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Volumn 1822, Issue 5, 2012, Pages 616-624

Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine

Author keywords

Acetyl l carnitine; Alzheimer's disease; Curcumin; Ginkgo biloba; Pharmacodynamics; Pharmacokinetics

Indexed keywords

ALKALINE PHOSPHATASE; AMYLOID BETA PROTEIN; CARNITINE; CURCUMIN; DONEPEZIL; GALANTAMINE; GINKGO BILOBA EXTRACT; GINKGOSELECT; LACTATE DEHYDROGENASE; OMEPRAZOLE; PHENYTOIN; PIPERINE; PLACEBO; TRAZODONE; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84858155062     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.09.004     Document Type: Review
Times cited : (86)

References (123)
  • 4
    • 77953522402 scopus 로고    scopus 로고
    • Early Alzheimer's disease
    • Mayeux R. Early Alzheimer's disease. N. Engl. J. Med. 2010, 362:2194-2201.
    • (2010) N. Engl. J. Med. , vol.362 , pp. 2194-2201
    • Mayeux, R.1
  • 6
    • 79954605836 scopus 로고    scopus 로고
    • Apolipoprotein E: implications for AD neurobiology, epidemiology and risk assessment
    • Schipper H.M. Apolipoprotein E: implications for AD neurobiology, epidemiology and risk assessment. Neurobiol. Aging 2011, 32:778-790.
    • (2011) Neurobiol. Aging , vol.32 , pp. 778-790
    • Schipper, H.M.1
  • 7
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: strategies for disease modification
    • Citron M. Alzheimer's disease: strategies for disease modification. Nat. Rev. Drug Discov. 2010, 9:387-398.
    • (2010) Nat. Rev. Drug Discov. , vol.9 , pp. 387-398
    • Citron, M.1
  • 10
    • 61849147931 scopus 로고    scopus 로고
    • Ferulic acid and its therapeutic potential as a hormetin for age-related diseases
    • Barone E., Calabrese V., Mancuso C. Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 2009, 10:97-108.
    • (2009) Biogerontology , vol.10 , pp. 97-108
    • Barone, E.1    Calabrese, V.2    Mancuso, C.3
  • 11
    • 75149118997 scopus 로고    scopus 로고
    • Role of oxidative stress in the progression of Alzheimer's disease
    • Sultana R., Butterfield D.A. Role of oxidative stress in the progression of Alzheimer's disease. J. Alzheimers Dis. 2010, 19:341-353.
    • (2010) J. Alzheimers Dis. , vol.19 , pp. 341-353
    • Sultana, R.1    Butterfield, D.A.2
  • 13
    • 67349253085 scopus 로고    scopus 로고
    • Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis
    • Sultana R., Perluigi M., Butterfield D.A. Oxidatively modified proteins in Alzheimer's disease (AD), mild cognitive impairment and animal models of AD: role of Abeta in pathogenesis. Acta Neuropathol. 2009, 118:131-150.
    • (2009) Acta Neuropathol. , vol.118 , pp. 131-150
    • Sultana, R.1    Perluigi, M.2    Butterfield, D.A.3
  • 15
    • 34547102265 scopus 로고    scopus 로고
    • Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment
    • Butterfield D.A., Reed T., Newman S.F., Sultana R. Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic. Biol. Med. 2007, 43:658-677.
    • (2007) Free Radic. Biol. Med. , vol.43 , pp. 658-677
    • Butterfield, D.A.1    Reed, T.2    Newman, S.F.3    Sultana, R.4
  • 17
    • 45249097300 scopus 로고    scopus 로고
    • Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    • Shelat P.B., Chalimoniuk M., Wang J.H., Strosznajder J.B., Lee J.C., Sun A.Y., Simonyi A., Sun G.Y. Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons. J. Neurochem. 2008, 106:45-55.
    • (2008) J. Neurochem. , vol.106 , pp. 45-55
    • Shelat, P.B.1    Chalimoniuk, M.2    Wang, J.H.3    Strosznajder, J.B.4    Lee, J.C.5    Sun, A.Y.6    Simonyi, A.7    Sun, G.Y.8
  • 19
    • 77955085839 scopus 로고    scopus 로고
    • Inflammatory neurodegeneration and mechanisms of microglial killing of neurons
    • Brown G.C., Neher J.J. Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol. Neurobiol. 2010, 41:242-247.
    • (2010) Mol. Neurobiol. , vol.41 , pp. 242-247
    • Brown, G.C.1    Neher, J.J.2
  • 20
    • 73949103706 scopus 로고    scopus 로고
    • Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease
    • Sultana R., Banks W.A., Butterfield D.A. Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease. J. Neurosci. Res. 2010, 88:469-477.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 469-477
    • Sultana, R.1    Banks, W.A.2    Butterfield, D.A.3
  • 22
    • 33750532308 scopus 로고    scopus 로고
    • Regulation of inflammation and redox signaling by dietary polyphenols
    • Rahman I., Biswas S.K., Kirkham P.A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem. Pharmacol. 2006, 72:1439-1452.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1439-1452
    • Rahman, I.1    Biswas, S.K.2    Kirkham, P.A.3
  • 23
    • 27744561942 scopus 로고    scopus 로고
    • Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys
    • Tirkey N., Kaur G., Vij G., Chopra K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC Pharmacol. 2005, 5:15.
