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Volumn 18, Issue 10, 2012, Pages 1331-1337

Acid-Extrusion from Tissue: The Interplay Between Membrane Transporters and pH Buffers

Author keywords

Cancer; Carbonic anhydrase; Membrane transport; Regulation

Indexed keywords

ACETAZOLAMIDE; BICARBONATE; BUFFER; CARBON DIOXIDE; CARBONATE DEHYDRATASE; DIMETHYL AMILORIDE; HYDROGEN; PROTON; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

EID: 84857738801     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799504920     Document Type: Article
Times cited : (14)

References (53)
  • 1
    • 10344248930 scopus 로고    scopus 로고
    • Regulation of intracellular pH
    • Boron WF. Regulation of intracellular pH. Adv Physiol Educ 2004; 28: 160-179.
    • (2004) Adv Physiol Educ , vol.28 , pp. 160-179
    • Boron, W.F.1
  • 6
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989; 49: 6449-6465.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 8
    • 0031888726 scopus 로고    scopus 로고
    • Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes
    • Nakhoul NL, Davis BA, Romero MF, Boron WF. Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes. Am J Physiol 1998; 274: C543-C548.
    • (1998) Am J Physiol , vol.274
    • Nakhoul, N.L.1    Davis, B.A.2    Romero, M.F.3    Boron, W.F.4
  • 9
    • 0017099416 scopus 로고
    • Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier
    • Halestrap AP. Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier. Biochem J 1976; 156: 193-207.
    • (1976) Biochem J , vol.156 , pp. 193-207
    • Halestrap, A.P.1
  • 10
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999; 343 Pt 2: 281-299.
    • Biochem J 1999; 343 Pt , vol.2 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 11
    • 80053640489 scopus 로고    scopus 로고
    • + symporters MCT1 and hypoxia-inducible MCT4 is critical for en ergetics and growth of glycolytic tumors
    • + symporters MCT1 and hypoxia-inducible MCT4 is critical for en ergetics and growth of glycolytic tumors. Proc Natl Acad Sci USA 2011; 108: 16663-16668.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3
  • 12
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Stubbs M, McSheehy PM, Griffiths JR, Bashford CL. Causes and consequences of tumour acidity and implications for treatment. Mol Med Today 2000; 6: 15-29.
    • (2000) Mol Med Today , vol.6 , pp. 15-29
    • Stubbs, M.1    McSheehy, P.M.2    Griffiths, J.R.3    Bashford, C.L.4
  • 13
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • Gatenby RA, Gawlinski ET. A reaction-diffusion model of cancer invasion. Cancer Res 1996; 56: 5745-5753.
    • (1996) Cancer Res , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 14
    • 0032080644 scopus 로고    scopus 로고
    • Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells
    • Lee AH, Tannock IF. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res 1998; 58: 1901-1908.
    • (1998) Cancer Res , vol.58 , pp. 1901-1908
    • Lee, A.H.1    Tannock, I.F.2
  • 15
    • 1242272754 scopus 로고    scopus 로고
    • Diversity of the mammalian sodium/proton exchanger SLC9 gene family
    • Orlowski J, Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch 2004; 447: 549-565.
    • (2004) Pflugers Arch , vol.447 , pp. 549-565
    • Orlowski, J.1    Grinstein, S.2
  • 17
    • 33646830005 scopus 로고
    • Ion motive ATPases. I. Ubiquity, properties and significance to cell function
    • Pedersen PL, Carafoli E. Ion motive ATPases. I. Ubiquity, properties and significance to cell function. Trends Biochem Sci 1987; 12: 146-150.
    • (1987) Trends Biochem Sci , vol.12 , pp. 146-150
    • Pedersen, P.L.1    Carafoli, E.2
  • 18
    • 67749145635 scopus 로고    scopus 로고
    • The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths
    • Swietach P, Patiar S, Supuran CT, Harris AL, Vaughan-Jones RD. The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths. J Biol Chem 2009; 284: 20299-20310.
    • (2009) J Biol Chem , vol.284 , pp. 20299-20310
    • Swietach, P.1    Patiar, S.2    Supuran, C.T.3    Harris, A.L.4    Vaughan-Jones, R.D.5
  • 19
    • 50649105780 scopus 로고    scopus 로고
    • Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellu-lar growths
    • Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, Vaughan-Jones RD. Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellu-lar growths. J Biol Chem 2008; 283: 20473-20483.
    • (2008) J Biol Chem , vol.283 , pp. 20473-20483
    • Swietach, P.1    Wigfield, S.2    Cobden, P.3    Supuran, C.T.4    Harris, A.L.5    Vaughan-Jones, R.D.6
  • 20
    • 79954600753 scopus 로고    scopus 로고
    • 3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths
