메뉴 건너뛰기




Volumn 302, Issue 5, 2012, Pages

R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles

Author keywords

Circadian rhythm; Lipid metabolism; Microarray

Indexed keywords

ACACA PROTEIN; ACACB PROTEIN; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE BETA; AMTL PROTEIN; BHLHE40 PROTEIN; BILE ACID; CHOLESTEROL; DBP PROTEIN; FASN PROTEIN; FATTY ACID; FATTY ACID SYNTHASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; NPAS2 PROTEIN; NRLD2 PROTEIN; PER PROTEIN; PER2 PROTEIN; PER3 PROTEIN; PROTEIN; THIOCTIC ACID; THRSP PROTEIN; TRANSCRIPTOME; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 84857837563     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00393.2011     Document Type: Article
Times cited : (23)

References (62)
  • 1
    • 13844298645 scopus 로고    scopus 로고
    • Gene expression profile of long-lived Ames dwarf mice and Little mice
    • Amador-Noguez D, Yagi K, Venable S, Darlington G. Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell 3: 423-441, 2004.
    • (2004) Aging Cell , vol.3 , pp. 423-441
    • Amador-Noguez, D.1    Yagi, K.2    Venable, S.3    Darlington, G.4
  • 2
    • 0001677717 scopus 로고
    • Controlling the false discovery rate-a practical and powerful approach to multiple testing
    • Benjamini Y, Hochberg Y. Controlling the false discovery rate-a practical and powerful approach to multiple testing. J Royal Stat Soc B Methodolog 57: 289-300, 1995.
    • (1995) J Royal Stat Soc B Methodolog , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 3
    • 64549088894 scopus 로고    scopus 로고
    • Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion
    • Butler JA, Hagen TM, Moreau R. Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Arch Biochem Biophys 485: 63-71, 2009.
    • (2009) Arch Biochem Biophys , vol.485 , pp. 63-71
    • Butler, J.A.1    Hagen, T.M.2    Moreau, R.3
  • 4
    • 33746591126 scopus 로고    scopus 로고
    • Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor-a defines a novel positive feedback loop in the rodent liver circadian clock
    • Canaple L, Rambaud J, Dkhissi-Benyahya O, Rayet B, Tan NS, Michalik L, Delaunay F, Wahli W, Laudet V. Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor-a defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol 20: 1715-1727, 2006.
    • (2006) Mol Endocrinol , vol.20 , pp. 1715-1727
    • Canaple, L.1    Rambaud, J.2    Dkhissi-Benyahya, O.3    Rayet, B.4    Tan, N.S.5    Michalik, L.6    Delaunay, F.7    Wahli, W.8    Laudet, V.9
  • 5
    • 33645863768 scopus 로고    scopus 로고
    • Transcriptional regulation of metabolism
    • Desvergne B, Michalik L, Wahli W. Transcriptional regulation of metabolism. Physiol Rev 86: 465-514, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 465-514
    • Desvergne, B.1    Michalik, L.2    Wahli, W.3
  • 6
    • 54049130826 scopus 로고    scopus 로고
    • Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by a-lipoic acid in human leukemia HL-60 cells
    • Elangovan S, Hsieh TC. Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by a-lipoic acid in human leukemia HL-60 cells. Int J Oncol 33: 833-838, 2008.
    • (2008) Int J Oncol , vol.33 , pp. 833-838
    • Elangovan, S.1    Hsieh, T.C.2
  • 7
    • 12744263365 scopus 로고    scopus 로고
    • Dyslipidemia and inflammation: An evolutionary conserved mechanism
    • Esteve E, Ricart W, Fernandez-Real JM. Dyslipidemia and inflammation: an evolutionary conserved mechanism. Clin Nutr 24: 16-31, 2005.
    • (2005) Clin Nutr , vol.24 , pp. 16-31
    • Esteve, E.1    Ricart, W.2    Fernandez-Real, J.M.3
  • 10
    • 0033743950 scopus 로고    scopus 로고
    • (R)-a-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo
    • Hagen TM, Vinarsky V, Wehr CM, Ames BN. (R)-a-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxid Redox Signal 2: 473-483, 2000.
