GSTP1 CpG island hypermethylation is responsible for the absence of GSTP1 expression in human prostate cancer cells

American Journal of Pathology

Volumn 159, Issue 5, 2001, Pages 1815-1826

  Lin, Xiaohui ^a   Tascilar, Metin ^a   Lee, Wen Hsiang ^a   Vles, Wouter J ^a   Lee, Byron H ^a   Veeraswamy, Ravi ^a   Asgari, Kekule ^a   Freije, Diha ^a   Van Rees, Bastian ^a   Gage, Wesley R ^a   Bova, G Steven ^a   Isaacs, William B ^a   Brooks, James D ^a   Deweese, Theodore L ^a   De Marzo, Angelo M ^a   Nelson, William G ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; CARCINOGEN; DNA METHYLTRANSFERASE;

ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; GENE DELETION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MUTATION; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROSTATE CANCER; TUMOR SUPPRESSOR GENE;

EID: 0035152120     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63028-3     Document Type: Article

References (71)

1. Genetic instability and Darwinian selection in tumours
2. Genetic instabilities in human cancers
3. A genetic model for colorectal tumorigenesis
4. Cancer-susceptibility genes. Gatekeepers and caretakers
5. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
6. DNA methylation: Past, present and future directions
7. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
8. Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids
9. CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: A new prostate cancer biomarker
10. Detailed methylation analysis of the glutathione S-transferase pi (GSTP1) gene in prostate cancer
11. High frequency of alterations in DNA methylation in adenocarcinoma of the prostate
12. Comparison of telomerase activity and GSTP1 promoter methylation in ejaculate as potential screening tests for prostate cancer
13. CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia
14. Glutathione S-transferase PI (GST-pi) class expression by immunohistochemistry in benign and malignant prostate tissue
15. Expression of pi-class glutathione S-transferase: Two populations of high grade prostatic intraepithelial neoplasia with different relations to carcinoma
16. Immunohistochemical expression of pi class glutathione S-transferase in the basal cell layer of benign prostate tissue following chronic treatment with finasteride
17. The immunohistochemical localization of drug-metabolizing enzymes in prostate cancer
18. Immunohistochemical expression of pi-class glutathione S-transferase is down-regulated in adenocarcinoma of the prostate
19. The structure of the human glutathione S-transferase pi gene
20. Structure of the human genomic glutathione S-transferase-pi gene
21. Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors
22. LNCaP model of human prostatic carcinoma
23. Allelic loss of chromosomes 16q and 10q in human prostate cancer
24. p53 gene mutations and MDM2 amplification are uncommon in primary carcinomas of the uterine cervix
25. DCC genetic alterations and expression in endometrial carcinoma
26. Tumor suppressor gene allelic loss in human renal cancers
27. Determination of DNA concentration with diphenylamine
28. Proliferative inflammatory atrophy of the prostate: Implications for prostatic carcinogenesis
29. High sensitivity mapping of methylated cytosines
30. GSTP1 CpG island DNA hypermethylation in hepatocellular carcinomas
31. Establishment and characterization of a human prostatic carcinoma cell line (PC-3)
32. Modulation of growth gene expression by selective alteration of polyamines in human colon carcinoma cells
33. Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells
34. Stimulation of human prostatic carcinoma tumor growth in athymic mice and control of migration in culture by extracellular matrix
35. Contribution of proximal promoter elements to the regulation of basal and differential glutathione S-transferase P1 gene expression in human breast cancer cells
36. Regulation of human glutathione S-transferase pi gene transcription: Influence of 5′-flanking sequences and trans-activating factors which recognize AP-1-binding sites
37. The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their, induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin
38. Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter
39. Functional characterization of the transcription silencer element located within the human Pi class glutathione S-transferase promoter
40. The organization of the human GSTP1-1 gene promoter and its response to retinoic acid and cellular redox status
41. Glutathione transferase pi its minimal promoter and downstream cisacting element
42. p53 protein overexpression is associated with increased cell proliferation in patients with locally recurrent prostate carcinoma after radiation therapy
43. Methylation-mediated regulation of the glutathione S-transferase P1 gene in human breast cancer cells
44. Regulation of JNK signaling by GSTp
45. Multiple domains are involved in the targeting of the mouse DNA methyltransferase to the DNA replication foci
46. Concurrent replication and methylation at mammalian origins of replication
47. A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei
48. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells
49. Expression of prokaryotic Hhal DNA methyltransferase is transforming and lethal to NIH 3T3 cells
50. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase
51. Role of DNA 5-methylcytosine transferase in cell transformation by fos
52. Suppression of intestinal neoplasia by DNA hypomethylation
53. DNMT1 forms a complex with Rb, E2Fl and HDAC1 and represses transcription from E2F-responsive promoters
54. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci
55. DNA methyltransferase Dnmtl associates with histone deacetylase activity
56. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
57. Active repression of methylated genes by the chromosomal protein MBD1
58. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex
59. Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
60. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
61. Mi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
62. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
63. Sp1 elements protect a CpG island from de novo methylation
64. Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island
65. Pi-class glutathione S-transferase: Regulation and function
66. The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance
67. Glutathione S-transferases: Gene structure and regulation of expression
68. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases
69. Protection against 2-hydroxy-amino-1-methyl-6-phenylaimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1
70. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
71. Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia