Brain Derived Neurotrophic Factor: A novel neurotrophin involved in psychiatric and neurological disorders

Pharmacology and Therapeutics

Volumn 134, Issue 1, 2012, Pages 116-124

  Balaratnasingam, Sivasankaran ^a,b   Janca, Aleksandar ^b  

^a Kimberley Mental Health and Drug Service   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

BDNF; Depression; Movement disorders; Neurodegenerative diseases; Neurotrophic factors; Schizophrenia

Indexed keywords

ARIPIPRAZOLE; BRAIN DERIVED NEUROTROPHIC FACTOR; CLOZAPINE; FLUOXETINE; OLANZAPINE; RISPERIDONE;

ADDICTION; ALCOHOLISM; ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; BIPOLAR DISORDER; GENETIC EPIGENESIS; GENOMICS; HUMAN; HUNTINGTON CHOREA; MAJOR DEPRESSION; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSYCHOPHARMACOLOGY; REVIEW; SCHIZOPHRENIA; SUICIDE;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; HUMANS; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES;

EID: 84857363735     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2012.01.006     Document Type: Review

References (104)

1. T. Aid, A. Kazantseva, M. Piirsoo, K. Palm, and T. Timmusk Mouse and rat BDNF gene structure and expression revisited J Neurosci Res 85 2007 525 535
2. E. Alleva, and N. Francia Psychiatric vulnerability: suggestions from animal models and role of neurotrophins Neurosci Biobehav Rev 33 2009 525 536
3. C.A. Altar, P. Laeng, L.W. Jurata, J.A. Brockman, A. Lemire, and J. Bullard Electroconvulsive seizures regulate gene expression of distinct neurotrophic signaling pathways J Neurosci 24 2004 2667 2677
4. F. Angelucci, G. Spalletta, F.d. Iulio, A. Ciaramella, F. Salani, and A.E. Varsi Alzheimers Disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels Curr Alzheimer Res 7 2010 15 20
5. D.P. Ankeny, D.M. McTigue, Z. Guan, Q. Yan, O. Kinstler, and B.T. Stokes Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury Exp Neurol 170 2001 85 100
6. N. Assaife-Lopes, V.C. Sousa, D.B. Pereira, J.A. Ribeiro, M.V. Chao, and A.M. Sebastiao Activation of adenosine A(2A) receptors induces TrkB translocation and increases BDNF-mediated phospho-TrkB localization in lipid rafts: implications for neuromodulation J Neurosci 30 2010 8468 8480
7. D.T. Balu, B.A. Hoshaw, J.E. Malberg, S. Rosenzweig-Lipson, L.E. Schechter, and I. Lucki Differential regulation of central BDNF protein levels by antidepressant and non-antidepressant drug treatments Brain Res 1211 2008 37 43
8. Z.C. Baquet, P.C. Bickford, and K.R. Jones Brain-derived neurotrophic factor is required for the establishment of the proper number of dopaminergic neurons in the substantia nigra pars compacta J Neurosci 25 2005 6251 6259
9. A. Bird Perceptions of epigenetics Nature 447 2007 396 398
10. M. Blurton-Jones, M. Kitazawa, H. Martinez-Coria, N.A. Castello, F. Müller, J.F. Loring, T.R. Yamasaki, W.W. Poon, K.N. Green, and F.M. LaFerla Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer's Disease Proc Natl Acad Sci 106 2009 13549 13599
11. M. Bothwell Functional interactions of neurotrophins and neurotrophin receptors Annu Rev Neurosci 18 1995 223 253
12. I. Branchi The mouse communal nest: investigating the epigenetic influences of the early social environment on brain and behavior development Neurosci Biobehav Rev 33 2009 551 559
13. J. Bremner Long-term effects of childhood abuse on brain and neurobiology Child Adolesc Psychiatr Clin N Am 12 2003 271 292
14. A.R. Brunoni, M. Lopes, and F. Fregni A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression Int J Neuropsychopharmacol 11 2008 1169 1180
15. J.M. Canals, J.R. Pineda, J.F. Torres-Peraza, M. Bosch, R. Martin-Ibanez, and M.T. Munoz Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's disease J Neurosci 24 2004 7727 7739
16. D. Carlino, E. Leone, F. Di Cola, G. Baj, R. Marin, and G. Dinelli Low serum truncated-BDNF isoform correlates with higher cognitive impairment in schizophrenia J Psychiatr Res 45 2011 273 279
