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Volumn 50, Issue 3, 2012, Pages 207-218

Xenopus: An ideal system for chemical genetics

Author keywords

Chemical genetics; Forward and reverse screens; Small molecules; Xenopus

Indexed keywords

CHEMICAL GENETICS; GENETIC ENGINEERING; GENETIC MODEL; GENETIC SCREENING; IN VIVO STUDY; MOLECULAR MODEL; NONHUMAN; PHENOTYPE; PHOTOACTIVATION; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; RNA TRANSLATION; SIGNAL NOISE RATIO; TRANSCRIPTION REGULATION; XENOPUS;

EID: 84857998497     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.22009     Document Type: Review
Times cited : (28)

References (74)
  • 1
    • 33751555418 scopus 로고    scopus 로고
    • Inverse drug screens: A rapid and inexpensive method for implicating molecular targets
    • Adams DS, Levin M. 2006. Inverse drug screens: A rapid and inexpensive method for implicating molecular targets. Genesis 44: 530-540.
    • (2006) Genesis , vol.44 , pp. 530-540
    • Adams, D.S.1    Levin, M.2
  • 3
    • 59149104140 scopus 로고    scopus 로고
    • Conditional protein stabilization via the small molecules Shld-1 and rapamycin increases the signal-to-noise ratio with tet-inducible gene expression
    • Almogy G, Nolan GP. 2009. Conditional protein stabilization via the small molecules Shld-1 and rapamycin increases the signal-to-noise ratio with tet-inducible gene expression. Biotechniques 46: 44-50.
    • (2009) Biotechniques , vol.46 , pp. 44-50
    • Almogy, G.1    Nolan, G.P.2
  • 4
    • 33748195107 scopus 로고    scopus 로고
    • A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
    • Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ. 2006. A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126: 995-1004.
    • (2006) Cell , vol.126 , pp. 995-1004
    • Banaszynski, L.A.1    Chen, L.C.2    Maynard-Smith, L.A.3    Ooi, A.G.4    Wandless, T.J.5
  • 5
    • 78650908705 scopus 로고    scopus 로고
    • Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway
    • Blackiston D, Adams DS, Lemire JM, Lobikin M, Levin M. 2011. Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway. Dis Models Mech 4: 67-85.
    • (2011) Dis Models Mech , vol.4 , pp. 67-85
    • Blackiston, D.1    Adams, D.S.2    Lemire, J.M.3    Lobikin, M.4    Levin, M.5
  • 6
    • 78650727332 scopus 로고    scopus 로고
    • A second-generation device for automated training and quantitative behavior analyses of molecularly tractable model organisms
    • Blackiston D, Shomrat T, Nicolas CL, Granata C, Levin M. 2010. A second-generation device for automated training and quantitative behavior analyses of molecularly tractable model organisms. PloS One 5: e14370.
    • (2010) PloS One , vol.5
    • Blackiston, D.1    Shomrat, T.2    Nicolas, C.L.3    Granata, C.4    Levin, M.5
  • 7
    • 8744282471 scopus 로고    scopus 로고
    • Prospects for the Xenopus embryo model in therapeutics technologies
    • Brändli A. 2004. Prospects for the Xenopus embryo model in therapeutics technologies. Chimia 58: 694-702.
    • (2004) Chimia , vol.58 , pp. 694-702
    • Brändli, A.1
  • 10
    • 0036768601 scopus 로고    scopus 로고
    • Inducible control of tissue-specific transgene expression in Xenopus tropicalis transgenic lines
    • Chae J, Zimmerman LB, Grainger RM. 2002. Inducible control of tissue-specific transgene expression in Xenopus tropicalis transgenic lines. Mech Dev 117: 235-241.
    • (2002) Mech Dev , vol.117 , pp. 235-241
    • Chae, J.1    Zimmerman, L.B.2    Grainger, R.M.3
  • 11
    • 85047693635 scopus 로고    scopus 로고
    • Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function
    • Chang P, Coughlin M, Mitchison TJ. 2005. Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol 7: 1133-1139.