    • (2005) BMC Pharmacol. , vol.5 , pp. 15
    • Tirkey, N.1    Kaur, G.2    Vij, G.3    Chopra, K.4
  • 25
    • 0020067035 scopus 로고
    • Metabolism of curcumin-studies with [3H]curcumin
    • Ravindranath V., Chandrasekhara N. Metabolism of curcumin-studies with [3H]curcumin. Toxicology 1981, 22:337-344.
    • (1981) Toxicology , vol.22 , pp. 337-344
    • Ravindranath, V.1    Chandrasekhara, N.2
  • 26
    • 0018873182 scopus 로고
    • Absorption and tissue distribution of curcumin in rats
    • Ravindranath V., Chandrasekhara N. Absorption and tissue distribution of curcumin in rats. Toxicology 1980, 16:259-265.
    • (1980) Toxicology , vol.16 , pp. 259-265
    • Ravindranath, V.1    Chandrasekhara, N.2
  • 27
    • 0031860081 scopus 로고    scopus 로고
    • Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers
    • Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998, 64:353-356.
    • (1998) Planta Med. , vol.64 , pp. 353-356
    • Shoba, G.1    Joy, D.2    Joseph, T.3    Majeed, M.4    Rajendran, R.5    Srinivas, P.S.6
  • 28
    • 33846234714 scopus 로고    scopus 로고
    • Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats
    • Maiti K., Mukherjee K., Gantait A., Saha B.P., Mukherjee P.K. Curcumin-phospholipid complex: preparation, therapeutic evaluation and pharmacokinetic study in rats. Int. J. Pharm. 2007, 330:155-163.
    • (2007) Int. J. Pharm. , vol.330 , pp. 155-163
    • Maiti, K.1    Mukherjee, K.2    Gantait, A.3    Saha, B.P.4    Mukherjee, P.K.5
  • 30
    • 78649812260 scopus 로고    scopus 로고
    • Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats
    • Kakkar V., Singh S., Singla D., Sahwney S., Chauhan A.S., Singh G., Kaur I.P. Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 2010, 878:3427-3431.
    • (2010) J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. , vol.878 , pp. 3427-3431
    • Kakkar, V.1    Singh, S.2    Singla, D.3    Sahwney, S.4    Chauhan, A.S.5    Singh, G.6    Kaur, I.P.7
  • 31
    • 70449637229 scopus 로고    scopus 로고
    • Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo
    • Anand P., Nair H.B., Sung B., Kunnumakkara A.B., Yadav V.R., Tekmal R.R., Aggarwal B.B. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem. Pharmacol. 2010, 79:330-338.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 330-338
    • Anand, P.1    Nair, H.B.2    Sung, B.3    Kunnumakkara, A.B.4    Yadav, V.R.5    Tekmal, R.R.6    Aggarwal, B.B.7
  • 32
    • 67349107075 scopus 로고    scopus 로고
    • Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer
    • Shaikh J., Ankola D.D., Beniwal V., Singh D., Kumar M.N. Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur. J. Pharm. Sci. 2009, 37:223-230.
    • (2009) Eur. J. Pharm. Sci. , vol.37 , pp. 223-230
    • Shaikh, J.1    Ankola, D.D.2    Beniwal, V.3    Singh, D.4    Kumar, M.N.5
  • 33
    • 1642360726 scopus 로고    scopus 로고
    • Herbal modulation of P-glycoprotein
    • Zhou S., Lim L.Y., Chowbay B. Herbal modulation of P-glycoprotein. Drug Metab. Rev. 2004, 36:57-104.
    • (2004) Drug Metab. Rev. , vol.36 , pp. 57-104
    • Zhou, S.1    Lim, L.Y.2    Chowbay, B.3
  • 37
    • 33846066817 scopus 로고    scopus 로고
    • Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives
    • Somparn P., Phisalaphong C., Nakornchai S., Unchern S., Morales N.P. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol. Pharm. Bull. 2007, 30:74-78.
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 74-78
    • Somparn, P.1    Phisalaphong, C.2    Nakornchai, S.3    Unchern, S.4    Morales, N.P.5
  • 39
    • 67649407501 scopus 로고    scopus 로고
    • Curcumin in clinical practice: myth or reality?
    • Mancuso C., Barone E. Curcumin in clinical practice: myth or reality?. Trends Pharmacol. Sci. 2009, 30:333-334.
