Acetyl-l-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism

Neuropharmacology

Volumn 55, Issue 2, 2008, Pages 223-229

  Bagetta, Vincenza ^a,c   Barone, Ilaria ^a   Ghiglieri, Veronica ^a   Di Filippo, Massimiliano ^b   Sgobio, Carmelo ^a   Bernardi, Giorgio ^a,d   Calabresi, Paolo ^a,b   Picconi, Barbara ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF PERUGIA   (Italy)

^c UNIVERSITY OF CALABRIA   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Basal ganglia; Corticostriatal synaptic plasticity; Ischemia; Mitochondrial respiratory chain; Neuronal death; Striatum

Indexed keywords

CARBONYL CYANIDE 4 (TRIFLUOROMETHOXY)PHENYLHYDRAZONE; LEVACECARNINE; SODIUM AZIDE;

ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN ISCHEMIA; BRAIN METABOLISM; BRAIN MITOCHONDRION; BRAIN SLICE; CORPUS STRIATUM; ENERGY METABOLISM; LONG TERM POTENTIATION; MALE; MITOCHONDRIAL RESPIRATION; NERVE CELL NECROSIS; NERVE CELL PLASTICITY; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCARNITINE; ANIMALS; CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYLHYDRAZONE; CELL HYPOXIA; CEREBRAL CORTEX; CORPUS STRIATUM; DRUG INTERACTIONS; ELECTRIC STIMULATION; ENERGY METABOLISM; IONOPHORES; LONG-TERM POTENTIATION; MALE; MITOCHONDRIA; NOOTROPIC AGENTS; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR;

EID: 47149086766     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.05.015     Document Type: Article

References (52)