    • (2005) Nat Cell Biol , vol.7 , pp. 1133-1139
    • Chang, P.1    Coughlin, M.2    Mitchison, T.J.3
  • 14
    • 0023107421 scopus 로고
    • Fate map for the 32-cell stage of Xenopus laevis
    • Dale L, Slack JM. 1987. Fate map for the 32-cell stage of Xenopus laevis. Development 99: 527-551.
    • (1987) Development , vol.99 , pp. 527-551
    • Dale, L.1    Slack, J.M.2
  • 15
    • 1842788238 scopus 로고    scopus 로고
    • Controlling transgene expression to study Xenopus laevis metamorphosis
    • Das B, Brown DD. 2004. Controlling transgene expression to study Xenopus laevis metamorphosis. Proc Natl Acad Sci USA 101: 4839-4842.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4839-4842
    • Das, B.1    Brown, D.D.2
  • 17
    • 78149274251 scopus 로고    scopus 로고
    • Photocaged morpholino oligomers for the light-regulation of gene function in zebrafish and Xenopus embryos
    • Deiters A, Garner RA, Lusic H, Govan JM, Dush M, Nascone-Yoder NM, Yoder JA. 2010. Photocaged morpholino oligomers for the light-regulation of gene function in zebrafish and Xenopus embryos. J Am Chem Soc 132: 15644-15650.
    • (2010) J Am Chem Soc , vol.132 , pp. 15644-15650
    • Deiters, A.1    Garner, R.A.2    Lusic, H.3    Govan, J.M.4    Dush, M.5    Nascone-Yoder, N.M.6    Yoder, J.A.7
  • 18
    • 79957807846 scopus 로고    scopus 로고
    • Peptide nucleic acid Pt(II) conjugates: A preliminary study of antisense effects in Xenopus laevis
    • Dodd DW, Damjanovski S, Hudson RE. 2011. Peptide nucleic acid Pt(II) conjugates: A preliminary study of antisense effects in Xenopus laevis. Nucleosides Nucleotides Nucleic Acids 30: 257-263.
    • (2011) Nucleosides Nucleotides Nucleic Acids , vol.30 , pp. 257-263
    • Dodd, D.W.1    Damjanovski, S.2    Hudson, R.E.3
  • 23
    • 18844368252 scopus 로고    scopus 로고
    • Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos
    • Fukumoto T, Kema IP, Levin M. 2005. Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Curr Biol 15: 794-803.
    • (2005) Curr Biol , vol.15 , pp. 794-803
    • Fukumoto, T.1    Kema, I.P.2    Levin, M.3
  • 26
    • 0034672039 scopus 로고    scopus 로고
    • Use of large-scale expression cloning screens in the Xenopus laevis tadpole to identify gene function
    • Grammer TC, Liu KJ, Mariani FV, Harland RM. 2000. Use of large-scale expression cloning screens in the Xenopus laevis tadpole to identify gene function. Dev Biol 228: 197-210.
    • (2000) Dev Biol , vol.228 , pp. 197-210
    • Grammer, T.C.1    Liu, K.J.2    Mariani, F.V.3    Harland, R.M.4
  • 28
    • 0037022290 scopus 로고    scopus 로고
    • Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system
    • Hartley KO, Nutt SL, Amaya E. 2002. Targeted gene expression in transgenic Xenopus using the binary Gal4-UAS system. Proc Natl Acad Sci USA 99: 1377-1382.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1377-1382
    • Hartley, K.O.1    Nutt, S.L.2    Amaya, E.3
  • 29
    • 0034213262 scopus 로고    scopus 로고
    • Beta-catenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach
    • Heasman J, Kofron M, Wylie C. 2000. Beta-catenin signaling activity dissected in the early Xenopus embryo: A novel antisense approach. Dev Biol 222: 124-134.
    • (2000) Dev Biol , vol.222 , pp. 124-134
    • Heasman, J.1    Kofron, M.2    Wylie, C.3
  • 30
    • 0032910597 scopus 로고    scopus 로고
    • Tbx5 is essential for heart development
    • Horb ME, Thomsen GH. 1999. Tbx5 is essential for heart development. Development 126: 1739-1751.
