Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

Journal of Molecular Biology

Volumn 277, Issue 5, 1998, Pages 1111-1128

  Clackson, Tim ^a   Ultsch, Mark H ^a   Wells, James A ^a   De Vos, Abraham M ^a  

^a GENENTECH INC   (United States)

Author keywords

Binding energy; Protein protein interactions; Site directed mutagenesis; Structure function; X ray crystallography

Indexed keywords

EPITOPE; GROWTH HORMONE RECEPTOR; HUMAN GROWTH HORMONE; MUTANT PROTEIN; TRYPTOPHAN;

ARTICLE; BINDING SITE; CHEMICAL REACTION KINETICS; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 0032540358     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.1669     Document Type: Article

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