17. M.V. Chao Neurotrophins and their receptors: a convergence point for many signalling pathways Nat Rev Neurosci 4 2003 299 309
18. M.V. Chao, R. Rajagopal, and F.S. Lee Neurotrophin signalling in health and disease Clin Sci 110 2006 167 173
19. C.-C. Chen, and T.-L. Huang Effects of antipsychotics on the serum BDNF levels in schizophrenia Psychiatry Res 189 2011 327 330
20. Z.-Y. Chen, D. Jing, K.G. Bath, A. Ieraci, T. Khan, and C.-J. Siao Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior Science 314 2006 140 143
21. Z.-Y. Chen, P.D. Patel, G. Sant, C.-X. Meng, K.K. Teng, and B.L. Hempstead Variant Brain-Derived Neurotrophic Factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons J Neurosci 24 2004 4401 4411
22. J.W. Dalley, R.N. Cardinal, and T.W. Robbins Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates Neurosci Biobehav Rev 28 2004 771 784
23. A. Duffy The early stages of bipolar disorder and recent developments in the understanding of its neurobiology Future Neurol 5 2010 317 323
24. R.S. Duman Pathophysiology of depression: the concept of synaptic plasticity Eur Psychiatry 17 Supplement 3 2002 306 310
25. R.S. Duman, and L.M. Monteggia A neurotrophic model for stress-related mood disorders Biol Psychiatry 59 2006 1116 1127
26. M.F. Egan, M. Kojima, J.H. Callicott, T.E. Goldberg, B.S. Kolachana, and A. Bertolino The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function Cell 112 2003 257 269
27. E.A. Fox, and M.S. Byerly A mechanism underlying mature-onset obesity: evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants Am J Physiol Regul Integr Comp Physiol 286 2004 R994 R1004
28. A. Fujinami, K. Ohta, H. Obayashi, M. Fukui, G. Hasegawa, and N. Nakamura Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: relationship to glucose metabolism and biomarkers of insulin resistance Clin Biochem 41 2008 812 817
29. T. Fukumoto, S. Morinobu, Y. Okamoto, A. Kagaya, and S. Yamawaki Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain Psychopharmacology 158 2001 100 106
30. U.E. Ghitza, H. Zhai, P. Wu, M. Airavaara, Y. Shaham, and L. Lu Role of BDNF and GDNF in drug reward and relapse: a review Neurosci Biobehav Rev 35 2010 157 171
31. A. Gonul, F. Akdeniz, F. Taneli, O. Donat, Ç. Eker, and S. Vahip Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients Eur Arch Psychiatry Clin Neurosci 255 2005 381 386
32. J. Gray, G.S.H. Yeo, J.J. Cox, J. Morton, A.-L.R. Adlam, and J.M. Keogh Hyperphagia, severe obesity, impaired cognitive function, and hyperactivity associated with functional loss of one copy of the Brain-Derived Neurotrophic Factor (BDNF) gene Diabetes 55 2006 3366 3371
33. M.J. Green, S.L. Matheson, A. Shepherd, C.S. Weickert, and V.J. Carr Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis Mol Psychiatry 16 2011 960 972
34. D.W. Howells, M.J. Porritt, J.Y.F. Wong, P.E. Batchelor, R. Kalnins, and A.J. Hughes Reduced BDNF mRNA expression in the Parkinson's disease substantia nigra Exp Neurol 166 2000 127 135
35. E. Huang, and L. Reichardt Neurotrophins: roles in neuronal development and function Annu Rev Neurosci 24 2001 677 736
36. M.-C. Huang, C.-H. Chen, H.-C. Liu, C.-C. Chen, C.-C. Ho, and S.-J. Leu Differential patterns of serum brain-derived neurotrophic factor levels in alcoholic patients with and without delirium tremens during acute withdrawal Alcohol Clin Exp Res 35 2011 126 131
37. G. Issa, C. Wilson, A.V. Terry Jr., and A. Pillai An inverse relationship between cortisol and BDNF levels in schizophrenia: data from human postmortem and animal studies Neurobiol Dis 39 2010 327 333
38. F. Kapczinski, B.N. Frey, M. Kauer-Sant'Anna, and R. Grassi-Oliveira Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder Expert Rev Neurother 8 2008 1101 1113
