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Volumn 20, Issue 1, 2010, Pages 24-33

The nuclear signaling of NF-κB: Current knowledge, new insights, and future perspectives

Author keywords

DNA binding; Immunity; RPS3

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; PROTEIN SUBUNIT; RIBOSOME PROTEIN; RPS3A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

EID: 73849095427     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2009.137     Document Type: Review
Times cited : (333)

References (68)
  • 1
    • 0022930702 scopus 로고
    • Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism
    • Sen R, Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a posttranslational mechanism. Cell 1986; 47:921-928.
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 2
    • 0023280348 scopus 로고
    • Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility
    • Lenardo M, Pierce JW, Baltimore D. Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science 1987; 236:1573-1577.
    • (1987) Science , vol.236 , pp. 1573-1577
    • Lenardo, M.1    Pierce, J.W.2    Baltimore, D.3
  • 3
    • 0024475227 scopus 로고
    • NF-kappa B: A pleiotropic mediator of inducible and tissue-specific gene control
    • Lenardo MJ, Baltimore D. NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989; 58:227-229.
    • (1989) Cell , vol.58 , pp. 227-229
    • Lenardo, M.J.1    Baltimore, D.2
  • 4
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18:2195-2224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 5
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008; 132:344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 6
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NFkappaB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NFkappaB transcription factors in the immune system. Annu Rev Immunol 2009; 27:693-733.
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 8
    • 20044368626 scopus 로고    scopus 로고
    • Requirement for caspase-8 in NF-kappaB activation by antigen receptor
    • Su H, Bidere N, Zheng L, et al.. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 2005; 307:1465-1468.
    • (2005) Science , vol.307 , pp. 1465-1468
    • Su, H.1    Bidere, N.2    Zheng, L.3
  • 9
    • 62049084688 scopus 로고    scopus 로고
    • Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival
    • Bidere N, Ngo VN, Lee J, et al.. Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature 2009; 458:92-96.
    • (2009) Nature , vol.458 , pp. 92-96
    • Bidere, N.1    Ngo, V.N.2    Lee, J.3
  • 10
    • 0027232067 scopus 로고
    • NF-kappa B and Rel: Participants in a multiform transcriptional regulatory system
    • Grilli M, Chiu JJ, Lenardo MJ. NF-kappa B and Rel: participants in a multiform transcriptional regulatory system. Int Rev Cytol 1993; 143:1-62.
    • (1993) Int Rev Cytol , vol.143 , pp. 1-62
    • Grilli, M.1    Chiu, J.J.2    Lenardo, M.J.3
  • 11
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NFkappaB
    • Chen LF, Greene WC. Shaping the nuclear action of NFkappaB. Nat Rev Mol Cell Biol 2004; 5:392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 12
    • 0033607313 scopus 로고    scopus 로고
    • The NF-kappaB activation pathway: A paradigm in information transfer from membrane to nucleus
    • Rothwarf DM, Karin M. The NF-kappaB activation pathway: a paradigm in information transfer from membrane to nucleus. Sci STKE 1999; 1999:RE1.
    • (1999) Sci STKE , vol.1999
    • Rothwarf, D.M.1    Karin, M.2
  • 13
    • 36248944103 scopus 로고    scopus 로고
    • Ribosomal protein S3: A KH domain subunit in NF-kappaB complexes that mediates selective gene regulation
    • Wan F, Anderson DE, Barnitz RA, et al.. Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell 2007; 131:927-939.
    • (2007) Cell , vol.131 , pp. 927-939
    • Wan, F.1    Anderson, D.E.2    Barnitz, R.A.3
  • 14
    • 0025782658 scopus 로고
    • NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit
    • Urban MB, Schreck R, Baeuerle PA. NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J 1991; 10:1817-1825.
    • (1991) EMBO J , vol.10 , pp. 1817-1825
    • Urban, M.B.1    Schreck, R.2    Baeuerle, P.A.3
  • 16
    • 73849146550 scopus 로고    scopus 로고
    • Specification of DNA binding activity of NF-kappaB proteins
    • Wan F, Lenardo MJ. Specification of DNA binding activity of NF-kappaB proteins. Cold Spring Harb Perspect Biol 2009; 1:a000067.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Wan, F.1    Lenardo, M.J.2
  • 17
    • 0024516201 scopus 로고
    • The involvement of NF-kappaB in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction
    • Lenardo MJ, Fan CM, Maniatis T, Baltimore D. The involvement of NF-kappaB in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 1989; 57:287-294.
