-
1
-
-
10344248930
-
Regulation of intracellular pH
-
Boron WF. Regulation of intracellular pH. Adv Physiol Educ 2004; 28: 160-179.
-
(2004)
Adv Physiol Educ
, vol.28
, pp. 160-179
-
-
Boron, W.F.1
-
5
-
-
33744942376
-
Acid-mediated tumor invasion: A multidisciplinary study
-
Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 2006; 66: 5216-5223.
-
(2006)
Cancer Res
, vol.66
, pp. 5216-5223
-
-
Gatenby, R.A.1
Gawlinski, E.T.2
Gmitro, A.F.3
Kaylor, B.4
Gillies, R.J.5
-
6
-
-
0024408986
-
Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
-
Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res 1989; 49: 6449-6465.
-
(1989)
Cancer Res
, vol.49
, pp. 6449-6465
-
-
Vaupel, P.1
Kallinowski, F.2
Okunieff, P.3
-
8
-
-
0031888726
-
Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes
-
Nakhoul NL, Davis BA, Romero MF, Boron WF. Effect of expressing the water channel aquaporin-1 on the CO2 permeability of Xenopus oocytes. Am J Physiol 1998; 274: C543-C548.
-
(1998)
Am J Physiol
, vol.274
-
-
Nakhoul, N.L.1
Davis, B.A.2
Romero, M.F.3
Boron, W.F.4
-
9
-
-
0017099416
-
Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier
-
Halestrap AP. Transport of pyruvate nad lactate into human erythrocytes. Evidence for the involvement of the chloride carrier and a chloride-independent carrier. Biochem J 1976; 156: 193-207.
-
(1976)
Biochem J
, vol.156
, pp. 193-207
-
-
Halestrap, A.P.1
-
10
-
-
0033569442
-
The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
-
Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999; 343 Pt 2: 281-299.
-
Biochem J 1999; 343 Pt
, vol.2
, pp. 281-299
-
-
Halestrap, A.P.1
Price, N.T.2
-
11
-
-
80053640489
-
+ symporters MCT1 and hypoxia-inducible MCT4 is critical for en ergetics and growth of glycolytic tumors
-
+ symporters MCT1 and hypoxia-inducible MCT4 is critical for en ergetics and growth of glycolytic tumors. Proc Natl Acad Sci USA 2011; 108: 16663-16668.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 16663-16668
-
-
Le Floch, R.1
Chiche, J.2
Marchiq, I.3
-
13
-
-
0029751950
-
A reaction-diffusion model of cancer invasion
-
Gatenby RA, Gawlinski ET. A reaction-diffusion model of cancer invasion. Cancer Res 1996; 56: 5745-5753.
-
(1996)
Cancer Res
, vol.56
, pp. 5745-5753
-
-
Gatenby, R.A.1
Gawlinski, E.T.2
-
14
-
-
0032080644
-
Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells
-
Lee AH, Tannock IF. Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells. Cancer Res 1998; 58: 1901-1908.
-
(1998)
Cancer Res
, vol.58
, pp. 1901-1908
-
-
Lee, A.H.1
Tannock, I.F.2
-
15
-
-
1242272754
-
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
-
Orlowski J, Grinstein S. Diversity of the mammalian sodium/proton exchanger SLC9 gene family. Pflugers Arch 2004; 447: 549-565.
-
(2004)
Pflugers Arch
, vol.447
, pp. 549-565
-
-
Orlowski, J.1
Grinstein, S.2
-
17
-
-
33646830005
-
Ion motive ATPases. I. Ubiquity, properties and significance to cell function
-
Pedersen PL, Carafoli E. Ion motive ATPases. I. Ubiquity, properties and significance to cell function. Trends Biochem Sci 1987; 12: 146-150.
-
(1987)
Trends Biochem Sci
, vol.12
, pp. 146-150
-
-
Pedersen, P.L.1
Carafoli, E.2
-
18
-
-
67749145635
-
The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths
-
Swietach P, Patiar S, Supuran CT, Harris AL, Vaughan-Jones RD. The Role of Carbonic Anhydrase 9 in Regulating Extracellular and Intracellular pH in Three-dimensional Tumor Cell Growths. J Biol Chem 2009; 284: 20299-20310.
