Induction of Activator Protein (AP)-1 and Nuclear Factor-κB by CD28 Stimulation Involves Both Phosphatidylinositol 3-Kinase and Acidic Sphingomyelinase Signals

Journal of Immunology

Volumn 157, Issue 8, 1996, Pages 3290-3297

  Edmead, Christine E ^a   Patel, Yusuf I ^a   Wilson, Anne ^a   Boulougouris, George ^a   Hall, Nicolas D ^a   Ward, Steven G ^a   Sansom, David M ^a  

^a University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; DNA BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; SPHINGOMYELIN PHOSPHODIESTERASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NFAT;

ANIMAL; ARTICLE; BIOSYNTHESIS; CHO CELL; CYTOLOGY; ENZYME ACTIVATION; GENETIC TRANSFECTION; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; IN VITRO STUDY; LYMPHOCYTE ACTIVATION; METABOLISM; PROMOTER REGION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD28; ANTIGENS, CD80; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 0030587924     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Linsley, P. S., W. Bradey, L. Grosmaire, A. Aruffo, N. K. Damle, and J. A. Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 173:721.
2. Jenkins, M. K., P. S. Taylor, S. D. Norton, and K. B. Urdahl. 1991. CD28 delivers a costimulatory signal involved in antigen specific IL-2 production by human T cells. J. Immunol. 147:2461.
3. 3 in T cells. Eur. J. Immunol. 23:2572.
4. Prasad. K. V. S., Y. Cai, M. Raab, B. Duckworth, L. Cantley, S. E. Shoelson, and C. E. Rudd. 1994. T cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(p)-Met-Xaa-Met motif. Proc. Natl. Acad. Sci. USA 91:2834.
5. Ward, S. G., A. Wilson, L. Turner, J. Westwick, and D. M. Sansom. 1995. Inhibition of CD28-mediated T cell costimulation by the phosphoinositide 3-kinase inhibitor wortmannin. Eur. J. Immunol. 25:526.
6. Boucher, L.-M., K. Wiegmann, A. Futterer, K. Pfeffer, T. Machleidt, S. Schutze, T. Mak, and M. Kronke. 1995. CD28 Signals through acidic sphingomyelinase. J. Exp. Med. 181:2059.
7. Wiegmann, K., S. Schutze, T. Machleidt, D. Witte, and M. Kronke. 1994. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78:1005.
8. Kolesnick, R., and D. W. Golde. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling. Cell 77:325.
9. Dressler, K. A., S. Mathias, and R. Kolesnick. 1992. Tumor necrosis factor-α activates the sphingomyelin signal transduction pathway in a cell free system. Science 255:1715.
10. Cifone, M. G., R. De Maria, P. Roncaioli, M. R. Rippo, M. Azuma, L. Lanier, A. Santoni, and R. Testi. 1993. Apoptotic signaling through CD95 (Fas/Apo-1) activates acidic sphingomyelinase. J. Exp. Med. 177:1547.
11. Kolesnick, R. 1991. Sphingomyelin and derivatives as cellular signals. Prog. Lipid Res. 30:1.
12. Yao, B., Y. Zhang, S. Delikat, S. Mathias, S. Basu, and R. Kolesnick. 1995. Phosphorylation of Raf by ceramide activated protein kinase. Nature 378:307.
13. Westwick, J. K., A. E. Bielawska, G. Dbaibo, Y. A. Hannun, and D. A. Brenner. 1995. Ceramide activates the stress-activated protein kinases. J. Biol. Chem. 270: 22689.
14. Muller, G., M. Ayaub, P. Storz, J. Rennecke, D. Fabbro, and K. Ptizenmaier. 1995. PKCζ is a molecular switch in signal transduction of TNFα bifunctionally regulated by ceramide and arachadonic acid. EMBO J. 14:1961.
15. Lozano, J., E. Berra, M. M. Municio, M. T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat. 1994. Protein kinase C isoform is critical for κB-dependent promoter activation by sphingomyelinase. J. Biol. Chem. 269:19200.
16. Thompson, C., T. Lindsten, J. Ledbetter, S. Kunkel, H. Young. S. Emerson, J. Leiden, and C. June. 1993. CD28 activation pathway regulates the production of multiple T cell-derived lymphokines/cytokines. Proc. Natl. Acad. Sci. USA 86:1333.
17. Lindsten, T., C. H. June, J. A. Ledbetter, G. Stella, and C. B. Thomson. 1989. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244:339.
18. Fraser, J. D., B. A. Irving, G. R. Crabtree, and A. Weiss. 1991. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251:313.
19. Sansom, D. M., A. Wilson, M. Boshell, J. Lewis, and N. D. Hall. 1993. B7/CD28 but not LFA-3 CD2 interactions can provide third party costimulation for human T cell activation. Immunology 80:242.
