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Volumn 13, Issue 5, 2012, Pages 649-653

Directed Evolution of Highly Selective Proteases by Using a Novel FACS-Based Screen that Capitalizes on the p53 Regulator MDM2

(4) Yoo, Tae Hyeon a Pogson, Mark b Iverson, Brent L b Georgiou, George b,c

a Ajou University (South Korea)

b UNIVERSITY OF TEXAS AT AUSTIN (United States)

c The University of Texas at Austin (United States)

Author keywords

Biotechnology; FACS; High throughput screening; Proteases; Protein engineering

Indexed keywords

ALANINE; ARGININE; BETA GALACTOSIDASE; GLUTAMINE; LYSINE; OUTER MEMBRANE PROTEIN; PROTEIN MDM2; PROTEIN OMPT; PROTEIN P53; RNA POLYMERASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; ENZYME ENGINEERING; ENZYME SPECIFICITY; ESCHERICHIA COLI; FLUORESCENCE ACTIVATED CELL SORTING; HIGH THROUGHPUT SEQUENCING; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE;

DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; FLOW CYTOMETRY; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, MOLECULAR; PEPTIDE HYDROLASES; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MDM2; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84858319627 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.201100718 Document Type: Article

Times cited : (25)

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