    • (1999) Development , vol.126 , pp. 1739-1751
    • Horb, M.E.1    Thomsen, G.H.2
  • 32
    • 66349132028 scopus 로고    scopus 로고
    • An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis
    • Kalin RE, Banziger-Tobler NE, Detmar M, Brandli AW. 2009. An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis. Blood 114: 1110-1122.
    • (2009) Blood , vol.114 , pp. 1110-1122
    • Kalin, R.E.1    Banziger-Tobler, N.E.2    Detmar, M.3    Brandli, A.W.4
  • 33
    • 0028788846 scopus 로고
    • Efficient hormone-inducible protein function in Xenopus laevis
    • Kolm PJ, Sive HL. 1995. Efficient hormone-inducible protein function in Xenopus laevis. Dev Biol 171: 267-272.
    • (1995) Dev Biol , vol.171 , pp. 267-272
    • Kolm, P.J.1    Sive, H.L.2
  • 35
    • 33646494605 scopus 로고    scopus 로고
    • Of minds and embryos: Left-right asymmetry and the serotonergic controls of preneural morphogenesis
    • Levin M, Buznikov GA, Lauder JM. 2006. Of minds and embryos: Left-right asymmetry and the serotonergic controls of preneural morphogenesis. Dev Neurosci 28: 171-185.
    • (2006) Dev Neurosci , vol.28 , pp. 171-185
    • Levin, M.1    Buznikov, G.A.2    Lauder, J.M.3
  • 37
    • 33847405867 scopus 로고    scopus 로고
    • Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice
    • Liu KJ, Arron JR, Stankunas K, Crabtree GR, Longaker MT. 2007. Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice. Nature 446: 79-82.
    • (2007) Nature , vol.446 , pp. 79-82
    • Liu, K.J.1    Arron, J.R.2    Stankunas, K.3    Crabtree, G.R.4    Longaker, M.T.5
  • 39
    • 48949116218 scopus 로고    scopus 로고
    • Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the frog embryo teratogenesis assay-xenopus (FETAX)
    • Longo M, Zanoncelli S, Della Torre P, Rosa F, Giusti A, Colombo P, Brughera M, Mazue G, Olliaro P. 2008. Investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) using the frog embryo teratogenesis assay-xenopus (FETAX). Reprod Toxicol 25: 433-441.
    • (2008) Reprod Toxicol , vol.25 , pp. 433-441
    • Longo, M.1    Zanoncelli, S.2    Della Torre, P.3    Rosa, F.4    Giusti, A.5    Colombo, P.6    Brughera, M.7    Mazue, G.8    Olliaro, P.9
  • 41
    • 79958025810 scopus 로고    scopus 로고
    • Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis
    • Lund E, Sheets MD, Imoden SB, Dahlberg JE. 2011. Limiting Ago protein restricts RNAi and microRNA biogenesis during early development in Xenopus laevis. Genes Dev 25: 1121-1131.
    • (2011) Genes Dev , vol.25 , pp. 1121-1131
    • Lund, E.1    Sheets, M.D.2    Imoden, S.B.3    Dahlberg, J.E.4
  • 43
    • 83755206269 scopus 로고    scopus 로고
    • A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos
    • Morckel AR, Lusic L, Farzana L, Yoder JA, Deiters A, Nascone-Yoder NM. 2012. A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos. Development 139: 437-442.
    • (2012) Development , vol.139 , pp. 437-442
    • Morckel, A.R.1    Lusic, L.2    Farzana, L.3    Yoder, J.A.4    Deiters, A.5    Nascone-Yoder, N.M.6
  • 44
    • 37549020046 scopus 로고    scopus 로고
    • Towards the optimal screening collection: a synthesis strategy
    • Nielsen TE, Schreiber SL. 2008. Towards the optimal screening collection: a synthesis strategy. Angew Chem 47: 48-56.
