Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats

Toxicological Sciences

Volumn 106, Issue 1, 2008, Pages 263-283

  Lee, Janice S ^a   Ward, William O ^a   Wolf, Douglas C ^a   Allen, James W ^a   Mills, Camilla ^b   Devito, Michael J ^a   Corton, J Christopher ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

Aging; Gene expression; Liver; Microarrays; Susceptibility; Xenobiotic metabolism

Indexed keywords

ABC TRANSPORTER; ALCOHOL; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; CARBOXYLESTERASE; CYTOCHROME P450 2A; CYTOCHROME P450 2A1; CYTOCHROME P450 2B; CYTOCHROME P450 2B2; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 3A; CYTOCHROME P450 4A; DIMETHYLANILINE MONOOXYGENASE; ERGOSTEROL; ESTERASE; FATTY ACID; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M3; GLUTATHIONE TRANSFERASE T1; HEME OXYGENASE; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; LIPID; ORGANIC ANION TRANSPORTER 4; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TOLUENE; XENOBIOTIC AGENT;

AGED; AGING; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BROWN NORWAY RAT; CONTROLLED STUDY; DETOXIFICATION; FATTY ACID METABOLISM; FEMINIZATION; FISCHER 344 RAT; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; LIFESPAN; LIPID METABOLISM; LIVER; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN EXPRESSION; RAT; STRAIN DIFFERENCE; TRANSPORT KINETICS; UNINDEXED SEQUENCE; XENOBIOTIC METABOLISM;

AGE FACTORS; AGING; ANIMALS; BIOTRANSFORMATION; CLUSTER ANALYSIS; ENZYMES; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRINCIPAL COMPONENT ANALYSIS; RATS; RATS, INBRED BN; RATS, INBRED F344; SEX FACTORS; TOLUENE; TRANSCRIPTION, GENETIC; XENOBIOTICS;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 54349122613     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn144     Document Type: Article

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