Small-molecule control of insulin and PDGF receptor signaling and the role of membrane attachment

Current Biology

Volumn 8, Issue 1, 1998, Pages 11-18

  Yang, Jian Xin ^a   Symes, Karen ^b,c   Mercola, Mark ^b   Schreiber, Stuart L ^a  

^a HARVARD UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 0031983955     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(98)70015-6     Document Type: Article

References (37)

1. Crabtree GR, Schreiber SL: Three-part inventions: intracellular signaling and induced proximity. Trends Biochem Sci 1996, 21:418-422.
2. Spencer DM, Wandless TJ, Schreiber SL, Crabtree GR: Controlling signal transduction with synthetic ligands. Science 1993, 262:1019-1024.
3. Pruschy MN, Spencer DM, Kapoor TM, Miyake H, Crabtree GR, Schreiber SL: Mechanistic studies of a signaling pathway activated by the organic ligand FK1012. Chem Biol 1994, 1:163-172.
4. Belshaw PJ, Spencer DM, Crabtree GR, Schreiber SL: Controlling programmed cell death with a cyclophilin-cyclosporin-based chemical inducer of dimerization. Chem Biol 1996, 3:731-738.
5. Spencer DM, Belshaw PJ, Chen L, Ho SN, Randazzo F, Crabtree GR, et al.: Functional analysis of Fas signaling in vivo using synthetic inducers of dimerization. Curr Biol 1996, 6:839-847.
6. Yap AS, Brieher WM, Pruschy M, Gumbiner BM: Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr Biol 1997, 7:308-315.
7. Blau CA, Peterson KR, Drachman JG, Spencer DM: A proliferation switch for genetically modified cells. Proc Natl Acad Sci USA 1997, 94:3076-3081.
8. Spencer DM, Graef I, Austin DJ, Schreiber SL, Crabtree GR: A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proc Natl Acad Sci USA 1995, 92:9805-9809.
9. Holsinger LJ, Spencer DM, Austin DJ, Schreiber SL, Crabtree GR: Signal transduction in T lymphocytes using a conditional allele of Sos. Proc Natl Acad Sci USA 1995, 92:9810-9814.
10. Luo Z, Tzivion G, Belshaw PJ, Vawas D, Marshall M, Avruch J: Oligomerization activates c-Raf-1 through a Ras-dependent mechanism. Nature 1996, 383:181-185.
11. Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR: Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. EMBO J 1997, 16:5618-5628.
12. Belshaw PJ, Ho SN, Crabtree GR, Schreiber SL: Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins. Proc Natl Acad Sci USA 1996, 93:4604-4607.
13. Klemm JD, Beals CR, Crabtree GR: Rapid targeting of nuclear proteins to the cytoplasm. Curr Biol 1997, 7:638-644.
14. Ho SN, Biggar SR, Spencer DM, Schreiber SL: Dimeric ligands define a role for transcriptional activation domains in reinitiation. Nature 1996, 382:822-826.
15. Rivera VM, Clackson T, Natesan S, Pollock R, Amara JF, Keenan T, et al.: A humanized system for pharmacologic control of gene expression. Nature Med 1996, 2:1028-1032.
16. Heldin CH: Dimerization of cell surface receptors in signal transduction. Cell 1995, 80:213-223.
17. Rosen MK, Yang D, Martrick PK, Schreiber SL: Activation of an inactive immunophilin by mutagenesis. J Am Chem Soc 1993, 115:821-822.
18. Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, et al.: Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1. Cell 1991, 65:1033-1042.
19. Ataliotis P, Mercola M: Distribution and functions or plateletderived growth factors and their receptors during embryogenesis. Int Rev Cytol 1997, 172:95-127.
20. Myers MG, White MF: Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol 1996, 36:615-658.
21. Freiberg RA, Spencer DM, Choate KA, Peng PD, Schreiber SL, Crabtree GR, et al.: Specific triggering of the Fas signal transduction pathway in normal human keratinocytes. J Biol Chem 1996, 271:31666-31669.
22. Freiberg RA, Spencer DM, Choate KA, Duh HJ, Schreiber SL, Crabtree GR, et al.: Fas signal transduction triggers either proliferation or apoptosis in human fibroblasts. J Invest Dermatol 1997, 108:215-219.
23. Sorkin A, Waters CM: Endocytosis of growth factor receptors. BioEssays 1993, 15:375-382.
24. Chou MM, Blenis J: The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling. Curr Opin Cell Biol 1995, 7:806-814.
25. Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL: Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 1995, 377:441-446.
26. Schatteman GC, Motley ST, Effmann EL, Bowen Pope DF: Plateletderived growth factor receptor alpha subunit deleted Patch mouse exhibits severe cardiovascular dysmorphogenesis. Teratology 1995, 51:351-366.
27. Ataliotis P, Symes K, Chou MM, Ho L, Mercola M: PDGF signalling is required for gastrulation of Xenopus laevis. Development 1995, 121:3099-3110.
28. Morrison Graham K, Schatteman GC, Bork T, Bowen Pope DF, Weston JA: A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 1992, 115:133-142.
29. Soriano P: Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev 1994, 8:1888-1896.
30. Smith JC: Mesoderm-inducing factors in early vertebrate development. EMBO J 1993, 12:4463-4470.
31. Nieuwkoop PD, Faber J: Normal Table of Xenopus laevis (Daudin), 2nd edn. Amsterdam: North-Holland Publishing Company; 1967.
32. Umbhauer M, Marshall CJ, Mason CS, Old RW, Smith JC: Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature 1995, 376:58-62.
33. Ballotti R, Lammers R, Scimeca JC, Dull T, Schlessinger J, Ullrich A, et al.: Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae. EMBO J 1989, 8:3303-3309.
34. Tartare S, Ballotti R, Lammers R, Alengrin F, Dull T, Schlessinger J, et al.: Insulin-EGF receptor chimerae mediate tyrosine transphosphorylation and serine/threonine phosphorylation of kinase-deficient EGF receptors. J Biol Chem 1991, 266:9900-9906.
35. Pawson T: Protein modules and signalling networks. Nature 1995, 373:573-580.
36. Yang J, Sato R, Goldstein JL, Brown MS: Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. Genes Dev 1994, 8:1910-1919.
37. Peng HB: Solutions and protocols. In Xenopus laevis: Practical Uses in Cell and Molecular Biology. Edited by Kay BK and Peng HB. San Diego: Academic Press; 1991:657-662.