Tbx5 is essential for heart development

Development

Volumn 126, Issue 8, 1999, Pages 1739-1751

  Horb, Marko E ^a,b   Thomsen, Gerald H ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b University of Bath   (United Kingdom)

Author keywords

Cardiac development; Heart; Holt Oram syndrome; Mesoderm; Organogenesis; T box; Tbx 5; Xenopus

Indexed keywords

TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; EMBRYO; GENE MUTATION; HEART DEVELOPMENT; HEART SEPTUM DEFECT; HOLT ORAM SYNDROME; HOMEOBOX; MORPHOGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN DISTRIBUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DNA, COMPLEMENTARY; EYE; GENE EXPRESSION; GENES, OVERLAPPING; HEART; HOMEODOMAIN PROTEINS; HORMONES; HUMANS; MESODERM; MICE; MOLECULAR SEQUENCE DATA; MORPHOGENESIS; PHENOTYPE; RECEPTORS, GLUCOCORTICOID; T-BOX DOMAIN PROTEINS; TRANSCRIPTION FACTORS; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA; BULBUS; VERTEBRATA;

EID: 0032910597     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (85)

1. Badiani, P., Corbella, P., Kioussis, D., Marvel, J. and Weston, K. (1994). Dominant-interfering alles define arole for c-Myb in T-cell development. Genes Dev. 8, 770-782.
2. Bamshad, M., Lin, R. C., Law, D. J., Watkins, W. S., Krakowiak, P. A., Moore, M. E., Franceschini, P., Lala, R., Holmes, I. B., Gebuhr, T. C., Bruneau, B. G., Schinzel, A., Seidman, J. G., Seidman, C. E. and Jorde, L. B. (1997). Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nature Gen. 16, 311-315.
3. Basson, C. T., Bachinsky, D. R., Lin, R. C., Levi, T., Elkins, J. A., Soults, J., Grayzel, D., Kroumpouzou, E., Traill, T. A., Leblanc-Straceski, J., Renault, B., Kucherlapati, R., Seidman, J. G. and Seidman, C. E. (1997). Mutations in human Tbx5 cause limb and cardiac malformation in Holt-Oram syndrome. Nature Gen. 15, 30-35.
4. Basson, C. T., Cowley, G. S., Solomon, S. D., Weissman, B., Poznanski, A. K., Traill, T. A., Seidman, J. G. and Seidman, C. E. (1994). The clinical and genetic spectrum of the Holt-Oram syndrome (Heart-Hand syndrome). New Eng. J. Med. 330, 885-891.
5. Biben, C. and Harvey, R. P. (1997). Homeodomain factor Nkx2-5 controls left/right assymetric expression of bHLH gene eHAND during murine heart development. Genes Dev. 11, 1357-1369.
6. Chambers, A. E., Logan, M., Kotecha, S., Towers, N., Sparrow, D. and Mohun, T. J. (1994). The RSRF/MEF2 protein SL1 regulates cardiac muscle-specific transcription of a myosin light-chain gene in Xenopus embryos. Genes Dev. 8, 1324-1334.
7. Chapman, D. L., Garvey, N., Hancock, S., Alexiou, M., Agulnik, S. I., Gibson-Brown, J. J., Cebra-Thomas, J., Bollag, R. J., Silver, L. M. and Papaioannou, V. E. (1996). Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev. Dyn. 206, 379-390.
8. Chapman, D. L. and Papaioannou, V. E. (1998). Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391, 695-697.
9. Chen, J. N. and Fishman, M. C. (1996). Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development 122, 3809-3816.
10. Cleaver, O., Tonissen, K. F., Saha, M. S. and Krieg, P. A. (1997). Neovascularization of the Xenopus embryo. Dev. Dyn. 210, 66-77.
11. Cleaver, O. B., Patterson, K. D. and Krieg, P. A. (1996). Overexpression of the tinman-related genes XNkx-2.5 and XNkx-2.3 in Xenopus embryos results in myocardial hyperplasia. Development 122, 3549-3556.
12. Conlon, F. L., Sedgwick, S. G., Weston, K. M. and Smith, J. C. (1996). Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm. Development 122, 2427-2435.
13. Danielian, P. S., White, R., Lees, J. A. and Parker, M. G. (1992). Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. EMBO J. 11, 1025-1033.
14. de Graaf, A. R. (1957). Investigations into the distribution of blood in the heart and aortic arches of Xenopus laevis (Daud.). Exp. Biol. 34, 143-172.
