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Volumn 47, Issue 2-3, 2000, Pages 63-83

Immunosuppressive drugs: The first 50 years and a glance forward

Author keywords

Alkylating agents; Apoptosis; Immunosuppressives; Kinases; Phosphatases; Purines; Pyrimidines

Indexed keywords

ALKYLATING AGENT; AZATHIOPRINE; BREQUINAR; CYCLOSPORIN; GLUCOCORTICOID; IMMUNOSUPPRESSIVE AGENT; LEFLUNOMIDE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PHOSPHATASE; PHOSPHOTRANSFERASE; PURINE; PYRIMIDINE; RAPAMYCIN; TACROLIMUS;

EID: 0034098326     PISSN: 01623109     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0162-3109(00)00186-7     Document Type: Article
Times cited : (325)

References (146)
  • 2
    • 0034081846 scopus 로고    scopus 로고
    • Methotrexate in rheumatoid arthritis. A clinician's perspective
    • Alarcón G.S. Methotrexate in rheumatoid arthritis. A clinician's perspective. Immunopharmacology. 2000.
    • (2000) Immunopharmacology
    • Alarcón, G.S.1
  • 3
    • 0023280787 scopus 로고
    • Evidence for direct inhibition of de novo purine synthesis by methotrexate
    • Allegra C.J., Hoeng K., Yeh G.C. Evidence for direct inhibition of de novo purine synthesis by methotrexate. J. Biol. Chem. 262:1987;13520-13526.
    • (1987) J. Biol. Chem. , vol.262 , pp. 13520-13526
    • Allegra, C.J.1    Hoeng, K.2    Yeh, G.C.3
  • 4
    • 0025847662 scopus 로고
    • In vitro immunosuppressive effects of mycophenolic acid and an ester prodrug, RS-61443
    • Allison A.C., Almquist S.J., Muller C.D., Eugui E.M. In vitro immunosuppressive effects of mycophenolic acid and an ester prodrug, RS-61443. Transplant. Proc. 23(Suppl. 2):1991;10-14.
    • (1991) Transplant. Proc. , vol.23 , Issue.SUPPL. 2 , pp. 10-14
    • Allison, A.C.1    Almquist, S.J.2    Muller, C.D.3    Eugui, E.M.4
  • 5
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • Allison A.C., Eugui E.M. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology. 2000.
    • (2000) Immunopharmacology
    • Allison, A.C.1    Eugui, E.M.2
  • 6
    • 0027397405 scopus 로고
    • Inhibition by glucocorticoids of the formation of interleukin-1α, interleukin-1β and interleukin-6; Mediation by decreased mRNA stability
    • Amano Y., Lee S.W., Allison A.C. Inhibition by glucocorticoids of the formation of interleukin-1α, interleukin-1β and interleukin-6; mediation by decreased mRNA stability. Molec. Pharm. 43:1993;176-182.
    • (1993) Molec. Pharm. , vol.43 , pp. 176-182
    • Amano, Y.1    Lee, S.W.2    Allison, A.C.3
  • 7
    • 0011169985 scopus 로고
    • Mizoribine (Bredinin®): Mode of action and effects on graft rejection
    • A.W. Thomson, & T.E. Starzl. Boston: Edward Arnold
    • Amemiya H., Itoh H. Mizoribine (Bredinin®): mode of action and effects on graft rejection. Thomson A.W., Starzl T.E. Immunosuppressive Drugs: Developments in Anti-rejection Therapy. 1993;161-176 Edward Arnold, Boston.
    • (1993) Immunosuppressive Drugs: Developments in Anti-rejection Therapy , pp. 161-176
    • Amemiya, H.1    Itoh, H.2
  • 8
    • 0034124993 scopus 로고    scopus 로고
    • Applications of tacrolimus for the treatment of skin disorders
    • Assmann T., Homey B., Ruzicka T. Applications of tacrolimus for the treatment of skin disorders. Immunopharmacology. 2000.
    • (2000) Immunopharmacology
    • Assmann, T.1    Homey, B.2    Ruzicka, T.3
  • 9
    • 0028956973 scopus 로고
    • Inhaled glucocorticoids for asthma
    • Barnes P.J. Inhaled glucocorticoids for asthma. N. Engl. J. Med. 322:1995;868-875.
    • (1995) N. Engl. J. Med. , vol.322 , pp. 868-875
    • Barnes, P.J.1
  • 10
    • 0022607220 scopus 로고
    • Immunopharmacological profile of HWA486, a novel isoxazol derivative: II. In vivo immunomodulating effects differ from those of cyclophosphamide, prednisolone or cyclosporin A
    • Bartlett R.R. Immunopharmacological profile of HWA486, a novel isoxazol derivative: II. In vivo immunomodulating effects differ from those of cyclophosphamide, prednisolone or cyclosporin A. Int. J. Immunopharmacol. 8:1986;199-204.
    • (1986) Int. J. Immunopharmacol. , vol.8 , pp. 199-204
    • Bartlett, R.R.1
  • 12
    • 0025866899 scopus 로고
    • 3 analogues: A novel class of potent regulators of cell growth and immune responses
    • 3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem. Pharmacol. 42:1991;1569-1575.
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 1569-1575
    • Binderup, L.1    Latini, S.2    Binderup, E.3
  • 13
    • 0001870667 scopus 로고    scopus 로고
    • High-dose/activation associated tolerance model for allografts: Lessons from spontaneous tolerance for transplanted livers
    • Bishop G.A., Sharland A.F., McCaughan G.W. High-dose/activation associated tolerance model for allografts: lessons from spontaneous tolerance for transplanted livers. Curr. Opin. Organ Transplant. 4:1999;58-69.
    • (1999) Curr. Opin. Organ Transplant. , vol.4 , pp. 58-69
    • Bishop, G.A.1    Sharland, A.F.2    McCaughan, G.W.3
  • 14
    • 0029934768 scopus 로고    scopus 로고
    • Tolerance to liver allografts III donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues
    • Bishop G.A., Sun J., De Cruz D.J.et al. Tolerance to liver allografts III donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. J. Immunol. 156:1996;4925-4931.
    • (1996) J. Immunol. , vol.156 , pp. 4925-4931
    • Bishop, G.A.1    Sun, J.2    De Cruz, D.J.3
  • 15
    • 0027182225 scopus 로고
    • Propriocidal apoptosis of mature T-lymphocytes occurs at the S phase of the cell cycle
    • Boehme S.A., Leonardo M.J. Propriocidal apoptosis of mature T-lymphocytes occurs at the S phase of the cell cycle. Eur. J. Immunol. 23:1993;1552-1560.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1552-1560
    • Boehme, S.A.1    Leonardo, M.J.2
  • 16
    • 0030975645 scopus 로고    scopus 로고
    • TGF β in kidney fibrosis: A target for gene therapy
    • Border W.A., Noble N.A. TGF β in kidney fibrosis: a target for gene therapy. Kidney Int. 51:1997;1388-1396.
    • (1997) Kidney Int. , vol.51 , pp. 1388-1396
    • Border, W.A.1    Noble, N.A.2
  • 17
    • 0017157814 scopus 로고
    • Biological effects of cyclosporin A: A new anti-lymphocytic agent
    • Borel J.F., Feurer C., Gubler H.V.et al. Biological effects of cyclosporin A: a new anti-lymphocytic agent. Agents Actions. 6:1976;468-475.
    • (1976) Agents Actions , vol.6 , pp. 468-475
    • Borel, J.F.1    Feurer, C.2    Gubler, H.V.3
  • 18
    • 0000881731 scopus 로고
    • Immunosuppressive role of rapamycin in allograft rejection
    • A.W. Thomson, & T.G. Starzl. Boston: Edward Arnold
    • Boyle M.J., Cahan B.D. Immunosuppressive role of rapamycin in allograft rejection. Thomson A.W., Starzl T.G. Immunosuppressive Drugs. 1994;129-140 Edward Arnold, Boston.