1. Abdul H.M., Calabrese V., Calvani M., and Butterfield D.A. Acetyl-l-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. J. Neurosci. Res. 84 (2006) 398-408
2. Al-Majed A.A., Sayed-Ahmed M.M., Al-Omar F.A., Al-Yahya A.A., Aleisa A.M., and Al-Shabanah O.A. Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus. Clin. Exp. Pharmacol. Physiol. 33 (2006) 725-733
3. Ando S., Tadenuma T., Tanaka Y., Fukui F., Kobayashi S., Ohashi Y., and Kawabata T. Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J. Neurosci. Res. 66 (2001) 266-271
4. 1H-NMR spectroscopy. Brain Res. 643 (1994) 92-99
5. Barhwal K., Singh S.B., Hota S.K., Jayalakshmi K., and Ilavazhagan G. Acetyl-l-carnitine ameliorates hypobaric hypoxic impairment and spatial memory deficits in rats. Eur. J. Pharmacol. 570 (2007) 97-107
6. Barnes C.A., Markowska A.L., Ingram D.K., Kametani H., Spangler E.L., Lemken V.J., and Olton D.S. Acetyl-l-carnitine. 2. Effects on learning and memory performance of aged rats in simple and complex mazes. Neurobiol. Aging 11 (1990) 499-506
7. Beal M.F. Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?. Ann. Neurol. 31 (1992) 119-130
8. Beal M.F. Bioenergetic approaches for neuroprotection in Parkinson's disease. Ann. Neurol. 53 Suppl. 3 (2003) S39-S47 discussion S47-S48
9. 2+ levels in brainstem motoneurones from mouse. J. Physiol. 555 (2004) 45-59
10. Bieber L.L. Carnitine. Annu. Rev. Biochem. 57 (1988) 261-283
11. Bliss T.V., and Collingridge G.L. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361 (1993) 31-39
12. Bremer J. Carnitine - metabolism and functions. Physiol. Rev. 63 (1983) 1420-1480
13. Calabrese V., Giuffrida Stella A.M., Calvani M., and Butterfield D.A. Acetylcarnitine and cellular stress response: roles in nutritional redox homeostasis and regulation of longevity genes. J. Nutr. Biochem. 17 (2006) 73-88
14. Calabrese V., Ravagna A., Colombrita C., Scapagnini G., Guagliano E., Calvani M., Butterfield D.A., and Giuffrida Stella A.M. Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2. J. Neurosci. Res. 79 (2005) 509-521
15. Calabrese V., Scapagnini G., Ravagna A., Bella R., Butterfield D.A., Calvani M., Pennisi G., and Giuffrida Stella A.M. Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine. Neurochem. Res. 28 (2003) 1321-1328
16. Calabresi P., Ascone C.M., Centonze D., Pisani A., Sancesario G., D'Angelo V., and Bernardi G. Opposite membrane potential changes induced by glucose deprivation in striatal spiny neurons and in large aspiny interneurons. J. Neurosci. 17 (1997) 1940-1949
17. Calabresi P., Centonze D., and Bernardi G. Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum. Neurology 55 (2000) 1249-1255
18. Calabresi P., Centonze D., Gubellini P., and Bernardi G. Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP. Neuropharmacology 38 (1999) 323-326
19. Calabresi P., Centonze D., Pisani A., Cupini L., and Bernardi G. Synaptic plasticity in the ischaemic brain. Lancet Neurol. 2 (2003) 622-629
20. Calabresi P., Picconi B., Tozzi A., and Di Filippo M. Dopamine-mediated regulation of corticostriatal synaptic plasticity. Trends Neurosci. 30 (2007) 211-219
21. Calabresi P., Pisani A., Mercuri N.B., and Bernardi G. On the mechanisms underlying hypoxia-induced membrane depolarization in striatal neurons. Brain 118 Pt 4 (1995) 1027-1038
22. Calabresi P., Saulle E., Centonze D., Pisani A., Marfia G.A., and Bernardi G. Post-ischaemic long-term synaptic potentiation in the striatum: a putative mechanism for cell type-specific vulnerability. Brain 125 (2002) 844-860
23. Calabresi P., Saulle E., Marfia G.A., Centonze D., Mulloy R., Picconi B., Hipskind R.A., Conquet F., and Bernardi G. Activation of metabotropic glutamate receptor subtype 1/protein kinase C/mitogen-activated protein kinase pathway is required for postischemic long-term potentiation in the striatum. Mol. Pharmacol. 60 (2001) 808-815
24. Calvani M., and Arrigoni-Martelli E. Attenuation by acetyl-l-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int. J. Tissue React. 21 (1999) 1-6
25. Caprioli A., Markowska A.L., and Olton D.S. Acetyl-l-Carnitine: chronic treatment improves spatial acquisition in a new environment in aged rats. J. Gerontol. A Biol. Sci. Med. Sci. 50 (1995) B232-236
26. Carta A., and Calvani M. Acetyl-l-carnitine: a drug able to slow the progress of Alzheimer's disease?. Ann. N. Y. Acad. Sci. 640 (1991) 228-232
27. Centonze D., Marfia G.A., Pisani A., Picconi B., Giacomini P., Bernardi G., and Calabresi P. Ionic mechanisms underlying differential vulnerability to ischemia in striatal neurons. Prog. Neurobiol. 63 (2001) 687-696