-
(2009)
J Biol Chem
, vol.284
, pp. 20299-20310
-
-
Swietach, P.1
Patiar, S.2
Supuran, C.T.3
Harris, A.L.4
Vaughan-Jones, R.D.5
-
19
-
-
50649105780
-
Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellu-lar growths
-
Swietach P, Wigfield S, Cobden P, Supuran CT, Harris AL, Vaughan-Jones RD. Tumor-associated carbonic anhydrase 9 spatially coordinates intracellular pH in three-dimensional multicellu-lar growths. J Biol Chem 2008; 283: 20473-20483.
-
(2008)
J Biol Chem
, vol.283
, pp. 20473-20483
-
-
Swietach, P.1
Wigfield, S.2
Cobden, P.3
Supuran, C.T.4
Harris, A.L.5
Vaughan-Jones, R.D.6
-
20
-
-
79954600753
-
3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths
-
Hulikova A, Vaughan-Jones RD, Swietach P. Dual role of CO2/HCO3(-) buffer in the regulation of intracellular pH of three-dimensional tumor growths. J Biol Chem 2011; 286: 13815-13826.
-
(2011)
J Biol Chem
, vol.286
, pp. 13815-13826
-
-
Hulikova, A.1
Vaughan-Jones, R.D.2
Swietach, P.3
-
22
-
-
0027373117
-
Vacuo-lar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells
-
Martinez-Zaguilan R, Lynch RM, Martinez GM, Gillies RJ. Vacuo-lar-type H(+)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol 1993; 265: C1015-C1029.
-
(1993)
Am J Physiol
, vol.265
-
-
Martinez-Zaguilan, R.1
Lynch, R.M.2
Martinez, G.M.3
Gillies, R.J.4
-
23
-
-
0022550159
-
Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle
-
Vanheel B, de Hemptinne A, Leusen I. Influence of surface pH on intracellular pH regulation in cardiac and skeletal muscle. Am J Physiol 1986; 250: C748-C760.
-
(1986)
Am J Physiol
, vol.250
-
-
Vanheel, B.1
de Hemptinne, A.2
Leusen, I.3
-
24
-
-
0025319198
-
Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle
-
Irving M, Maylie J, Sizto NL, Chandler WK. Intracellular diffusion in the presence of mobile buffers. Application to proton movement in muscle. Biophys J 1990; 57: 717-721.
-
(1990)
Biophys J
, vol.57
, pp. 717-721
-
-
Irving, M.1
Maylie, J.2
Sizto, N.L.3
Chandler, W.K.4
-
25
-
-
0023119889
-
The role of fixed and mobile buffers in the kinetics of proton movement
-
Junge W, McLaughlin S. The role of fixed and mobile buffers in the kinetics of proton movement. Biochim Biophys Acta 1987; 890: 1-5.
-
(1987)
Biochim Biophys Acta
, vol.890
, pp. 1-5
-
-
Junge, W.1
McLaughlin, S.2
-
26
-
-
0028111173
-
Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment
-
Pastorek J, Pastorekova S, Callebaut I, et al. Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix- loop-helix DNA binding segment. Oncogene 1994; 9: 2877-2888.
-
(1994)
Oncogene
, vol.9
, pp. 2877-2888
-
-
Pastorek, J.1
Pastorekova, S.2
Callebaut, I.3
-
27
-
-
0041062296
-
Human carbonic anhydrase XII: CDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers
-
Tureci O, Sahin U, Vollmar E, et al. Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers. Proc Natl Acad Sci USA 1998; 95: 7608-13.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7608-7613
-
-
Tureci, O.1
Sahin, U.2
Vollmar, E.3
-
29
-
-
0034671307
-
Hypoxia-inducible expression of tumor-associated carbonic anhydrases
-
Wykoff CC, Beasley NJ, Watson PH, et al. Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000; 60: 7075-7083.