39. F. Karege, G. Perret, G. Bondolfi, M. Schwald, G. Bertschy, and J.M. Aubry Decreased serum brain-derived neurotrophic factor levels in major depressed patients Psychiatry Res 109 2002 143 148
40. F. Karege, G. Vaudan, M. Schwald, N. Perroud, and R. La Harpe Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs Mol Brain Res 136 2005 29 37
41. S.G. Kernie, D.J. Liebl, and L.F. Parada BDNF regulates eating behavior and locomotor activity in mice EMBO J 19 2000 1290 1300
42. M. Koda, M. Hashimoto, M. Murakami, H. Shirasawa, S. Sakao, and H. Ino Adenovirus vector-mediated in vivo gene transfer of brain-derived neurotrophic factor (BDNF) promotes rubrospinal axonal regeneration and functional recovery after complete transection of the adult rat spinal cord J Neurotrauma 21 2004 329 337
43. E. Koponen, T. Rantamaki, V. Voikar, T. Saarelainen, E. MacDonald, and E. Castren Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines Cell Mol Neurobiol 25 2005 973 980
44. A. Korosi, and T.Z. Baram The pathways from mother's love to baby's future Front Behav Neurosci 3 2009
45. A.E. Lang, S. Gill, N.K. Patel, A. Lozano, J.G. Nutt, and R. Penn Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease Ann Neurol 59 2006 459 466
46. B. Lee, and Y. Kim The roles of BDNF in the pathophysiology of major depression and in antidepressant treatment Psychiatry Invest 7 2010 231 235
47. F.S. Lee, and M.V. Chao Activation of Trk neurotrophin receptors in the absence of neurotrophins Proc Natl Acad Sci U S A 98 2001 3555 3560
48. R. Levi-Montalcini The nerve growth factor 35 years later Science 237 1987 1154 1162
49. D. Levinson The genetics of depression: a review Biol Psychiatry 60 2006 84 92
50. M. Levivier, S. Przedborski, C. Bencsics, and U.J. Kang Intrastriatal implantation of fibroblasts genetically engineered to produce Brain Derived Neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's Disease J Neurosci 15 12 1995 7810 7820
51. T. Leyhe, G.W. Eschweiler, E. Stransky, T. Gasser, P. Annas, and H. Basun Increase of BDNF serum concentration in lithium treated patients with early Alzheimer's Disease J Alzheimers Dis 16 2009 649 656
52. M. Lippmann, A. Bress, C. Nemeroff, P. Plotsky, and L. Monteggia Long-term behavioural and molecular alterations associated with maternal separation in rats Eur J Neurosci 25 2007 3091 3098
53. Y. Liu, B.T. Himes, J. Moul, W.L. Huang, S.Y. Chow, and A. Tessler Application of recombinant adenovirus for in vivo gene delivery to spinal cord Brain Res 768 1997 19 29
54. Y. Liu, D. Kim, B. Himes, S. Chow, M. Murray, and A. Tessler Transplants of fibroblasts genetically modified to express BDNF promote regeneration of adult rat rubrospinal axons and recovery of forelimb function J Neurosci 19 1999 4370 4387
55. B. Lu, and J.H. Chang Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory Neuron Glia Biol 1 2004 377 384
56. R. Machado-Vieira, M.O. Dietrich, R. Leke, V.H. Cereser, V. Zanatto, and F. Kapczinski Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode Biol Psychiatry 61 2007 142 144
57. P.C. Maisonpierre, L. Belluscio, S. Squinto, N.Y. Ip, M.E. Furth, and R.M. Lindsay Neurotrophin-3-a neurotrophic factor related to NGF and BDNF Science 247 1990 1446 1451
58. R. Marmorstein, and R.C. Trievel Histone modifying enzymes: structures, mechanisms, and specificities Biochim Biophys Acta, Gene Regul Mech 1789 2009 58 68
59. K. Martinowich, and B. Lu Interaction between BDNF and serotonin: role in mood disorders Neuropsychopharmacology 33 2008 73 83
60. K. Martinowich, H. Manji, and B. Lu New insights into BDNF function in depression and anxiety Nat Neurosci 10 2007 1089 1093
61. S.M. Massa, T. Yang, Y. Xie, J. Shi, M. Bilgen, and J.N. Joyce Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents J Clin Invest 120 2010 1774 1785
62. A.K. McAllister, L.C. Katz, and D.C. Lo Neurotrophins and synaptic plasticity Annu Rev Neurosci 22 1999 295 318