    • (1994) Immunosuppressive Drugs , pp. 129-140
    • Boyle, M.J.1    Cahan, B.D.2
  • 19
    • 0032525253 scopus 로고    scopus 로고
    • Hyperlipidemia in renal transplant patients treated with sirolimus (rapamaycin)
    • Brattström C., Wilczek H., Tyden G.et al. Hyperlipidemia in renal transplant patients treated with sirolimus (rapamaycin). Transplantation. 65:1998;1272-1274.
    • (1998) Transplantation , vol.65 , pp. 1272-1274
    • Brattström, C.1    Wilczek, H.2    Tyden, G.3
  • 20
    • 0000940438 scopus 로고    scopus 로고
    • FTY720 suppresses immune responses by modulating G-protein coupled receptors on lymphocytes resulting in altered lymphocyte homing
    • Brinkmann V., Pinschewer D., Feng L. FTY720 suppresses immune responses by modulating G-protein coupled receptors on lymphocytes resulting in altered lymphocyte homing. Transplantation. 67:1999;S226.
    • (1999) Transplantation , vol.67 , pp. 226
    • Brinkmann, V.1    Pinschewer, D.2    Feng, L.3
  • 21
    • 0028914056 scopus 로고
    • Azathioprine alone is bone sparing and does not alter cyclosporin induced osteopenia in the rat
    • Bryer H.P., Isserow J.A., Armstrong E.C.et al. Azathioprine alone is bone sparing and does not alter cyclosporin induced osteopenia in the rat. J. Bone Miner. Res. 10:1995;132-138.
    • (1995) J. Bone Miner. Res. , vol.10 , pp. 132-138
    • Bryer, H.P.1    Isserow, J.A.2    Armstrong, E.C.3
  • 22
    • 0031957338 scopus 로고    scopus 로고
    • Cholesterol control: Long-term benefit of pancreas-kidney transplantation with FK506 immunosuppression
    • Burke G.W., Giancio G., Alejandro R.et al. Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK506 immunosuppression. Transplant. Proc. 30:1998;513-514.
    • (1998) Transplant. Proc. , vol.30 , pp. 513-514
    • Burke, G.W.1    Giancio, G.2    Alejandro, R.3
  • 23
    • 0027169272 scopus 로고
    • Effects of orally administered rapamycin in animal models of arthritis and other autoimmune diseases
    • Carlson R.P., Baeder W.L., Caccese R.G.et al. Effects of orally administered rapamycin in animal models of arthritis and other autoimmune diseases. Ann. N.Y. Acad. Sci. 685:1993;86-113.
    • (1993) Ann. N.Y. Acad. Sci. , vol.685 , pp. 86-113
    • Carlson, R.P.1    Baeder, W.L.2    Caccese, R.G.3
  • 24
    • 0022410582 scopus 로고
    • Polyglutamation of methotrexate. Is methotrexate a prodrug?
    • Chabner B.A., Allegra C.J., Curt G.A.et al. Polyglutamation of methotrexate. Is methotrexate a prodrug? J. Clin. Invest. 76:1985;907-912.
    • (1985) J. Clin. Invest. , vol.76 , pp. 907-912
    • Chabner, B.A.1    Allegra, C.J.2    Curt, G.A.3
  • 26
    • 0025034447 scopus 로고
    • Pharmacokinetics of 6-MP, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients
    • Chang G.L., Erdmann G.R., Gruber S.A.et al. Pharmacokinetics of 6-MP, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. J. Clin. Pharmacol. 30:1990;358-363.
    • (1990) J. Clin. Pharmacol. , vol.30 , pp. 358-363
    • Chang, G.L.1    Erdmann, G.R.2    Gruber, S.A.3
  • 27
    • 0011206938 scopus 로고    scopus 로고
    • Elevated triglyceride levels are associated with early endothelial dysfunction (ED) after heart transplantation (HT)
    • Chang G., Wilensky R., Loh E.et al. Elevated triglyceride levels are associated with early endothelial dysfunction (ED) after heart transplantation (HT). Transplantation. 67:1999;S103.
    • (1999) Transplantation , vol.67 , pp. 103
    • Chang, G.1    Wilensky, R.2    Loh, E.3
  • 28
    • 0022445044 scopus 로고
    • Mechanism of action of the novel anticancer agent 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt (NSC 368390): Inhibition of de novo pyrimidine nucleotide biosynthesis
    • Chen S.-F., Ruben R., Dexter D. Mechanism of action of the novel anticancer agent 6-fluoro-2-(2′-fluoro-1,1′-biphenyl-4-yl)-3-methyl-4-quinoline carboxylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis. Cancer Res. 46:1986;5014-5019.
    • (1986) Cancer Res. , vol.46 , pp. 5014-5019
    • Chen, S.-F.1    Ruben, R.2    Dexter, D.3
  • 29
    • 0029591467 scopus 로고
    • The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis
    • Cherwinski H.M., Cohn R.G., Cheung P.et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J. Pharmacol. Exp. Ther. 275:1995;1043-1049.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 1043-1049
    • Cherwinski, H.M.1    Cohn, R.G.2    Cheung, P.3
  • 30
    • 0033567353 scopus 로고    scopus 로고
    • Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines
    • Cohn R.G., Mirkovich A., Dunlap B.et al. Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines. Transplantation. 68:1999;411-418.
    • (1999) Transplantation , vol.68 , pp. 411-418
    • Cohn, R.G.1    Mirkovich, A.2    Dunlap, B.3
  • 31
  • 32
    • 0032525243 scopus 로고    scopus 로고
    • Peritransplant tolerance induction with anti-CD3 immunotoxin: A matter of proinflammatory cytokine control
    • Contreras J.L., Wang P.X., Eckhoff D.E.et al. Peritransplant tolerance induction with anti-CD3 immunotoxin: a matter of proinflammatory cytokine control. Transplantation. 65:1998;1159-1169.
    • (1998) Transplantation , vol.65 , pp. 1159-1169
    • Contreras, J.L.1    Wang, P.X.2    Eckhoff, D.E.3
  • 33
    • 0007272952 scopus 로고
    • La greffe de foie orthotopique chez le porc; Premiers resultats
    • Cordier G., Garnier H., Clot J.et al. La greffe de foie orthotopique chez le porc; premiers resultats. Mem. Acad. Chir. 92:1965;27-35.
    • (1965) Mem. Acad. Chir. , vol.92 , pp. 27-35
    • Cordier, G.1    Garnier, H.2    Clot, J.3
  • 34
    • 0026607658 scopus 로고
    • The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat
    • Cramer D.V., Chapman F.A., Jaffeeet al. The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat. Transplantation. 53:1992;303-308.
    • (1992) Transplantation , vol.53 , pp. 303-308
    • Cramer, D.V.1    Chapman, F.A.2    Jaffeeet, Al.3
  • 35
    • 0022494054 scopus 로고
    • Cyclosporine in therapeutic doses increases renal allograft vascular resistance
    • Curtis J.J., Luke R.G., Duborsky E.et al. Cyclosporine in therapeutic doses increases renal allograft vascular resistance. Lancet. 2:1986;477-479.
    • (1986) Lancet , vol.2 , pp. 477-479
    • Curtis, J.J.1    Luke, R.G.2    Duborsky, E.3
  • 36
    • 0032529195 scopus 로고    scopus 로고
    • Impaired alloantigen-mediated T-cell apoptosis and failure to induce long-term allograft survival in IL-2 deficient mice
    • Dai Z.H., Konieczny B.T., Baddoura F.K.et al. Impaired alloantigen-mediated T-cell apoptosis and failure to induce long-term allograft survival in IL-2 deficient mice. J. Immunol. 161:1998;1659-1663.