    • (1989) Cell , vol.57 , pp. 287-294
    • Lenardo, M.J.1    Fan, C.M.2    Maniatis, T.3    Baltimore, D.4
  • 18
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-kappaB pathway
    • Chen ZJ. Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 2005; 7:758-765.
    • (2005) Nat Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 19
    • 0034649424 scopus 로고    scopus 로고
    • NF-kappaB defects in humans: The NEMO/incontinentia pigmenti connection
    • Courtois G, Israel A. NF-kappaB defects in humans: the NEMO/incontinentia pigmenti connection. Sci STKE 2000; 2000:PE1.
    • (2000) Sci STKE , vol.2000
    • Courtois, G.1    Israel, A.2
  • 20
    • 33750443289 scopus 로고    scopus 로고
    • IkappaB kinase complexes: Gateways to NFkappaB activation and transcription
    • Scheidereit C. IkappaB kinase complexes: gateways to NFkappaB activation and transcription. Oncogene 2006; 25:6685-6705.
    • (2006) Oncogene , vol.25 , pp. 6685-6705
    • Scheidereit, C.1
  • 21
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKKrelated kinases
    • Hacker H, Karin M. Regulation and function of IKK and IKKrelated kinases. Sci STKE 2006; 2006:re13.
    • (2006) Sci STKE , vol.2006
    • Hacker, H.1    Karin, M.2
  • 22
    • 0032556894 scopus 로고    scopus 로고
    • Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA
    • Chen FE, Huang DB, Chen YQ, Ghosh G. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature 1998; 391:410-413.
    • (1998) Nature , vol.391 , pp. 410-413
    • Chen, F.E.1    Huang, D.B.2    Chen, Y.Q.3    Ghosh, G.4
  • 23
    • 18244379306 scopus 로고    scopus 로고
    • Interactions of NFkappaB with chromatin: The art of being at the right place at the right time
    • Natoli G, Saccani S, Bosisio D, Marazzi I. Interactions of NFkappaB with chromatin: the art of being at the right place at the right time. Nat Immunol 2005; 6:439-445.
    • (2005) Nat Immunol , vol.6 , pp. 439-445
    • Natoli, G.1    Saccani, S.2    Bosisio, D.3    Marazzi, I.4
  • 24
    • 33750448661 scopus 로고    scopus 로고
    • Transcriptional regulation via the NF-kappaB signaling module
    • Hoffmann A, Natoli G, Ghosh G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene 2006; 25:6706-6716.
    • (2006) Oncogene , vol.25 , pp. 6706-6716
    • Hoffmann, A.1    Natoli, G.2    Ghosh, G.3
  • 25
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • Sun SC, Ley SC. New insights into NF-kappaB regulation and function. Trends Immunol 2008; 29:469-478.
    • (2008) Trends Immunol , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 27
    • 0142105387 scopus 로고    scopus 로고
    • Genetic analysis of NFkappaB/ Rel transcription factors defines functional specificities
    • Hoffmann A, Leung TH, Baltimore D. Genetic analysis of NFkappaB/ Rel transcription factors defines functional specificities. EMBO J 2003; 22:5530-5539.
    • (2003) EMBO J , vol.22 , pp. 5530-5539
    • Hoffmann, A.1    Leung, T.H.2    Baltimore, D.3
  • 28
    • 4644252538 scopus 로고    scopus 로고
    • One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers
    • Leung TH, Hoffmann A, Baltimore D. One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers. Cell 2004; 118:453-464.
    • (2004) Cell , vol.118 , pp. 453-464
    • Leung, T.H.1    Hoffmann, A.2    Baltimore, D.3
  • 29
    • 0142027777 scopus 로고    scopus 로고
    • Distribution of NFkappaB- Binding sites across human chromosome 22
    • Martone R, Euskirchen G, Bertone P, et al.. Distribution of NFkappaB- binding sites across human chromosome 22. Proc Natl Acad Sci USA 2003; 100:12247-12252.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12247-12252
    • Martone, R.1    Euskirchen, G.2    Bertone, P.3
  • 30
    • 33645809747 scopus 로고    scopus 로고
    • Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide
    • Schreiber J, Jenner RG, Murray HL, et al.. Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide. Proc Natl Acad Sci USA 2006; 103:5899-5904.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5899-5904
    • Schreiber, J.1    Jenner, R.G.2    Murray, H.L.3
  • 31
    • 34547838179 scopus 로고    scopus 로고
    • Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation
    • Lim CA, Yao F, Wong JJ, et al.. Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation. Mol Cell 2007; 27:622-635.
