-
1
-
-
76649131263
-
Biochemical characterization of AMG 102: A neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor
-
Burgess TL, Sun J, Meyer S, et al. Biochemical characterization of AMG 102: a neutralizing, fully human monoclonal antibody to human and nonhuman primate hepatocyte growth factor. Mol Cancer Ther 2010;9:400-409
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 400-409
-
-
Burgess, T.L.1
Sun, J.2
Meyer, S.3
-
3
-
-
44449151030
-
Drug development of MET inhibitors: Targeting oncogene addiction and expedience
-
DOI 10.1038/nrd2530, PII NRD2530
-
Comoglio PM, Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov 2008;7:504-516 (Pubitemid 351767118)
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.6
, pp. 504-516
-
-
Comoglio, P.M.1
Giordano, S.2
Trusolino, L.3
-
4
-
-
17344381429
-
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L, Duh FM, Chen F, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 1997;16:68-73.
-
(1997)
Nat Genet
, vol.16
, pp. 68-73
-
-
Schmidt, L.1
Duh, F.M.2
Chen, F.3
-
5
-
-
0033535530
-
Novel mutations of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L, Junker K, Nakaigawa N, et al. Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene 1999;18: 2343-2350
-
(1999)
Oncogene
, vol.18
, pp. 2343-2350
-
-
Schmidt, L.1
Junker, K.2
Nakaigawa, N.3
-
6
-
-
0034869788
-
Papillary renal cell carcinoma: Analysis of germline mutations in the MET proto-oncogene in a clinic-based population
-
Lindor NM, Dechet CB, Greene MH, et al. Papillary renal cell carcinoma: analysis of germline mutations in the MET proto-oncogene in a clinic-based population. Genet Test 2001;5:101-106
-
(2001)
Genet Test
, vol.5
, pp. 101-106
-
-
Lindor, N.M.1
Dechet, C.B.2
Greene, M.H.3
-
7
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007;316:1039-1043
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
8
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci U S A 2007; 104:20932-20937
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
9
-
-
32944467848
-
Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors
-
Burgess T, Coxon A, Meyer S, et al. Fully human monoclonal antibodies to hepatocyte growth factor with therapeutic potential against hepatocyte growth factor/c-Met-dependent human tumors. Cancer Res 2006;66:1721-1729
-
(2006)
Cancer Res
, vol.66
, pp. 1721-1729
-
-
Burgess, T.1
Coxon, A.2
Meyer, S.3
-
10
-
-
4544338194
-
Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in met binding and signaling
-
DOI 10.1074/jbc.M404795200
-
Kirchhofer D, Yao X, Peek M, et al. Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in Met binding and signaling. J Biol Chem 2004;279:39915-39924 (Pubitemid 39258264)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.38
, pp. 39915-39924
-
-
Kirchhofer, D.1
Yao, X.2
Peek, M.3
Eigenbrot, C.4
Lipari, M.T.5
Billeci, K.L.6
Maun, H.R.7
Moran, P.8
Santell, L.9
Wiesmann, C.10
Lazarus, R.A.11
-
11
-
-
3142595278
-
Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor
-
DOI 10.1038/sj.emboj.7600243
-
Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor. EMBO J 2004;23:2325-2335 (Pubitemid 38954840)
-
(2004)
EMBO Journal
, vol.23
, Issue.12
, pp. 2325-2335
-
-
Stamos, J.1
Lazarus, R.A.2
Yao, X.3
Kirchhofer, D.4
Wiesmann, C.5
-
12
-
-
74549174584
-
Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors
-
Gordon MS, Sweeney CS, Mendelson DS, et al. Safety, pharmacokinetics, and pharmacodynamics of AMG 102, a fully human hepatocyte growth factor-neutralizing monoclonal antibody, in a first-in-human study of patients with advanced solid tumors. Clin Cancer Res 2010;16:699-710.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 699-710
-
-
Gordon, M.S.1
Sweeney, C.S.2
Mendelson, D.S.3
-
13
-
-
44449131293
-
ARQ 197, a highly selective small molecule inhibitor of c-Met, with selective antitumor properties in a broad spectrum of human cancer cells
-
abstract 2369. Philadelphia: AACR
-
Jeay S, Munshi N, Hill J, et al. ARQ 197, a highly selective small molecule inhibitor of c-Met, with selective antitumor properties in a broad spectrum of human cancer cells [abstract 2369]. Proceedings of the American Association for Cancer Research Annual Meeting, Los Angeles, CA. 2007 Apr 14-18, Philadelphia: AACR; 2007.
