
    • 3242726932 scopus 로고    scopus 로고
    • Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and non smokers
    • BARBER, R., BAILLIE, G.S., BERGMANN, R., SHEPHERD, M.C., SEPPER, R., HOUSLAY, M.D. & HEEKE, G.V. (2004). Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and non smokers. Am. J. Physiol. Lung Cell Mol. Physiol., 287, L332-L343.
    • (2004) Am. J. Physiol. Lung Cell Mol. Physiol. , vol.287
    • Barber, R.1    Baillie, G.S.2    Bergmann, R.3    Shepherd, M.C.4    Sepper, R.5    Houslay, M.D.6    Heeke, G.V.7
  • 6
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • BEAVO, J.A. (1995). Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev., 75, 725-748.
    • (1995) Physiol. Rev. , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 7
    • 0014940682 scopus 로고
    • Hydrolysis of cyclic guanosine and adenosine 3′,5′- monophosphates by rat and bovine tissues
    • BEAVO, J.A., HARDMAN, J.G. & SUTHERLAND, E.W. (1970). Hydrolysis of cyclic guanosine and adenosine 3′,5′-monophosphates by rat and bovine tissues. J. Biol. Cliem., 245, 5649-5655.
    • (1970) J. Biol. Cliem. , vol.245 , pp. 5649-5655
    • Beavo, J.A.1    Hardman, J.G.2    Sutherland, E.W.3
  • 9
    • 18144427196 scopus 로고    scopus 로고
    • Cilomilast GlaxoSmithKline
    • BROWN, W.M. (2005). Cilomilast GlaxoSmithKline. Curr. Opin. Inves. Drug, 6, 545-558.
    • (2005) Curr. Opin. Inves. Drug , vol.6 , pp. 545-558
    • Brown, W.M.1
  • 10
    • 33847612208 scopus 로고
    • Adenosine 3′,5′-phosphate in biological materials. I. Purification and properties of cyclic 3′,5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′,5′-phosphate in human urine
    • BUTCHER, R.W. & SUTHERLAND, E.W. (1962). Adenosine 3′,5′-phosphate in biological materials. I. Purification and properties of cyclic 3′,5′-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3′,5′-phosphate in human urine. J. Biol. Chem., 237, 1244-1250.
    • (1962) J. Biol. Chem. , vol.237 , pp. 1244-1250
    • Butcher, R.W.1    Sutherland, E.W.2
  • 11
    • 0027194175 scopus 로고
    • Immunochemical characterisation of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis
    • CHAN, S.C., REIFSNYDER, D., BEAVO, J.A. & HANIFIN, J.M. (1993). Immunochemical characterisation of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J. Allergy Clin. Immunol., 91, 1179-1188.
    • (1993) J. Allergy Clin. Immunol. , vol.91 , pp. 1179-1188
    • Chan, S.C.1    Reifsnyder, D.2    Beavo, J.A.3    Hanifin, J.M.4
  • 12
    • 0027535918 scopus 로고
    • Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus
    • CORTIJO, J., BOU, J., BELETA, J., CARDELUS, I., LLENAS, J., MORCILLO, E. & GRISTWOOD, R.W. (1993). Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Br. J. Pharmacol., 108, 562-568.
    • (1993) Br. J. Pharmacol. , vol.108 , pp. 562-568
    • Cortijo, J.1    Bou, J.2    Beleta, J.3    Cardelus, I.4    Llenas, J.5    Morcillo, E.6    Gristwood, R.W.7
  • 13
    • 0026741623 scopus 로고
    • Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: Biochemical and pharmacological analysis using selective inhibitors
    • DE BOER, J., PHILPOTT, A.J., VAN AMSTERDAM, R.G., SHAHID, M., ZAAGSMA, J. & NICHOLSON, C.D. (1992). Human bronchial cyclic nucleotide phosphodiesterase isoenzymes: biochemical and pharmacological analysis using selective inhibitors. Br. J. Pharmacol., 106, 1028-1034.