28. Dell'Anna E., Iuvone L., Calzolari S., and Geloso M.C. Effect of acetyl-l-carnitine on hyperactivity and spatial memory deficits of rats exposed to neonatal anoxia. Neurosci. Lett. 223 (1997) 201-205
29. Dhitavat S., Ortiz D., Rogers E., Rivera E., and Shea T.B. Folate, vitamin E, and acetyl-l-carnitine provide synergistic protection against oxidative stress resulting from exposure of human neuroblastoma cells to amyloid-beta. Brain Res. 1061 (2005) 114-117
30. Di Filippo M., Picconi B., Costa C., Bagetta V., Tantucci M., Parnetti L., and Calabresi P. Pathways of neurodegeneration and experimental models of basal ganglia disorders: downstream effects of mitochondrial inhibition. Eur. J. Pharmacol. 545 (2006) 65-72
31. Duchen M.R. Mitochondria and calcium: from cell signalling to cell death. J. Physiol. 1 529 Pt (2000) 57-68
32. Ghirardi O., Milano S., Ramacci M.T., and Angelucci L. Long-term acetyl-l-carnitine preserves spatial learning in the senescent rat. Prog. Neuropsychopharmacol. Biol. Psychiatry 13 (1989) 237-245
33. Greene J.G., and Greenamyre J.T. Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol. 48 (1996) 613-634
34. Gubellini P., Pisani A., Centonze D., Bernardi G., and Calabresi P. Metabotropic glutamate receptors and striatal synaptic plasticity: implications for neurological diseases. Prog. Neurobiol. 74 (2004) 271-300
35. Hawker K., and Lang A.E. Hypoxic-ischemic damage of the basal ganglia. Case reports and a review of the literature. Mov. Disord. 5 (1990) 219-224
36. Koroshetz W.J., and Moskowitz M.A. Emerging treatments for stroke in humans. Trends Pharmacol. Sci. 17 (1996) 227-233
37. Liu Y., Rosenthal R.E., Starke-Reed P., and Fiskum G. Inhibition of postcardiac arrest brain protein oxidation by acetyl-l-carnitine. Free Radic. Biol. Med. 15 (1993) 667-670
38. Lolic M.M., Fiskum G., and Rosenthal R.E. Neuroprotective effects of acetyl-l-carnitine after stroke in rats. Ann. Emerg. Med. 29 (1997) 758-765
39. Mancuso C., Bates T.E., Butterfield D.A., Calafato S., Cornelius C., De Lorenzo A., Dinkova Kostova A.T., and Calabrese V. Natural antioxidants in Alzheimer's disease. Expert Opin. Investig. Drugs 16 (2007) 1921-1931
40. Mazzio E., Yoon K.J., and Soliman K.F. Acetyl-l-carnitine cytoprotection against 1-methyl-4-phenylpyridinium toxicity in neuroblastoma cells. Biochem. Pharmacol. 66 (2003) 297-306
41. Picconi B., Barone I., Pisani A., Nicolai R., Benatti P., Bernardi G., Calvani M., and Calabresi P. Acetyl-l-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine. Neuropharmacology 50 (2006) 917-923
42. Picconi B., Centonze D., Hakansson K., Bernardi G., Greengard P., Fisone G., Cenci M.A., and Calabresi P. Loss of bidirectional striatal synaptic plasticity in l-DOPA-induced dyskinesia. Nat. Neurosci. 6 (2003) 501-506
43. Pisani A., Bonsi P., Bernardi G., and Calabresi P. Impairment of mitochondrial metabolism differentially affects striatal neuronal subtypes. Neuroreport 13 (2002) 641-644
44. Pulsinelli W.A., Brierley J.B., and Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11 (1982) 491-498
45. Rosenthal R.E., Bogaert Y.E., and Fiskum G. Delayed therapy of experimental global cerebral ischemia with acetyl-l-carnitine in dogs. Neurosci. Lett. 378 (2005) 82-87
46. Rosenthal R.E., Williams R., Bogaert Y.E., Getson P.R., and Fiskum G. Prevention of postischemic canine neurological injury through potentiation of brain energy metabolism by acetyl-l-carnitine. Stroke 23 (1992) 1312-1317 discussion 1317-1318
47. Saulle E., Centonze D., Martin A.B., Moratalla R., Bernardi G., and Calabresi P. Endogenous dopamine amplifies ischemic long-term potentiation via D1 receptors. Stroke 33 (2002) 2978-2984
48. Shuaib A., Waqaar T., Wishart T., Kanthan R., and Howlett W. Acetyl-l-carnitine attenuates neuronal damage in gerbils with transient forebrain ischemia only when given before the insult. Neurochem. Res. 20 (1995) 1021-1025
49. Tozzi A., Costa C., Di Filippo M., Tantucci M., Siliquini S., Belcastro V., Parnetti L., Picconi B., and Calabresi P. Memantine reduces neuronal dysfunctions triggered by in vitro ischemia and 3-nitropropionic acid. Exp. Neurol. 207 (2007) 218-226
50. Virmani A., and Binienda Z. Role of carnitine esters in brain neuropathology. Mol. Aspects Med. 25 (2004) 533-549
51. White B.C., Grossman L.I., and Krause G.S. Brain injury by global ischemia and reperfusion: a theoretical perspective on membrane damage and repair. Neurology 43 (1993) 1656-1665
52. Zanelli S.A., Solenski N.J., Rosenthal R.E., and Fiskum G. Mechanisms of ischemic neuroprotection by acetyl-l-carnitine. Ann. N. Y. Acad. Sci. 1053 (2005) 153-161