15. DeHaan, R. L. (1965). Morphogenesis of the Vertebrate Heart. In Organogenesis, pp. 377-419. New York: Holt, Rinehart, and Winston.
16. Devic, E., Paquereau, L., Vernier, P., Knibiehler, B. and Audigier, Y. (1996). Expression of a new G protein-coupled receptor X-msr is associated with an endothelial lineage in Xenopus laevis. Mech. Dev. 59, 129-140.
17. Dorsky, R. I., Rapaport, D. H. and Harris, W. A. (1995). Xotch inhibits cell differentiation in the Xenopus retina. Neuron 14, 487-496.
18. Evans, S. M., Van, W., Murillo, M. P., Ponce, J. and Papalopulu, N. (1995). tinman, a Drosophila homeobox gene required for heart and visceral mesoderm specfication, may be represented by a family of genes in vertebrates: XNkx-2.3, a second vertebrate homologue of tinman. Development 121, 2889-2899.
19. Fishman, M. C. and Chien, K. R. (1997). Fashioning the vertebrate heart: earlest embryonic decisions. Development 124, 2099-2117.
20. Fishman, M. C. and Olson, E. N. (1997). Parsing the heart: genetic modules for organ assembly. Cell 91, 153-156.
21. Fukuda-Taira, S. (1981). Location of pre-hepatic cells in the early developmental stages of quail embryos. J. Embryol. Exp. Morphol. 64, 73-85.
22. Gammill, L. S. and Sive, H. (1997). Identification of otx2 target genes and restrictions in ectodermal competence during Xenopus cement gland formation. Development 124, 471-481.
23. Gibson-Brown, J., Agulnik, S. I., Silver, L. E., Niswander, L. and Papaioannou, V. E. (1998a). Involvement of T-box genes Tbx2-Tbx5 in vertebrate limb specification and development. Development 125, 2499-2509.
24. Gibson-Brown, J. J., Agulnik, S. I., Silver, L. M. and Papaioannou, V. E. (1998b). Expression of T-box genes Tbx2-Tbx5 during chick organogenesis. Mech. Dev. 74.
25. Gove, C., Walmsley, M., Nijjar, S., Bertwistle, D., Guille, M., Partington, G., Bomford, A. and Patient, R. (1997). Over-expression of GATA-6 in Xenopus embryos blocks the differentiation of heart precursors. EMBO J. 16, 355-368.
26. Han, K. and Manley, J. L. (1993). Functional domains of the Drosophila engrailed protein. EMBO J. 12, 2723-2733.
27. Harland, R. M. (1991). In situ hybridization: an improved whole mount method for Xenopus embryos. Methods in Cell Biology 36, 675-685.
28. Harvey, R. P. (1996). NK-2 homeobox genes and heart development. Dev. Biol. 178, 203-216.
29. Heikinheimo, M., Scandrett, J. M. and Wilson, D. B. (1994). Localization of transcription factor GATA-4 to regions of the mouse embryo involved in cardiac development. Dev. Biol. 164, 361-373.
30. Herrmann, B. G., ed. (1995). The Brachyury gene. Semin. Dev. Biol. 6, 381-435.
31. Hiruma, T. and Hirakow, R. (1989). Epicardial formation in embryonic chick heart: computer aided reconstruction, scanning, and transmission electron microscopic studies. Am. J. Anat. 184, 129-138.
32. Ho, E. and Shimada, Y. (1978). Formation of the epicardium studied with the scanning electron microscope. Dev. Biol. 66, 579-585.
33. Holt, M. and Oram, S. (1960). Familial heart disease with skeletal malformations. Br. Heart J. 22, 236-242.
34. Horb, M. E. and Thomsen, G. H. (1997). A vegetally-localized Xenopus T-box gene specifies mesoderm and endoderm and is essential for mesoderm formation. Development 124, 1689-1698.
35. Hurst, J. A., Hall, C. M. and Baraitser, M. (1991). The Holt-Oram syndrome. J. Med. Genet. 28, 406-410.
36. Isaac, A., Rodriguez-Esteban, C., Ryan, A., Altabef, M., Tsukui, T., Patel, K., Tickle, C. and Izpisua-Belmonte, J. C. (1998). Tbx genes and limb identity in chick embryo development. Development 125, 1867-1875.
37. Jacobson, A. G. (1961). Heart determination in the Newt. J. Exp. Zool. 146, 139-152.
38. Jiang, Y. and Evans, T. (1996). The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev. Biol. 174, 258-270.