    • (2008) Angew Chem , vol.47 , pp. 48-56
    • Nielsen, T.E.1    Schreiber, S.L.2
  • 45
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C, Wieschaus E. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287: 795-801.
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 47
    • 0037022382 scopus 로고    scopus 로고
    • Stable suppression of gene expression by RNAi in mammalian cells
    • Paddison PJ, Caudy AA, Hannon GJ. 2002. Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci USA 99: 1443-1448.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1443-1448
    • Paddison, P.J.1    Caudy, A.A.2    Hannon, G.J.3
  • 48
    • 33847195428 scopus 로고    scopus 로고
    • Matrix metalloproteinases and the regulation of tissue remodelling
    • Page-McCaw A, Ewald AJ, Werb Z. 2007. Matrix metalloproteinases and the regulation of tissue remodelling. Nat Rev Mol Cell Biol 8: 221-233.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 221-233
    • Page-McCaw, A.1    Ewald, A.J.2    Werb, Z.3
  • 49
    • 33646073413 scopus 로고    scopus 로고
    • Biochemical suppression of small-molecule inhibitors: A strategy to identify inhibitor targets and signaling pathway components
    • Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW. 2006. Biochemical suppression of small-molecule inhibitors: A strategy to identify inhibitor targets and signaling pathway components. Chem Biol 13: 443-452.
    • (2006) Chem Biol , vol.13 , pp. 443-452
    • Peterson, J.R.1    Lebensohn, A.M.2    Pelish, H.E.3    Kirschner, M.W.4
  • 50
    • 0035845540 scopus 로고    scopus 로고
    • A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions
    • Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. 2001. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci USA 98: 10624-10629.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10624-10629
    • Peterson, J.R.1    Lokey, R.S.2    Mitchison, T.J.3    Kirschner, M.W.4
  • 53
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. 2005. Wnt signalling in stem cells and cancer. Nature 434: 843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 54
    • 33751095609 scopus 로고    scopus 로고
    • A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae
    • Richards SM, Cole SE. 2006. A toxicity and hazard assessment of fourteen pharmaceuticals to Xenopus laevis larvae. Ecotoxicology 15: 647-656.
    • (2006) Ecotoxicology , vol.15 , pp. 647-656
    • Richards, S.M.1    Cole, S.E.2
  • 55
    • 0033835494 scopus 로고    scopus 로고
    • Serrate and notch specify cell fates in the heart field by suppressing cardiomyogenesis
    • Rones MS, McLaughlin KA, Raffin M, Mercola M. 2000. Serrate and notch specify cell fates in the heart field by suppressing cardiomyogenesis. Development 127: 3865-3876.
    • (2000) Development , vol.127 , pp. 3865-3876
    • Rones, M.S.1    McLaughlin, K.A.2    Raffin, M.3    Mercola, M.4
  • 56
    • 79953049835 scopus 로고    scopus 로고
    • Use of fully modified 2′-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos
    • Schneider PN, Olthoff JT, Matthews AJ, Houston DW. 2011. Use of fully modified 2′-O-methyl antisense oligos for loss-of-function studies in vertebrate embryos. Genesis 49: 117-123.
    • (2011) Genesis , vol.49 , pp. 117-123
    • Schneider, P.N.1    Olthoff, J.T.2    Matthews, A.J.3    Houston, D.W.4
  • 57
    • 34548671921 scopus 로고    scopus 로고
    • Light-controlled gene silencing in zebrafish embryos
    • Shestopalov IA, Sinha S, Chen JK. 2007. Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol 3: 650-651.
    • (2007) Nat Chem Biol , vol.3 , pp. 650-651
    • Shestopalov, I.A.1    Sinha, S.2    Chen, J.K.3
  • 60
    • 26644435056 scopus 로고    scopus 로고
    • Xenopus as a model organism in developmental chemical genetic screens
    • Tomlinson ML, Field RA, Wheeler GN. 2005. Xenopus as a model organism in developmental chemical genetic screens. Mol Biosyst 1: 223-228.
