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Volumn 9, Issue 7-8, 2009, Pages 949-958

Anti-inflammatory effects of plumbagin are mediated by inhibition of NF-kappaB activation in lymphocytes

Author keywords

Anti inflammatory; Cell cycle; Cytokines; Proliferation; T cell

Indexed keywords

CD69 ANTIGEN; CONCANAVALIN A; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 4; INTERLEUKIN 6; MITOGENIC AGENT; PLUMBAGIN;

EID: 67349083623     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.03.022     Document Type: Article
Times cited : (135)

References (34)
  • 1
    • 11144231798 scopus 로고    scopus 로고
    • Novel immunosuppressants
    • Krieger N.R., and Emre S. Novel immunosuppressants. Pediatr Transplant 8 6 (2004) 594-599
    • (2004) Pediatr Transplant , vol.8 , Issue.6 , pp. 594-599
    • Krieger, N.R.1    Emre, S.2
  • 2
    • 33747866082 scopus 로고    scopus 로고
    • Antiapoptotic and immunomodulatory effects of chlorophyllin
    • Sharma D., Kumar S.S., and Sainis K.B. Antiapoptotic and immunomodulatory effects of chlorophyllin. Mol Immunol 44 4 (2007) 347-359
    • (2007) Mol Immunol , vol.44 , Issue.4 , pp. 347-359
    • Sharma, D.1    Kumar, S.S.2    Sainis, K.B.3
  • 3
    • 21344434138 scopus 로고    scopus 로고
    • Secondary metabolites in in vitro cultured plants of the genus Drosera
    • Marczak L., Kawiak A., Lojkowska E., and Stobiecki M. Secondary metabolites in in vitro cultured plants of the genus Drosera. Phytochem Anal 16 3 (2005) 143-149
    • (2005) Phytochem Anal , vol.16 , Issue.3 , pp. 143-149
    • Marczak, L.1    Kawiak, A.2    Lojkowska, E.3    Stobiecki, M.4
  • 4
    • 0037319816 scopus 로고    scopus 로고
    • Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica
    • Lin L.C., Yang L.L., and Chou C.J. Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica. Phytochemistry 62 4 (2003) 619-622
    • (2003) Phytochemistry , vol.62 , Issue.4 , pp. 619-622
    • Lin, L.C.1    Yang, L.L.2    Chou, C.J.3
  • 5
    • 37049005766 scopus 로고    scopus 로고
    • Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
    • Wang C.C., Chiang Y.M., Sung S.C., Hsu Y.L., Chang J.K., and Kuo P.L. Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Lett 259 1 (2008) 82-98
    • (2008) Cancer Lett , vol.259 , Issue.1 , pp. 82-98
    • Wang, C.C.1    Chiang, Y.M.2    Sung, S.C.3    Hsu, Y.L.4    Chang, J.K.5    Kuo, P.L.6
  • 6
    • 41549142664 scopus 로고    scopus 로고
    • Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents
    • Thasni K.A., Rakesh S., Rojini G., Ratheeshkumar T., Srinivas G., and Priya S. Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. Ann Oncol 19 4 (2008) 696-705
    • (2008) Ann Oncol , vol.19 , Issue.4 , pp. 696-705
    • Thasni, K.A.1    Rakesh, S.2    Rojini, G.3    Ratheeshkumar, T.4    Srinivas, G.5    Priya, S.6
  • 7
    • 0031666507 scopus 로고    scopus 로고
    • Effect of plumbagin on the radiation induced cytogenetic and cell cycle changes in mouse Ehrlich ascites carcinoma in vivo
    • Devi P.U., Rao B.S., and Solomon F.E. Effect of plumbagin on the radiation induced cytogenetic and cell cycle changes in mouse Ehrlich ascites carcinoma in vivo. Indian J Exp Biol 36 9 (1998) 891-895
    • (1998) Indian J Exp Biol , vol.36 , Issue.9 , pp. 891-895
    • Devi, P.U.1    Rao, B.S.2    Solomon, F.E.3
  • 8
    • 0028811390 scopus 로고
    • Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage functions in BALB/c mice. I. Potentiation of macrophage bactericidal activity