    • (1998) J. Immunol. , vol.161 , pp. 1659-1663
    • Dai, Z.H.1    Konieczny, B.T.2    Baddoura, F.K.3
  • 37
    • 0027094084 scopus 로고
    • Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine and mycophenolic acid on T-lymphocyte proliferation and purine metabolism
    • Dayton J.S., Turka L.A., Thompson C.B., Mitchell B.S. Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine and mycophenolic acid on T-lymphocyte proliferation and purine metabolism. Molec. Pharmacol. 41:1992;671-676.
    • (1992) Molec. Pharmacol. , vol.41 , pp. 671-676
    • Dayton, J.S.1    Turka, L.A.2    Thompson, C.B.3    Mitchell, B.S.4
  • 38
    • 0024554774 scopus 로고
    • Bone histomorphometry in glucocorticoid-induced osteoporosis
    • Dempster D.W. Bone histomorphometry in glucocorticoid-induced osteoporosis. J. Bone Miner. Res. 4:1989;137-141.
    • (1989) J. Bone Miner. Res. , vol.4 , pp. 137-141
    • Dempster, D.W.1
  • 39
    • 0342612636 scopus 로고    scopus 로고
    • Liver allografts, but not lung allografts, induce a decrease in donor-specific cytotoxic T-cell precursors in the early post-transplant period: Correlation with freedom from chronic graft dysfunction
    • de Haan A., Van den Berg A., van der Bij W.et al. Liver allografts, but not lung allografts, induce a decrease in donor-specific cytotoxic T-cell precursors in the early post-transplant period: correlation with freedom from chronic graft dysfunction. Sixth Basic Sciences Symposium of the Transplantation Society:1999;141.
    • (1999) Sixth Basic Sciences Symposium of the Transplantation Society , pp. 141
    • De Haan, A.1    Van Den Berg, A.2    Van Der Bij, W.3
  • 40
    • 0032570298 scopus 로고    scopus 로고
    • Mycophenolate mofetil: A promising new immunosuppressant that does not cause bone loss in the rat
    • Dissanayake I.R., Goodman G.R., Bowman A.R.et al. Mycophenolate mofetil: a promising new immunosuppressant that does not cause bone loss in the rat. Transplantation. 65:1998;275-278.
    • (1998) Transplantation , vol.65 , pp. 275-278
    • Dissanayake, I.R.1    Goodman, G.R.2    Bowman, A.R.3
  • 41
    • 0343482601 scopus 로고    scopus 로고
    • Rapamycin induces TGF-β production in lymphocytes
    • Dodge I.L., Li X.C., Strom T.B. Rapamycin induces TGF-β production in lymphocytes. Transplantation. 67:1999;S50.
    • (1999) Transplantation , vol.67 , pp. 50
    • Dodge, I.L.1    Li, X.C.2    Strom, T.B.3
  • 42
    • 0024554561 scopus 로고
    • The purine path to chemotherapy
    • Elion G.B. The purine path to chemotherapy. Science. 244:1989;41-47.
    • (1989) Science , vol.244 , pp. 41-47
    • Elion, G.B.1
  • 43
    • 0023630355 scopus 로고
    • Mycophenolic acid for psoriasis. A review of pharmacology, long-term efficacy and safety
    • Epinette W.W., Parker C.M., Jones E.L., Greist M.C. Mycophenolic acid for psoriasis. A review of pharmacology, long-term efficacy and safety. J. Am. Acad. Dermatol. 17:1987;962-967.
    • (1987) J. Am. Acad. Dermatol. , vol.17 , pp. 962-967
    • Epinette, W.W.1    Parker, C.M.2    Jones, E.L.3    Greist, M.C.4
  • 44
  • 45
    • 0014546166 scopus 로고
    • The inhibition of nucleic acid synthesis by mycophenolic acid
    • Franklin T.J., Cook J.M. The inhibition of nucleic acid synthesis by mycophenolic acid. Biochem. J. 113:1969;515.
    • (1969) Biochem. J. , vol.113 , pp. 515
    • Franklin, T.J.1    Cook, J.M.2
  • 46
    • 0343918351 scopus 로고
    • The effect of aminomethylpteryl glutamic acid on the development of skin hypersensitivity and antibody formation in guinea pigs
    • Friedman R.M., Buckler C.E., Baron S. The effect of aminomethylpteryl glutamic acid on the development of skin hypersensitivity and antibody formation in guinea pigs. J. Exp. Med. 114:1961;173-183.
    • (1961) J. Exp. Med. , vol.114 , pp. 173-183
    • Friedman, R.M.1    Buckler, C.E.2    Baron, S.3
  • 47
    • 0031022844 scopus 로고    scopus 로고
    • Prevention of atherosclerosis in coronary-artery bypass grafts
    • Fuster V., Vorchheimm D.A. Prevention of atherosclerosis in coronary-artery bypass grafts. N. Engl. J. Med. 336:1997;212-213.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 212-213
    • Fuster, V.1    Vorchheimm, D.A.2
  • 48
    • 0032528186 scopus 로고    scopus 로고
    • Immunosuppressive properties of methotrexate: Apoptosis and clonal deletion of activated peripheral T-cells
    • Genestier L., Paillot R., Fournel S.et al. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T-cells. J. Clin. Invest. 102:1998;322-328.
    • (1998) J. Clin. Invest. , vol.102 , pp. 322-328
    • Genestier, L.1    Paillot, R.2    Fournel, S.3
  • 50
    • 0001060019 scopus 로고
    • The biological actions and therapeutic applications of β-chlorethylanines and sulfides
    • Gilman A., Phillips F.S. The biological actions and therapeutic applications of β-chlorethylanines and sulfides. Science. 103:1946;409-415.
    • (1946) Science , vol.103 , pp. 409-415
    • Gilman, A.1    Phillips, F.S.2
  • 51
    • 0000395398 scopus 로고
    • Richerche batteriologiche e chemiche sulle alterazoni dei Mais Riv
    • Gosio B. Richerche batteriologiche e chemiche sulle alterazoni dei Mais Riv. D'Igiene Sanita Pub. Ann. 7:1896;825-849.
    • (1896) d'Igiene Sanita Pub. Ann. , vol.7 , pp. 825-849
    • Gosio, B.1
  • 52
    • 0027471316 scopus 로고
    • Treatment with rapamycin blocks arterial intimal thickening following mechanical and alloimmune injury
    • Gregory C.R., Huie P., Shorthouse R.et al. Treatment with rapamycin blocks arterial intimal thickening following mechanical and alloimmune injury. Transplant. Proc. 25:1993;120-121.
    • (1993) Transplant. Proc. , vol.25 , pp. 120-121
    • Gregory, C.R.1    Huie, P.2    Shorthouse, R.3
  • 53
    • 0343918350 scopus 로고    scopus 로고
    • In 6 month protocol renal transplant biopsies long-term allograft outcome is predicted by using the Banff score or quantitation of fibrosis using image analysis of Sirius red staining
    • Grimm P.C., Jeffery J., Niderson P.et al. In 6 month protocol renal transplant biopsies long-term allograft outcome is predicted by using the Banff score or quantitation of fibrosis using image analysis of Sirius red staining. Transplantation. 67:1999;S56.
    • (1999) Transplantation , vol.67 , pp. 56
    • Grimm, P.C.1    Jeffery, J.2    Niderson, P.3
  • 54
    • 0345161813 scopus 로고    scopus 로고
    • Sirolimus (rapamycin)-based therapy in human renal transplantation
    • Groth C.G., Bäckman L., Morales J.-M.et al. Sirolimus (rapamycin)-based therapy in human renal transplantation. Transplantation. 67:1999;1036-1042.
    • (1999) Transplantation , vol.67 , pp. 1036-1042
    • Groth, C.G.1    Bäckman, L.2    Morales, J.-M.3
  • 55
    • 84958107344 scopus 로고
    • The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone, compound 8E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis
    • Hench P.S., Kendall E.C., Slocumb C.H., Polley H.F. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone, compound 8E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc. Staff Meet Mayo Clin. 24:1949;181-197.