    • (2005) Mol Biosyst , vol.1 , pp. 223-228
    • Tomlinson, M.L.1    Field, R.A.2    Wheeler, G.N.3
  • 61
    • 55249118574 scopus 로고    scopus 로고
    • Three matrix metalloproteinases are required in vivo for macrophage migration during embryonic development
    • Tomlinson ML, Garcia-Morales C, Abu-Elmagd M, Wheeler GN. 2008. Three matrix metalloproteinases are required in vivo for macrophage migration during embryonic development. Mech Dev 125: 1059-1070.
    • (2008) Mech Dev , vol.125 , pp. 1059-1070
    • Tomlinson, M.L.1    Garcia-Morales, C.2    Abu-Elmagd, M.3    Wheeler, G.N.4
  • 62
    • 58849103612 scopus 로고    scopus 로고
    • A chemical genomic approach identifies matrix metalloproteinases as playing an essential and specific role in Xenopus melanophore migration
    • Tomlinson ML, Guan P, Morris RJ, Fidock MD, Rejzek M, Garcia-Morales C, Field RA, Wheeler GN. 2009b. A chemical genomic approach identifies matrix metalloproteinases as playing an essential and specific role in Xenopus melanophore migration. Chem Biol 16: 93-104.
    • (2009) Chem Biol , vol.16 , pp. 93-104
    • Tomlinson, M.L.1    Guan, P.2    Morris, R.J.3    Fidock, M.D.4    Rejzek, M.5    Garcia-Morales, C.6    Field, R.A.7    Wheeler, G.N.8
  • 64
    • 16844386134 scopus 로고    scopus 로고
    • Wnt/frizzled signaling during vertebrate retinal development
    • Van Raay TJ, Vetter ML. 2004. Wnt/frizzled signaling during vertebrate retinal development. Dev Neurosci 26: 352-358.
    • (2004) Dev Neurosci , vol.26 , pp. 352-358
    • Van Raay, T.J.1    Vetter, M.L.2
  • 65
    • 79960379493 scopus 로고    scopus 로고
    • V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis
    • Vandenberg LN, Morrie RD, Adams DS. 2011. V-ATPase-dependent ectodermal voltage and pH regionalization are required for craniofacial morphogenesis. Dev Dyn Off Publication Am Assoc Anatom 240: 1889-1904.
    • (2011) Dev Dyn Off Publication Am Assoc Anatom , vol.240 , pp. 1889-1904
    • Vandenberg, L.N.1    Morrie, R.D.2    Adams, D.S.3
  • 68
    • 33745726644 scopus 로고    scopus 로고
    • Chemical genetics
    • Walsh DP, Chang YT. 2006. Chemical genetics. Chem Rev 106: 2476-2530.
    • (2006) Chem Rev , vol.106 , pp. 2476-2530
    • Walsh, D.P.1    Chang, Y.T.2
  • 69
    • 66349117984 scopus 로고    scopus 로고
    • Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus
    • Wheeler GN, Brandli AW. 2009. Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus. Dev Dyn Off Publication Am Assoc Anatom 238: 1287-1308.
    • (2009) Dev Dyn Off Publication Am Assoc Anatom , vol.238 , pp. 1287-1308
    • Wheeler, G.N.1    Brandli, A.W.2
  • 73
    • 0025304672 scopus 로고
    • The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos
    • Woolf TM, Jennings CG, Rebagliati M, Melton DA. 1990. The stability, toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides in Xenopus oocytes and embryos. Nucleic Acids Res 18: 1763-1769.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1763-1769
    • Woolf, T.M.1    Jennings, C.G.2    Rebagliati, M.3    Melton, D.A.4
  • 74
    • 0031983955 scopus 로고    scopus 로고
    • Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment
    • Yang J, Symes K, Mercola M, Schreiber SL. 1998. Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment. Curr Biol 8: 11-18.
    • (1998) Curr Biol , vol.8 , pp. 11-18
    • Yang, J.1    Symes, K.2    Mercola, M.3    Schreiber, S.L.4


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