    • Hulikova A, Vaughan-Jones RD, Swietach P. Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths. J Biol Chem 2011; 286: 13815-13826.
    • (2011) J Biol Chem , vol.286 , pp. 13815-13826
    • Hulikova, A.1    Vaughan-Jones, R.D.2    Swietach, P.3
  • 22
    • 0027373117 scopus 로고
    • Vacuo-lar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells
    • Martinez-Zaguilan R, Lynch RM, Martinez GM, Gillies RJ. Vacuo-lar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol 1993; 265: C1015-C1029.
    • (1993) Am J Physiol , vol.265
    • Martinez-Zaguilan, R.1    Lynch, R.M.2    Martinez, G.M.3    Gillies, R.J.4
  • 23
    • 0022550159 scopus 로고
    • Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle
    • Vanheel B, de Hemptinne A, Leusen I. Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle. Am J Physiol 1986; 250: C748-C760.
    • (1986) Am J Physiol , vol.250
    • Vanheel, B.1    de Hemptinne, A.2    Leusen, I.3
  • 24
    • 0025319198 scopus 로고
    • Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle
    • Irving M, Maylie J, Sizto NL, Chandler WK. Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle. Biophys J 1990; 57: 717-721.
    • (1990) Biophys J , vol.57 , pp. 717-721
    • Irving, M.1    Maylie, J.2    Sizto, N.L.3    Chandler, W.K.4
  • 25
    • 0023119889 scopus 로고
    • The role of fixed and mobile buffers in the kinetics of proton movement
    • Junge W, McLaughlin S. The role of fixed and mobile buffers in the kinetics of proton movement. Biochim Biophys Acta 1987; 890: 1-5.
    • (1987) Biochim Biophys Acta , vol.890 , pp. 1-5
    • Junge, W.1    McLaughlin, S.2
  • 26
    • 0028111173 scopus 로고
    • Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment
    • Pastorek J, Pastorekova S, Callebaut I, et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment. Oncogene 1994; 9: 2877-2888.
    • (1994) Oncogene , vol.9 , pp. 2877-2888
    • Pastorek, J.1    Pastorekova, S.2    Callebaut, I.3
  • 27
    • 0041062296 scopus 로고    scopus 로고
    • Human carbonic anhydrase XII: CDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers
    • Tureci O, Sahin U, Vollmar E, et al. Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. Proc Natl Acad Sci USA 1998; 95: 7608-13.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7608-7613
    • Tureci, O.1    Sahin, U.2    Vollmar, E.3
  • 29
    • 0034671307 scopus 로고    scopus 로고
    • Hypoxia-inducible expression of tumor-associated carbonic anhydrases
    • Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000; 60: 7075-7083.
    • (2000) Cancer Res , vol.60 , pp. 7075-7083
    • Wykoff, C.C.1    Beasley, N.J.2    Watson, P.H.3
  • 30
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach P, Hulikova A, Vaughan-Jones RD, Harris AL. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene 2010; 29: 6509-21.
    • (2010) Oncogene , vol.29 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 31
    • 0017760271 scopus 로고
    • The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones
    • Thomas RC. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones. J Physiol 1977; 273: 317-338.
    • (1977) J Physiol , vol.273 , pp. 317-338
    • Thomas, R.C.1
  • 32
    • 33644816650 scopus 로고    scopus 로고
    • Molecular physiology of SLC4 anion exchangers
    • Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol 2006; 91: 153-161.
    • (2006) Exp Physiol , vol.91 , pp. 153-161
    • Alper, S.L.1
  • 34
    • 74549168941 scopus 로고    scopus 로고
    • Evaluating the role of carbonic anhydrases in the transport of HCO3--related species
    • Boron WF. Evaluating the role of carbonic anhydrases in the transport of HCO3--related species. Biochim Biophys Acta 2010; 1804: 410-421.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 410-421
    • Boron, W.F.1
  • 35
    • 0020624853 scopus 로고
    • Stoichiometry and ion dependencies of the intracellular-pH-regulating mechanism in squid giant axons
    • Boron WF, Russell JM. Stoichiometry and ion dependencies of the intracellular-pH-regulating mechanism in squid giant axons. J Gen Physiol 1983; 81: 373-99.
    • (1983) J Gen Physiol , vol.81 , pp. 373-399
    • Boron, W.F.1    Russell, J.M.2
  • 36
    • 0000633287 scopus 로고
    • The theorem of neutrality regulation in the animal organism
    • Henderson LJ. The theorem of neutrality regulation in the animal organism. Am J Physiol 1908; 21: 427-448.
    • (1908) Am J Physiol , vol.21 , pp. 427-448
    • Henderson, L.J.1
  • 37
    • 0024500243 scopus 로고
    • i response
    • Thomas RC. Cell growth factors. Bicarbonate and pHi response. Nature 1989; 337: 601.
    • (1989) Nature , vol.337 , pp. 601
    • Thomas, R.C.1
  • 38
    • 0037100861 scopus 로고    scopus 로고