    • (2009) Trends Pharmacol. Sci. , vol.30 , pp. 333-334
    • Mancuso, C.1    Barone, E.2
  • 40
    • 47949101818 scopus 로고    scopus 로고
    • Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor
    • Volak L.P., Ghirmai S., Cashman J.R., Court M.H. Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab. Dispos. 2008, 36:1594-1605.
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 1594-1605
    • Volak, L.P.1    Ghirmai, S.2    Cashman, J.R.3    Court, M.H.4
  • 41
    • 33845224136 scopus 로고    scopus 로고
    • The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin
    • Hayeshi R., Mutingwende I., Mavengere W., Masiyanise V., Mukanganyama S. The inhibition of human glutathione S-transferases activity by plant polyphenolic compounds ellagic acid and curcumin. Food Chem. Toxicol. 2007, 45:286-295.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 286-295
    • Hayeshi, R.1    Mutingwende, I.2    Mavengere, W.3    Masiyanise, V.4    Mukanganyama, S.5
  • 42
    • 34247646955 scopus 로고    scopus 로고
    • Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products
    • Appiah-Opong R., Commandeur J.N., van Vugt-Lussenburg B., Vermeulen N.P. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 2007, 235:83-91.
    • (2007) Toxicology , vol.235 , pp. 83-91
    • Appiah-Opong, R.1    Commandeur, J.N.2    van Vugt-Lussenburg, B.3    Vermeulen, N.P.4
  • 45
    • 0346656621 scopus 로고    scopus 로고
    • Donepezil: a clinical review of current and emerging indications
    • Roman G.C., Rogers S.J. Donepezil: a clinical review of current and emerging indications. Expert. Opin. Pharmacother. 2004, 5:161-180.
    • (2004) Expert. Opin. Pharmacother. , vol.5 , pp. 161-180
    • Roman, G.C.1    Rogers, S.J.2
  • 46
    • 70350673942 scopus 로고    scopus 로고
    • Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer's disease: systematic review of the 'real-world' evidence
    • Lockhart I.A., Mitchell S.A., Kelly S. Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer's disease: systematic review of the 'real-world' evidence. Dement. Geriatr. Cogn. Disord. 2009, 28:389-403.
    • (2009) Dement. Geriatr. Cogn. Disord. , vol.28 , pp. 389-403
    • Lockhart, I.A.1    Mitchell, S.A.2    Kelly, S.3
  • 50
    • 0035957872 scopus 로고    scopus 로고
    • Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult
    • Kim D.S., Park S.Y., Kim J.K. Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA(1-42) insult. Neurosci. Lett. 2001, 303:57-61.
    • (2001) Neurosci. Lett. , vol.303 , pp. 57-61
    • Kim, D.S.1    Park, S.Y.2    Kim, J.K.3
  • 51
    • 79953905604 scopus 로고    scopus 로고
    • Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices
    • Ahmed T., Gilani A.H., Hosseinmardi N., Semnanian S., Enam S.A., Fathollahi Y. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse 2011, 65:572-582.
    • (2011) Synapse , vol.65 , pp. 572-582
    • Ahmed, T.1    Gilani, A.H.2    Hosseinmardi, N.3    Semnanian, S.4    Enam, S.A.5    Fathollahi, Y.6
  • 52
    • 77349084360 scopus 로고    scopus 로고
    • Naturally occurring phytochemicals for the prevention of Alzheimer's disease
    • Kim J., Lee H.J., Lee K.W. Naturally occurring phytochemicals for the prevention of Alzheimer's disease. J. Neurochem. 2010, 112:1415-1430.
    • (2010) J. Neurochem. , vol.112 , pp. 1415-1430
    • Kim, J.1    Lee, H.J.2    Lee, K.W.3
  • 53
    • 0031799304 scopus 로고    scopus 로고
    • Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver
    • Piper J.T., Singhal S.S., Salameh M.S., Torman R.T., Awasthi Y.C., Awasthi S. Mechanisms of anticarcinogenic properties of curcumin: the effect of curcumin on glutathione linked detoxification enzymes in rat liver. Int. J. Biochem. Cell Biol. 1998, 30:445-456.
    • (1998) Int. J. Biochem. Cell Biol. , vol.30 , pp. 445-456
    • Piper, J.T.1    Singhal, S.S.2    Salameh, M.S.3    Torman, R.T.4    Awasthi, Y.C.5    Awasthi, S.6
  • 55
    • 70450137050 scopus 로고    scopus 로고
    • The heme oxygenase/biliverdin reductase pathway in drug research and development
    • Mancuso C., Barone E. The heme oxygenase/biliverdin reductase pathway in drug research and development. Curr. Drug Metab. 2009, 10:579-594.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 579-594
    • Mancuso, C.1    Barone, E.2
  • 57
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim G.P., Chu T., Yang F., Beech W., Frautschy S.A., Cole G.M. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 2001, 21:8370-8377.
