Diversification and specialization of HIV protease function during in vitro evolution

Molecular Biology and Evolution

Volumn 23, Issue 4, 2006, Pages 764-772

  O'Loughlin, Taryn L ^a   Greene, Dina N ^a   Matsumura, Ichiro ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aspartic protease; Directed evolution; High throughput screening; Random mutagenesis

Indexed keywords

BETA GALACTOSIDASE; PROTEINASE;

ARTICLE; CYTOTOXICITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; EVOLUTION; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS; IN VITRO STUDY; MUTAGENESIS; PROTEIN FUNCTION; RANDOMIZATION; WILD TYPE;

ADAPTATION, BIOLOGICAL; BETA-GALACTOSIDASE; CLONING, MOLECULAR; DIRECTED MOLECULAR EVOLUTION; ENZYME ACTIVATION; ESCHERICHIA COLI; GENE PRODUCTS, POL; HIV; HIV PROTEASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33644900247     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msj098     Document Type: Article

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