    • Cytostatic potential of novel agents that inhibit the regulation of intracellular pH
    • Wong P, Kleemann HW, Tannock IF. Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. Br J Cancer 2002; 87: 238-245.
    • (2002) Br J Cancer , vol.87 , pp. 238-245
    • Wong, P.1    Kleemann, H.W.2    Tannock, I.F.3
  • 39
    • 77955057718 scopus 로고    scopus 로고
    • i regulation and chemotherapy resistance
    • Lauritzen G, Jensen MB, Boedtkjer E, et al. NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance. Exp Cell Res 2010; 316: 2538-2553.
    • (2010) Exp Cell Res , vol.316 , pp. 2538-2553
    • Lauritzen, G.1    Jensen, M.B.2    Boedtkjer, E.3
  • 40
    • 0035930581 scopus 로고    scopus 로고
    • A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers
    • Sterling D, Reithmeier RA, Casey JR. A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. J Biol Chem 2001; 276: 47886-47894.
    • (2001) J Biol Chem , vol.276 , pp. 47886-47894
    • Sterling, D.1    Reithmeier, R.A.2    Casey, J.R.3
  • 41
    • 0033746761 scopus 로고    scopus 로고
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
    • + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. Faseb J 2000; 14: 2185-2197.
    • (2000) Faseb J , vol.14 , pp. 2185-2197
    • Reshkin, S.J.1    Bellizzi, A.2    Caldeira, S.3
  • 43
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 44
    • 0030614893 scopus 로고    scopus 로고
    • 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997; 3: 177-182.
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 45
    • 42549134089 scopus 로고    scopus 로고
    • Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte
    • Niederer SA, Swietach P, Wilson DA, Smith NP, Vaughan-Jones RD. Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte. Biophys J 2008; 94: 2385-2403.
    • (2008) Biophys J , vol.94 , pp. 2385-2403
    • Niederer, S.A.1    Swietach, P.2    Wilson, D.A.3    Smith, N.P.4    Vaughan-Jones, R.D.5
  • 46
    • 0030583209 scopus 로고    scopus 로고
    • Symmetry and pH dependency of the lactate/proton carrier in skeletal muscle studied with rat sarcolemmal giant vesicles
    • Juel C. Symmetry and pH dependency of the lactate/proton carrier in skeletal muscle studied with rat sarcolemmal giant vesicles. Bio-chim Biophys Acta 1996; 1283: 106-110.
    • (1996) Bio-chim Biophys Acta , vol.1283 , pp. 106-110
    • Juel, C.1
  • 47
    • 8844249356 scopus 로고    scopus 로고
    • Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
    • Svastova E, Hulikova A, Rafajova M, et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004; 577: 439-445.
    • (2004) FEBS Lett , vol.577 , pp. 439-445
    • Svastova, E.1    Hulikova, A.2    Rafajova, M.3
  • 48
    • 33644849887 scopus 로고    scopus 로고
    • Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
    • Koukourakis MI, Bentzen SM, Giatromanolaki A, et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol 2006; 24: 727-735.
    • (2006) J Clin Oncol , vol.24 , pp. 727-735
    • Koukourakis, M.I.1    Bentzen, S.M.2    Giatromanolaki, A.3
  • 49
    • 79960359073 scopus 로고    scopus 로고
    • Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation
    • Dubois L, Peeters S, Lieuwes NG, et al. Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiother Oncol 2011; 99: 424-431.
    • (2011) Radiother Oncol , vol.99 , pp. 424-431
    • Dubois, L.1    Peeters, S.2    Lieuwes, N.G.3
  • 50
    • 58249094845 scopus 로고    scopus 로고
    • Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
    • Chiche J, Ilc K, Laferriere J, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009; 69: 358-368.
    • (2009) Cancer Res , vol.69 , pp. 358-368
    • Chiche, J.1    Ilc, K.2    Laferriere, J.3
  • 51
    • 78649813619 scopus 로고    scopus 로고
    • Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain
    • Zatovicova M, Jelenska L, Hulikova A, et al. Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain. Curr Pharm Des 2010; 16: 3255-3263.
    • (2010) Curr Pharm Des , vol.16 , pp. 3255-3263
    • Zatovicova, M.1    Jelenska, L.2    Hulikova, A.3
  • 52
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
    • Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nature Rev (Drug Discoveries) 2008; 7: 1-14.
    • (2008) Nature Rev (Drug Discoveries) , vol.7 , pp. 1-14
    • Supuran, C.T.1
  • 53
    • 65549166946 scopus 로고    scopus 로고
    • Bicarbonate increases tumor pH and inhibits spontaneous metastases
    • Robey IF, Baggett BK, Kirkpatrick ND, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res 2009; 69: 2260-2268.
    • (2009) Cancer Res , vol.69 , pp. 2260-2268
    • Robey, I.F.1    Baggett, B.K.2    Kirkpatrick, N.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.