-
(2007)
Proceedings of the American Association for Cancer Research Annual Meeting, Los Angeles, CA. 2007 Apr 14-18
-
-
Jeay, S.1
Munshi, N.2
Hill, J.3
-
14
-
-
77952132642
-
One-armed 5D5 (OA5D5) is a potent humanized HGF-blocking anti-c-Met monovalent antibody that inhibits HGF-dependent activity in vitro and demonstrates anti-tumor efficacy in vivo
-
Merchant M, Zheng Z, Romero M, et al. One-armed 5D5 (OA5D5) is a potent humanized HGF-blocking anti-c-Met monovalent antibody that inhibits HGF-dependent activity in vitro and demonstrates anti-tumor efficacy in vivo. American Association for Cancer Research Meeting Abstracts. 2007, LB-372.
-
(2007)
American Association for Cancer Research Meeting Abstracts
-
-
Merchant, M.1
Zheng, Z.2
Romero, M.3
-
15
-
-
34548850403
-
ARQ 197, a highly selective small molecule inhibitor of c-Met, inhibits invasive and metastatic growth of cancer cells
-
abstract 2367. Philadelphia: AACR
-
Munshi N, Jeay S, Hill J, et al. ARQ 197, a highly selective small molecule inhibitor of c-Met, inhibits invasive and metastatic growth of cancer cells [abstract 2367]. Proceedings of the American Association for Cancer Research Annual Meeting, Los Angeles, CA. 2007 Apr 14-18, Philadelphia: AACR; 2007.
-
(2007)
Proceedings of the American Association for Cancer Research Annual Meeting, Los Angeles, CA. 2007 Apr 14-18
-
-
Munshi, N.1
Jeay, S.2
Hill, J.3
-
16
-
-
79251639665
-
Phase I, open-label, dose escalation study of the safety and pharmacology of MetMAb, a monovalent antagonist antibody to the recetor c-Met, administered IV in patients with locally advanced or metastatic solid tumors
-
abstract 411
-
Salgia R, Peterson A, Eppler SA. Phase I, open-label, dose escalation study of the safety and pharmacology of MetMAb, A monovalent antagonist antibody to the recetor c-Met, administered IV in patients with locally advanced or metastatic solid tumors [abstract 411]. Proceedings of the 20th Annual AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Geneva, Switzerland. 2008 Oct 21-24.
-
Proceedings of the 20th Annual AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics, Geneva, Switzerland. 2008 Oct 21-24
-
-
Salgia, R.1
Peterson, A.2
Eppler, S.A.3
-
17
-
-
70350145733
-
Final results of a pharmacokinetic (PK) and pharmacodynamic (PD) phase I trial of ARQ 197 incorporating dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) studies investigating the antiangiogenic activity of selective c-Met inhibition
-
Yap T, Frentzas S, Tunariu N, et al. Final results of a pharmacokinetic (PK) and pharmacodynamic (PD) phase I trial of ARQ 197 incorporating dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) studies investigating the antiangiogenic activity of selective c-Met inhibition. J Clin Oncol 2009;27:3523.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3523
-
-
Yap, T.1
Frentzas, S.2
Tunariu, N.3
-
18
-
-
76749109321
-
Final results: A dose escalation phase I study of ARQ 197, a selective c-Met inhibitor, in patients with metastatic solid tumors
-
Mekhail T, Rich T, Rosen L, et al. Final results: A dose escalation phase I study of ARQ 197, a selective c-Met inhibitor, in patients with metastatic solid tumors. J Clin Oncol 2009;27:3548.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3548
-
-
Mekhail, T.1
Rich, T.2
Rosen, L.3
-
19
-
-
77952152632
-
-
Bethesda, MD: U S. National Institutes of Health. Available from
-
ClinicalTrails gov. Bethesda, MD: U S. National Institutes of Health. Available from: http://www.clinicaltrials.gov.