    • (1949) Proc. Staff Meet Mayo Clin. , vol.24 , pp. 181-197
    • Hench, P.S.1    Kendall, E.C.2    Slocumb, C.H.3    Polley, H.F.4
  • 56
    • 0343811125 scopus 로고    scopus 로고
    • Cyclosporine activates the endothelin converting enzyme: Implications for acute and chronic nephrotoxicity
    • Herman W.H., Hircik D.E., Simonson M.S. Cyclosporine activates the endothelin converting enzyme: implications for acute and chronic nephrotoxicity. Transplantation. 67:1999;S52.
    • (1999) Transplantation , vol.67 , pp. 52
    • Herman, W.H.1    Hircik, D.E.2    Simonson, M.S.3
  • 57
    • 0034122123 scopus 로고    scopus 로고
    • Leflunomide: An immuno-modulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases
    • Herrmann M.L., Schleyerbach R., Kirschbaum B.J. Leflunomide: an immuno-modulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases. Immunopharmacology. 2000.
    • (2000) Immunopharmacology
    • Herrmann, M.L.1    Schleyerbach, R.2    Kirschbaum, B.J.3
  • 58
    • 0033545299 scopus 로고    scopus 로고
    • Cyclosporine induces cancer progression by a cell autonomous mechanism
    • Hojo M., Morimoto T., Maluccio M.et al. Cyclosporine induces cancer progression by a cell autonomous mechanism. Nature. 397:1999;530-534.
    • (1999) Nature , vol.397 , pp. 530-534
    • Hojo, M.1    Morimoto, T.2    Maluccio, M.3
  • 59
    • 0023937507 scopus 로고
    • Organo-specific activation of azathioprine in mice: Role of liver metabolism in mutation induction
    • Hrelia P., Murelli L., Scotti M.et al. Organo-specific activation of azathioprine in mice: role of liver metabolism in mutation induction. Carcinogenesis. 9:1988;1011-1015.
    • (1988) Carcinogenesis , vol.9 , pp. 1011-1015
    • Hrelia, P.1    Murelli, L.2    Scotti, M.3
  • 61
    • 0343046720 scopus 로고
    • Azodicarbonamide as a new immunosuppressive agent
    • Ismaili J., Tassignon J., Lemoine A.et al. Azodicarbonamide as a new immunosuppressive agent. Transplantation. 67:1989;S61.
    • (1989) Transplantation , vol.67 , pp. 61
    • Ismaili, J.1    Tassignon, J.2    Lemoine, A.3
  • 62
    • 0020264035 scopus 로고
    • Synthesis of (-)-15-deoxysperguelin and (-)-spergualin-15-phosphate
    • Iwasawa H., Kondo S., Ikeda D.et al. Synthesis of (-)-15-deoxysperguelin and (-)-spergualin-15-phosphate. J. Antibiot. (Tokyo). 35:1982;1665-1669.
    • (1982) J. Antibiot. (Tokyo) , vol.35 , pp. 1665-1669
    • Iwasawa, H.1    Kondo, S.2    Ikeda, D.3
  • 63
    • 0031803555 scopus 로고    scopus 로고
    • In vitro study of BCX-34: A new human T-lymphocyte-specific purine phosphorylase inhibitor
    • Iwata H., Wada Y., Walsh M.et al. In vitro study of BCX-34: a new human T-lymphocyte-specific purine phosphorylase inhibitor. Transplant. Proc. 30:1998;983-986.
    • (1998) Transplant. Proc. , vol.30 , pp. 983-986
    • Iwata, H.1    Wada, Y.2    Walsh, M.3
  • 64
    • 0026573788 scopus 로고
    • 17-β estradiol prevents osteopenia induced in the oophorectomized rat treated with cyclosporin A
    • Joffe I., Katz I., Jacobs T.et al. 17-β estradiol prevents osteopenia induced in the oophorectomized rat treated with cyclosporin A. Endocrinology. 130:1992;1578-1585.
    • (1992) Endocrinology , vol.130 , pp. 1578-1585
    • Joffe, I.1    Katz, I.2    Jacobs, T.3
  • 65
    • 0028104877 scopus 로고
    • MC1288 - A vitamin D analogue with immunosuppressive effects of heart and small bowel grafts
    • Johnsson C., Tufveson G. MC1288 - a vitamin D analogue with immunosuppressive effects of heart and small bowel grafts. Transplant Int. 7:1994;392-397.
    • (1994) Transplant Int. , vol.7 , pp. 392-397
    • Johnsson, C.1    Tufveson, G.2
  • 66
    • 0343482593 scopus 로고    scopus 로고
    • Cyclosporine A stimulation of smooth muscle cell proliferation is associated with increased expression of 14-3-3γ protein
    • Jones J.W., Guo S., Su S., Fernandez R. Cyclosporine A stimulation of smooth muscle cell proliferation is associated with increased expression of 14-3-3γ protein. Transplantation. 67:1999;S65.
    • (1999) Transplantation , vol.67 , pp. 65
    • Jones, J.W.1    Guo, S.2    Su, S.3    Fernandez, R.4
  • 67
    • 0021792088 scopus 로고
    • The immunology of experimental liver transplantation in the rat
    • (review article)
    • Kamada N. The immunology of experimental liver transplantation in the rat. Immunology. 55:1985;369-389. (review article).
    • (1985) Immunology , vol.55 , pp. 369-389
    • Kamada, N.1
  • 68
    • 0023724486 scopus 로고
    • Cellular basis of transplantation tolerance induced by liver grafting in rats. Extent of clonal deletion among thoracic duct lymphocytes, spleen and lymph node cells
    • Kamada N., Teramoto K., Baguiero A.et al. Cellular basis of transplantation tolerance induced by liver grafting in rats. Extent of clonal deletion among thoracic duct lymphocytes, spleen and lymph node cells. Transplantation. 46:1988;165-167.
    • (1988) Transplantation , vol.46 , pp. 165-167
    • Kamada, N.1    Teramoto, K.2    Baguiero, A.3
  • 69
    • 0026068601 scopus 로고
    • Programmed cell death and extrathymic reduction of Vβ8+CD4+ T-cells in mice tolerant to Staphyloccus aureus enterotixin B
    • Kawabe Y., Ochi A. Programmed cell death and extrathymic reduction of Vβ8+CD4+ T-cells in mice tolerant to Staphyloccus aureus enterotixin B. Nature. 349:1991;245-248.
    • (1991) Nature , vol.349 , pp. 245-248
    • Kawabe, Y.1    Ochi, A.2
  • 70
    • 0343482511 scopus 로고    scopus 로고
    • TGF-beta provides the rationale for the synergistic immunosuppression with rapamycin (RAPA), cyclosporine (CsA) and tacrolimus (TAC)
    • Khanna A. TGF-beta provides the rationale for the synergistic immunosuppression with rapamycin (RAPA), cyclosporine (CsA) and tacrolimus (TAC). Transplantation. 67:1999;S58.
    • (1999) Transplantation , vol.67 , pp. 58
    • Khanna, A.1
  • 71
    • 0001772219 scopus 로고    scopus 로고
    • Intrarenal expression of fibrogenic genes in renal allografts with tacrolimus and cyclosporine nephrotoxicity
    • Khanna A., Bresnahan B., Plummer M.et al. Intrarenal expression of fibrogenic genes in renal allografts with tacrolimus and cyclosporine nephrotoxicity. Transplantation. 67:1999;S84.
    • (1999) Transplantation , vol.67 , pp. 84
    • Khanna, A.1    Bresnahan, B.2    Plummer, M.3
  • 72
    • 0011254394 scopus 로고    scopus 로고
    • Intra-graft expression of fibrogenic genes is decreased in calcineurin inhibitors sparing immunosuppression protocol
    • Khanna A., Vincent F. Intra-graft expression of fibrogenic genes is decreased in calcineurin inhibitors sparing immunosuppression protocol. Transplantation. 67:1999;S80.
