Anti-invasive activity of ursolic acid correlates with the reduced expression of matrix metalloproteinase-9 (MMP-9) in HT1080 human fibrosarcoma cells

Cancer Research

Volumn 56, Issue 10, 1996, Pages 2281-2284

  Cha, Hee Jae ^a   Bae, Soo Kyung ^a   Lee, Ho Young ^a   Lee, Ok Hee ^a   Sato, Hiroshi ^b   Seiki, Motoharu ^b   Park, Byung Chae ^c   Kim, Kyu Won ^a  

^a Pusan National University   (South Korea)

^b KANAZAWA UNIVERSITY   (Japan)

^c Kosin University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE B; TISSUE INHIBITOR OF METALLOPROTEINASE; URSOLIC ACID;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; FIBROSARCOMA; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METASTASIS INHIBITION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION;

BASEMENT MEMBRANE; COLLAGENASES; DEPRESSION, CHEMICAL; ENZYME INDUCTION; FIBROSARCOMA; GELATINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BIOSYNTHESIS; PROTEINS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASES; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 0030002548     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Liotta, L A Tumor Invasion and metastases: role of the extracellular matrix Cancer Res., 46: 1-7, 1986.
2. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature (Lond.), 370. 61-65, 1994.
3. Stetler-Stevenson, W. G., Krutzch, H. C., and Liotta, L. A. Tissue inhibitor of metalloproteinase (TIMP-2). J Biol. Chem., 264: 17374-17378, 1989.
4. Huang, M. T , Ho, C. T., Wang, Z. Y., Ferraro T., Lou, Y. R., Stauber, K , Ma, W , Georgiadis, C., Laskin, J., and Conney, A. H Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid Cancer Res., 54: 701-708, 1994
5. Lee, H. Y., Chung, H. Y , Kim, K. H., Lee, J J . and Kim, K W. Induction of differentiation in the cultured F9 teratocarcinoma stem cells by triterpene acids. J. Cancer Res Clin. Oncol , 120: 513-518, 1994.
6. Tokuda, H , Ohigashi, H , Koshimizu, K., and Ito, Y. Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-tetradecanoylphorbol-13-acetate Cancer Lett., 33: 279-285, 1986
7. Ohigashi, H., Takamura, H., Koshimizu, H., Tokuda, H., and Ito, Y Search for possible antitumor promoters by inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation, ursolic and oleanotic acid from an anti-inflammatory Chinese medicinal plant. Glechoma hederaceae L. Cancer Lett., 30: 143-151, 1986
8. Sohn, K. H., Lee, H. Y., Chung, H Y , Young, H S., Yi, S Y., and Kim, K. W. Anti-angiogenic activity of triterpene acids. Cancer Lett., 94: 213-218, 1995.
9. Saiki, I., Fujii, H., Yoneda, J., Abe, F , Nakajima, M., Tsuruo, T., and Azuma, I. Role of aminopeptidase N (CD13) in tumor-cell invasion and extracellular matrix degradation. Int J. Cancer, 54: 137-143, 1993.
10. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid-guanidimum thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987
11. Sato, H , Kida, Y., Mai, M., Endo, Y., Sasaki, T., Tanaka, J., and Seiki. M Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitor of metalloproteinases in various human tumor cells. Oncogene, 7: 77-83, 1992.
12. Takino, T., Sato, H., Yamamoto, E., and Seiki, M. Cloning of a gene potentially encoding a novel matrix metalloproteinase having a trans-membrane domain at the C-terminus. Gene (Amst.), 115: 293-298, 1995.
13. Herron, G S , Werb, Z , Dwyer, K., and Banda, M. J. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors. J. Biol. Chem., 261: 2814-2819, 1986
14. Sato, H , and Seiki, M. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene, 8: 395-405, 1993.
15. Sato, H., Kita, M., and Seiki, M. v-Src activates the transcription of 92 kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements (RCEs) J. Biol Chem., 168: 23460-23468, 1993.
16. Sambrook, J., Fritsch, E F., and Maniatis, T. Transfection of coprecipitates of calcium phosphate. In: Molecular Cloning: A Laboratory Manual, Ed. 2, pp 16.32-16.40. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1989
17. Cullen, B. R , and Malim, M. H. Secreted placental alkaline phosphatase as a eukaryotic reporter gene In: Methods in Enzymology, Vol. 216, pp 362-368 New York: Academic Press, Inc., 1992.
18. Vistica, D. T., Skehan, P., Scudiero, D., Monks, A., Pittman, A , and Boyd, M. R. Tetrazolium-based assays for cellular viability a critical examination of selected parameters affecting formazan production. Cancer Res , 51: 2515-2520, 1991.
19. Nakajima, M., Welch, D , Belloni, P N., and Nicolson, G. L. Degradation of basement membrane type IV collagen and lung subendothelial matrix by rat mammary adenocarcinoma cell clones of differing metastatic potentials. Cancer Res., 47: 4869-4876, 1987.
20. Tsuchiya, Y., Endo, Y., Sato, H., Okada, Y , Mai, M., Sasaki, T., and Seiki, M. Expression of type IV collagenases in human tumor cell lines that can form liver colonies in chick embryo. Int. J Cancer, 56: 46-51, 1994.