Oxidation of human cytochrome P450 1A2 substrates by Bacillus megaterium cytochrome P450 BM3

Journal of Molecular Catalysis B: Enzymatic

Volumn 63, Issue 3-4, 2010, Pages 179-187

  Kim, Dong Hyun ^a   Kim, Keon Hee ^a   Kim, Dooil ^b   Jung, Heung Chae ^b   Pan, Jae Gu ^b   Chi, Youn Tai ^a   Ahn, Taeho ^a   Yun, Chul Ho ^a  

^a Chonnam National University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

Drug metabolism; Human drug metabolites; Human P450 1A2; Oxidation; P450 BM3

Indexed keywords

ACTIVE SITE; BACILLUS MEGATERIUM; BIOCATALYSIS; CATALYTIC ACTIVITY; CAVITY SIZE; CONFORMATIONAL CHANGE; CYTOCHROME P450; CYTOCHROME P450 BM3; DRUG CANDIDATES; DRUG METABOLISMS; DRUG METABOLITES; HPLC ANALYSIS; HUMAN CYTOCHROME; HUMAN DRUG METABOLITES; MODELING RESULTS; OXIDATION REACTIONS; PRODUCTION OF FINE CHEMICALS; SCALABLE PRODUCTION; WILD TYPES;

BACTERIOLOGY; BIOMOLECULES; CATALYSTS; ENZYMES; HYDROXYLATION; MAMMALS; METABOLITES; OXIDATION; SUBSTRATES;

METABOLISM;

CYTOCHROME P450 1A2; CYTOCHROME P450 BM3; ETHOXYRESORUFIN; METHOXYRESORUFIN; PHENACETIN; PHENOXAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACILLUS MEGATERIUM; BIOTRANSFORMATION; CATALYSIS; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME METABOLISM; ENZYME STABILITY; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; NONHUMAN; OXIDATION; PROTEIN DETERMINATION; WILD TYPE;

BACILLUS MEGATERIUM; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 77949540506     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2010.01.017     Document Type: Article

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