    • (2000) Antioxid Redox Signal , vol.2 , pp. 473-483
    • Hagen, T.M.1    Vinarsky, V.2    Wehr, C.M.3    Ames, B.N.4
  • 11
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman D. The biologic clock: the mitochondria? J Am Geriatr Soc 20: 145-147, 1972.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 12
    • 58549112996 scopus 로고    scopus 로고
    • Bioinformatics enrichment tools: Paths toward the comprehensive functional analysis of large gene lists
    • Huang da W, Sherman BT, Lempicki RA. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13, 2009.
    • (2009) Nucleic Acids Res , vol.37 , pp. 1-13
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 13
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57, 2009.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • da Huang, W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 15
    • 53049102636 scopus 로고    scopus 로고
    • Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats
    • Huong DT, Ide T. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Br J Nutr 100: 79-87, 2008.
    • (2008) Br J Nutr , vol.100 , pp. 79-87
    • Huong, D.T.1    Ide, T.2
  • 21
    • 33845665236 scopus 로고    scopus 로고
    • A sense of time: How molecular clocks organize metabolism
    • Kohsaka A, Bass J. A sense of time: how molecular clocks organize metabolism. Trends Endocrinol Metab 18: 4-11, 2007.
    • (2007) Trends Endocrinol Metab , vol.18 , pp. 4-11
    • Kohsaka, A.1    Bass, J.2
  • 22
    • 69849095325 scopus 로고    scopus 로고
    • A time to fast, a time to feast: The crosstalk between metabolism and the circadian clock
    • Kovac J, Husse J, Oster H. A time to fast, a time to feast: the crosstalk between metabolism and the circadian clock. Mol Cells 28: 75-80, 2009.
    • (2009) Mol Cells , vol.28 , pp. 75-80
    • Kovac, J.1    Husse, J.2    Oster, H.3
  • 23
    • 0032902482 scopus 로고    scopus 로고
    • α-Lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced glycation end products
    • Kunt T, Forst T, Wilhelm A, Tritschler H, Pfuetzner A, Harzer O, Engelbach M, Zschaebitz A, Stofft E, Beyer J. A-Lipoic acid reduces expression of vascular cell adhesion molecule-1 and endothelial adhesion of human monocytes after stimulation with advanced glycation end products. Clin Sci (Lond) 96: 75-82, 1999.
    • (1999) Clin Sci (Lond) , vol.96 , pp. 75-82
    • Kunt, T.1    Forst, T.2    Wilhelm, A.3    Tritschler, H.4    Pfuetzner, A.5    Harzer, O.6    Engelbach, M.7    Zschaebitz, A.8    Stofft, E.9    Beyer, J.10
  • 24
    • 0033610079 scopus 로고    scopus 로고
    • Gene expression profile of aging and its retardation by caloric restriction
    • Lee CK, Klopp RG, Weindruch R, Prolla TA. Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390-1393, 1999.
    • (1999) Science , vol.285 , pp. 1390-1393
    • Lee, C.K.1    Klopp, R.G.2    Weindruch, R.3    Prolla, T.A.4
  • 25
    • 1642588198 scopus 로고    scopus 로고
    • The impact of a-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice
    • Lee CK, Pugh TD, Klopp RG, Edwards J, Allison DB, Weindruch R, Prolla TA. The impact of a-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice. Free Radic Biol Med 36: 1043-1057, 2004.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1043-1057
    • Lee, C.K.1    Pugh, T.D.2    Klopp, R.G.3    Edwards, J.4    Allison, D.B.5    Weindruch, R.6    Prolla, T.A.7
  • 27
    • 77956242964 scopus 로고    scopus 로고
    • Vascular oxidative stress and inflammation increase with age: Ameliorating effects of a-lipoic acid supplementation
    • Li L, Smith A, Hagen TM, Frei B. Vascular oxidative stress and inflammation increase with age: ameliorating effects of a-lipoic acid supplementation. Ann NY Acad Sci 1203: 151-159, 2010.
