Endothelial dysfunction in MELAS improved by L-arginine supplementation

Neurology

Volumn 66, Issue 11, 2006, Pages 1766-1769

  Koga, Y ^a   Akita, Y ^a   Junko, N ^a   Yatsuga, S ^a   Povalko, N ^a,b   Fukiyama, R ^a   Ishii, M ^c   Matsuishi, T ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b RESEARCH CENTRE FOR MEDICAL GENETICS   (Russian Federation)

^c KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ARUGI U; NITRIC OXIDE;

ADULT; AMINO ACID ANALYSIS; ARTICLE; BRAIN DISEASE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FLOW MEDIATED VASODILATATION; HUMAN; LACTIC ACIDOSIS; MALE; MELAS SYNDROME; MITOCHONDRIAL MYOPATHY; PRIORITY JOURNAL; STROKE; VASODILATATION;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ARGININE; BLOOD FLOW VELOCITY; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; CHILD; DIETARY SUPPLEMENTS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MELAS SYNDROME; MIDDLE AGED; VASODILATOR AGENTS;

EID: 33745648369     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000220197.36849.1e     Document Type: Article

References (10)

1. Pavlakis SG, Phillips PC, DiMauro S, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 1984;16:481-488.
2. Kishi M, Yamamura Y, Kurihara T, et al. An autopsy case of mitochondrial encephalomyopathy: biochemical and electron microscopic studies of he brain. J Neurol Sci 1988;86:31-40.
3. Hasegawa H, Matsuoka T, Goto Y, et al. Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. Ann Neurol 1991;13:1439-1445.
4. Koga Y, Ishibashi M, Ueki I, et al. Effects of L-arginine on the acute phase of strokes in three patients with MELAS. Neurology 2002;58:827-828.
5. Koga Y, Akita Y, Nishioka J, et al. L-arginine improves the symptoms of stroke-like episodes in MELAS. Neurology 2005;64:710-712.
6. Kubota M, Sakakihara Y, Mori M, et al. Beneficial effect of L-arginine for stroke-like episode in MELAS. Brain Dev 2004;26:481-483.
7. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-1115.
8. Sakuta R, Nonaka I. Vascular involvement in mitochondrial myopathy. Ann Neurol 1989;25:594-601.
9. Clark JM, Marks MP, Adalsteinsson E, et al. MELAS: clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy. Neurology 1996;46:223-227.
10. Wang XL, Sim AS, Badenhop RF, et al. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat Med 1996;2:41-45.