Exploring c-Met kinase flexibility by sampling and clustering its conformational space

Proteins: Structure, Function and Bioinformatics

Volumn 80, Issue 4, 2012, Pages 1227-1238

  Asses, Yasmine ^a,b   Venkatraman, Vishwesh ^a,b   Leroux, Vincent ^a,b   Ritchie, David W ^a   Maigret, Bernard ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

C Met protein ligand complexes; Conformational preselection; Conformational sampling; Induced fit; Protein flexibility

Indexed keywords

C MET KINASE; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CLUSTER ANALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME BINDING; ENZYME CONFORMATION; ENZYME FLEXIBILITY; ENZYME STRUCTURE; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN FUNCTION;

ADENOSINE TRIPHOSPHATE; ALGORITHMS; BINDING SITES; CLUSTER ANALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PHOSPHOTRANSFERASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-MET;

EID: 84857782921     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24021     Document Type: Article

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