39. Keller, R. E. (1976). Vital dye mapping of the gastrula and neurula of Xenopus laevis. II. Prospective areas and morphogenetic movements of the deep layer. Dev. Biol. 51, 118-137.
40. Kelley, C., Blumberg, H., Zon, L. I. and Evans, T. (1993). GATA-4 is a novel transcription factor expressed in endocardium of the developing heart. Dev. 118, 817-827.
41. Kispert, A. (1995). The Brachyury protein: a T-domain transcription factor. Sem. Dev. Biol. 6, 395-404.
42. Kolm, P. J. and Sive, H. L. (1995). Efficient hormone-inducible protein function in Xenopus laevis. Dev. Biol. 171, 267-272.
43. Komuro, I. and Izumo, S. (1993). Csx: a murine homeobox-containing gene specifically expressed in the developing heart. Proc. Natl. Acad. Sci. USA 90, 8145-8149.
44. Kuo, C. T., Morrisey, E. E., Anandappa, R., Sigrist, K., Lu, M. M., Parmacek, M. S., Sooudais, C. and Leiden, J. M. (1997). GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. Genes Dev. 11, 1048-1060.
45. Laverriere, A. C., MacNeill, C., Mueller, C., Poelmann, R. E., Burch, J. B. E. and Evans, T. (1994). GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut. J. Biol. Chem. 269, 23177-23184.
46. Li, H., Tierney, C., Wen, L., Wu, J. Y. and Rao, Y. (1997a). A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development 124, 603-615.
47. Li, Q. Y., Newbury-Ecob, R. A., Terrett, J. A., Wilson, D. I., Curtis, A. R. J., Yi, C. H., Gebuhr, T., Bullen, P. J., Robson, S. C., Strachan, T., Bonnet, D., Lyonnet, S., Young, I. D., Raeburn, J. A., Buckler, A. J., Law, D. J. and Brook, J. D. (1997b). Holt-Oram syndrome is caused by mutations in TBX5, a member os the Brachyury (T) gene family. Nature Gen. 15, 21-29.
48. Lints, T. J., Parsons, L. M., Hartley, L., Lyons, I. and Harvey, R. P. (1993). Nkx-2.5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants. Development 119, 419-431.
49. Lustig, K. D., Kroll, K. L., Sun, E. E. and W., K. M. (1996). Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development 122, 4001-4012.
50. Lyons, G. E. (1996). Vertebrate heart development. Curr. Opin. Gen. Dev. 6, 454-460.
51. Lyons, I., Parsons, L. M., Hartley, L., Li, R., Andrews, J. E., Robb, L. and Harvey, R. P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 9, 1654-1666.
52. Markwald, R., Eisenberg, C., Eisenberg, L., Trusk, T. and Sugi, Y. (1996). Epithelial-Mesenchymal transformations in early avian heart development. Acta Anat. 156, 173-186.
53. Mattioni, T., Louvion, J. F. and Picard, D. (1994). Regulation of protein activities by fusion to steroid binding domains. Methods in Cell Biology 43, 335-352.
54. Mohun, T. and Sparrow, D. (1997). Early steps in vertebrate cardiogenesis. Curr. Opin. Gen. Dev. 7, 628-633.
55. Molkentin, J. D., Lin, Q., Duncan, S. A. and Olson, E. N. (1997). Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 11, 1061-1072.
56. Morrisey, E. E., Ip, H. S., Lu, M. M. and Parmacek, M. S. (1996). GATA-6: a zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm. Dev. Biol. 177, 309-322.
57. Newbury-Ecob, R. A., Leanage, R., Raeburn, J. A. and Young, I. D. (1996). Holt-Oram syndrome: a clinical genetic study. J. Med. Genet. 33, 300-307.
58. Newman, C. S., Chia, F. and Krieg, P. A. (1997). The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Mech. Dev. 66, 83-93.
59. Nieuwkoop, P. D. and Faber, J. (1967). Normal table of Xenopus laevis (Daudin). Amsterdam: North Holland Publishing Company.
60. Ohuchi, H., Takeuchi, J., Yoshioka, H., Ishimaru, Y., Ogura, K., Takahashi, N., Ogura, T. and Noji, S. (1998). Correlation of wing-leg identity in ectopic FGF-induced chimeric limbs with the differential expresison of chick Tbx5 and Tbx4. Development 125, 51-60.
61. Papaioannou, V. E. and Silver, L. M. (1998). The T-box gene family. BioEssays 20, 9-19.