    • (1999) Transplantation , vol.67 , pp. 80
    • Khanna, A.1    Vincent, F.2
  • 73
    • 0028872616 scopus 로고
    • Development and selection of T-cells: Facts and puzzles
    • Kieslow P., von Boehmer H. Development and selection of T-cells: facts and puzzles. Adv. Immunol. 58:1995;87-209.
    • (1995) Adv. Immunol. , vol.58 , pp. 87-209
    • Kieslow, P.1    Von Boehmer, H.2
  • 74
    • 0023261356 scopus 로고
    • FK506, a novel immunosuppressant isolated from a streptomyces: III. Immunosuppressive effect of FK-506 in vitro
    • Kino T., Hatanaka H., Miyata S.et al. FK506, a novel immunosuppressant isolated from a streptomyces: III. Immunosuppressive effect of FK-506 in vitro. J. Antibiot. (Tokyo). 40:1987;1256-1265.
    • (1987) J. Antibiot. (Tokyo) , vol.40 , pp. 1256-1265
    • Kino, T.1    Hatanaka, H.2    Miyata, S.3
  • 75
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk A.D., Burkly L.C., Patty D.S.et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat. Med. (N.Y.). 5:1999;686-693.
    • (1999) Nat. Med. (N.Y.) , vol.5 , pp. 686-693
    • Kirk, A.D.1    Burkly, L.C.2    Patty, D.S.3
  • 76
    • 20244364353 scopus 로고    scopus 로고
    • The functional relevance of passenger leukocytes and microchimerism for heart graft acceptance in the rat
    • Ko S., Deiwick A., Jäger M.D.et al. The functional relevance of passenger leukocytes and microchimerism for heart graft acceptance in the rat. Nat. Med. (N.Y.). 5:1999;1292-1297.
    • (1999) Nat. Med. (N.Y.) , vol.5 , pp. 1292-1297
    • Ko, S.1    Deiwick, A.2    Jäger, M.D.3
  • 77
    • 0028928231 scopus 로고
    • Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat
    • Kobayashi E., Kamada N., Delriviere L.et al. Migration of donor cells into the thymus is not essential for induction and maintenance of systemic tolerance after liver transplantation in the rat. Immunology. 84:1995;333-336.
    • (1995) Immunology , vol.84 , pp. 333-336
    • Kobayashi, E.1    Kamada, N.2    Delriviere, L.3
  • 78
    • 0028821452 scopus 로고
    • The pharmacology of T-cell apoptosis
    • Kroemer G. The pharmacology of T-cell apoptosis. Adv. Immunol. 58:1995;211-296.
    • (1995) Adv. Immunol. , vol.58 , pp. 211-296
    • Kroemer, G.1
  • 79
    • 0001240467 scopus 로고
    • Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription
    • Kronke M., Leonard W.J., Depper J.M.et al. Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription. Proc. Natl. Acad. Sci. U.S.A. 81:1984;5214-5218.
    • (1984) Proc. Natl. Acad. Sci. U.S.A. , vol.81 , pp. 5214-5218
    • Kronke, M.1    Leonard, W.J.2    Depper, J.M.3
  • 81
    • 0026017971 scopus 로고
    • Interleukin-2 programs mouse alpha-beta T-lymphocytes for apoptosis
    • Leonardo M.J. Interleukin-2 programs mouse alpha-beta T-lymphocytes for apoptosis. Nature. 353:1991;763-769.
    • (1991) Nature , vol.353 , pp. 763-769
    • Leonardo, M.J.1
  • 82
    • 0026009177 scopus 로고
    • Differential regulation of transforming growth factor-β And interleukin 2 genes in human T cells: Demonstration by usage of novel competitor DNA constructs in quantitative polymerase chain reaction
    • Li B., Sehajpal P., Khanna A.et al. Differential regulation of transforming growth factor-β and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in quantitative polymerase chain reaction. J. Exp. Med. 174:1991;1259-1264.
    • (1991) J. Exp. Med. , vol.174 , pp. 1259-1264
    • Li, B.1    Sehajpal, P.2    Khanna, A.3
  • 83
    • 0344613988 scopus 로고    scopus 로고
    • Blocking signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T-cells and induction of peripheral tolerance
    • Li Y., Li X.C., Zheng X.X.et al. Blocking signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T-cells and induction of peripheral tolerance. Nat. Med. (N.Y.). 5:1999;1298-1302.
    • (1999) Nat. Med. (N.Y.) , vol.5 , pp. 1298-1302
    • Li, Y.1    Li, X.C.2    Zheng, X.X.3
  • 84
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes
    • Liu J., Farmer J.D., Lane W.S.et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:1991;807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3
  • 85
    • 0011169985 scopus 로고
    • Brequinar sodium: Mode of action and effects on graft rejection
    • A.W. Thomson, & T.E. Starzl. Boston: Edward Arnold
    • Makowka L., Cramer D.V. Brequinar sodium: mode of action and effects on graft rejection. Thomson A.W., Starzl T.E. Immunosuppressive Drugs: Developments in Anti-rejection Therapy. 1993;177-186 Edward Arnold, Boston.
    • (1993) Immunosuppressive Drugs: Developments in Anti-rejection Therapy , pp. 177-186
    • Makowka, L.1    Cramer, D.V.2
  • 86
    • 0017362502 scopus 로고
    • Inhibition of the immune response by rapamycin, a new antifungal antibiotic
    • Martel R.R., Klicius J., Galet S. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can. J. Physiol. Pharmacol. 55:1977;48-51.
    • (1977) Can. J. Physiol. Pharmacol. , vol.55 , pp. 48-51
    • Martel, R.R.1    Klicius, J.2    Galet, S.3
  • 87
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massagúe J. The transforming growth factor-β family. Annu. Rev. Cell Biol. 6:1990;597-641.
    • (1990) Annu. Rev. Cell Biol. , vol.6 , pp. 597-641
    • Massagúe, J.1
  • 88
    • 0032526253 scopus 로고    scopus 로고
    • Tricontinental mycophenolate mofetil renal transplantation study group. A blinded, long-term, randomized multicenter study of mycophenolate mofetil in renal transplantation. Results at three years
    • Mathew T.H. Tricontinental mycophenolate mofetil renal transplantation study group. A blinded, long-term, randomized multicenter study of mycophenolate mofetil in renal transplantation. Results at three years. Transplantation. 65:1999;1450-1454.
    • (1999) Transplantation , vol.65 , pp. 1450-1454
    • Mathew, T.H.1
  • 90
    • 0344889014 scopus 로고    scopus 로고
    • Apoptosis of alloreactive T-cells in liver grafts during tolerance induction
    • Meyer D., Thorwath M., Otto C.et al. Apoptosis of alloreactive T-cells in liver grafts during tolerance induction. Transplant. Proc. 31:1999;474.
    • (1999) Transplant. Proc. , vol.31 , pp. 474
    • Meyer, D.1    Thorwath, M.2    Otto, C.3
  • 91
    • 0028938020 scopus 로고
    • Renal transplant morphology after long-term therapy with cyclosporine
    • Mihatsch M.J., Morozumi K., Strom E.H.et al. Renal transplant morphology after long-term therapy with cyclosporine. Transplant. Proc. 27:1995;39-42.
    • (1995) Transplant. Proc. , vol.27 , pp. 39-42
    • Mihatsch, M.J.1    Morozumi, K.2    Strom, E.H.3
  • 92
    • 0032518281 scopus 로고    scopus 로고
    • Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires 5′-ectonucleotidase conversion of adenine nucleotides
    • Morabito L., Mortesino M.C., Schreibman D.M.et al. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires 5′-ectonucleotidase conversion of adenine nucleotides. J. Clin. Invest. 101:1998;295-300.