    • (2007) Mol Cell , vol.27 , pp. 622-635
    • Lim, C.A.1    Yao, F.2    Wong, J.J.3
  • 32
    • 0027273728 scopus 로고
    • The premRNA binding K protein contains a novel evolutionarily conserved motif
    • Siomi H, Matunis MJ, Michael WM, Dreyfuss G. The premRNA binding K protein contains a novel evolutionarily conserved motif. Nucleic Acids Res 1993; 21:1193-1198.
    • (1993) Nucleic Acids Res , vol.21 , pp. 1193-1198
    • Siomi, H.1    Matunis, M.J.2    Michael, W.M.3    Dreyfuss, G.4
  • 33
    • 68149160774 scopus 로고    scopus 로고
    • NF-kappaB activity marks cells engaged in receptor editing
    • Cadera EJ, Wan F, Amin RH, et al.. NF-kappaB activity marks cells engaged in receptor editing. J Exp Med 2009; 206: 1803-1816.
    • (2009) J Exp Med , vol.206 , pp. 1803-1816
    • Cadera, E.J.1    Wan, F.2    Amin, R.H.3
  • 34
    • 36849040640 scopus 로고    scopus 로고
    • Complex formation of p65/ RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB
    • Kwon O, Kim KA, He L, et al.. Complex formation of p65/ RelA with nuclear Akt1 for enhanced transcriptional activation of NF-kappaB. Biochem Biophys Res Commun 2008; 365:771-776.
    • (2008) Biochem Biophys Res Commun , vol.365 , pp. 771-776
    • Kwon, O.1    Kim, K.A.2    He, L.3
  • 35
    • 0035936797 scopus 로고    scopus 로고
    • The TNF and TNF receptor superfamilies: Integrating mammalian biology
    • Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 2001; 104:487-501.
    • (2001) Cell , vol.104 , pp. 487-501
    • Locksley, R.M.1    Killeen, N.2    Lenardo, M.J.3
  • 36
    • 33745829370 scopus 로고    scopus 로고
    • Nuclear localization in the biology of the CD40 receptor in normal and neoplastic human B lymphocytes
    • Lin-Lee YC, Pham LV, Tamayo AT, et al.. Nuclear localization in the biology of the CD40 receptor in normal and neoplastic human B lymphocytes. J Biol Chem 2006; 281:18878-18887.
    • (2006) J Biol Chem , vol.281 , pp. 18878-18887
    • Lin-Lee, Y.C.1    Pham, L.V.2    Tamayo, A.T.3
  • 37
    • 34548831056 scopus 로고    scopus 로고
    • Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma
    • Zhou HJ, Pham LV, Tamayo AT, et al.. Nuclear CD40 interacts with c-Rel and enhances proliferation in aggressive B-cell lymphoma. Blood 2007; 110:2121-2127.
    • (2007) Blood , vol.110 , pp. 2121-2127
    • Zhou, H.J.1    Pham, L.V.2    Tamayo, A.T.3
  • 38
    • 66549095183 scopus 로고    scopus 로고
    • BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells
    • Fu L, Lin-Lee YC, Pham LV, et al.. BAFF-R promotes cell proliferation and survival through interaction with IKKbeta and NF-kappaB/c-Rel in the nucleus of normal and neoplastic B-lymphoid cells. Blood 2009; 113:4627-4636.
    • (2009) Blood , vol.113 , pp. 4627-4636
    • Fu, L.1    Lin-Lee, Y.C.2    Pham, L.V.3
  • 39
    • 58149380071 scopus 로고    scopus 로고
    • The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription
    • Wright CW, Duckett CS. The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. Science 2009; 323:251-255.
    • (2009) Science , vol.323 , pp. 251-255
    • Wright, C.W.1    Duckett, C.S.2
  • 40
    • 26844572062 scopus 로고    scopus 로고
    • RelA repression of RelB activity induces selective gene activation downstream of TNF receptors
    • Jacque E, Tchenio T, Piton G, Romeo PH, Baud V. RelA repression of RelB activity induces selective gene activation downstream of TNF receptors. Proc Natl Acad Sci USA 2005; 102:14635-14640.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14635-14640
    • Jacque, E.1    Tchenio, T.2    Piton, G.3    Romeo, P.H.4    Baud, V.5
  • 41
    • 37349109479 scopus 로고    scopus 로고
    • Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice
    • Goto A, Matsushita K, Gesellchen V, et al.. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat Immunol 2008; 9:97-104.
    • (2008) Nat Immunol , vol.9 , pp. 97-104
    • Goto, A.1    Matsushita, K.2    Gesellchen, V.3
  • 43
    • 43149105404 scopus 로고    scopus 로고
    • AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65
    • Gao N, Asamitsu K, Hibi Y, Ueno T, Okamoto T. AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. J Biol Chem 2008; 283:7834-7843.