    • (2010) Ann NY Acad Sci , vol.1203 , pp. 151-159
    • Li, L.1    Smith, A.2    Hagen, T.M.3    Frei, B.4
  • 28
    • 77951480791 scopus 로고    scopus 로고
    • Sul-foraphane and a-lipoic acid upregulate the expression of the it class of glutathione S-transferase through c-Jun and Nrf2 activation
    • Lii CK, Liu KL, Cheng YP, Lin AH, Chen HW, Tsai CW. Sul-foraphane and a-lipoic acid upregulate the expression of the it class of glutathione S-transferase through c-Jun and Nrf2 activation. J Nutr 140: 885-892, 2010.
    • (2010) J Nutr , vol.140 , pp. 885-892
    • Lii, C.K.1    Liu, K.L.2    Cheng, Y.P.3    Lin, A.H.4    Chen, H.W.5    Tsai, C.W.6
  • 29
    • 34249275727 scopus 로고    scopus 로고
    • Transcriptional coactivator PGC-1a integrates the mammalian clock and energy metabolism
    • Liu C, Li S, Liu T, Borjigin J, Lin JD. Transcriptional coactivator PGC-1a integrates the mammalian clock and energy metabolism. Nature 447: 477-481, 2007.
    • (2007) Nature , vol.447 , pp. 477-481
    • Liu, C.1    Li, S.2    Liu, T.3    Borjigin, J.4    Lin, J.D.5
  • 30
    • 29744460145 scopus 로고    scopus 로고
    • α-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kB and AP-1 transcription factors in human neuroblastoma IMR-32 cells
    • Mackenzie GG, Zago MP, Erlejman AG, Aimo L, Keen CL, Oteiza PI. a-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kB and AP-1 transcription factors in human neuroblastoma IMR-32 cells. Free Radic Res 40: 75-84, 2006.
    • (2006) Free Radic Res , vol.40 , pp. 75-84
    • Mackenzie, G.G.1    Zago, M.P.2    Erlejman, A.G.3    Aimo, L.4    Keen, C.L.5    Oteiza, P.I.6
  • 36
    • 34447556690 scopus 로고    scopus 로고
    • Multiple mechanisms regulate circadian expression of the gene for cholesterol 7a-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis
    • Noshiro M, Usui E, Kawamoto T, Kubo H, Fujimoto K, Furukawa M, Honma S, Makishima M, Honma K, Kato Y. Multiple mechanisms regulate circadian expression of the gene for cholesterol 7a-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis. J Biol Rhythms 22: 299-311, 2007.
    • (2007) J Biol Rhythms , vol.22 , pp. 299-311
    • Noshiro, M.1    Usui, E.2    Kawamoto, T.3    Kubo, H.4    Fujimoto, K.5    Furukawa, M.6    Honma, S.7    Makishima, M.8    Honma, K.9    Kato, Y.10
  • 39
    • 67651183792 scopus 로고    scopus 로고
    • Gene expression profiling of aging in multiple mouse strains: Identification of aging biomarkers and impact of dietary antioxidants
    • Park SK, Kim K, Page GP, Allison DB, Weindruch R, Prolla TA. Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants. Aging Cell 8: 484-495, 2009.
    • (2009) Aging Cell , vol.8 , pp. 484-495
    • Park, S.K.1    Kim, K.2    Page, G.P.3    Allison, D.B.4    Weindruch, R.5    Prolla, T.A.6
  • 40
    • 11144321344 scopus 로고    scopus 로고
    • Lessons learned from gene expression profile studies of aging and caloric restriction
    • Park SK, Prolla TA. Lessons learned from gene expression profile studies of aging and caloric restriction. Ageing Res Rev 4: 55-65, 2005.
    • (2005) Ageing Res Rev , vol.4 , pp. 55-65
    • Park, S.K.1    Prolla, T.A.2
  • 42
    • 34548815191 scopus 로고    scopus 로고
    • The orphan Rev-erb nuclear receptors: A link between metabolism, circadian rhythm and inflammation?
    • Ramakrishnan SN, Muscat GE. The orphan Rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation? Nucl Recept Signal 4: e009, 2006.