    • (1998) J. Clin. Invest. , vol.101 , pp. 295-300
    • Morabito, L.1    Mortesino, M.C.2    Schreibman, D.M.3
  • 93
    • 0026063950 scopus 로고
    • Use of rapamycin for the suppression of alloimmune reactions in vivo-schedule dependence, tolerance induction, and synergy with cyclosporine and FK-506 and effect on host-versus-graft and graft-versus-host reactions
    • Morris R.E., Meiser B.M., Wu T.et al. Use of rapamycin for the suppression of alloimmune reactions in vivo-schedule dependence, tolerance induction, and synergy with cyclosporine and FK-506 and effect on host-versus-graft and graft-versus-host reactions. Transplant. Proc. 23:1991;521-524.
    • (1991) Transplant. Proc. , vol.23 , pp. 521-524
    • Morris, R.E.1    Meiser, B.M.2    Wu, T.3
  • 94
    • 0008223553 scopus 로고    scopus 로고
    • Effect of sirolimus on plasma lipid and lipoprotein levels and metabolism in renal transplant recipients
    • Morrisett J.D., Ballantyne C.M., Pownall H.J.et al. Effect of sirolimus on plasma lipid and lipoprotein levels and metabolism in renal transplant recipients. Transplantation. 67:1999;S60.
    • (1999) Transplantation , vol.67 , pp. 60
    • Morrisett, J.D.1    Ballantyne, C.M.2    Pownall, H.J.3
  • 95
    • 73649153279 scopus 로고
    • Prolonged survival of human kidney homografts by immunosuppressive drug therapy
    • Murray J.E., Merrill J.P., Harrison J.H.et al. Prolonged survival of human kidney homografts by immunosuppressive drug therapy. N. Engl. J. Med. 268:1963;1315-1323.
    • (1963) N. Engl. J. Med. , vol.268 , pp. 1315-1323
    • Murray, J.E.1    Merrill, J.P.2    Harrison, J.H.3
  • 96
    • 58149205695 scopus 로고
    • Determinants of long-term allograft survival
    • Naimark D.M.J., Cole E. Determinants of long-term allograft survival. Transplant. Rev. 8:1994;931.
    • (1994) Transplant. Rev. , vol.8 , pp. 931
    • Naimark, D.M.J.1    Cole, E.2
  • 97
    • 0023154229 scopus 로고
    • New immunosuppressive drugs. Effect of a new immunosuppressive agent, FK-506, on heterotopic cardiac allotransplantation in the rat
    • Ochiai T., Nakajima K., Nagata M.et al. New immunosuppressive drugs. Effect of a new immunosuppressive agent, FK-506, on heterotopic cardiac allotransplantation in the rat. Transplant. Proc. 19:1987;1284-1286.
    • (1987) Transplant. Proc. , vol.19 , pp. 1284-1286
    • Ochiai, T.1    Nakajima, K.2    Nagata, M.3
  • 98
    • 0019191595 scopus 로고
    • Effect of Bredinin on cellular and humoral immune responses and on canine kidney allograft survival
    • Okubo M., Kamata K., Yakota K.et al. Effect of Bredinin on cellular and humoral immune responses and on canine kidney allograft survival. Transplant. Proc. 12:1980;515-519.
    • (1980) Transplant. Proc. , vol.12 , pp. 515-519
    • Okubo, M.1    Kamata, K.2    Yakota, K.3
  • 99
    • 0029557697 scopus 로고
    • Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative transplant study
    • Opelz G. Efficacy of rejection prophylaxis with OKT3 in renal transplantation. Collaborative transplant study. Transplantation. 60:1995;1220-1224.
    • (1995) Transplantation , vol.60 , pp. 1220-1224
    • Opelz, G.1
  • 100
    • 0033058907 scopus 로고    scopus 로고
    • Decreased apoptosis rate in patients treated with mycophenolate mofetil
    • Pardo-Mindán F.J., Errasti P., Panizo A.et al. Decreased apoptosis rate in patients treated with mycophenolate mofetil. Nephron. 82:1996;232-237.
    • (1996) Nephron , vol.82 , pp. 232-237
    • Pardo-Mindán, F.J.1    Errasti, P.2    Panizo, A.3
  • 101
    • 0027987849 scopus 로고
    • Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian simvastatin survival study (45)
    • Pedersen T.R., Kjekshus J., Berg K.et al. Randomized trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian simvastatin survival study (45). Lancet. 349:1994;1383-1389.
    • (1994) Lancet , vol.349 , pp. 1383-1389
    • Pedersen, T.R.1    Kjekshus, J.2    Berg, K.3
  • 102
    • 0031570116 scopus 로고    scopus 로고
    • Apoptosis within spontaneously accepted mouse liver-allografts. Evidence for deletion of cytotoxic T-cells and implications for tolerance induction
    • Qian S., Lu L., Fu F.et al. Apoptosis within spontaneously accepted mouse liver-allografts. Evidence for deletion of cytotoxic T-cells and implications for tolerance induction. J. Immunol. 158:1997;4654-4661.
    • (1997) J. Immunol. , vol.158 , pp. 4654-4661
    • Qian, S.1    Lu, L.2    Fu, F.3
  • 103
    • 0029993753 scopus 로고    scopus 로고
    • Effect of MC1288, a vitamin D analogue, on lymphocyte proliferation and rat aortic allograft arteriosclerosis in vivo
    • Räisänen-Sokolowski A., Pakkala I., Vuoristo P.et al. Effect of MC1288, a vitamin D analogue, on lymphocyte proliferation and rat aortic allograft arteriosclerosis in vivo. Transplant. Proc. 28:1996;919.
    • (1996) Transplant. Proc. , vol.28 , pp. 919
    • Räisänen-Sokolowski, A.1    Pakkala, I.2    Vuoristo, P.3
  • 104
    • 0343918334 scopus 로고    scopus 로고
    • Transforming growth factor-β1 inducible gene-h3 (βig-h3) mRNA expression correlates with TGF-β1 mRNA hyperexpression in human renal allografts
    • Ranich T., Li B., Sharma U.K.et al. Transforming growth factor-β1 inducible gene-h3 (βig-h3) mRNA expression correlates with TGF-β1 mRNA hyperexpression in human renal allografts. Transplantation. 67:1999;S251.
    • (1999) Transplantation , vol.67 , pp. 251
    • Ranich, T.1    Li, B.2    Sharma, U.K.3
  • 105
    • 0017345190 scopus 로고
    • Cyclophosphamide-sensitive T-lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T-lymphocytes
    • Rollinghoff M., Starzinski-Powitz A., Pfizenmaier K., Wagner H. Cyclophosphamide-sensitive T-lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T-lymphocytes. J. Exp. Med. 145:1977;455-459.
    • (1977) J. Exp. Med. , vol.145 , pp. 455-459
    • Rollinghoff, M.1    Starzinski-Powitz, A.2    Pfizenmaier, K.3    Wagner, H.4
  • 106
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with disrupted IL-2 gene
    • Sadlack B., Merz H., Schorle H.et al. Ulcerative colitis-like disease in mice with disrupted IL-2 gene. Cell. 75:1993;253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3
  • 107
  • 108
    • 0029923360 scopus 로고    scopus 로고
    • A review of immune modifier therapy for inflammatory bowel disease: Azathioprine, 6-mercaptopurine, cyclosporine and methotrexate
    • Sandborn W.J. A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine and methotrexate. Am. J. Gastroenterol. 91:1996;423-433.
    • (1996) Am. J. Gastroenterol. , vol.91 , pp. 423-433
    • Sandborn, W.J.1
  • 109
    • 0343375538 scopus 로고
    • Role of hypertension in chronic allograft dysfunction
    • Sanders C.F.J., Curtis J.J. Role of hypertension in chronic allograft dysfunction. Kidney Int. 48:1995;S431.