    • Abdul K.M., and Ramchender R.P. Modulatory effect of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) on macrophage functions in BALB/c mice. I. Potentiation of macrophage bactericidal activity. Immunopharmacology 30 3 (1995) 231-236
    • (1995) Immunopharmacology , vol.30 , Issue.3 , pp. 231-236
    • Abdul, K.M.1    Ramchender, R.P.2
  • 9
    • 29844432739 scopus 로고    scopus 로고
    • Plant-based formulation in the management of chronic obstructive pulmonary disease: a randomized double-blind study
    • Murali P.M., Rajasekaran S., Paramesh P., Krishnarajasekar O.R., Vasudevan S., Nalini K., et al. Plant-based formulation in the management of chronic obstructive pulmonary disease: a randomized double-blind study. Respir Med 100 1 (2006) 39-45
    • (2006) Respir Med , vol.100 , Issue.1 , pp. 39-45
    • Murali, P.M.1    Rajasekaran, S.2    Paramesh, P.3    Krishnarajasekar, O.R.4    Vasudevan, S.5    Nalini, K.6
  • 10
    • 0036689830 scopus 로고    scopus 로고
    • NF-kappaB activation and inhibition: a review
    • Sun Z., and Andersson R. NF-kappaB activation and inhibition: a review. Shock 18 2 (2002) 99-106
    • (2002) Shock , vol.18 , Issue.2 , pp. 99-106
    • Sun, Z.1    Andersson, R.2
  • 11
    • 33745220306 scopus 로고    scopus 로고
    • Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents
    • Sandur S.K., Ichikawa H., Sethi G., Ahn K.S., and Aggarwal B.B. Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents. J Biol Chem 281 25 (2006) 17023-17033
    • (2006) J Biol Chem , vol.281 , Issue.25 , pp. 17023-17033
    • Sandur, S.K.1    Ichikawa, H.2    Sethi, G.3    Ahn, K.S.4    Aggarwal, B.B.5
  • 12
    • 30444458109 scopus 로고    scopus 로고
    • NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145
    • Vodanovic-Jankovic S., Hari P., Jacobs P., Komorowski R., and Drobyski W.R. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood 107 2 (2006) 827-834
    • (2006) Blood , vol.107 , Issue.2 , pp. 827-834
    • Vodanovic-Jankovic, S.1    Hari, P.2    Jacobs, P.3    Komorowski, R.4    Drobyski, W.R.5
  • 13
    • 2542599273 scopus 로고    scopus 로고
    • Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib
    • Sun K., Welniak L.A., Panoskaltsis-Mortari A., O'Shaughnessy M.J., Liu H., Barao I., et al. Inhibition of acute graft-versus-host disease with retention of graft-versus-tumor effects by the proteasome inhibitor bortezomib. Proc Natl Acad Sci U S A 101 21 (2004) 8120-8125
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.21 , pp. 8120-8125
    • Sun, K.1    Welniak, L.A.2    Panoskaltsis-Mortari, A.3    O'Shaughnessy, M.J.4    Liu, H.5    Barao, I.6
  • 14
    • 0034663755 scopus 로고    scopus 로고
    • Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction
    • Smiley S.T., Csizmadia V., Gao W., Turka L.A., and Hancock W.W. Differential effects of cyclosporine A, methylprednisolone, mycophenolate, and rapamycin on CD154 induction and requirement for NFkappaB: implications for tolerance induction. Transplantation 70 3 (2000) 415-419
    • (2000) Transplantation , vol.70 , Issue.3 , pp. 415-419
    • Smiley, S.T.1    Csizmadia, V.2    Gao, W.3    Turka, L.A.4    Hancock, W.W.5
  • 15
    • 0035889230 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB-dependent T cell activation abrogates acute allograft rejection
    • Finn P.W., Stone J.R., Boothby M.R., and Perkins D.L. Inhibition of NF-kappaB-dependent T cell activation abrogates acute allograft rejection. J Immunol 167 10 (2001) 5994-6001
    • (2001) J Immunol , vol.167 , Issue.10 , pp. 5994-6001
    • Finn, P.W.1    Stone, J.R.2    Boothby, M.R.3    Perkins, D.L.4
  • 16
    • 33947260093 scopus 로고    scopus 로고
