Lycopene oxidation, uptake, and activity in human prostate cell cultures

Carotenoids: Physical, Chemical, and Biological Functions and Properties

Volumn , Issue , 2009, Pages 437-464

  Bowen, Phyllis E ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BIOACTIVITY; CELLS; DISEASES; FRUITS; POLYPHENOLIC COMPOUNDS; TISSUE CULTURE; UROLOGY;

ANTIOXIDANT EFFECT; BIOLOGICALLY ACTIVE COMPOUNDS; CARCINOGENIC PROCESS; CELLULAR PROCESS; PLAUSIBLE MECHANISMS; POPULATION STUDIES; PROSTATE CANCERS; PROSTATE SPECIFIC ANTIGEN;

CELL CULTURE;

EID: 84858315566     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420052312     Document Type: Chapter

References (122)

1. Ablin, AJ. 2005. Lycopene: A word of caution. Am J Health Syst Pharm 62:899.
2. Aust, O, N Ale-Agha, LX Zhang, H Wollersen, H Sies, and W Stahl. 2003. Lycopene oxidation product enhances gap junctional communication. Food Chem Toxicol 41(10):1399-1407.
3. Balakumaran BS and PG Febbo. 2006. New insights into prostate cancer biology. Hematol Oncol Clin North Am 20:773-796.
4. Barber, NJ, X Zhang, G Zhu et al. 2006. Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer Prostatic Dis 9:407-413.
5. Bastian, PJ, J Ellinger, LC Heukamp, P Kahl, SC Muller, and A von Rucker. 2007. Prognostic value of CpG island methylation of PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy. Eur Urol 51(3):665-674.
6. Bathaie, SK, A Bolhasan, R Hoshyar, B Ranjbar, F Sabouni, and A-A Moosavi-Movahedi. 2007. Interaction of saffron carotenoids as anticancer compounds with ctDNA, Oligo (dG.dC)15, and Oligo (dA.dT)15. DNA Cell Biol 26(8):533-540.
7. Ben-Dor, A, A Naham, M Danilenko et al. 2001. Effect of acyclo-retinoic acid and lycopene on activation of the retinoic acid receptor and proliferation of mammary cancer cells. Arch Biochem Biophys 391(2):295-302.
8. Ben-Dor, A, M Steiner, L Gheber et al. 2005. Carotenoids activate the antioxidant response element transcription system. Mol Cancer Ther 4(1):177-186.
9. Bohm, F, R Edge, M Burke, and TG Truscott. 2001. Dietary uptake of lycopene protects human cells from singlet oxygen and ntirogen dioxide—ROS components from cigarette smoke. J Photochem Photobiol B 64:176-178.
10. Borthakur G, K Sprandel, ES Hwang et al. 2005. Effect of chronic dosing of lycopene as a tomato-based beverage on oxidative stress biomarkers. FASEB J 19(4):A472.
11. Burton, GW and KU Ingold. 1984. Beta-carotene: An unusual type of lipid antioxidant. Science 224:569-573.
12. Caris-Veyrat, C, A Schmid, M Carail, and V Bohm. 2003. Cleavage products of lycopene produced by in vitro oxidations: Characterization and mechanisms of formation. J Agric Food Chem 51(25):7318-7325.
13. Chalabi, N, L Delort, S Satih, P Dechelotte, YJ Bignon, and DJ Bernard-Gallon. 2007. Immunohistochemical expression of RARalpha, RARbeta, and Cx43 in breast tumor cell lines after treatment with lycopene and correlation with RT-QPCR. J Histochem Cytochem 55(9):877-883.
14. Chen, JT, YW Cheng, MC Chou et al. 2003. The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodal micrometastasis in non-small cell lung cancer. Clin Cancer Res 9:4200-4204.
15. Chen, L, M Stacewicz-Sapuntzakis, C Duncan et al. 2001. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole food intervention. J Natl Cancer Inst 93:1872-1879.
16. Chiang, H-S, W-B Wu, J-Y Fang et al. 2007. Lycopene inhibits PDGF-BB-induced signaling and migration of human dermal fibroblasts through interaction with PDGF-BB. Life Sci 81:1509-1517.
17. Clinton, SK, C Emenhiser, SJ Schwartz et al. 1996. Cis-trans lycopene isomers, carotenoids, and retinol in human prostate. Cancer Epidemiol Biomarkers Prev 5(10):823-833.