    • (2001) J. Neurosci. , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 58
    • 34547451145 scopus 로고    scopus 로고
    • Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model
    • Garcia-Alloza M., Borrelli L.A., Rozkalne A., Hyman B.T., Bacskai B.J. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J. Neurochem. 2007, 102:1095-1104.
    • (2007) J. Neurochem. , vol.102 , pp. 1095-1104
    • Garcia-Alloza, M.1    Borrelli, L.A.2    Rozkalne, A.3    Hyman, B.T.4    Bacskai, B.J.5
  • 60
    • 66049161455 scopus 로고    scopus 로고
    • Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex
    • Rossi R., Basilico F., Rossoni G., Riva A., Morazzoni P., Mauri P.L. Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex. J. Pharm. Biomed. Anal. 2009, 50:224-227.
    • (2009) J. Pharm. Biomed. Anal. , vol.50 , pp. 224-227
    • Rossi, R.1    Basilico, F.2    Rossoni, G.3    Riva, A.4    Morazzoni, P.5    Mauri, P.L.6
  • 62
    • 78549261367 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats
    • Chen Z.P., Sun J., Chen H.X., Xiao Y.Y., Liu D., Chen J., Cai H., Cai B.C. Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats. Fitoterapia 2010, 81:1045-1052.
    • (2010) Fitoterapia , vol.81 , pp. 1045-1052
    • Chen, Z.P.1    Sun, J.2    Chen, H.X.3    Xiao, Y.Y.4    Liu, D.5    Chen, J.6    Cai, H.7    Cai, B.C.8
  • 64
    • 0022551907 scopus 로고
    • Absorption, distribution and elimination of a labelled extract of Ginkgo biloba leaves in the rat
    • Moreau J.P., Eck C.R., McCabe J., Skinner S. Absorption, distribution and elimination of a labelled extract of Ginkgo biloba leaves in the rat. Presse Med. 1986, 15:1458-1461.
    • (1986) Presse Med. , vol.15 , pp. 1458-1461
    • Moreau, J.P.1    Eck, C.R.2    McCabe, J.3    Skinner, S.4
  • 66
    • 77958534784 scopus 로고    scopus 로고
    • Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761(R)
    • Rangel-Ordonez L., Noldner M., Schubert-Zsilavecz M., Wurglics M. Plasma levels and distribution of flavonoids in rat brain after single and repeated doses of standardized Ginkgo biloba extract EGb 761(R). Planta Med. 2010, 76:1683-1690.
    • (2010) Planta Med. , vol.76 , pp. 1683-1690
    • Rangel-Ordonez, L.1    Noldner, M.2    Schubert-Zsilavecz, M.3    Wurglics, M.4
  • 67
    • 0034961776 scopus 로고    scopus 로고
    • Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts
    • Mauri P., Simonetti P., Gardana C., Minoggio M., Morazzoni P., Bombardelli E., Pietta P. Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts. Rapid Commun. Mass Spectrom. 2001, 15:929-934.
    • (2001) Rapid Commun. Mass Spectrom. , vol.15 , pp. 929-934
    • Mauri, P.1    Simonetti, P.2    Gardana, C.3    Minoggio, M.4    Morazzoni, P.5    Bombardelli, E.6    Pietta, P.7
  • 68
    • 79551683865 scopus 로고    scopus 로고
    • Plasma and brain levels of terpene trilactones in rats after an oral single dose of standardized Ginkgo biloba extract EGb 761(R)
    • Ude C., Paulke A., Noldner M., Schubert-Zsilavecz M., Wurglics M. Plasma and brain levels of terpene trilactones in rats after an oral single dose of standardized Ginkgo biloba extract EGb 761(R). Planta Med. 2011, 77:259-264.
    • (2011) Planta Med. , vol.77 , pp. 259-264
    • Ude, C.1    Paulke, A.2    Noldner, M.3    Schubert-Zsilavecz, M.4    Wurglics, M.5
  • 69
    • 11144232127 scopus 로고    scopus 로고
    • Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole
    • Yin O.Q., Tomlinson B., Waye M.M., Chow A.H., Chow M.S. Pharmacogenetics and herb-drug interactions: experience with Ginkgo biloba and omeprazole. Pharmacogenetics 2004, 14:841-850.
    • (2004) Pharmacogenetics , vol.14 , pp. 841-850
    • Yin, O.Q.1    Tomlinson, B.2    Waye, M.M.3    Chow, A.H.4    Chow, M.S.5
  • 70
    • 29144432784 scopus 로고    scopus 로고
    • Fatal seizures due to potential herb-drug interactions with Ginkgo biloba
    • Kupiec T., Raj V. Fatal seizures due to potential herb-drug interactions with Ginkgo biloba. J. Anal. Toxicol. 2005, 29:755-758.
    • (2005) J. Anal. Toxicol. , vol.29 , pp. 755-758
    • Kupiec, T.1    Raj, V.2
  • 72
    • 0034883315 scopus 로고    scopus 로고
    • The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats
    • Bridi R., Crossetti F.P., Steffen V.M., Henriques A.T. The antioxidant activity of standardized extract of Ginkgo biloba (EGb 761) in rats. Phytother Res. 2001, 15:449-451.