-
(2000)
Cancer Res
, vol.60
, pp. 7075-7083
-
-
Wykoff, C.C.1
Beasley, N.J.2
Watson, P.H.3
-
30
-
-
78650308850
-
New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
-
Swietach P, Hulikova A, Vaughan-Jones RD, Harris AL. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene 2010; 29: 6509-21.
-
(2010)
Oncogene
, vol.29
, pp. 6509-6521
-
-
Swietach, P.1
Hulikova, A.2
Vaughan-Jones, R.D.3
Harris, A.L.4
-
31
-
-
0017760271
-
The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones
-
Thomas RC. The role of bicarbonate, chloride and sodium ions in the regulation of intracellular pH in snail neurones. J Physiol 1977; 273: 317-338.
-
(1977)
J Physiol
, vol.273
, pp. 317-338
-
-
Thomas, R.C.1
-
32
-
-
33644816650
-
Molecular physiology of SLC4 anion exchangers
-
Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol 2006; 91: 153-161.
-
(2006)
Exp Physiol
, vol.91
, pp. 153-161
-
-
Alper, S.L.1
-
34
-
-
74549168941
-
Evaluating the role of carbonic anhydrases in the transport of HCO3--related species
-
Boron WF. Evaluating the role of carbonic anhydrases in the transport of HCO3--related species. Biochim Biophys Acta 2010; 1804: 410-421.
-
(2010)
Biochim Biophys Acta
, vol.1804
, pp. 410-421
-
-
Boron, W.F.1
-
35
-
-
0020624853
-
Stoichiometry and ion dependencies of the intracellular-pH-regulating mechanism in squid giant axons
-
Boron WF, Russell JM. Stoichiometry and ion dependencies of the intracellular-pH-regulating mechanism in squid giant axons. J Gen Physiol 1983; 81: 373-99.
-
(1983)
J Gen Physiol
, vol.81
, pp. 373-399
-
-
Boron, W.F.1
Russell, J.M.2
-
36
-
-
0000633287
-
The theorem of neutrality regulation in the animal organism
-
Henderson LJ. The theorem of neutrality regulation in the animal organism. Am J Physiol 1908; 21: 427-448.
-
(1908)
Am J Physiol
, vol.21
, pp. 427-448
-
-
Henderson, L.J.1
-
37
-
-
0024500243
-
i response
-
Thomas RC. Cell growth factors. Bicarbonate and pHi response. Nature 1989; 337: 601.
-
(1989)
Nature
, vol.337
, pp. 601
-
-
Thomas, R.C.1
-
38
-
-
0037100861
-
Cytostatic potential of novel agents that inhibit the regulation of intracellular pH
-
Wong P, Kleemann HW, Tannock IF. Cytostatic potential of novel agents that inhibit the regulation of intracellular pH. Br J Cancer 2002; 87: 238-245.
-
(2002)
Br J Cancer
, vol.87
, pp. 238-245
-
-
Wong, P.1
Kleemann, H.W.2
Tannock, I.F.3
-
39
-
-
77955057718
-
i regulation and chemotherapy resistance
-
Lauritzen G, Jensen MB, Boedtkjer E, et al. NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance. Exp Cell Res 2010; 316: 2538-2553.
-
(2010)
Exp Cell Res
, vol.316
, pp. 2538-2553
-
-
Lauritzen, G.1
Jensen, M.B.2
Boedtkjer, E.3
-
40
-
-
0035930581
-
A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers
-
Sterling D, Reithmeier RA, Casey JR. A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. J Biol Chem 2001; 276: 47886-47894.
-
(2001)
J Biol Chem
, vol.276
, pp. 47886-47894
-
-
Sterling, D.1
Reithmeier, R.A.2
Casey, J.R.3
-
41
-
-
0033746761
-
+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
-
+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. Faseb J 2000; 14: 2185-2197.
-
(2000)
Faseb J
, vol.14
, pp. 2185-2197
-
-
Reshkin, S.J.1
Bellizzi, A.2
Caldeira, S.3
-
42
-
-
0025047493
-
Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions
-
Gillies RJ, Martinez-Zaguilan R, Martinez GM, Serrano R, Perona R. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiological conditions. Proc Natl Acad Sci USA 1990; 87: 7414-7418.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 7414-7418
-
-
Gillies, R.J.1
Martinez-Zaguilan, R.2
Martinez, G.M.3
Serrano, R.4
Perona, R.5
-
43
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-732.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
44
-
-
0030614893
-
2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
-
Helmlinger G, Yuan F, Dellian M, Jain RK. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat Med 1997; 3: 177-182.