18. Comstock, C and KE Knudsen. 2007. The complex role of AR signaling after cytotoxic insult. Cell Cycle 6(11):1307-1313.
19. Crawford, BH and DH Blankenhorn. 1991. Arterial wall oxygenation, oxyradicals, and atherosclerosis. Atherosclerosis 89:97-108.
20. Cunningham, FX, B Pogson, Z Sun, KA McDonald, D Della Penna, and E Gantt. 1996. Functional analysis of the beta and epsilon lycopene cyclase enzymes of arabidopsis reveals a mechanism for control of cyclic carotenoid formation. Plant Cell 8:1613-1626.
21. De Marzo, A, N Yasutomo, and WG Nelson. 2007. Inflammation, atrophy, and prostate carcinogenesis. Urol Oncol 25:398-400.
22. Edge, R and TG Truscott. 1997. Prooxidant and antioxidant reaction mechanisms of carotene and radical interactions with vitamins E and C. Nutrition 13(11/12):992-994.
23. Eichler, O, H Sies, and W Stahl. 2002. Divergent optimum levels of lycopene, beta-carotene and lutein protecting against UVB irradiation in human fibroblasts. Photochem Photobiol 75(5):503-506.
24. Ferreira, ALA, KJ Yeum, RM Russell, NI Krinsky, and G Tang. 2004. Enzymatic and oxidative metabolites of lycopene. J Nutr Biochem 15:493-502.
25. Festuccia, C, V Dolo, F Guerra et al. 1998. Plasminogen activator system modulated invasive capacity and proliferation in prostatic tumor cells. Clin Exp Metastasis 16:513-528.
26. Forbes, K, K Gillette, and I Sehgal. 2003. Lycopene increases urokinase receptor and fails to inhibit growth or connexin expression in a metastatically passaged prostate cancer cell line: a brief communication. Exp Biol Med 228:967-971.
27. Formari, FA, JK Randolph, JC Yalowich, MK Ritke, and DA Gewirtz. 1994. Interference by Doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Mol Pharmacol 45:649-656.
28. Fry, PM, DL Hudson, MH O’Hare, and JRW Masters. 2000. Comparison of marker protein expression in benign prostatic hyperplasia in vivo and in vitro. BJU Int 85:504-513.
29. Giovannucci, E. 2007. Does prostate-specific antigen screening influence the results of studies of tomatoes, lycopene, and prostate cancer risk? J Natl Cancer Inst 99(14):1060-1062.
30. Gitenay, D, B Lyan, J Talvas, A Mazur, S George, C Caris-Veyrat, and E Rock. 2007. Serum from rats fed red or yellow tomatoes induced Connexin-43 expression independently from lycopene in a prostate cancer cell line. Biochem Biophys Res Commun 364:578-582.
31. Goyal, A, GH Delves, M Chopra, BA Lwaleed, and AJ Cooper. 2006a. Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies. Int J Androl 29:528-533.
32. Goyal A, GH Delves GH, M Chopra, BA Lwaleed, and AJ Cooper. 2006b. Prostate cells exposed to lycopene in vitro liberate lycopene-enriched exosomes. BJU Int 98(4):907-911.
33. Graf, BA, C Ameho, GG Doinikowski, PE Mibury, CY Chen, and JB Blumberg. 2006. Rat gestrointestinal tissues metabolize quercetin. J Nutr 136(1):39-44.
34. Graydon, R, SE Gilchrist, IS Young, U Obermuller-Jevic, O Hasselwander, and JV Woodside. 2007. Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3: a double-blind, placebo-controlled trial. Eur J Clin Nutr 61(10):1196-2000.
35. Gunnell, D, SE Oliver, TJ Peters et al. 2003. Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men. Br J Cancer 88(11):1682-1686.
36. Gustin, DM, Rodvold KA, Sosman JA et al. 2004. Single-does pharmakinetic study of lycopene delivered in a well-defined food-based lycopene delivery system (tomato pasted-oil mixture) in healthy adult male subjects. Cancer Epidemiol Biomarkers Prev 13(5):850-860.
37. Hantz, H, LF Young, and KR Martin. 2005. Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells. Exp Biol Med 230:171-179.
38. Hazai, E, Z Bikadi, F Zsila, and SF. Lockwood. 2006. Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophill, and selected oxidative metabolites with 5-lipoxygenase. Bio Med Chem 14:6859-6867.