63. N.N.H. McGough, D.Y. He, M.L. Logrip, J. Jeanblanc, K. Phamluong, and K. Luong RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction J Neurosci 24 2004 10542 10552
64. M.B. Müller, N. Toschi, A.E. Kresse, A. Post, and M.E., K. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain Neuropsychopharmacology 23 2000 205 215
65. C. Murgatroyd, A.V. Patchev, Y. Wu, V. Micale, Y. Bockmuehl, and D. Fischer Dynamic DNA methylation programs persistent adverse effects of early-life stress Nat Neurosci 12 2009 1559-U1108
66. A.H. Nagahara, D.A. Merrill, G. Coppola, S. Tsukada, B.E. Schroeder, and G.M. Shaked Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease Nat Med 15 2009 331 337
67. A.H. Nagahara, and M.H. Tuszynski Potential therapeutic uses of BDNF in neurological and psychiatric disorders Nat Rev Drug Discov 10 2011 209 219
68. T. Nakagawa, A. Tsuchida, Y. Itakura, T. Nonomura, M. Ono, and F. Hirota Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice Diabetes 49 2000 436 444
69. M. Nibuya, S. Morinobu, and R.S. Duman Regulation of BDNF and trkB messenger-MRNA in rat-brain by chronic electroconvulsive seizure and antidepressant drug treatments J Neurosci 15 1995 7539 7547
70. T. Numakawa, S. Suzuki, E. Kumamaru, N. Adachi, M. Richards, and H. Kunugi BDNF function and intracellular signaling in neurons Histol Histopathol 25 2010 237 258
71. P. Oswald, J. Del-Favero, I. Massat, D. Souery, S. Claes, and C. Van Broeckhoven No implication of brain-derived neurotrophic factor (BDNF) gene in unipolar affective disorder: evidence from Belgian first and replication patient-control studies Eur Neuropsychopharmacol 15 2005 491 495
72. E. Ozan, H. Okur, C. Eker, O.D. Eker, A.S. Gonul, and N. Akarsu The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels Brain Res Bull 81 2010 61 65
73. J. Park, E. Lim, S. Back, H. Na, Y. Park, and K. Sun Nerve regeneration following spinal cord injury using matrix metalloproteinase-sensitive, hyaluronic acid-based biomimetic hydrogel scaffold containing brain-derived neurotrophic factor J Biomed Mater Res A 93A 2010 1091 1099
74. S.W. Park, V.T. Phuong, C.H. Lee, J.G. Lee, M.K. Seo, and H.Y. Cho Effects of antipsychotic drugs on BDNF, GSK-3β, and β-catenin expression in rats subjected to immobilization stress Neurosci Res 71 2011 335 340 Dec
75. P.P. Pattabiraman, D. Tropea, C. Chiaruttini, E. Tongiorgi, A. Cattaneo, and L. Domenici Neuronal activity regulates the developmental expression and subcellular localization of cortical BDNF mRNA isoforms in vivo Mol Cell Neurosci 28 2005 556 570
76. M. Pedrini, I. Chendo, I. Grande, M.I. Lobato, P.S. Belmonte-de-Abreu, and C. Lersch Serum brain-derived neurotrophic factor and clozapine daily dose in patients with schizophrenia: a positive correlation Neurosci Lett 491 2011 207 210
77. S. Peng, J. Wuu, E.J. Mufson, and M. Fahnestock Precursor form of brain derived neurotrophic factor and mature brain derived neurotrophic factor are decreased in the pre clinical stages of Alzheimer's disease J Neurochem 93 2005 1412 1421
78. A. Piccinni, D. Marazziti, M. Catena, L. Domenici, A. Del Debbio, and C. Bianchi Plasma and serum brain-derived neurotrophic factor depressed patients during 1 year of antidepressant (BDNF) in treatments J Affect Disord 105 2008 279 283
79. A. Pillai Brain-derived neurotropic factor/TrkB signaling in the pathogenesis and novel pharmacotherapy of schizophrenia Neurosignals 16 2008 183 193
80. A. Pillai, A. Kale, S. Joshi, N. Naphade, M. Raju, and H. Nasrallah Decreased BDNF levels in CSF of drug-naive first-episode psychotic subjects: correlation with plasma BDNF and psychopathology Int J Neuropsychopharmacol 13 2010 535 539
81. R.F. Ren-Patterson, L.W. Cochran, A. Holmes, S. Sherrill, S.J. Huang, and T. Tolliver Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice J Neurosci Res 79 2005 756 771
82. A. Riccio, S. Ahn, C.M. Davenport, J.A. Blendy, and D.D. Ginty Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons Science 286 1999 2358