    • Differential modulation of mitogen driven proliferation and homeostasis driven proliferation of T cells by rapamycin, Ly294002 and chlorophyllin
    • Sharma D., Kumar S.S., Raghu R., Khanam S., and Sainis K.B. Differential modulation of mitogen driven proliferation and homeostasis driven proliferation of T cells by rapamycin, Ly294002 and chlorophyllin. Mol Immunol 44 11 (2007) 2831-2840
    • (2007) Mol Immunol , vol.44 , Issue.11 , pp. 2831-2840
    • Sharma, D.1    Kumar, S.S.2    Raghu, R.3    Khanam, S.4    Sainis, K.B.5
  • 17
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    • Campbell K.J., Rocha S., and Perkins N.D. Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol Cell 13 6 (2004) 853-865
    • (2004) Mol Cell , vol.13 , Issue.6 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 18
    • 0033023431 scopus 로고    scopus 로고
    • c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
    • Liou H.C., Jin Z., Tumang J., Andjelic S., Smith K.A., and Liou M.L. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol 11 3 (1999) 361-371
    • (1999) Int Immunol , vol.11 , Issue.3 , pp. 361-371
    • Liou, H.C.1    Jin, Z.2    Tumang, J.3    Andjelic, S.4    Smith, K.A.5    Liou, M.L.6
  • 19
    • 0032212138 scopus 로고    scopus 로고
    • The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc
    • Lord J.D., McIntosh B.C., Greenberg P.D., and Nelson B.H. The IL-2 receptor promotes proliferation, bcl-2 and bcl-x induction, but not cell viability through the adapter molecule Shc. J Immunol 161 9 (1998) 4627-4633
    • (1998) J Immunol , vol.161 , Issue.9 , pp. 4627-4633
    • Lord, J.D.1    McIntosh, B.C.2    Greenberg, P.D.3    Nelson, B.H.4
  • 20
    • 0035827347 scopus 로고    scopus 로고
    • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
    • Mullen A.C., High F.A., Hutchins A.S., Lee H.W., Villarino A.V., Livingston D.M., et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292 5523 (2001) 1907-1910
    • (2001) Science , vol.292 , Issue.5523 , pp. 1907-1910
    • Mullen, A.C.1    High, F.A.2    Hutchins, A.S.3    Lee, H.W.4    Villarino, A.V.5    Livingston, D.M.6
  • 21
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-gamma: an overview of signals, mechanisms and functions
    • Schroder K., Hertzog P.J., Ravasi T., and Hume D.A. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75 2 (2004) 163-189
    • (2004) J Leukoc Biol , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 22
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 4 (1997) 587-596
    • (1997) Cell , vol.89 , Issue.4 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 23
    • 0142197612 scopus 로고    scopus 로고
    • Regulation of IL4 gene expression by T cells and therapeutic perspectives
    • Li-Weber M., and Krammer P.H. Regulation of IL4 gene expression by T cells and therapeutic perspectives. Nat Rev Immunol 3 7 (2003) 534-543
    • (2003) Nat Rev Immunol , vol.3 , Issue.7 , pp. 534-543
    • Li-Weber, M.1    Krammer, P.H.2
  • 24
    • 39549085138 scopus 로고    scopus 로고
    • The central role of the Th17 lineage in regulating the inflammatory/autoimmune axis
    • Weaver C.T., and Murphy K.M. The central role of the Th17 lineage in regulating the inflammatory/autoimmune axis. Semin Immunol 19 6 (2007) 351-352
    • (2007) Semin Immunol , vol.19 , Issue.6 , pp. 351-352
    • Weaver, C.T.1    Murphy, K.M.2
  • 25
    • 3342892420 scopus 로고    scopus 로고
    • Inhibition of IL-6 for the treatment of inflammatory diseases
    • Nishimoto N., and Kishimoto T. Inhibition of IL-6 for the treatment of inflammatory diseases. Curr Opin Pharmacol 4 4 (2004) 386-391