    • (2006) Nucl Recept Signal , vol.4
    • Ramakrishnan, S.N.1    Muscat, G.E.2
  • 43
    • 0032881613 scopus 로고    scopus 로고
    • Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (a-lipoic acid): A two year multicenter randomized double-blind placebo-controlled trial (ALADIN II) a-Lipoic Acid in Diabetic Neuropathy
    • Reljanovic M, Reichel G, Rett K, Lobisch M, Schuette K, Moller W, Tritschler HJ, Mehnert H. Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (a-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II) a-Lipoic Acid in Diabetic Neuropathy. Free Radic Res 31: 171-179, 1999.
    • (1999) Free Radic Res , vol.31 , pp. 171-179
    • Reljanovic, M.1    Reichel, G.2    Rett, K.3    Lobisch, M.4    Schuette, K.5    Moller, W.6    Tritschler, H.J.7    Mehnert, H.8
  • 44
    • 0037194790 scopus 로고    scopus 로고
    • Coordination of circadian timing in mammals
    • Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 418: 935-941, 2002.
    • (2002) Nature , vol.418 , pp. 935-941
    • Reppert, S.M.1    Weaver, D.R.2
  • 46
    • 69949104384 scopus 로고    scopus 로고
    • α-Lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
    • Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. a-Lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochim Biophys Acta 1790: 1149-1160, 2009.
    • (2009) Biochim Biophys Acta , vol.1790 , pp. 1149-1160
    • Shay, K.P.1    Moreau, R.F.2    Smith, E.J.3    Smith, A.R.4    Hagen, T.M.5
  • 47
    • 12844260091 scopus 로고    scopus 로고
    • Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: Results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study
    • Sola S, Mir MQ, Cheema FA, Khan-Merchant N, Menon RG, Parthasarathy S, Khan BV. Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. Circulation 111: 343-348, 2005.
    • (2005) Circulation , vol.111 , pp. 343-348
    • Sola, S.1    Mir, M.Q.2    Cheema, F.A.3    Khan-Merchant, N.4    Menon, R.G.5    Parthasarathy, S.6    Khan, B.V.7
  • 48
    • 77951935429 scopus 로고    scopus 로고
    • Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases
    • Straub RH, Cutolo M, Buttgereit F, Pongratz G. Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. J Intern Med 267: 543-560, 2010.
    • (2010) J Intern Med , vol.267 , pp. 543-560
    • Straub, R.H.1    Cutolo, M.2    Buttgereit, F.3    Pongratz, G.4
  • 49
    • 1542723493 scopus 로고    scopus 로고
    • Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
    • Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci USA 101: 3381-3386, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3381-3386
    • Suh, J.H.1    Shenvi, S.V.2    Dixon, B.M.3    Liu, H.4    Jaiswal, A.K.5    Liu, R.M.6    Hagen, T.M.7
  • 50
    • 0035087926 scopus 로고    scopus 로고
    • Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-a-lipoic acid
    • Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-a-lipoic acid. FASEB J 15: 700-706, 2001.
    • (2001) FASEB J , vol.15 , pp. 700-706
    • Suh, J.H.1    Shigeno, E.T.2    Morrow, J.D.3    Cox, B.4    Rocha, A.E.5    Frei, B.6    Hagen, T.M.7
  • 51
    • 1042290476 scopus 로고    scopus 로고
    • (R)-α-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: Evidence for increased cysteine requirement for GSH synthesis
    • Suh JH, Wang H, Liu RM, Liu J, Hagen TM. (R)-a-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Arch Biochem Biophys 423: 126-135, 2004.
    • (2004) Arch Biochem Biophys , vol.423 , pp. 126-135
    • Suh, J.H.1    Wang, H.2    Liu, R.M.3    Liu, J.4    Hagen, T.M.5
  • 52
    • 0026356525 scopus 로고
    • Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species
    • Suzuki YJ, Tsuchiya M, Packer L. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species. Free Radic Res Commun 15: 255-263, 1991.