-
(1997)
Nat Med
, vol.3
, pp. 177-182
-
-
Helmlinger, G.1
Yuan, F.2
Dellian, M.3
Jain, R.K.4
-
45
-
-
42549134089
-
Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte
-
Niederer SA, Swietach P, Wilson DA, Smith NP, Vaughan-Jones RD. Measuring and modeling chloride-hydroxyl exchange in the Guinea-pig ventricular myocyte. Biophys J 2008; 94: 2385-2403.
-
(2008)
Biophys J
, vol.94
, pp. 2385-2403
-
-
Niederer, S.A.1
Swietach, P.2
Wilson, D.A.3
Smith, N.P.4
Vaughan-Jones, R.D.5
-
46
-
-
0030583209
-
Symmetry and pH dependency of the lactate/proton carrier in skeletal muscle studied with rat sarcolemmal giant vesicles
-
Juel C. Symmetry and pH dependency of the lactate/proton carrier in skeletal muscle studied with rat sarcolemmal giant vesicles. Bio-chim Biophys Acta 1996; 1283: 106-110.
-
(1996)
Bio-chim Biophys Acta
, vol.1283
, pp. 106-110
-
-
Juel, C.1
-
47
-
-
8844249356
-
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
-
Svastova E, Hulikova A, Rafajova M, et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004; 577: 439-445.
-
(2004)
FEBS Lett
, vol.577
, pp. 439-445
-
-
Svastova, E.1
Hulikova, A.2
Rafajova, M.3
-
48
-
-
33644849887
-
Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial
-
Koukourakis MI, Bentzen SM, Giatromanolaki A, et al. Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J Clin Oncol 2006; 24: 727-735.
-
(2006)
J Clin Oncol
, vol.24
, pp. 727-735
-
-
Koukourakis, M.I.1
Bentzen, S.M.2
Giatromanolaki, A.3
-
49
-
-
79960359073
-
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation
-
Dubois L, Peeters S, Lieuwes NG, et al. Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiother Oncol 2011; 99: 424-431.
-
(2011)
Radiother Oncol
, vol.99
, pp. 424-431
-
-
Dubois, L.1
Peeters, S.2
Lieuwes, N.G.3
-
50
-
-
58249094845
-
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
-
Chiche J, Ilc K, Laferriere J, et al. Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH. Cancer Res 2009; 69: 358-368.
-
(2009)
Cancer Res
, vol.69
, pp. 358-368
-
-
Chiche, J.1
Ilc, K.2
Laferriere, J.3
-
51
-
-
78649813619
-
Carbonic anhydrase IX as an anticancer therapy target: Preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain
-
Zatovicova M, Jelenska L, Hulikova A, et al. Carbonic anhydrase IX as an anticancer therapy target: preclinical evaluation of internalizing monoclonal antibody directed to catalytic domain. Curr Pharm Des 2010; 16: 3255-3263.
-
(2010)
Curr Pharm Des
, vol.16
, pp. 3255-3263
-
-
Zatovicova, M.1
Jelenska, L.2
Hulikova, A.3
-
52
-
-
38849143765
-
Carbonic anhydrases: Novel therapeutic applications for inhibitors and activators
-
Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nature Rev (Drug Discoveries) 2008; 7: 1-14.
-
(2008)
Nature Rev (Drug Discoveries)
, vol.7
, pp. 1-14
-
-
Supuran, C.T.1
-
53
-
-
65549166946
-
Bicarbonate increases tumor pH and inhibits spontaneous metastases
-
Robey IF, Baggett BK, Kirkpatrick ND, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res 2009; 69: 2260-2268.
-
(2009)
Cancer Res
, vol.69
, pp. 2260-2268
-
-
Robey, I.F.1
Baggett, B.K.2
Kirkpatrick, N.D.3
|