    • (2001) Phytother Res. , vol.15 , pp. 449-451
    • Bridi, R.1    Crossetti, F.P.2    Steffen, V.M.3    Henriques, A.T.4
  • 73
    • 77952875785 scopus 로고    scopus 로고
    • 2+ dyshomeostasis that is blocked by EGb761
    • 2+ dyshomeostasis that is blocked by EGb761. Neurochem. Int. 2010, 56:893-905.
    • (2010) Neurochem. Int. , vol.56 , pp. 893-905
    • Shi, C.1    Wu, F.2    Xu, J.3
  • 74
    • 75349090576 scopus 로고    scopus 로고
    • Ginkgo biloba extract in Alzheimer's disease: from action mechanisms to medical practice
    • Shi C., Liu J., Wu F., Yew D.T. Ginkgo biloba extract in Alzheimer's disease: from action mechanisms to medical practice. Int. J. Mol. Sci. 2010, 11:107-123.
    • (2010) Int. J. Mol. Sci. , vol.11 , pp. 107-123
    • Shi, C.1    Liu, J.2    Wu, F.3    Yew, D.T.4
  • 75
    • 2942596005 scopus 로고    scopus 로고
    • Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis
    • Samhan-Arias A.K., Martin-Romero F.J., Gutierrez-Merino C. Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis. Free Radic Biol. Med. 2004, 37:48-61.
    • (2004) Free Radic Biol. Med. , vol.37 , pp. 48-61
    • Samhan-Arias, A.K.1    Martin-Romero, F.J.2    Gutierrez-Merino, C.3
  • 77
    • 39149105236 scopus 로고    scopus 로고
    • Ginkgo biloba extract and its flavonol and terpenelactone fractions do not affect beta-secretase mRNA and enzyme activity levels in cultured neurons and in mice
    • Augustin S., Huebbe P., Matzner N., Augustin K., Schliebs R., Cermak R., Wolffram S., Rimbach G. Ginkgo biloba extract and its flavonol and terpenelactone fractions do not affect beta-secretase mRNA and enzyme activity levels in cultured neurons and in mice. Planta Med. 2008, 74:6-13.
    • (2008) Planta Med. , vol.74 , pp. 6-13
    • Augustin, S.1    Huebbe, P.2    Matzner, N.3    Augustin, K.4    Schliebs, R.5    Cermak, R.6    Wolffram, S.7    Rimbach, G.8
  • 79
    • 0034121829 scopus 로고    scopus 로고
    • The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid
    • Bastianetto S., Ramassamy C., Dore S., Christen Y., Poirier J., Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by beta-amyloid. Eur. J. Neurosci. 2000, 12:1882-1890.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 1882-1890
    • Bastianetto, S.1    Ramassamy, C.2    Dore, S.3    Christen, Y.4    Poirier, J.5    Quirion, R.6
  • 80
    • 61749103704 scopus 로고    scopus 로고
    • Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease
    • Ansari M.A., Abdul H.M., Joshi G., Opii W.O., Butterfield D.A. Protective effect of quercetin in primary neurons against Abeta(1-42): relevance to Alzheimer's disease. J. Nutr. Biochem. 2009, 20:269-275.
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 269-275
    • Ansari, M.A.1    Abdul, H.M.2    Joshi, G.3    Opii, W.O.4    Butterfield, D.A.5
  • 81
    • 0034122940 scopus 로고    scopus 로고
    • The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C
    • Bastianetto S., Zheng W.H., Quirion R. The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. J. Neurochem. 2000, 74:2268-2277.
    • (2000) J. Neurochem. , vol.74 , pp. 2268-2277
    • Bastianetto, S.1    Zheng, W.H.2    Quirion, R.3
  • 82
    • 0242467845 scopus 로고    scopus 로고
    • Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761
    • Smith J.V., Luo Y. Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761. J. Alzheimers Dis. 2003, 5:287-300.
    • (2003) J. Alzheimers Dis. , vol.5 , pp. 287-300
    • Smith, J.V.1    Luo, Y.2
  • 83
    • 34547824397 scopus 로고    scopus 로고
    • EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease
    • Tchantchou F., Xu Y., Wu Y., Christen Y., Luo Y. EGb 761 enhances adult hippocampal neurogenesis and phosphorylation of CREB in transgenic mouse model of Alzheimer's disease. FASEB J. 2007, 21:2400-2408.
    • (2007) FASEB J. , vol.21 , pp. 2400-2408
    • Tchantchou, F.1    Xu, Y.2    Wu, Y.3    Christen, Y.4    Luo, Y.5
  • 84
    • 79953181232 scopus 로고    scopus 로고
    • Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection
    • Shah Z.A., Nada S.E., Dore S. Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection. Neuroscience 2011, 180:248-255.