    • (1991) Free Radic Res Commun , vol.15 , pp. 255-263
    • Suzuki, Y.J.1    Tsuchiya, M.2    Packer, L.3
  • 53
    • 73149086166 scopus 로고    scopus 로고
    • Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse
    • Swindell WR. Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse. BMC Genomics 10: 585, 2009.
    • (2009) BMC Genomics , vol.10 , pp. 585
    • Swindell, W.R.1
  • 55
    • 53549112749 scopus 로고    scopus 로고
    • Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: Causal effect or epiphenome-non?
    • Targher G, Marra F, Marchesini G. Increased risk of cardiovascular disease in non-alcoholic fatty liver disease: causal effect or epiphenome-non? Diabetologia 51: 1947-1953, 2008.
    • (2008) Diabetologia , vol.51 , pp. 1947-1953
    • Targher, G.1    Marra, F.2    Marchesini, G.3
  • 56
    • 77749271191 scopus 로고    scopus 로고
    • Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats
    • Wu T, Ni Y, Kato H, Fu Z. Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats. Chronobiol Int 27: 1-18, 2010.
    • (2010) Chronobiol Int , vol.27 , pp. 1-18
    • Wu, T.1    Ni, Y.2    Kato, H.3    Fu, Z.4
  • 57
    • 10844290766 scopus 로고    scopus 로고
    • A model-based background adjustment for oligonucleotide expressoin arrays
    • Wu ZIR, Gentleman R, Martinez-Murillo F, Spencer F. A model-based background adjustment for oligonucleotide expressoin arrays. J Am Stat Assoc 99: 909-917, 2004.
    • (2004) J Am Stat Assoc , vol.99 , pp. 909-917
    • Wu, Z.I.R.1    Gentleman, R.2    Martinez-Murillo, F.3    Spencer, F.4
  • 58
    • 77949444189 scopus 로고    scopus 로고
    • Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat
    • Xie Z, Li H, Wang K, Lin J, Wang Q, Zhao G, Jia W, Zhang Q. Analysis of transcriptome and metabolome profiles alterations in fatty liver induced by high-fat diet in rat. Metabolism 59: 554-560, 2010.
    • (2010) Metabolism , vol.59 , pp. 554-560
    • Xie, Z.1    Li, H.2    Wang, K.3    Lin, J.4    Wang, Q.5    Zhao, G.6    Jia, W.7    Zhang, Q.8
  • 59
    • 38349144351 scopus 로고    scopus 로고
    • Dietary a-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice
    • Zhang WJ, Bird KE, McMillen TS, LeBoeuf RC, Hagen TM, Frei B. Dietary a-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117: 421-428, 2008.
    • (2008) Circulation , vol.117 , pp. 421-428
    • Zhang, W.J.1    Bird, K.E.2    McMillen, T.S.3    Leboeuf, R.C.4    Hagen, T.M.5    Frei, B.6
  • 60
    • 0035158577 scopus 로고    scopus 로고
    • α-Lipoic acid inhibits TNF-a-induced NF-kB activation and adhesion molecule expression in human aortic endothelial cells
    • Zhang WJ, Frei B. a-Lipoic acid inhibits TNF-a-induced NF-kB activation and adhesion molecule expression in human aortic endothelial cells. FASEB J 15: 2423-2432, 2001.
    • (2001) FASEB J , vol.15 , pp. 2423-2432
    • Zhang, W.J.1    Frei, B.2
  • 61
    • 34247220265 scopus 로고    scopus 로고
    • α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-ki-nase/Akt signaling pathway
    • Zhang WJ, Wei H, Hagen T, Frei B. a-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-ki-nase/Akt signaling pathway. Proc Natl Acad Sci USA 104: 4077-4082, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4077-4082
    • Zhang, W.J.1    Wei, H.2    Hagen, T.3    Frei, B.4
  • 62
    • 1242337352 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: A meta-analysis
    • Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment of symptomatic diabetic polyneuropathy with the antioxidant a-lipoic acid: a meta-analysis. Diabet Med 21: 114-121, 2004.
    • (2004) Diabet Med , vol.21 , pp. 114-121
    • Ziegler, D.1    Nowak, H.2    Kempler, P.3    Vargha, P.4    Low, P.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.