62. Papalopulu, N. and Kintner, C. (1996). A Xenopus gene, Xbr-1, defines a novel class of homeobox genes and is expressed in the dorsal ciliary margin of the eye. Dev. Biol. 174, 104-114.
63. Ryan, K., Garrett, N., Mitchel, A. and Gurdon, J. B. (1996). Eomesodermin, a key early gene in Xenopus mesoderm differentiation. Cell 87, 989-1000.
64. Sater, A. and Jacobson, A. (1990). The restriction of the heart morphogenetic field in Xenopus laevis. Dev. Biol. 140, 328-336.
65. Schott, J.-J., Benson, D. W., Basson, C. T., Pease, W., Silberbach, G. M., Moak, J. P., Maron, B. J., Seidman, C. E. and Seidman, J. G. (1998). Congentital heart disease caused by mutations in the transcription factor Nkx2-5. Science 281, 108-111.
66. Sebedzija, G. N., Chen, J. N. and Fishman, M. C. (1998). Regulation in the heart field of zebrafish. Development 125, 1095-1101.
67. Simon, H. G., Kittappa, R., Khan, P. A., Tsilfidis, C., Liversage, R. A. and Appenheimer, S. (1997). A novel family of T-box genes in urodele amphibian limb development and regeneration: candidate genes involved in vertebrate forelimb/hindlimb patterning. Development 124, 1355-1366.
68. Smith, A. T., Sack, G. H. and Taylor, G. T. (1979). Holt-Oram Syndrome. J. Pediatrics 95, 538-543.
69. Smith, D. F. and Toft, D. O. (1993). Steroid receptors and their associated proteins. Mol. Endo. 7, 4-11.
70. Smith, J. C. (1997). Brachyury and the T-box genes. Curr. Opin. Gen. Dev. 7, 474-480.
71. Smith, J. C., Price, B. M. J., Green, J. B. A., Weigel, D. and Herrmann, B. G. (1991). Expression of a Xenopus Homolog of Brachyury (T) is an immediate-early response to mesoderm induction. Cell 67, 79-87.
72. Stainier, D. Y. R., Lee, R. K. and Fishman, M. C. (1993). Cardiovascular development in the zebrafish. I. Myocardial fate map and heart tube formation. Development 119, 31-40.
73. Stennard, F., Carnac, G. and Gurdon, J. B. (1996). A Xenopus T-box gene, antipodean, encodes a vegetally-localized maternal mRNA that can trigger mesoderm formation. Development 122, 4179-4188.
74. Tada, M., O'Reilly, M. A. J. and Smith, J. C. (1997). Analysis of competence and of Brachyury autoinduction by use of hormone-inducible Xbra. Development 124, 2225-2234.
75. Tonissen, K. F., Drysdale, T. A., Lints, T. J., Harvey, R. P. and Krieg, P. A. (1994). XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: evidence for a conserved role in cardiac development. Dev. Biol. 162, 325-328.
76. Tsai, M. and O'Malley, B. W. (1994). Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu. Rev. Biochem. 63, 451-486.
77. Turner, D. L. and Weintraub, H. (1994). Expression of achaetescute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate. Genes Dev. 8, 1434-1447.
78. Viragh, S. and Challice, C. E. (1973). Origin and differentiation of cardiac muscle cells in the mouse. J. Ultrastruct. Res. 42, 1-24.
79. Viragh, S. and Challice, C. E. (1981). The origin of the epicardium and the embryonic myocardial circulation in the mouse. Anat. Rec. 201, 157-168.
80. Wetts, R. and Fraser, S. E. (1988). Multipotent precursors can give rise to all major cell types of the frog retina. Science 239, 1142-1144.
81. Wetts, R., Serbedzija, G. N. and Fraser, S. E. (1989). Cell lineage analysis reveals multipotent precursors in the ciliary margin of the frog retina. Dev. Biol. 136, 254-263.
82. Wilens, S. (1955). The migration of heart mesoderm and associated areas in Amblystoma Punctatum. J. Exp. Zool. 129, 579-605.
83. Yutzey, K. E., Gannon, M. and Bader, D. (1995). Diversification of cardiomyogenic cell lineages in vitro. Dev. Biol. 170, 531-541.
84. Zaret, K. S. (1996). Molecular genetics of early liver development. Annu. Rev. Physiol. 58, 231-251.
85. Zhang, J. and King, M. L. (1996). Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning. Development 122, 4119-4129.