    • (1995) Kidney Int. , vol.48 , pp. 431
    • Sanders, C.F.J.1    Curtis, J.J.2
  • 110
    • 0009354274 scopus 로고
    • Effect of selected agents on antibody production in man: A preliminary report
    • Santos G., Owens A.H. Jr., Sensenbrenner L.L. Effect of selected agents on antibody production in man: a preliminary report. Am. N.Y. Acad. Sci. 114:1964;404-423.
    • (1964) Am. N.Y. Acad. Sci. , vol.114 , pp. 404-423
    • Santos, G.1    Owens, A.h.jr.2    Sensenbrenner, L.L.3
  • 111
    • 0343918333 scopus 로고    scopus 로고
    • Malononitrilamides (MNAs) exert their immunosuppressive activity primarily by inhibition of dihydroorotate dehydrogenase (DHOH)
    • Schorlemmer H.U., Milbert U., Schleyerbach R., Kirchbaum R. Malononitrilamides (MNAs) exert their immunosuppressive activity primarily by inhibition of dihydroorotate dehydrogenase (DHOH). Transplantation. 67:1999;S60.
    • (1999) Transplantation , vol.67 , pp. 60
    • Schorlemmer, H.U.1    Milbert, U.2    Schleyerbach, R.3    Kirchbaum, R.4
  • 112
    • 36949079215 scopus 로고
    • Drug-induced immunological tolerance
    • Schwartz R., Dameshek W. Drug-induced immunological tolerance. Nature. 183:1959;1682-1683.
    • (1959) Nature , vol.183 , pp. 1682-1683
    • Schwartz, R.1    Dameshek, W.2
  • 113
    • 84961043552 scopus 로고
    • The effects of 6-mercaptopurine on homograft reactions
    • Schwartz R., Dameshek W. The effects of 6-mercaptopurine on homograft reactions. J. Clin. Invest. 39:1960;952-958.
    • (1960) J. Clin. Invest. , vol.39 , pp. 952-958
    • Schwartz, R.1    Dameshek, W.2
  • 114
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), a new fungal antibiotic: 11. Fermentation, isolation and characterization
    • Sehgal S.N., Baker H., Vezina C. Rapamycin (AY-22,989), a new fungal antibiotic: 11. Fermentation, isolation and characterization. J. Antibiot. 38:1975;727-732.
    • (1975) J. Antibiot. , vol.38 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 115
    • 0343446130 scopus 로고    scopus 로고
    • Evidence that apoptosis of activated T-cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations that break tolerance
    • (in press)
    • Sharland A., Yau Y., Wang C.et al. Evidence that apoptosis of activated T-cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations that break tolerance. Transplantation. 1999;. (in press).
    • (1999) Transplantation
    • Sharland, A.1    Yau, Y.2    Wang, C.3
  • 116
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • Shepherd J., Cobbe S.M., Ford I.et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med. 33:1995;1301-1305.
    • (1995) N. Engl. J. Med. , vol.33 , pp. 1301-1305
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 117
    • 0342940198 scopus 로고    scopus 로고
    • The expression of pro-apoptotic genes is favored in chronic cyclosporine nephrotoxicity
    • Shihab F., Andoh T., Tamer A., Bennett W. The expression of pro-apoptotic genes is favored in chronic cyclosporine nephrotoxicity. Transplantation. 67:1999;S214.
    • (1999) Transplantation , vol.67 , pp. 214
    • Shihab, F.1    Andoh, T.2    Tamer, A.3    Bennett, W.4
  • 118
    • 0006458915 scopus 로고    scopus 로고
    • Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes
    • Shimizu Y., Goto S., Varí F.et al. Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes. Transplant. Int. 6:1996;593-595.
    • (1996) Transplant. Int. , vol.6 , pp. 593-595
    • Shimizu, Y.1    Goto, S.2    Varí, F.3
  • 119
    • 0342505923 scopus 로고    scopus 로고
    • Endothelin-1 mediates transplant vasculopathy and chronic rejection in LEW/F344 cardiac allografts
    • Simonson M., Robinson A., Herman W.et al. Endothelin-1 mediates transplant vasculopathy and chronic rejection in LEW/F344 cardiac allografts. Transplantation. 67:1999;S52.
    • (1999) Transplantation , vol.67 , pp. 52
    • Simonson, M.1    Robinson, A.2    Herman, W.3
  • 120
    • 0034121721 scopus 로고    scopus 로고
    • The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors
    • Sintchak M.D., Nimmesgern E. The structure of inosine 5′-monophosphate dehydrogenase and the design of novel inhibitors. Immunopharmacology. 2000.
    • (2000) Immunopharmacology
    • Sintchak, M.D.1    Nimmesgern, E.2
  • 121
    • 0343918330 scopus 로고    scopus 로고
    • Cyclosporine administration prevents intrathymic (IT) tolerance induction and precipitates rejection of established IT tolerant rat cardiac allografts
    • Smith C., Shimizu Y., Otomo N.et al. Cyclosporine administration prevents intrathymic (IT) tolerance induction and precipitates rejection of established IT tolerant rat cardiac allografts. Sixth Basic Sciences Symposium of the Transplantation Society, Monterey, CA:1999;178.
    • (1999) Sixth Basic Sciences Symposium of the Transplantation Society, Monterey, CA , pp. 178
    • Smith, C.1    Shimizu, Y.2    Otomo, N.3
  • 122
    • 0000346814 scopus 로고    scopus 로고
    • Decreasing expression of transforming growth factor-beta in human renal biopsies with improvement of renal pathological score and renal function following chronic cyclosporine reduction
    • Song H., Seta K., Kinjo P.et al. Decreasing expression of transforming growth factor-beta in human renal biopsies with improvement of renal pathological score and renal function following chronic cyclosporine reduction. Transplantation. 67:1999;S236.
    • (1999) Transplantation , vol.67 , pp. 236
    • Song, H.1    Seta, K.2    Kinjo, P.3
  • 123
    • 84965059977 scopus 로고
    • Die Beinflussing der Antikörper-bildung durch Zytostatika and Rontgenbestrahling
    • Stender H.S., Ringleb D., Strauch D., Winter H. Die Beinflussing der Antikörper-bildung durch Zytostatika and Rontgenbestrahling. Strahlentherapie. 43:1959;392-399.
    • (1959) Strahlentherapie , vol.43 , pp. 392-399
    • Stender, H.S.1    Ringleb, D.2    Strauch, D.3    Winter, H.4
  • 124
    • 0030457356 scopus 로고    scopus 로고
    • Tolerance to rat liver allografts: IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes
    • Sun J., Shiel A.G.R., Wang C.et al. Tolerance to rat liver allografts: IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes. Transplantation. 62:1996;1725-1730.
    • (1996) Transplantation , vol.62 , pp. 1725-1730
    • Sun, J.1    Shiel, A.G.R.2    Wang, C.3
  • 125
    • 0011859894 scopus 로고
    • Deoxyspergualin: Mode of action and effects on graft rejection
    • A.W. Thomson, & T.E. Starzl. Boston: Edward Arnold
    • Suzuki S. Deoxyspergualin: mode of action and effects on graft rejection. Thomson A.W., Starzl T.E. Immunosuppressive Drugs: Developments in Anti-rejection Therapy. 1994;187-202 Edward Arnold, Boston.
    • (1994) Immunosuppressive Drugs: Developments in Anti-rejection Therapy , pp. 187-202
    • Suzuki, S.1
  • 126
    • 0029028363 scopus 로고
    • Deregulated T-cell activation and autoimmunity in mice lacking interleukin-2 receptor
    • Suzuki H., Kumdig T.M., Furlonger C.et al. Deregulated T-cell activation and autoimmunity in mice lacking interleukin-2 receptor. Science. 268:1995;1472-1476.
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1    Kumdig, T.M.2    Furlonger, C.3
  • 127
    • 0030271801 scopus 로고    scopus 로고
    • Chimerism and central tolerance
    • Sykes M. Chimerism and central tolerance. Curr. Opin. Immunol. 81:1996;694-703.