    • (2011) Neuroscience , vol.180 , pp. 248-255
    • Shah, Z.A.1    Nada, S.E.2    Dore, S.3
  • 85
    • 58149339691 scopus 로고    scopus 로고
    • Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury
    • Saleem S., Zhuang H., Biswal S., Christen Y., Dore S. Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury. Stroke 2008, 39:3389-3396.
    • (2008) Stroke , vol.39 , pp. 3389-3396
    • Saleem, S.1    Zhuang, H.2    Biswal, S.3    Christen, Y.4    Dore, S.5
  • 86
    • 0029871249 scopus 로고    scopus 로고
    • Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia
    • Kanowski S., Herrmann W.M., Stephan K., Wierich W., Horr R. Proof of efficacy of the Ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996, 29:47-56.
    • (1996) Pharmacopsychiatry , vol.29 , pp. 47-56
    • Kanowski, S.1    Herrmann, W.M.2    Stephan, K.3    Wierich, W.4    Horr, R.5
  • 87
    • 0030759072 scopus 로고    scopus 로고
    • A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group
    • Le Bars P.L., Katz M.M., Berman N., Itil T.M., Freedman A.M., Schatzberg A.F. A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study Group. JAMA 1997, 278:1327-1332.
    • (1997) JAMA , vol.278 , pp. 1327-1332
    • Le Bars, P.L.1    Katz, M.M.2    Berman, N.3    Itil, T.M.4    Freedman, A.M.5    Schatzberg, A.F.6
  • 88
    • 0030775196 scopus 로고    scopus 로고
    • Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type
    • Maurer K., Ihl R., Dierks T., Frolich L. Clinical efficacy of Ginkgo biloba special extract EGb 761 in dementia of the Alzheimer type. J. Psychiatr. Res. 1997, 31:645-655.
    • (1997) J. Psychiatr. Res. , vol.31 , pp. 645-655
    • Maurer, K.1    Ihl, R.2    Dierks, T.3    Frolich, L.4
  • 89
    • 0034125340 scopus 로고    scopus 로고
    • A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo biloba extract EGb 761 in dementia
    • Le Bars P.L., Kieser M., Itil K.Z. A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo biloba extract EGb 761 in dementia. Dement. Geriatr. Cogn. Disord. 2000, 11:230-237.
    • (2000) Dement. Geriatr. Cogn. Disord. , vol.11 , pp. 230-237
    • Le Bars, P.L.1    Kieser, M.2    Itil, K.Z.3
  • 90
    • 0346373723 scopus 로고    scopus 로고
    • Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial
    • Kanowski S., Hoerr R. Ginkgo biloba extract EGb 761 in dementia: intent-to-treat analyses of a 24-week, multi-center, double-blind, placebo-controlled, randomized trial. Pharmacopsychiatry 2003, 36:297-303.
    • (2003) Pharmacopsychiatry , vol.36 , pp. 297-303
    • Kanowski, S.1    Hoerr, R.2
  • 91
    • 0033785945 scopus 로고    scopus 로고
    • The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial
    • van Dongen M.C., van Rossum E., Kessels A.G., Sielhorst H.J., Knipschild P.G. The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial. J. Am. Geriatr. Soc. 2000, 48:1183-1194.
    • (2000) J. Am. Geriatr. Soc. , vol.48 , pp. 1183-1194
    • van Dongen, M.C.1    van Rossum, E.2    Kessels, A.G.3    Sielhorst, H.J.4    Knipschild, P.G.5
  • 92
    • 0037951799 scopus 로고    scopus 로고
    • Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial
    • van Dongen M., van Rossum E., Kessels A., Sielhorst H., Knipschild P. Ginkgo for elderly people with dementia and age-associated memory impairment: a randomized clinical trial. J. Clin. Epidemiol. 2003, 56:367-376.
    • (2003) J. Clin. Epidemiol. , vol.56 , pp. 367-376
    • van Dongen, M.1    van Rossum, E.2    Kessels, A.3    Sielhorst, H.4    Knipschild, P.5
  • 93
    • 28244446721 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type
    • Schneider L.S., DeKosky S.T., Farlow M.R., Tariot P.N., Hoerr R., Kieser M. A randomized, double-blind, placebo-controlled trial of two doses of Ginkgo biloba extract in dementia of the Alzheimer's type. Curr. Alzheimer Res. 2005, 2:541-551.
    • (2005) Curr. Alzheimer Res. , vol.2 , pp. 541-551
    • Schneider, L.S.1    DeKosky, S.T.2    Farlow, M.R.3    Tariot, P.N.4    Hoerr, R.5    Kieser, M.6
  • 96
    • 77950278582 scopus 로고    scopus 로고
    • Effects of Ginkgo biloba in dementia: systematic review and meta-analysis
    • Weinmann S., Roll S., Schwarzbach C., Vauth C., Willich S.N. Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. BMC Geriatr. 2010, 10:14.
