Prostate cells exposed to lycopene in vitro liberate lycopene-enriched exosomes

BJU International

Volumn 98, Issue 4, 2006, Pages 907-911

  Goyal, Anuj ^a   Delves, George H ^a   Chopra, Mridula ^a   Lwaleed, Bashir A ^b   Cooper, Alan J ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Exosomes; In vitro; Infertility; Lycopene; Prostasomes; Prostate

Indexed keywords

ANTIOXIDANT; FREE RADICAL; L 9887; LYCOPENE; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL ORGANELLE; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROSTATE; PROSTATE CANCER; PROSTATE HYPERTROPHY; PROTEIN EXPRESSION; RISK REDUCTION; SEMINAL PLASMA; SPERMATOZOON;

ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; CAROTENOIDS; CELL LINE, TUMOR; CHEMOPREVENTION; HUMANS; MALE; PROSTATIC HYPERPLASIA; PROSTATIC NEOPLASMS; TRANSPORT VESICLES;

EID: 33748576262     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2006.06434.x     Document Type: Article

References (26)

1. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch Biochem Biophys 1989; 274: 532-8
2. Clinton SK, Emenhiser C, Schwartz SJ et al. Cis-trans lycopene isomers, carotenoids and retinol in the human prostate. Cancer Epidemiol Biomarkers Prev 1996; 5: 823-33
3. Palan P, Naz R. Changes in various antioxidant levels in human plasma related to immunoinfertility. Arch Androl 1996; 36: 139-43
4. Obermuller-Jevic UC, Olano-Martin E, Corbacho AM et al. Lycopene inhibits the growth of normal human prostate epithelial cells in vitro. J Nutr 2003; 133: 3356-60
5. Bowen P, Chen L, Stacewicz-Sapuntzakis M et al. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med (Maywood) 2002; 227: 886-93
6. Kucuk O, Sarkar FH, Sakr W et al. Phase II randomised clinical trial of lycopene supplementation before radical prostatectomy. Cancer Epidemiol Biomarker Prev 2001; 10: 861-8
7. Siler U, Barella L, Spitzer V et al. Lycopene and vitamin E interfere with autocrine/ paracrine loops in the Dunning prostate cancer model. FASEB J 2004; 18: 1019-21
8. Giovannucci E, Ascherio A, Rimm EB, Stampfer MJ, Colditz GA, Willett WC. Intake of carotenoids and retinol in relation to risk of prostate cancer. J Natl Cancer Inst 1995; 87: 1767-76
9. Gann PH, Ma J, Giovannucci E et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res 1999; 59: 1225-30
10. Giovannucci E. A review of epidemiological studies of tomatoes, lycopene and prostate cancer. Exp Biol Med (Maywood) 2002; 227: 852-9
11. Chen L, Stacewicz-Sapuntzakis M, Duncan C et al. Oxidative DNA damage in prostate cancer patients consuming tomato sauce-based entrees as a whole-food intervention. J Natl Cancer Inst 2001; 93: 1872-9
12. Mohanty NK, Saxena S, Singh UP, Goyal NK, Arora RP. Lycopene as a chemopreventative agent in the treatment of high-grade prostate intraepithelial neoplasia. Urol Oncol 2005; 23: 383-5
13. Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility - a preliminary report. Int Urol Nephrol 2002; 34: 369-72
14. Ronquist G, Brody I. The prostasome: its secretion and function in man. Biochim Biophys Acta 1985; 822: 203-18
15. Stewart AB, Anderson W, Delves G, Lwaleed BA, Birch B, Cooper A. Prostasomes: a role in prostatic disease? BJU Int 2004; 94: 985-9
16. Utleg A, Yi E, Xie T et al. Proteomic analysis of human prostasomes. Prostate 2003; 56: 150-61
17. Arvidson G, Ronquist G, Wikander G, Ojteg AC. Human prostasome membranes exhibit very high cholesterol/ phospholipid ratios yielding high molecular ordering. Biochim Biophys Acta 1989; 984: 167-73
18. Arienti G, Carlini E, Polci A, Cosmi EV, Palmerini CA. Fatty acid pattern of human prostasomes lipid. Arch Biochem Biophys 1998; 358: 391-5
19. Nilsson BO, Lennartsson L, Carlsson L, Nilsson S, Ronquist G. Expression of prostasome-like granules by the prostate cancer cell lines PC3, Du145 and LnCaP grown in monolayer. Ups J Med Sci 1999; 104: 199-206
20. Sahlen G, Ahlander A, Frost A, Ronquist G, Norlen BJ, Nilsson BO. Prostasomes are secreted from poorly differentiated cells of prostate cancer metastases. Prostate 2004; 61: 291-7
21. Hwang ES, Bowen PE. Cell cycle arrest and induction of apoptosis by lycopene in LNCaP human prostate cancer cells. J Med Food 2004; 7: 284-9
22. Goyal A, Delves GH, Chopra M, Lwaleed BA, Cooper AJ. Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies. Int J Androl 2006 (e-pub ahead of print): DOI:10.1111/j.1365-2605.2006. 00690.x
23. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilising the principle of protein-dye binding. Anal Biochem 1976; 72: 248-54
24. Talwar D, Ha TK, Cooney J, Brownlee C, O'Reilly DS. A routine method for simultaneous measurement of retinol, α-tocopherol and five carotenoids in human plasma by reverse phase HPLC. Clin Chim Acta 1998; 270: 85-100
25. Steinman RM, Mellman IS, Muller WA, Cohn ZA. Endocytosis and the recycling of plasma membrane. J Cell Biol 1983; 96: 1-27
26. Saez F. Antioxidant properties of prostasomes. In Ronquist G, Nilsson BO eds, Prostasomes: Proceedings from a Symposium Held at the Wenner-Gren Centre. Stockholm. June 2001, Wenner-Gren International Series: Vol. 81, Chapt. 13. London: Portland Press, 2002: 101-8