    • (1996) Curr. Opin. Immunol. , vol.81 , pp. 694-703
    • Sykes, M.1
  • 128
    • 0030200829 scopus 로고    scopus 로고
    • The roles of Fas/Apo 1 (CD95) and TNF in antigen-induced programmed cell death in T-cell receptor transgenic mice
    • Sytwu H.K., Lieblau R.S., McDevitt H.O. The roles of Fas/Apo 1 (CD95) and TNF in antigen-induced programmed cell death in T-cell receptor transgenic mice. Immunity. 5:1996;17-30.
    • (1996) Immunity , vol.5 , pp. 17-30
    • Sytwu, H.K.1    Lieblau, R.S.2    McDevitt, H.O.3
  • 129
    • 0028223847 scopus 로고
    • Generalized lymphoproliferative disease caused by a point mutation in the Fas ligand
    • Takahashi T., Tanaka M., Brannan C.I.et al. Generalized lymphoproliferative disease caused by a point mutation in the Fas ligand. Cell. 76:1994;969-976.
    • (1994) Cell , vol.76 , pp. 969-976
    • Takahashi, T.1    Tanaka, M.2    Brannan, C.I.3
  • 130
    • 0019769255 scopus 로고
    • A new antitumor antibiotic, spergualin: Isolation and antitumor activity
    • Takeuchi T., Iinuma H., Kunimoto S. A new antitumor antibiotic, spergualin: isolation and antitumor activity. J. Antibiot. (Tokyo). 34:1981;1619-1621.
    • (1981) J. Antibiot. (Tokyo) , vol.34 , pp. 1619-1621
    • Takeuchi, T.1    Iinuma, H.2    Kunimoto, S.3
  • 131
    • 0029763501 scopus 로고    scopus 로고
    • Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation
    • Thiebaud D., Krieg M.A., Gillard-Berguer D.et al. Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation. J. Clin. Invest. 26:1996;549.
    • (1996) J. Clin. Invest. , vol.26 , pp. 549
    • Thiebaud, D.1    Krieg, M.A.2    Gillard-Berguer, D.3
  • 132
    • 0008908944 scopus 로고    scopus 로고
    • Induction of long-term allograft survival by post-transplant infusion of allogeneic leukocytes and delayed low-dose cyclosporine
    • Abstracts
    • Tsui T.Y., Schlitt H.J. Induction of long-term allograft survival by post-transplant infusion of allogeneic leukocytes and delayed low-dose cyclosporine. The Sixth Basic Sciences Symposium of the Transplantation Society. 1999;203. Abstracts.
    • (1999) The Sixth Basic Sciences Symposium of the Transplantation Society , pp. 203
    • Tsui, T.Y.1    Schlitt, H.J.2
  • 133
    • 78651144357 scopus 로고
    • Studies on the mechanism of action of methotrexate and cyclophosphamide on contact sensitivity in the guinea pig
    • Turk J.L. Studies on the mechanism of action of methotrexate and cyclophosphamide on contact sensitivity in the guinea pig. Int. Arch. Allergy. 24:1964;191-200.
    • (1964) Int. Arch. Allergy , vol.24 , pp. 191-200
    • Turk, J.L.1
  • 134
    • 0032502801 scopus 로고    scopus 로고
    • Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
    • Van Parijs L., Abbas A.K. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. Science. 280:1998;243-248.
    • (1998) Science , vol.280 , pp. 243-248
    • Van Parijs, L.1    Abbas, A.K.2
  • 136
    • 0030249285 scopus 로고    scopus 로고
    • The use of leflunomide in transplantation immunology
    • Waer M. The use of leflunomide in transplantation immunology. Transplant Immunol. 4:1996;181-185.
    • (1996) Transplant Immunol. , vol.4 , pp. 181-185
    • Waer, M.1
  • 137
    • 0026568919 scopus 로고
    • Lymphoproliferation disorder explained by defects in Fas antigen that mediates apoptosis
    • Watanabe-Fukunagas R., Brannan C.I., Copland N.G.et al. Lymphoproliferation disorder explained by defects in Fas antigen that mediates apoptosis. Nature. 356:1992;314-317.
    • (1992) Nature , vol.356 , pp. 314-317
    • Watanabe-Fukunagas, R.1    Brannan, C.I.2    Copland, N.G.3
  • 138
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T-cells: Clonal elimination as a consequence of immunity
    • Webb S., Morris C., Sprent J. Extrathymic tolerance of mature T-cells: clonal elimination as a consequence of immunity. Cell. 63:1990;1249-1256.
    • (1990) Cell , vol.63 , pp. 1249-1256
    • Webb, S.1    Morris, C.2    Sprent, J.3
  • 139
    • 0004345745 scopus 로고    scopus 로고
    • Chronic cyclosporine reduction decreases apoptosis and p53 expression in human renal biopsies with improvement of renal pathological score and renal function
    • Wei C., Song H., Seta K.et al. Chronic cyclosporine reduction decreases apoptosis and p53 expression in human renal biopsies with improvement of renal pathological score and renal function. Transplantation. 67:1999;S51.
    • (1999) Transplantation , vol.67 , pp. 51
    • Wei, C.1    Song, H.2    Seta, K.3
  • 140
    • 0342505924 scopus 로고
    • Antipurines and purine metabolism
    • Wolberg G. Antipurines and purine metabolism. Handb. Exp. Pharmacol. 85:1988;517-530.
    • (1988) Handb. Exp. Pharmacol. , vol.85 , pp. 517-530
    • Wolberg, G.1
  • 141
    • 0345476290 scopus 로고    scopus 로고
    • Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance
    • Wells A.D., Li X.C., Li Y.et al. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat. Med. (N.Y.). 5:1999;1303-1307.
    • (1999) Nat. Med. (N.Y.) , vol.5 , pp. 1303-1307
    • Wells, A.D.1    Li, X.C.2    Li, Y.3
  • 143
    • 0343918315 scopus 로고    scopus 로고
    • Effects of a novel immunosuppressant, FTY720, on heart and liver transplantation
    • Yamashita K., Nomura M., Takehara M.et al. Effects of a novel immunosuppressant, FTY720, on heart and liver transplantation. Transplantation. 1999;S226.
    • (1999) Transplantation , pp. 226
    • Yamashita, K.1    Nomura, M.2    Takehara, M.3
  • 144
    • 0029112253 scopus 로고
    • Induction of apoptosis in mature T-cells by tumor necrosis factor
    • Zheng L., Fisher G., Miller R.E.et al. Induction of apoptosis in mature T-cells by tumor necrosis factor. Nature. 377:1995;348-351.
    • (1995) Nature , vol.377 , pp. 348-351
    • Zheng, L.1    Fisher, G.2    Miller, R.E.3
  • 145
    • 0033010882 scopus 로고    scopus 로고
    • Bisindolylamide VIV facilitates Fas-mediated apoptosis and inhibits T-cell-mediated autoimmune diseases
    • Zhou T., Song L., Yang P.et al. Bisindolylamide VIV facilitates Fas-mediated apoptosis and inhibits T-cell-mediated autoimmune diseases. Nat. Med. (N.Y.). 5:1999;42-48.
    • (1999) Nat. Med. (N.Y.) , vol.5 , pp. 42-48
    • Zhou, T.1    Song, L.2    Yang, P.3
  • 146
    • 0021250344 scopus 로고
    • Orthotopic liver allografts in the rat: Influence of strain combination on the fate of the graft
    • Zimmermann F.A., Davies H.S., Knoll P.P.et al. Orthotopic liver allografts in the rat: influence of strain combination on the fate of the graft. Transplantation. 37:1984;406-410.
    • (1984) Transplantation , vol.37 , pp. 406-410
    • Zimmermann, F.A.1    Davies, H.S.2    Knoll, P.P.3


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