    • (2010) BMC Geriatr. , vol.10 , pp. 14
    • Weinmann, S.1    Roll, S.2    Schwarzbach, C.3    Vauth, C.4    Willich, S.N.5
  • 98
    • 10644229056 scopus 로고    scopus 로고
    • Kinetics, pharmacokinetics, and regulation of l-carnitine and acetyl-l-carnitine metabolism
    • Rebouche C.J. Kinetics, pharmacokinetics, and regulation of l-carnitine and acetyl-l-carnitine metabolism. Ann. N. Y. Acad. Sci. 2004, 1033:30-41.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1033 , pp. 30-41
    • Rebouche, C.J.1
  • 99
    • 0028222594 scopus 로고
    • Effect of intravenous l-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans
    • Brass E.P., Hoppel C.L., Hiatt W.R. Effect of intravenous l-carnitine on carnitine homeostasis and fuel metabolism during exercise in humans. Clin. Pharmacol. Ther. 1994, 55:681-692.
    • (1994) Clin. Pharmacol. Ther. , vol.55 , pp. 681-692
    • Brass, E.P.1    Hoppel, C.L.2    Hiatt, W.R.3
  • 100
    • 0027372004 scopus 로고
    • Effect of development and nutritional state on the uptake, metabolism and release of free and acetyl-l-carnitine by the rodent small intestine
    • Gross C.J., Savaiano D.A. Effect of development and nutritional state on the uptake, metabolism and release of free and acetyl-l-carnitine by the rodent small intestine. Biochim. Biophys. Acta 1993, 1170:265-274.
    • (1993) Biochim. Biophys. Acta , vol.1170 , pp. 265-274
    • Gross, C.J.1    Savaiano, D.A.2
  • 101
    • 0033729907 scopus 로고    scopus 로고
    • Pharmacokinetics of propionyl-l-carnitine in humans: evidence for saturable tubular reabsorption
    • Pace S., Longo A., Toon S., Rolan P., Evans A.M. Pharmacokinetics of propionyl-l-carnitine in humans: evidence for saturable tubular reabsorption. Br. J. Clin. Pharmacol. 2000, 50:441-448.
    • (2000) Br. J. Clin. Pharmacol. , vol.50 , pp. 441-448
    • Pace, S.1    Longo, A.2    Toon, S.3    Rolan, P.4    Evans, A.M.5
  • 102
    • 21644478786 scopus 로고    scopus 로고
    • HPLC determination and pharmacokinetics of endogenous acetyl-l-carnitine (ALC) in human volunteers orally administered a single dose of ALC
    • Kwon O.S., Chung Y.B. HPLC determination and pharmacokinetics of endogenous acetyl-l-carnitine (ALC) in human volunteers orally administered a single dose of ALC. Arch. Pharm. Res. 2004, 27:676-681.
    • (2004) Arch. Pharm. Res. , vol.27 , pp. 676-681
    • Kwon, O.S.1    Chung, Y.B.2
  • 103
    • 0344406177 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier
    • Friedrich A., Prasad P.D., Freyer D., Ganapathy V., Brust P. Molecular cloning and functional characterization of the OCTN2 transporter at the RBE4 cells, an in vitro model of the blood-brain barrier. Brain Res. 2003, 968:69-79.
    • (2003) Brain Res. , vol.968 , pp. 69-79
    • Friedrich, A.1    Prasad, P.D.2    Freyer, D.3    Ganapathy, V.4    Brust, P.5
  • 104
    • 0026516050 scopus 로고
    • Pharmacokinetics of IV and oral acetyl-l-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type
    • Parnetti L., Gaiti A., Mecocci P., Cadini D., Senin U. Pharmacokinetics of IV and oral acetyl-l-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type. Eur. J. Clin. Pharmacol. 1992, 42:89-93.
    • (1992) Eur. J. Clin. Pharmacol. , vol.42 , pp. 89-93
    • Parnetti, L.1    Gaiti, A.2    Mecocci, P.3    Cadini, D.4    Senin, U.5
  • 105
    • 0028025440 scopus 로고
    • Effect of aging and acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria
    • Paradies G., Ruggiero F.M., Petrosillo G., Gadaleta M.N., Quagliariello E. Effect of aging and acetyl-l-carnitine on the activity of cytochrome oxidase and adenine nucleotide translocase in rat heart mitochondria. FEBS Lett. 1994, 350:213-215.
    • (1994) FEBS Lett. , vol.350 , pp. 213-215
    • Paradies, G.1    Ruggiero, F.M.2    Petrosillo, G.3    Gadaleta, M.N.4    Quagliariello, E.5
  • 107
    • 0242580631 scopus 로고    scopus 로고
    • "Brain-specific" nutrients: a memory cure?
    • McDaniel M.A., Maier S.F., Einstein G.O. "Brain-specific" nutrients: a memory cure?. Nutrition 2003, 19:957-975.
