Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Checker, Rahul ^a   Sandur, Santosh K ^a   Sharma, Deepak ^a   Patwardhan, Raghavendra S ^a   Jayakumar, S ^a   Kohli, Vineet ^a   Sethi, Gautam ^b   Aggarwal, Bharat B ^c   Sainis, Krishna B ^a  

^a BHABHA ATOMIC RESEARCH CENTRE   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT; URSOLIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; CD28 ANTIGEN; CD3 ANTIGEN; CONCANAVALIN A; MONOCLONAL ANTIBODY; REACTIVE OXYGEN METABOLITE; TRITERPENE;

ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE MODEL; DRUG EFFICACY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENE EXPRESSION REGULATION; GRAFT VERSUS HOST REACTION; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; UPREGULATION; ANIMAL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; OXIDATION REDUCTION REACTION; PATHOLOGY; SECRETION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; ANTIOXIDANTS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CONCANAVALIN A; CYTOKINES; GRAFT VS HOST DISEASE; LYMPHOCYTE ACTIVATION; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MITOGENS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR AP-1; TRITERPENES; UP-REGULATION;

EID: 84857425215     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031318     Document Type: Article

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