-
-
-
-
20
-
-
70350230210
-
Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases
-
Qian F, Engst S, Yamaguchi K, et al. Inhibition of tumor cell growth, invasion, and metastasis by EXEL-2880 (XL880, GSK1363089), a novel inhibitor of HGF and VEGF receptor tyrosine kinases. Cancer Res 2009;69:8009-8016
-
(2009)
Cancer Res
, vol.69
, pp. 8009-8016
-
-
Qian, F.1
Engst, S.2
Yamaguchi, K.3
-
21
-
-
77952119744
-
Targeting MET with XL184 to reverse EGFR tyrosine kinase inhibitor (TKI) resistance in NSCLC: Impact of preclinical studies on clinical design
-
Janne P, Wax M, Leach J, Engelman J. Targeting MET with XL184 to reverse EGFR tyrosine kinase inhibitor (TKI) resistance in NSCLC: impact of preclinical studies on clinical design. Eur J Cancer 2008;6:552.
-
(2008)
Eur J Cancer
, vol.6
, pp. 552
-
-
Janne, P.1
Wax, M.2
Leach, J.3
Engelman, J.4
-
22
-
-
38049124932
-
Phase I experience with c-MET inhibitor XL880 administered orally to patients (pts) with solid tumors
-
Eder J, Heath E, Appleman L, et al. Phase I experience with c-MET inhibitor XL880 administered orally to patients (pts) with solid tumors. J Clin Oncol 2007;25:3526.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3526
-
-
Eder, J.1
Heath, E.2
Appleman, L.3
-
23
-
-
55349093866
-
A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma (PRC)
-
Srinivasan R, Choueiri T, Vaishampayan U, et al. A phase II study of the dual MET/VEGFR2 inhibitor XL880 in patients (pts) with papillary renal carcinoma (PRC). J Clin Oncol 2008;26:5103.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5103
-
-
Srinivasan, R.1
Choueiri, T.2
Vaishampayan, U.3
-
24
-
-
56849132326
-
A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC)
-
Salgia R, Sherman S, Hong D, et al. A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC). J Clin Oncol 2008;26:3522.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3522
-
-
Salgia, R.1
Sherman, S.2
Hong, D.3
-
25
-
-
76749144538
-
A phase II study of XL184 in patients (pts) with progressive glioblastoma multiforme (GBM) in first or second relapse
-
De Groot J, Prados M, Urquhart T, et al. A phase II study of XL184 in patients (pts) with progressive glioblastoma multiforme (GBM) in first or second relapse. J Clin Oncol 2009;27:2047.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2047
-
-
De Groot, J.1
Prados, M.2
Urquhart, T.3
-
26
-
-
71049154727
-
A phase II study of two dosing regimens of GSK 1363089 (GSK089), a dual MET/ VEGFR2 inhibitor, in patients (pts) with papillary renal carcinoma (PRC)
-
Srinivasan R, Linehan W, Vaishampayan U, et al. A phase II study of two dosing regimens of GSK 1363089 (GSK089), a dual MET/ VEGFR2 inhibitor, in patients (pts) with papillary renal carcinoma (PRC). J Clin Oncol 2009;27:5103.
-
(2009)
J Clin Oncol
, vol.27
, pp. 5103
-
-
Srinivasan, R.1
Linehan, W.2
Vaishampayan, U.3
-
27
-
-
77950558200
-
Assessment of two dosing schedules of GSK1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in metastatic gastric cancer (GC): Interim results of a multicenter phase II study
-
Jhawer M, Kindler H, Wainberg Z, et al. Assessment of two dosing schedules of GSK1363089 (GSK089), a dual MET/VEGFR2 inhibitor, in metastatic gastric cancer (GC): Interim results of a multicenter phase II study. J Clin Oncol 2009;27:4502.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4502
-
-
Jhawer, M.1
Kindler, H.2
Wainberg, Z.3
-
28
-
-
75149113069
-
Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development?
-
Carden CP, Sarker D, Postel-Vinay S, et al. Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development? Drug Discov Today 2009.
-
(2009)
Drug Discov Today
-
-
Carden, C.P.1
Sarker, D.2
Postel-Vinay, S.3
-
29
-
-
70350140489
-
Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066
-
Kwak E, Camidge D, Clark J, et al. Clinical activity observed in a phase I dose escalation trial of an oral c-met and ALK inhibitor, PF-02341066. J Clin Oncol 2009;27:3509.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3509
-
-
Kwak, E.1
Camidge, D.2
Clark, J.3
|