    • (2008) J Biol Chem , vol.283 , pp. 7834-7843
    • Gao, N.1    Asamitsu, K.2    Hibi, Y.3    Ueno, T.4    Okamoto, T.5
  • 44
    • 68049148471 scopus 로고    scopus 로고
    • CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB
    • Kashima L, Toyota M, Mita H, et al.. CHFR, a potential tumor suppressor, downregulates interleukin-8 through the inhibition of NF-kappaB. Oncogene 2009; 28:2643-2653.
    • (2009) Oncogene , vol.28 , pp. 2643-2653
    • Kashima, L.1    Toyota, M.2    Mita, H.3
  • 45
    • 40449089338 scopus 로고    scopus 로고
    • Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1
    • Sarkar D, Park ES, Emdad L, et al.. Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1. Cancer Res 2008; 68:1478-1484.
    • (2008) Cancer Res , vol.68 , pp. 1478-1484
    • Sarkar, D.1    Park, E.S.2    Emdad, L.3
  • 46
    • 55449102824 scopus 로고    scopus 로고
    • The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes
    • Nozell S, Laver T, Moseley D, et al.. The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. Mol Cell Biol 2008; 28:6632-6645.
    • (2008) Mol Cell Biol , vol.28 , pp. 6632-6645
    • Nozell, S.1    Laver, T.2    Moseley, D.3
  • 47
    • 33749051214 scopus 로고    scopus 로고
    • Keeping up NF-kappaB appearances: Epigenetic control of immunity or inflammation-triggered epigenetics
    • Vanden Berghe W, Ndlovu MN, Hoya-Arias R, et al.. Keeping up NF-kappaB appearances: epigenetic control of immunity or inflammation-triggered epigenetics. Biochem Pharmacol 2006; 72:1114-1131.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1114-1131
    • Vanden Berghe, W.1    Ndlovu, M.N.2    Hoya-Arias, R.3
  • 48
    • 58149090925 scopus 로고    scopus 로고
    • SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span
    • Kawahara TL, Michishita E, Adler AS, et al.. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009; 136:62-74.
    • (2009) Cell , vol.136 , pp. 62-74
    • Kawahara, T.L.1    Michishita, E.2    Adler, A.S.3
  • 49
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NFkappaB- dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, et al.. Modulation of NFkappaB- dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23:2369-2380.
    • (2004) EMBO J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3
  • 50
    • 33745312695 scopus 로고    scopus 로고
    • C/EBP beta blocks p65 phosphorylation and thereby NF-kappaB-mediated transcription in TNF-tolerant cells
    • Zwergal A, Quirling M, Saugel B, et al.. C/EBP beta blocks p65 phosphorylation and thereby NF-kappaB-mediated transcription in TNF-tolerant cells. J Immunol 2006; 177:665-672.
    • (2006) J Immunol , vol.177 , pp. 665-672
    • Zwergal, A.1    Quirling, M.2    Saugel, B.3
  • 51
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo K, Winner B, Carson CT, et al.. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009; 137:47-59.
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1    Winner, B.2    Carson, C.T.3
  • 52
    • 63049089544 scopus 로고    scopus 로고
    • A Nurr1 pathway for neuroprotection
    • Bensinger SJ, Tontonoz P. A Nurr1 pathway for neuroprotection. Cell 2009; 137:26-28.
    • (2009) Cell , vol.137 , pp. 26-28
    • Bensinger, S.J.1    Tontonoz, P.2
  • 53
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 2002; 298:1241-1245.
    • (2002) Science , vol.298 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 54
    • 45149090556 scopus 로고    scopus 로고
    • Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation
    • Natoli G, Chiocca S. Nuclear ubiquitin ligases, NF-kappaB degradation, and the control of inflammation. Sci Signal 2008; 1:pe1.
    • (2008) Sci Signal , vol.1
    • Natoli, G.1    Chiocca, S.2
  • 55
    • 37149040167 scopus 로고    scopus 로고
    • Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export
    • Chen Y, Li HH, Fu J, et al.. Oncoprotein p28 GANK binds to RelA and retains NF-kappaB in the cytoplasm through nuclear export. Cell Res 2007; 17:1020-1029.
    • (2007) Cell Res , vol.17 , pp. 1020-1029
    • Chen, Y.1    Li, H.H.2    Fu, J.3
  • 56
    • 64849104716 scopus 로고    scopus 로고
    • Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription
    • Ashall L, Horton CA, Nelson DE, et al.. Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription. Science 2009; 324:242-246.