39. Herzog, A, U Siler, V Spitzer et al. 2005. Lycopene reduced gene expression of steroid targets and inflammatory markers in normal rat prostate. FASEB J 19:272-274.
40. Hirsch, K, A Atzmon, M Danilenko, J Levy, and Y Sharoni. 2007. Lycopene and other carotenoids inhibit estrogenic activity of 17 beta-estradiol and genistein in cancer cells. Breast Cancer Res Treat 104:221-230.
41. Huang, C-S, Y-E Fan, C-Y Lin, and M-L Hu. 2007. Lycopene inhbitis matrix metalloproteinase-9 expression and down-regulates the binding activity of nuclear facter-kappa B and stimulatory protein-1. J Nutr Biochem 18:449-456.
42. Huang, C-S, S Ming-Kuei, C-H Chuang, and M-L Hu. 2005. Lycopene inhibits cell migration and invasion and upregulates Nm23-H1 in a highly invasive hepatocarinoma, SK-Hep-1 cells. J Nutr 135:2119-2123.
43. Hussain, MZ, LR Wilkens, PP Mehta, WR Lowenstein, and JS Bertram. 1989. Enhancement of gap junctional communication by retinoids correlates with their ability to inhibit neoplastic transformation. Carcinogenesis 10:1743-1748.
44. Hwang, E-S and PE Bowen. 2004. Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells. J Med Food 2004(3):284-289.
45. Hwang, E-S and PE Bowen. 2005a. Effects of lycopene and tomato paste extracts on DNA and lipid oxidation in LNCaP human prostate cells. BioFactors 23:97-105.
46. Hwang, E-S and PE Bowen. 2005b. Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells. Biofactors 23:75-84.
47. Ivonov, NI, SP Cowell, P Brown, PS Rennie, ES Guns, and ME Cox. 2007. Lycopene differentially induces quiescence and apoptosis in adrogen-responsive and-independent prostate cell lines. Clin Nutr 26:252-263.
48. Kanagaraj, P, MR Vijayababu, B Ravisankar, J Anbalagan, MM Aruldhas, and J Aranakaran. 2007. Effect of lycopene on insulin-like growth factor-1, IGF binding protein-3, and IGF type-1 receptor in prostate cancer cells. J Cancer Res Clin Oncol 133:351-359.
49. Kangaspeska, S, B Stride, R Metivier et al. 2008. Transient cyclical methylation of promoter DNA. Nature 452:112-115.
50. Kawada, M, H Inoue, T Masuda, and D Ikeda. 2006. Insulin-like growth factor 1 secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer. Cancer Res 66(8):4419-4425.
51. Kim, G-Y, Kim J-H, Ahn S-C et al. 2004. Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor NF-kappa B. Immunology 113:203-211.
52. Kim, JS, E Nara, H Kobayashi, J Terao, and A Nagao. 2001. Formation of cleavage products by autooxidation of lycopene. Lipids 36(2):191-199.
53. Kim, L, AV Rao, and LG Rao. 2002. Effect of lycopene on prostate LNCaP cancer cells in culture. J Med Food 5(4):181-187.
54. King-Batoon, A, JM Leszczynska, and CB Klein. 2008. Modulation of gene methylation by genistein or lycopene in breast cancer cells. Environ Mol Mutagen 46:36-45.
55. Klaholz, BP and D Moras. 1998. A structural view of ligand binding to the retinoid receptors. Pure Appl Chem 70(1):41-47.
56. Kotake-Nara, E, JS Kim, M Kobori, K Miyashita, and A Nagao. 2002. Acylo-retinoic acid induces apoptosis in human prostate cancer cells. Anticancer Res 22(2A):689-95.
57. Kotake-Nara, E, M Kushiro, Zhang H, T Sugawara, K Miyashita, and A Nagao. 2001. Carotenoids affect proliferation of human prostate cancer cells. J Nutr 131:3303-3306.
58. Kozuki, Y, Y Miura, and K Yagasaki. 2000. Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture. Cancer Lett 151:111-115.
59. Kravets, FG, J Lee, B Singh, A Trocchia, SN Pentyala, and S Khan. 2000. Prostasomes: Current concepts. Prostate 43:169-174.