    • (1992) Br. J. Pharmacol. , vol.106 , pp. 1028-1034
    • De Boer, J.1    Philpott, A.J.2    Van Amsterdam, R.G.3    Shahid, M.4    Zaagsma, J.5    Nicholson, C.D.6
  • 14
    • 0025805846 scopus 로고
    • Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors
    • DENT, G., GIEMBYCZ, M.A., RABE, K.F. & BARNES, P.J. (1991). Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors. Br. J. Pharmacol., 103, 1339-1346.
    • (1991) Br. J. Pharmacol. , vol.103 , pp. 1339-1346
    • Dent, G.1    Giembycz, M.A.2    Rabe, K.F.3    Barnes, P.J.4
  • 15
    • 0029833842 scopus 로고    scopus 로고
    • Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: Role in regulating proliferation and the biosynthesis of interleukin-2
    • GIEMBYCZ, M.A., CORRIGAN, C.J., SEYBOLD, J., NEWTON, R. & BARNES, P.J. (1996). Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2. Br. J. Pharmacol., 118, 1945-1958.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1945-1958
    • Giembycz, M.A.1    Corrigan, C.J.2    Seybold, J.3    Newton, R.4    Barnes, P.J.5
  • 16
    • 84858528236 scopus 로고    scopus 로고
    • GLENMARK PHARMACEUTICALS (2005). GRC3886. Report. http://www. glenmarkpharma.com/research/clinical.html.
    • (2005) GRC3886. Report
  • 18
    • 0018090019 scopus 로고
    • Cyclic GMP binding and cyclic GMP phosphodiesterase in rat platelets
    • HAMET, P. & COQUIL, J.F. (1978). Cyclic GMP binding and cyclic GMP phosphodiesterase in rat platelets. J. Cyclic. Nucleotide. Res., 4, 281-290.
    • (1978) J. Cyclic. Nucleotide. Res. , vol.4 , pp. 281-290
    • Hamet, P.1    Coquil, J.F.2
  • 19
    • 0034612334 scopus 로고    scopus 로고
    • Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
    • HANSEN, G., JIN, S., UMETSU, D.T. & CONTI, M. (2000). Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D. Proc. Natl. Acad. Sci. U.S.A., 97, 6751-6756.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 6751-6756
    • Hansen, G.1    Jin, S.2    Umetsu, D.T.3    Conti, M.4
  • 21
    • 0021295772 scopus 로고
    • Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase-basic and potential clinical applications
    • HIDAKA, H. & ENDO, T. (1984). Selective inhibitors of three forms of cyclic nucleotide phosphodiesterase-basic and potential clinical applications. Adv. Cyclic. Nucleotide. Protein Phosphorylation. Res., 16, 245-259.
    • (1984) Adv. Cyclic. Nucleotide. Protein Phosphorylation. Res. , vol.16 , pp. 245-259
    • Hidaka, H.1    Endo, T.2
  • 24
    • 0025081992 scopus 로고
    • Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle
    • IGNARRO, L.J., BUSH, P.A., BUGA, G.M., WOOD, K.S., FUKUTO, J.M. & RAJFER, J. (1990). Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem. Biophys. Res. Commun., 170, 843-850.
    • (1990) Biochem. Biophys. Res. Commun. , vol.170 , pp. 843-850
    • Ignarro, L.J.1    Bush, P.A.2    Buga, G.M.3    Wood, K.S.4    Fukuto, J.M.5    Rajfer, J.6
  • 26
    • 0037188511 scopus 로고    scopus 로고
    • Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses
    • JIN, S.L. & CONTI, M. (2002). Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses. Proc. Natt. Acad. Sci. U.S.A., 99, 7628-7633.
    • (2002) Proc. Natt. Acad. Sci. U.S.A. , vol.99 , pp. 7628-7633
    • Jin, S.L.1    Conti, M.2
  • 29
    • 11844267183 scopus 로고    scopus 로고
    • Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease
    • LIPWORTH, B.J. (2005). Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease. Lancet. 365, 167-175.
    • (2005) Lancet , vol.365 , pp. 167-175
    • Lipworth, B.J.1
  • 30
    • 30444440289 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
    • Epub ahead of print
    • LUGNIER, C. (2005). Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents. Pharmacol. Ther, Epub ahead of print.
    • (2005) Pharmacol. Ther.
