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Volumn 3, Issue 5, 2007, Pages 641-665
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Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety
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Author keywords
ADME; ADMET; Bioavailability; Compound profiling; In vitro in vivo correlation
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Indexed keywords
ANTIINFECTIVE AGENT;
ANTIINFLAMMATORY AGENT;
ANTINEOPLASTIC AGENT;
ANTIVIRUS AGENT;
BUFURALOL;
CYCLOSPORIN A;
CYTOCHROME P450;
DICLOFENAC;
ELACRIDAR;
MEPHENYTOIN;
MIDAZOLAM;
NEW DRUG;
POTASSIUM CHANNEL HERG;
SERTINDOLE;
TERFENADINE;
VALSPODAR;
VERAPAMIL;
ZOSUQUIDAR;
DRUG;
BLOOD TOXICITY;
BONE MARROW TOXICITY;
CARDIOTOXICITY;
CELL LINE;
COMPUTER PROGRAM;
DRUG ABSORPTION;
DRUG BIOAVAILABILITY;
DRUG CLEARANCE;
DRUG DISTRIBUTION;
DRUG EFFICACY;
DRUG EXCRETION;
DRUG METABOLISM;
DRUG PROTEIN BINDING;
DRUG PURITY;
DRUG SAFETY;
DRUG SCREENING;
DRUG SOLUBILITY;
DRUG STABILITY;
DRUG WITHDRAWAL;
ENZYME INDUCTION;
ENZYME INHIBITION;
FIRST PASS EFFECT;
GASTROINTESTINAL ABSORPTION;
HIGH THROUGHPUT SCREENING;
HUMAN;
IN VITRO STUDY;
IN VIVO STUDY;
IONIZATION;
LIGHT SCATTERING;
LIPOPHILICITY;
LIQUID CHROMATOGRAPHY;
LIVER TOXICITY;
MASS SPECTROMETRY;
MEMBRANE PERMEABILITY;
NEOPLASM;
NEPHROTOXICITY;
NEUROTOXICITY;
NONHUMAN;
PATCH CLAMP;
PHYSICAL CHEMISTRY;
PREDICTION;
PROCESS OPTIMIZATION;
PROTEIN TARGETING;
QT PROLONGATION;
REVIEW;
SHELF LIFE;
THERMODYNAMICS;
TOXICITY TESTING;
ANIMAL;
BIOAVAILABILITY;
CHEMISTRY;
DRUG DESIGN;
INTESTINE ABSORPTION;
METABOLIC CLEARANCE RATE;
PH;
SOLUBILITY;
TOXICOLOGY;
ANIMALS;
BIOLOGICAL AVAILABILITY;
CHEMISTRY, PHARMACEUTICAL;
DRUG DESIGN;
DRUG STABILITY;
HUMANS;
HYDROGEN-ION CONCENTRATION;
INTESTINAL ABSORPTION;
METABOLIC CLEARANCE RATE;
PHARMACEUTICAL PREPARATIONS;
SOLUBILITY;
TOXICOLOGY;
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EID: 85047683939
PISSN: 17425255
EISSN: None
Source Type: Journal
DOI: 10.1517/17425255.3.5.641 Document Type: Review |
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Times cited : (54)
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References (222)
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