60. Li, L, H Ya, F Schumacher, G Casey, and JS Witte. 2003. Relations of serum insulin-like growth factor-1-(IGF-1) and IGF binding protein-3 to risk of prostate cancer(United States). Cancer Causes Control 14:721-726.
61. Lin C-Y, Huang C-S, and Hu M-L. 2007. The use of fetal bovine serum as delivery vehicle to improve the uptake and stability of lycopene in cell culture studies.Br J Nutr 98:226-232.
62. Lin, X, M Tascilar, WH Lee et al. 2001. GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells. Am J Pathol 159:1815-1826.
63. Lindshield, BL, K Canene-Adams, and JW Erdman. 2007. Lycopenoids: Are lycopene metabolites bioactive? Arch Biochem Biophys 458:136-140.
64. Liu, A, N Pajkovic, Y Pang, D Zhu, B Calamini, AL Mesecar, and RB van Breemen. 2006. Absorption and subcellular localization of lycopene in human prostate cancer cells. Mol Cancer Ther 5(11):2879-2885.
65. Liu, X, JD Allen, JT Arnold, and MR Blackman. 2008. Lycopene inhibits IGF-1 signal transduction and growth of normal prostate epithelial cells by decreasing DHT-modulated IGF-1 production in cocultured reactive stromal cells. Carcinogenesis 29(4):816-823.
66. Livny, O, I Kaplan, R Reifen, S Polak-Charcon, Z Madar, and B Schwartz. 2003. Oral cancer cells differ from normal oral epithelial cells in tissuelike organization and in response to lycopene treatment: An organotypic cell culture study. Nutr Cancer 47(2):195-209.
67. Lo, H-M, C-F Hung, Y-L Tseng, B-H Chen, J-S Jian, and W-B Wu. 2007. Lycopene binds PDGF-Bb and inhibits PDGD-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Biochem Pharmacol 74:54-63.
68. Lodi, F, R Jimenez, C Menendez, PW Needs, J Buaret, and E Perez-Vizcaino. 2008. Glucuronidated metabolites of the flavonoid of quercetin do not auto-oxidize, do not generate free radicals and do not decrease nitric oxide bioavailability. Planta Med 74(7):741-746.
69. Lowe, GM, LA Booth, AJ Young, and R Bilton. 1999. Lycopene and beta-carotene protect against oxidative damage in HT29 cells at low concentrations but rapidly lose this capacity at higher doses. Free Radic Res 30:141-151.
70. Matos, HR, P Di Mascio, and MHG Medieros. 2000. Protective effect of lycopene on lipid peroxidation and oxidative DNA damage in cell culture. Arch Biochem Biophys 383(1):56-59.
71. Mercurio, F and AM Manning. 1999. NF-kappa B as a primary regulator of the stress response. Oncogene 18:6163-6171.
72. Metivier, R, R Gallais, C Tiffoche et al. 2008. Cyclical DNA methylation of a transcriptionally active promoter. Nature 452:45-50.
73. Miki, J and JS Rhim. 2007. Prostate cell cultures as in vitro models for the study of normal stem cells and cancer stem cells. Prostate Cancer Prostatic Dis 11(1):32-39.
74. Miyata, Y, H Sakai, T Hayashi, and H Kanetake. 2003. Serum insulin-like growth factor binding protein-3/prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer. Prostate 54:125-132.
75. Moon, YJ, L Wang, R DiCenzo, and ME Morris. 2008. Quercetin pharmacokinetics in humans. Biopharm Drug Dispos 29:205-217.
76. Mucci, LA, R Tamimi, P Lagiou et al. 2001. Are dietary influences on the risk of prostate cancer mediated through the insulin-like growth factor system. BJU Int 87:814-820.
77. Murphy, TM, AS Perry, and M Lawler. 2008. The emergence of DNA methylation as a key modulator of aberrant cell death in prostate cancer. Endocr Relat Cancer 15:11-25.
78. Nagao A 2004. Oxidative conversion of carotenoids to retinoids and other products. J Nutr 143:237s-240s.
79. Nahum A, Kirsch K, Danilenko M et al. 2001. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27-Kip1 in the cyclin E-cdk2 complexes. Oncogene 20:3428-3436.
80. Nara, E, H Hayashi, M Kotake, K Miyashita, and A Nagao. 2001. Acyclic carotenoids and their oxidation mixtures inhibit the growth of HL-60 human promyelocytic leukemia cells. Nutr Cancer 39(2):273-83.