    • Lugnier, C.1
  • 31
    • 0020614634 scopus 로고
    • Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity
    • LUGNIER, C., STIERLE, A., BERETZ, A., SCHOEFFTER, P., LEBEC, A., WERMUTH, C.G., CAZENAVE, J.P. & STOCLET, J.C. (1983). Tissue and substrate specificity of inhibition by alkoxy-aryl-lactams of platelet and arterial smooth muscle cyclic nucleotide phosphodiesterases relationship to pharmacological activity. Biochem. Biophys. Res. Commun., 113, 954-959.
    • (1983) Biochem. Biophys. Res. Commun. , vol.113 , pp. 954-959
    • Lugnier, C.1    Stierle, A.2    Beretz, A.3    Schoeffter, P.4    Lebec, A.5    Wermuth, C.G.6    Cazenave, J.P.7    Stoclet, J.C.8
  • 32
    • 0033861491 scopus 로고    scopus 로고
    • Erectile dysfunction: From biochemical pharmacology to advances in medical therapy
    • MAGGI, M., FILIPPI, S., LEDDA, F., MAGINI, A. & FORTI, G. (2000). Erectile dysfunction: from biochemical pharmacology to advances in medical therapy. Eur. J. Endocrinol., 143, 143-154.
    • (2000) Eur. J. Endocrinol. , vol.143 , pp. 143-154
    • Maggi, M.1    Filippi, S.2    Ledda, F.3    Magini, A.4    Forti, G.5
  • 33
    • 0029075805 scopus 로고
    • Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family)
    • MANGANIELLO, V.C., TAIRA, M., DEGERMAN, E. & BELFRAGE, P. (1995). Type III cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE3 gene family). Cell Signal., 7, 445-455.
    • (1995) Cell Signal. , vol.7 , pp. 445-455
    • Manganiello, V.C.1    Taira, M.2    Degerman, E.3    Belfrage, P.4
  • 34
    • 0001074646 scopus 로고    scopus 로고
    • Subtypes of the type 4 cAMP phosphodiesterases: Structure, regulation and selective inhibition
    • MULLER, T., ENGELS, P. & FOZARD, J.R. (1996). Subtypes of the type 4 cAMP phosphodiesterases: structure, regulation and selective inhibition. Trends Pharmacol. Sci., 17, 294-298.
    • (1996) Trends Pharmacol. Sci. , vol.17 , pp. 294-298
    • Muller, T.1    Engels, P.2    Fozard, J.R.3
  • 36
    • 0026008409 scopus 로고
    • Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes
    • NICHOLSON, C.D., CHALLISS, R.A. & SHAHID, M. (1991). Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmacol. Sci., 12, 19-27.
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 19-27
    • Nicholson, C.D.1    Challiss, R.A.2    Shahid, M.3
  • 37
    • 0025225659 scopus 로고
    • Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst
    • NIELSON, C.P., VESTAL, R.E., STURM, R.J. & HEASLIP, R. (1990). Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst. J. Allergy Clin. Immunol., 86, 801-808.
    • (1990) J. Allergy Clin. Immunol. , vol.86 , pp. 801-808
    • Nielson, C.P.1    Vestal, R.E.2    Sturm, R.J.3    Heaslip, R.4
  • 39
    • 23744451716 scopus 로고    scopus 로고
    • Roflumilast - An oral anti-inflammatory treatment for chronic obstructive pulmonary disease: A randomised controlled trial
    • RABE, K.F., BATEMAN, E.D., O'DONNELL, D., WITTE, S., BREDENBROKER, D. & BETHKE, T.D. (2005). Roflumilast - an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial. Lancet, 366, 563-571.
    • (2005) Lancet , vol.366 , pp. 563-571
    • Rabe, K.F.1    Bateman, E.D.2    O'Donnell, D.3    Witte, S.4    Bredenbroker, D.5    Bethke, T.D.6
  • 40
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • RAJFER, J., ARONSON, W.J., BUSH, P.A., DOREY, F.J. & IGNARRO, L.J. (1992). Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med., 326, 90-94.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 41
    • 0020950891 scopus 로고
    • Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: Role of cyclic GMP
    • RAPOPORT, R.M. & MURAD, F. (1983). Endothelium-dependent and nitrovasodilator-induced relaxation of vascular smooth muscle: role of cyclic GMP. J. Cyclic. Nucleotide. Protein Phosphor. Res., 9, 281-296.