    • (2004) Curr Opin Pharmacol , vol.4 , Issue.4 , pp. 386-391
    • Nishimoto, N.1    Kishimoto, T.2
  • 26
    • 49049094291 scopus 로고    scopus 로고
    • Dynamic protein complexes regulate NF-kappaB signaling
    • Wegener E., and Krappmann D. Dynamic protein complexes regulate NF-kappaB signaling. Handb Exp Pharmacol 186 (2008) 237-259
    • (2008) Handb Exp Pharmacol , vol.186 , pp. 237-259
    • Wegener, E.1    Krappmann, D.2
  • 27
    • 33846528701 scopus 로고    scopus 로고
    • Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10
    • Lobry C., Lopez T., Israel A., and Weil R. Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10. Proc Natl Acad Sci U S A 104 3 (2007) 908-913
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.3 , pp. 908-913
    • Lobry, C.1    Lopez, T.2    Israel, A.3    Weil, R.4
  • 28
    • 33846228444 scopus 로고    scopus 로고
    • Antigen-receptor signaling to nuclear factor kappa B
    • Schulze-Luehrmann J., and Ghosh S. Antigen-receptor signaling to nuclear factor kappa B. Immunity 25 5 (2006) 701-715
    • (2006) Immunity , vol.25 , Issue.5 , pp. 701-715
    • Schulze-Luehrmann, J.1    Ghosh, S.2
  • 29
    • 0345826149 scopus 로고    scopus 로고
    • Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO
    • Zhou H., Wertz I., O'Rourke K., Ultsch M., Seshagiri S., Eby M., et al. Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO. Nature 427 6970 (2004) 167-171
    • (2004) Nature , vol.427 , Issue.6970 , pp. 167-171
    • Zhou, H.1    Wertz, I.2    O'Rourke, K.3    Ultsch, M.4    Seshagiri, S.5    Eby, M.6
  • 30
    • 34247205985 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways
    • Shambharkar P.B., Blonska M., Pappu B.P., Li H., You Y., Sakurai H., et al. Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. Embo J 26 7 (2007) 1794-1805
    • (2007) Embo J , vol.26 , Issue.7 , pp. 1794-1805
    • Shambharkar, P.B.1    Blonska, M.2    Pappu, B.P.3    Li, H.4    You, Y.5    Sakurai, H.6
  • 31
    • 34648837499 scopus 로고    scopus 로고
    • The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?
    • Paule B., Terry S., Kheuang L., Soyeux P., Vacherot F., and de la Taille A. The NF-kappaB/IL-6 pathway in metastatic androgen-independent prostate cancer: new therapeutic approaches?. World J Urol 25 5 (2007) 477-489
    • (2007) World J Urol , vol.25 , Issue.5 , pp. 477-489
    • Paule, B.1    Terry, S.2    Kheuang, L.3    Soyeux, P.4    Vacherot, F.5    de la Taille, A.6
  • 32
    • 0030613857 scopus 로고    scopus 로고
    • Interaction of NF-kappaB and NFAT with the interferon-gamma promoter
    • Sica A., Dorman L., Viggiano V., Cippitelli M., Ghosh P., Rice N., et al. Interaction of NF-kappaB and NFAT with the interferon-gamma promoter. J Biol Chem 272 48 (1997) 30412-30420
    • (1997) J Biol Chem , vol.272 , Issue.48 , pp. 30412-30420
    • Sica, A.1    Dorman, L.2    Viggiano, V.3    Cippitelli, M.4    Ghosh, P.5    Rice, N.6
  • 33
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    • Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16 (1998) 225-260
    • (1998) Annu Rev Immunol , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 34
    • 0032483991 scopus 로고    scopus 로고
    • Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28
    • Li-Weber M., Giasi M., and Krammer P.H. Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28. J Biol Chem 273 49 (1998) 32460-32466
    • (1998) J Biol Chem , vol.273 , Issue.49 , pp. 32460-32466
    • Li-Weber, M.1    Giasi, M.2    Krammer, P.H.3


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