    • (2003) Nutrition , vol.19 , pp. 957-975
    • McDaniel, M.A.1    Maier, S.F.2    Einstein, G.O.3
  • 109
    • 0028009683 scopus 로고
    • Acetyl-l-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection
    • Piovesan P., Pacifici L., Taglialatela G., Ramacci M.T., Angelucci L. Acetyl-l-carnitine treatment increases choline acetyltransferase activity and NGF levels in the CNS of adult rats following total fimbria-fornix transection. Brain Res. 1994, 633:77-82.
    • (1994) Brain Res. , vol.633 , pp. 77-82
    • Piovesan, P.1    Pacifici, L.2    Taglialatela, G.3    Ramacci, M.T.4    Angelucci, L.5
  • 110
    • 0028175075 scopus 로고
    • Acetyl-l-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats
    • Taglialatela G., Navarra D., Cruciani R., Ramacci M.T., Alema G.S., Angelucci L. Acetyl-l-carnitine treatment increases nerve growth factor levels and choline acetyltransferase activity in the central nervous system of aged rats. Exp. Gerontol. 1994, 29:55-66.
    • (1994) Exp. Gerontol. , vol.29 , pp. 55-66
    • Taglialatela, G.1    Navarra, D.2    Cruciani, R.3    Ramacci, M.T.4    Alema, G.S.5    Angelucci, L.6
  • 111
    • 0028307043 scopus 로고
    • Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-l-carnitine
    • Castorina M., Ambrosini A.M., Pacific L., Ramacci M.T., Angelucci L. Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-l-carnitine. Neurochem. Res. 1994, 19:795-798.
    • (1994) Neurochem. Res. , vol.19 , pp. 795-798
    • Castorina, M.1    Ambrosini, A.M.2    Pacific, L.3    Ramacci, M.T.4    Angelucci, L.5
  • 112
    • 33746468121 scopus 로고    scopus 로고
    • Acetyl-l-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease
    • Abdul H.M., Calabrese V., Calvani M., Butterfield D.A. Acetyl-l-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J. Neurosci. Res. 2006, 84:398-408.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 398-408
    • Abdul, H.M.1    Calabrese, V.2    Calvani, M.3    Butterfield, D.A.4
  • 113
    • 33646675336 scopus 로고    scopus 로고
    • Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function
    • Calabrese V., Colombrita C., Sultana R., Scapagnini G., Calvani M., Butterfield D.A., Stella A.M. Redox modulation of heat shock protein expression by acetylcarnitine in aging brain: relationship to antioxidant status and mitochondrial function. Antioxid. Redox. Signal 2006, 8:404-416.
    • (2006) Antioxid. Redox. Signal , vol.8 , pp. 404-416
    • Calabrese, V.1    Colombrita, C.2    Sultana, R.3    Scapagnini, G.4    Calvani, M.5    Butterfield, D.A.6    Stella, A.M.7
  • 114
    • 0024786493 scopus 로고
    • Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia
    • Rai G., Wright G., Scott L., Beston B., Rest J., Exton-Smith A.N. Double-blind, placebo controlled study of acetyl-l-carnitine in patients with Alzheimer's dementia. Curr. Med. Res. Opin. 1990, 11:638-647.
    • (1990) Curr. Med. Res. Opin. , vol.11 , pp. 638-647
    • Rai, G.1    Wright, G.2    Scott, L.3    Beston, B.4    Rest, J.5    Exton-Smith, A.N.6
  • 117
    • 0034718466 scopus 로고    scopus 로고
    • A 1-year controlled trial of acetyl-l-carnitine in early-onset AD
    • Thal L.J., Calvani M., Amato A., Carta A. A 1-year controlled trial of acetyl-l-carnitine in early-onset AD. Neurology 2000, 55:805-810.
    • (2000) Neurology , vol.55 , pp. 805-810
    • Thal, L.J.1    Calvani, M.2    Amato, A.3    Carta, A.4
  • 118
    • 0028867742 scopus 로고
    • Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]
    • Singh S., Aggarwal B.B. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected]. J. Biol. Chem. 1995, 270:24995-25000.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24995-25000
    • Singh, S.1    Aggarwal, B.B.2
  • 121
    • 0034655773 scopus 로고    scopus 로고
    • Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    • Motterlini R., Foresti R., Bassi R., Green C.J. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic. Biol. Med. 2000, 28:1303-1312.
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 1303-1312
    • Motterlini, R.1    Foresti, R.2    Bassi, R.3    Green, C.J.4
  • 122
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    • Balogun E., Hoque M., Gong P., Killeen E., Green C.J., Foresti R., Alam J., Motterlini R. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 2003, 371:887-895.
    • (2003) Biochem. J. , vol.371 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3    Killeen, E.4    Green, C.J.5    Foresti, R.6    Alam, J.7    Motterlini, R.8


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