83. E.N. Rizos, P.G. Michalopoulou, N. Siafakas, N. Stefanis, A. Douzenis, and I. Rontos Association of serum brain-derived neurotrophic factor and duration of untreated psychosis in first-episode patients with schizophrenia Neuropsychobiology 62 2010 87 90
84. E.N. Rizos, I. Rontos, E. Laskos, G. Arsenis, P.G. Michalopoulou, and D. Vasilopoulos Investigation of serum BDNF levels in drug-naive patients with schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 32 2008 1308 1311
85. A. Rodriguez-Tebar, G. Dechant, and Y.-A. Barde Neurotrophins: structural relatedness and receptor interactions Philos Trans R Soc Lond B Biol Sci 331 1991 255 258
86. T.L. Roth, and J.D. Sweatt Epigenetic marking of the BDNF gene by early-life adverse experiences Horm Behav 59 2011 315 320
87. P.P. Roux, and P.A. Barker Neurotrophin signaling through the p75 neurotrophin receptor Prog Neurobiol 67 2002 203 233
88. J.K. Rybakowski, and A. Suwalska Excellent lithium responders have normal cognitive functions and plasma BDNF levels Int J Neuropsychopharmacol 13 2010 617 622
89. K.E.A. Saunders, and G.M. Goodwin The course of bipolar disorder Adv Psychiatr Treat 16 2010 318 328
90. O. Schulte-Herbrüggen, A. Braun, S. Rochlitzer, M.C. Jockers-Scherübl, and R. Hellweg Neurotrophic factors-a tool for therapeutic strategies in neurological, neuropsychiatric and neuroimmunological diseases? Curr Med Chem 14 2007 2318 2329
91. J. Schumacher, R.A. Jamra, T. Becker, S. Ohlraun, N. Klopp, and E.B. Binder Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression Biol Psychiatry 58 2005 307 314
92. E. Shimizu, K. Hashimoto, and M. Iyo Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits Am J Med Genet B Neuropsychiatr Genet 126B 2004 122 123
93. M.A. Smith, S. Makino, R. Kvetnansky, and R.M. Post Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neu-rotrophin-3 mRNAs in the hippocampus J Neurosci 15 1995 1768 1777
94. X.-Y. Song, F. Li, F.-H. Zhang, J.-H. Zhong, and X.-F. Zhou Peripherally-derived BDNF promotes regeneration of ascending sensory neurons after spinal cord injury PLoS One 3 2008
95. A.D. Strand, Z.C. Baquet, A.K. Aragaki, P. Holmans, L. Yang, and C. Cleren Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration J Neurosci 27 2007 11758 11768
96. A. Tadic, S. Wagner, K.F. Schlicht, D. Peetz, L. Borysenko, and N. Dreimueller The early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study Prog Neuropsychopharmacol Biol Psychiatry 35 2011 415 420
97. K.K. Teng, and B.L. Hempstead Neurotrophins and their receptors: signaling trios in complex biological systems Cell Mol Life Sci 61 2004 35 48
98. H. Thoenen, and M. Sendtner Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches Nat Neurosci 5 2002 1046 1050
99. A. Tsuchida, T. Nonomura, M. Ono-Kishino, T. Nakagawa, M. Taiji, and H. Noguchi Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice Int J Obes 25 2001 1286 1293
100. T. Tsukahara, M. Takeda, S. Shimohama, O. Ohara, and N. Hashimoto Effects of brain-derived neurotrophic factor on 1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine induced parkinsonism in monkeys Neurosurgery 37 1995 733 739
101. M.H. Ultsch, C. Wiesmann, L.C. Simmons, J. Henrich, M. Yang, and D. Reilly Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC1 J Mol Biol 290 1999 149 159
102. M. Verhagen, A. van der Meij, P.A.M. van Deurzen, J.G.E. Janzing, A. Arias-Vasquez, and J.K. Buitelaar Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity Mol Psychiatry 15 2010 260 271
103. D. Zala, A. Benchoua, E. Brouillet, V. Perrin, M.C. Gaillard, and A.D. Zurn Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment Neurobiol Dis 20 2005 785 798
104. X.Y. Zhang, D.F. Zhou, G.Y. Wu, L.Y. Cao, Y.L. Tan, and C.N. Haile BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia Neuropsychopharmacology 33 2008 2200 2205