81. Obermuller-Jevic, UC, E Olano-Martin, AM Carbach et al. 2003. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J Nutr 133:3356-3360.
82. Offord, EA, JC Gautier, O Avanti et al. 2002. Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radic Biol Med 32(12):1293-1303.
83. Oliver, SE, D Gunnell, J Donovan et al. 2004. Screen-detected prostate cancer and the insulin-like growth factor axis: results of a population-based case-control study (United States). Int J Cancer 108(6):887-892.
84. Palozza, P, S Serini, A Torsello et al. 2003. Beta-carotene regulates NF-kappa B DNA-binding activity by a redox mechanism in human leukemia and colon adenocarcinoma cells. J Nutr 133:381-388.
85. Pasquali, D, V Rossi, G Bellastella, A Ballastella, and AA Sinisi. 2006. Natural and synthetic retinoids in prostate cancer. Curr Pharm Des 12:1923-1929.
86. Pastori, M, H Pfander, D Boscoboinik, and A Azzi. 1998. Lycopene in association with alpha-tocopherol inhibits at physiological concentrations proliferation of prostate carcinoma cells. Biochem Biophys Res Commun 250:582-585.
87. Paule, B, S Terry, L Kheuang, P Soyeux, F Vacherot, and A de la Taille. 2007. The NF-kappa B/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches. World J Urol 25:477-489.
88. Peehl, DM. 2004. Are primary cultures realistic models for prostate cancer? J Cell Biochem 91:185-195.
89. Perry, AS, B Loftus, R Moroose et al. 2007. In silico mining identifies IGFBP-3 as a novel target of methylation in prostate cancer. Br J Cancer 96:1587-1594.
90. Porrini, M and P Riso. 2000. Lymphocyte lycopene concentration and DNA protection from oxidative damage is increased in women after a short period of tomato consumption. J Nutr 130:189-192.
91. Poulter LW and Janossy G. 1985. The involvement of dendritic cells in chronic inflammatory disease. Scand J Immunol 21:401-411.
92. Riso, P, A Brusamolino, A Martinetti, and M Porrini. 2006. Effect of a tomoto drink intervention on insulin-like growth factor (IGF)-1 serum levels in health subjects. Nutr Cancer 55(2):157-162.
93. Riso, P, F Visioli, D Erba, G Testolin, and M Porrini. 2004. Lycopene and vitamin C concentrations increase in plasma and lymphocytes after tomato intake. Effects on cellular antioxidant protection. Eur J Clin Nutr 58:1350-1358.
94. Ryan, CJ, CM Haqq, J Simko et al. 2007. Expression of insulin-like growth factor-1 receptor in local and metastatic prostate cancer. Urol Oncol 2007(2):134-140.
95. Sampson, N, G Untergasser, E Plas, and P Berger. 2007. The ageing male reproductive tract. J Pathol 211:206-218.
96. Schulz, WA, Burchardt M, and Cronauer MV. 2003. Molecular biology of prostate cancer. Mol Hum Reprod 9(8):437-448.
97. Shahrzad, S, E Cardenas, A Sevanian, and L Packer. 2002. Impact of water-dispersible beadlets as a vehicle for the delivery of carotenoids to cultured cells. Biofactors 16:83-91.
98. Shaklai, S, N Amariglio, G Rechavi, and AJ Simon. 2007. Gene silencing at the nuclear periphery. FEBS J 274:1383-1392.
99. Siler U, Barella L, Spitzer V et al. 2004. Lycopene and vitamin E interfere with autocrine/paracrine loops in the Dunning prostate cancer model. FASEB J 18:1019-1021.
100. Sobel, RE and MD Sadar. 2005. Cell lines used in prostate cancer research: A compendium of old and new lines-Part 1. J Urol 173:342-359.
101. Stahl, W, J von Laar, H-D Martin, T Emmerich, and H Sies. 2000. Stimulation of gap junctional communication: comparison of acyclo-retinoic acid and lycopene. Arch Biochem Biophys 373(1):271-274.
102. Suh, J and AB Rabson. 2004. NF-kappa B activation in human prostate cancer: important mediator or epiphenomenon. J Cell Biochem 91:100-112.
103. Tang L, Jin T, Zeng X, Wang J-S. 2005. Lycopene inhibits the growth of human androgen-independent prostate cancer cells in vitro and in BALB/c nude mice. J Nutr 135:287-290.
