Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 6859-6867

  Hazai, Eszter ^a   Bikádi, Zsolt ^a   Zsila, Ferenc ^b   Lockwood, Samuel F ^c  

^a Virtua Drug Ltd   (Hungary)

^b Cardax Pharmaceuticals Inc ^*

^c Cardax Pharmaceuticals Inc   (United States)

Author keywords

5 HETE; 5 Lipoxygenase; 5 LOX; 5 oxo EET; Astaxanthin; Blind docking; Homology modeling; Lycopene; Lycophyll; Oxidative metabolites

Indexed keywords

2,7,11 TRIMETHYLTETRADECAHEXAENE 1,4 DIAL; 4 METHYL 8 OXO 2,4,6 NONATRIENAL; ARACHIDONATE 5 LIPOXYGENASE; ASTAXANTHIN; CARDAX; CAROTENOID; LYCOPENE; LYCOPHYLL; SCAVENGER; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CIS ISOMER; COVALENT BOND; DRUG BINDING SITE; DRUG PROTEIN BINDING; ENZYME STRUCTURE; MATHEMATICAL COMPUTING; MOLECULAR MODEL; PROTEIN DOMAIN; TOMATO; TRANS ISOMER; VALIDATION PROCESS;

ARACHIDONATE 5-LIPOXYGENASE; BINDING SITES; CAROTENOIDS; CRYSTALLOGRAPHY, X-RAY; LIGANDS; LYCOPERSICON ESCULENTUM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

LYCOPERSICON ESCULENTUM; MURINAE;

EID: 33748119839     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.045     Document Type: Article

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