20. Tan, P., C. Anasetti, J. Hansen, J. Melrose, M. Brunvand, J. Bradshaw, J. Ledbetter, and P. Linsley. 1993. Induction of alloantigen specific hyporesponsiveness in human T lymphocytes by blocking interaction of CD28 with its natural ligand B7/BB1. J. Exp. Med. 177:165.
21. Ueda, Y., B. L. Levine, M. L. Huang, G. J. Freeman, L. M. Nadler, C. H. June, and S. G. Ward. 1995. Both CD28 ligands CD80 (B7-1) and CD86(B7-2) activate phosphatidylinositol 3-kinase and wortmannin reveals heterogeneity in the regulation of T cell IL-2 secretion. Int. Immunol. 7:957.
22. Schwartz, R. H. 1990. A cell culture model for T lymphocyte clonal anergy. Science 248:1349.
23. Hurding, F., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling co-stimulates murine T cells and prevents the induction of anergy in T cell clones. Nature 356:607.
24. + T cells from human immunodeficiency virus-infected individuals. J. Exp. Med. 175:331.
25. Durand, D. B., J. P. Shaw, M. R. Bush, R. E. Replogle, R. Belagaje, and G. R. Crabtree. 1988. Characterization of antigen receptor response elements within the IL-2 enhancer. Mol. Cell. Biol. 8:1715.
26. Shaw, J. P., P. J. Ulz, D. B. Durand. J. J. Toole, E. A. Emmel, and G. R. Crabtree. 1988. Identification of a putative regulator of early T cell activation genes. Science 241:202.
27. Damle, N., K. Klussman, G. Leytze, and P. Linsley. 1993. Proliferation of human T lymphocytes induced with superantigens is not dependent on costimulation by the CD28 counter-receptor B7. J. Immunol. 150:726.
28. Su, B., E. Jacinto, M. Hibi, T. Kallunki, M. Karin, and Y. Ben-Neriuh. 1994. JNK is involved in signal integration during coslimulation of T lymphocytes. Cell 77:727.
29. Bryan, R. G., Y. Li, J. H. Lai, M. Van, N. R. Rice, R. R. Rich, and T. H. Tan. 1994. Effect of CD28 signal transduction on c-rel in human peripheral blood T cells. Mol. Cell. Biol. 14:7933.
30. Ghosh, P., T. Tan, N. R. Rice, A. Sica, and H. A. Young. 1993. The interleukin 2 CD28-responsive complex contains at least three members of the NF-κB family: c-rel, p50, and p-65. Proc. Natl. Acad. Sci. USA 90:1696.
31. Lai, J. H., G. Horvath, J. Subleski, J. Bruder, P. Ghosh, and T. H. Tan. 1995. Rel A is a potent transcriptional activator of the CD28 response element within the IL-2 promoter. Mol. Cell. Biol. 15:4260.
32. Lai, J., and T. Tan. 1994. CD28 signalling causes a sustained down-regulation of IκBα which can be prevented by the immunosupressant rapamycin. J. Biol. Chem. 269:30077.
33. Pages, F., M. Ragueneau, R. Rottapel, A. Truneh, J. Nunes, J. Imbert, and D. Olive. 1994. Binding of phosphatidylinositol-3-OH kinuse to CD28 is required for T cell signalling. Nature 369:327.
34. Crooks, M. E. C., D. R. Littman, R. H. Carter, D. T. Fearon, A. Weiss, and P. H. Stein. 1995. CD28-mediated costimulation in the absence of phosphatidylinositol-3-kinase association and activation. Mol. Cell. Biol. 15:6820.
35. Hawkins, P. T., A. Eguinoa, R. Qiu, D. Stokoe, F. T. Cooke, R. Walters, S. Wennstrom, L. Claesson-Welsh, T. Evans, M. Symons, and L. Stephens. 1995. PDGF stimulates an increase in GTP rac via activation of phosphoinositide 3-kinase. Curr. Biol. 5:393.
36. Coso, O. A., M. Chiariello, J. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137.
37. Sluss, H. K., T. Barrett, B. Derijard, and R. J. Davis. 1994. Signal transduction by tumor necrosis factor mediated by JNK. Mol. Cell. Biol. 14:8376.
38. Burgering, B. M. T., and P. J. Coffer. 1995. Protein kinase B (c-akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599.
39. S6K activation mediated by phosphatidylinositol-3-OH kinase. Nature 370:71.
40. Yao, R., and G. M. Cooper. 1995. Requirement for phosphatidylinositol-3 kinase in prevention of apoptosis by nerve growth factor. Science 267:2003.
41. L. Immunity 3:87.
42. August, A., S. Gibson, Y. Kawakami, G. B. Mills, and B. Dupont. 1994. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human leukemic T cell line. Proc. Natl. Acad. Sci. USA 91:9347.
43. Rudd, C. E., O. Janssen, Y. C. Cai, A. J. Silva, M. Raab, and K. V. S. Prasad. 1994. Two step TCR/CD3-CD4 and CD28 signaling in T cells: SH2/SH3 domains, protein-tyrosine and lipid kinases. Immunol. Today 15:225.
44. fyn regulate CD28 binding to PI3 kinase, growth factor receptor hound GRB-2 and T cell specific PTK, ITK: implications for T cell costimulation. Proc. Natl. Acad. Sci. USA 92:8891.