    • (1983) J. Cyclic. Nucleotide. Protein Phosphor. Res. , vol.9 , pp. 281-296
    • Rapoport, R.M.1    Murad, F.2
  • 42
    • 2342442163 scopus 로고    scopus 로고
    • The potential of phosphodiesterase 4 inhibitors for the treatment of depression: Opportunities and challenges
    • RENAU, T.E. (2004). The potential of phosphodiesterase 4 inhibitors for the treatment of depression: opportunities and challenges. Curr. Opin. Investig. Drugs, 5, 34-39.
    • (2004) Curr. Opin. Investig. Drugs , vol.5 , pp. 34-39
    • Renau, T.E.1
  • 44
    • 0020678270 scopus 로고
    • Inhibition of exercise-induced asthma by an orally absorbed mast cell stabilizer (M & B 22,948)
    • RUDD, R.M., GELLERT, A.R., STUDDY, P.R. & GEDDES, D.M. (1983). Inhibition of exercise-induced asthma by an orally absorbed mast cell stabilizer (M & B 22,948). Br. J. Dis. Chest., 77, 78-86.
    • (1983) Br. J. Dis. Chest. , vol.77 , pp. 78-86
    • Rudd, R.M.1    Gellert, A.R.2    Studdy, P.R.3    Geddes, D.M.4
  • 45
  • 46
    • 0029185805 scopus 로고
    • The analysis and assay of cyclic nucleotide phosphodiesterase isoenzyme activity
    • SHAHID, M. & NICHOLSON, C.D. (1995). The analysis and assay of cyclic nucleotide phosphodiesterase isoenzyme activity. Methods Mol. Biol., 41, 129-150.
    • (1995) Methods Mol. Biol. , vol.41 , pp. 129-150
    • Shahid, M.1    Nicholson, C.D.2
  • 47
    • 0030925148 scopus 로고    scopus 로고
    • Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases
    • SOUNESS, J.E. & RAO, S. (1997). Proposal for pharmacologically distinct conformers of PDE4 cyclic AMP phosphodiesterases. Cell Signal., 9, 227-236.
    • (1997) Cell Signal. , vol.9 , pp. 227-236
    • Souness, J.E.1    Rao, S.2
  • 48
    • 0001559662 scopus 로고
    • Fractionation and characterisation of a cyclic adenine ribonucleotide formed by tissue particles
    • SUTHERLAND, E.W. (1958). Fractionation and characterisation of a cyclic adenine ribonucleotide formed by tissue particles. J. Biol. Chem., 232, 1077-1091.
    • (1958) J. Biol. Chem. , vol.232 , pp. 1077-1091
    • Sutherland, E.W.1
  • 49
    • 0025868447 scopus 로고
    • Phosphodiesterase inhibitors: New opportunities for the treatment of asthma
    • TORPHY, T.J. & UNDEM, B.J. (1991). Phosphodiesterase inhibitors: new opportunities for the treatment of asthma. Thorax, 46, 512-523.
    • (1991) Thorax , vol.46 , pp. 512-523
    • Torphy, T.J.1    Undem, B.J.2
  • 50
    • 0027442594 scopus 로고
    • Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle
    • TORPHY, T.J., UNDEM, B.J., CIESLINSKI, L.B., LUTTMANN, M.A., REEVES, M.L. & HAY, D.W. (1993). Identification, characterization and functional role of phosphodiesterase isozymes in human airway smooth muscle. J. Pharmacol. Exp. Ther., 265, 1213-1223.
    • (1993) J. Pharmacol. Exp. Ther. , vol.265 , pp. 1213-1223
    • Torphy, T.J.1    Undem, B.J.2    Cieslinski, L.B.3    Luttmann, M.A.4    Reeves, M.L.5    Hay, D.W.6
  • 53
    • 0030946351 scopus 로고    scopus 로고
    • Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function
    • WESTON, M.C., ANDERSON, N. & PEACHELL, P.T. (1997). Effects of phosphodiesterase inhibitors on human lung mast cell and basophil function. Br. J. Pharmacol., 121, 287-295.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 287-295
    • Weston, M.C.1    Anderson, N.2    Peachell, P.T.3


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