104. Tomlins, SA, MA Rubin, and AM Chinnaiyan. 2006. Integrative biology of prostate cancer progression. Annu Rev Pathol Mech Dis 1:243-271.
105. Trachootham, D, W Lu, MA Ogasawara, N Rivera-Del Valle, and P Huang. 2008. Redox regulation of cell survival. Antioxid Redox Signal 10(8):1342-1374.
106. Unlu, NZ, T Bohn, DM Francis, HN Nagaraja, SK Clinton, and SJ Schwartz. 2007. Lycopene from heat-treated cis-isomer-rich tomato sauce is more bioavailable than from all-trans-rich tomato sauce in human subjects. Br J Nutr 98(1):140-146.
107. van Breemen, RB, X Xu, MA Viana et al. 2002. Liquid chromatography-mass spectrometry of cis-and translycopene in human serum and prostate tissue after dietary supplementation with tomato sauce. J Agric Food Chem 50(8):2214-2219.
108. Vine, AL, YM Leung, and JS Bertram. 2005. Transcriptional regulation of connexin 43 expression by retinoids and carotenoids: similarities and differences. Mol Carcinog 43:75-85.
109. Voskuil, DW, A Vrieling, CM Korse et al. 2008. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer surviviors and women at high familial breast cancer risk. Nutr Cancer 60(3):342-353.
110. Vrieling, A, DW Voskull, JM Bonfrer et al. 2007. Lycopene supplementation elevates circulatng insulin-like growth factor binding protein-1 and-2 concentrations in persons at great risk of colorectal cancer. Am J Clin Nutr 86(5):1456-1462.
111. Webber, MM, D Bello, and S Quader. 1997. Immortalized and tumorgenic adult human prostatic epithelial cell lines: characteristics and applications. Part 2: Tumorogenic cell lines. Prostate 30:58-64.
112. Wertz, K, U Siler, and R Goralczyk. 2004. Lycopene: Modes of action to promote prostate health. Arch Biochem Biophys 430:127-134.
113. Woodall, AA, SW Lee, RJ Weesie, MJ Jackson, and G Britton. 1997. Oxidation of carotenoids by free radicals: Relationship between structure and reactivity. Biochim Biophys Act 1336(1):33-42.
114. Woodson, K, J Gillespie, J Hanson, M Emmert-Buck, JM Phillips et al. 2004. Heterogeneous gene methylation patterns among pre-invasive and cancerous lesions of the prostate: a histopathologic study of whole mount prostate specimens. Prostate 60(1):25-31.
115. Xing, N, Y Chen, SH Mitchell, and CYF Young. 2001. Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis 22(3):409-414.
116. Xu, X, Yan Wang, AI Constantinou, M Stacewicz-Sapuntzakis, PE Bowen, and RB van Breemen. 1999. Solubilization and stabilization of carotenoids using micelles: Delivery of lycopene in cells in culture. Lipids 34:1031-1036.
117. Yeh, SL, and ML Hu. 2000. Antioxidant and pro-oxidant effects of lycopene in comparison with beta-carotene on oxidant-induced damage in Hs68 cells. J Nutr Biochem 11:548-554.
118. Yeh, SL and ML Hu. 2001. Induction of oxidative DNA damage in human foreskin fibroblast HS68 cells by oxidized beta-carotene and lycopene. Free Radic Res 35(2):203-213.
119. Zhang, H, E Kotake-Nara, H Ono, and A Nagao. 2003. A novel cleavage product formed by autooxidation of lycopene induces apoptosis in HL-60 cells. Free Radic Biol Med 35(12):1653-1663.
120. Zhang, LX, RV Cooney, and JS Bertram. 1991. Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: Relationship to their cancer prevention action. Carcinogenesis 12(11):2109-2114.
121. Zhang, LX, RV Cooney, and JS Bertram. 1992. Carotenoids up-regulate Connexin 43 expression independent of their provitamin A or antioxidant properties. Cancer Res 52:5707-5712.
122. Zhao, X, G Aldini, E Johnson, H Rasmussen, K Kraemer, H Woolf, N Musaeus, NI Krinsky, RM Russell, and K Yeum. 2006. Modification of lymphocyte DNA damage by carotenoid supplementation in postmenopausal women. Am J Clin Nutr 83:163-169.