    • (2009) Science , vol.324 , pp. 242-246
    • Ashall, L.1    Horton, C.A.2    Nelson, D.E.3
  • 57
    • 3142771914 scopus 로고    scopus 로고
    • Degradation of promoter-bound p65/RelA is essential for the prompt termination of the uclear factor kappaB response
    • Saccani S, Marazzi I, Beg AA, Natoli G. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the uclear factor kappaB response. J Exp Med 2004; 200:107-113.
    • (2004) J Exp Med , vol.200 , pp. 107-113
    • Saccani, S.1    Marazzi, I.2    Beg, A.A.3    Natoli, G.4
  • 58
    • 34249066486 scopus 로고    scopus 로고
    • PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
    • Tanaka T, Grusby MJ, Kaisho T. PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol 2007; 8:584-591.
    • (2007) Nat Immunol , vol.8 , pp. 584-591
    • Tanaka, T.1    Grusby, M.J.2    Kaisho, T.3
  • 60
    • 0347955360 scopus 로고    scopus 로고
    • Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin- mediated proteolysis of p65/RelA
    • Ryo A, Suizu F, Yoshida Y, et al.. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin- mediated proteolysis of p65/RelA. Mol Cell 2003; 12:1413-1426.
    • (2003) Mol Cell , vol.12 , pp. 1413-1426
    • Ryo, A.1    Suizu, F.2    Yoshida, Y.3
  • 61
    • 33846475712 scopus 로고    scopus 로고
    • COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase
    • Maine GN, Mao X, Komarck CM, Burstein E. COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. EMBO J 2007; 26:436-447.
    • (2007) EMBO J , vol.26 , pp. 436-447
    • Maine, G.N.1    Mao, X.2    Komarck, C.M.3    Burstein, E.4
  • 62
    • 64349114240 scopus 로고    scopus 로고
    • GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA
    • Mao X, Gluck N, Li D, et al.. GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA. Gene Dev 2009; 23:849-861.
    • (2009) Gene Dev , vol.23 , pp. 849-861
    • Mao, X.1    Gluck, N.2    Li, D.3
  • 63
    • 64049112777 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination
    • Geng H, Wittwer T, Dittrich-Breiholz O, Kracht M, Schmitz ML. Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination. EMBO Rep 2009; 10:381-386.
    • (2009) EMBO Rep , vol.10 , pp. 381-386
    • Geng, H.1    Wittwer, T.2    Dittrich-Breiholz, O.3    Kracht, M.4    Schmitz, M.L.5
  • 64
    • 65649128907 scopus 로고    scopus 로고
    • Termination of NFkappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase
    • Rodrigues L, Filipe J, Seldon MP, et al.. Termination of NFkappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase. EMBO J 2009; 28:1283-1295.
    • (2009) EMBO J , vol.28 , pp. 1283-1295
    • Rodrigues, L.1    Filipe, J.2    Seldon, M.P.3
  • 65
    • 38849196277 scopus 로고    scopus 로고
    • Peptide-mediated disruption of NFkappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori
    • Bartels M, Schweda AT, Dreikhausen U, et al.. Peptide-mediated disruption of NFkappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori. J Immunol 2007; 179:7605-7613.
    • (2007) J Immunol , vol.179 , pp. 7605-7613
    • Bartels, M.1    Schweda, A.T.2    Dreikhausen, U.3
  • 66
    • 0035830875 scopus 로고    scopus 로고
    • The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element
    • Nourbakhsh M, Kalble S, Dorrie A, et al.. The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element. J Biol Chem 2001; 276:4501-4508.
    • (2001) J Biol Chem , vol.276 , pp. 4501-4508
    • Nourbakhsh, M.1    Kalble, S.2    Dorrie, A.3
  • 67
    • 58349094740 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation
    • Choi KC, Jung MG, Lee YH, et al.. Epigallocatechin-3-gallate, a histone acetyltransferase inhibitor, inhibits EBV-induced B lymphocyte transformation via suppression of RelA acetylation. Cancer Res 2009; 69:583-592.
    • (2009) Cancer Res , vol.69 , pp. 583-592
    • Choi, K.C.1    Jung, M.G.2    Lee, Y.H.3
  • 68
    • 33750446341 scopus 로고    scopus 로고
    • Inhibitors of NF-kappaB signaling and counting
    • Gilmore TD, Herscovitch M. Inhibitors of NF-kappaB signaling and counting. Oncogene 2006; 25:6887-6899.
    • (2006) Oncogene , vol.25 , pp. 6887-6899
    • Gilmore, T.D.1    Herscovitch, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.