Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age

Toxicologic Pathology

Volumn 35, Issue 2, 2007, Pages 242-251

  Mori, Kazuhiko ^a,e   Blackshear, Pamela E ^b   Lobenhofer, Edward K ^c   Parker, Joel S ^d   Orzech, Denise P ^a   Roycroft, Joseph H ^a   Walker, Kimwa L ^b   Johnson, Kennita A ^a   Marsh, Tiwanda A ^a   Irwin, Richard D ^a   Boorman, Gary A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b INTEGRATED LABORATORY SYSTEMS   (United States)

^c Division of A Clinical Data ^*  (United States)

^d Constella Group Inc ^*  (United States)

^e DAIICHI SANKYO CO   (Japan)

Author keywords

Aging; Cytochrome P450; Liver; Rat; Transcriptome; Xenobiotic metabolism

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 2C11; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; XENOBIOTIC AGENT;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; LIVER; LIVER METABOLISM; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STATISTICAL SIGNIFICANCE; XENOBIOTIC METABOLISM;

AGE FACTORS; AGING; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; MEMBRANE PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; STEROID 16-ALPHA-HYDROXYLASE; TOXICITY TESTS; TRANSCRIPTION, GENETIC; XENOBIOTICS;

RATTUS; RODENTIA;

EID: 33847772073     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1080/01926230601156286     Document Type: Article

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