A mechanism underlying mature-onset obesity: Evidence from the hyperphagic phenotype of brain-derived neurotrophic factor mutants

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 286, Issue 6 55-6, 2004, Pages

  Fox, Edward A ^a   Byerly, Mardi S ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Homeostasis; Meal pattern; Microstructural analysis; Neurotrophins

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADOLESCENT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; HYPERPHAGIA; LIPID DIET; MALE; MOUSE; MUTANT; NEGATIVE FEEDBACK; NONHUMAN; OBESITY; OVERNUTRITION; PHENOTYPE; POSITIVE FEEDBACK; PRIORITY JOURNAL; SATIETY; WEIGHT GAIN;

AGE OF ONSET; ANIMALS; BODY WEIGHT; BRAIN-DERIVED NEUROTROPHIC FACTOR; DIET; EATING; HYPERPHAGIA; MALE; MICE; MICE, KNOCKOUT; MUTATION; OBESITY;

EID: 2442663015     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00727.2003     Document Type: Article

References (47)

1. Achour L, Meance S, and Briend A. Comparison of gastric emptying of a solid and a liquid nutritional rehabilitation food. Eur J Clin Nutr 55: 769-772, 2001.
2. Brady R, Zaidi SI, Mayer C, and Katz DM. BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons. J Neurosci 19: 2131-2142, 1999.
3. Bray GA and York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev 59: 719-809, 1979.
4. Butler AA and Cone RD. The melanocortin receptors: lessons from knockout models. Neuropeptides 36: 77-84, 2002.
5. Butler AA, Marks DL, Fan W, Kuhn CM, Bartolome M, and Cone RD. Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat. Nat Neurosci 4: 605-611, 2001.
6. Canteras NS, Simerly RB, and Swanson LW. Organization of projections from the ventromedial nucleus of the hypothalamus: a Phaseolus vulgaris-leucoagglutinin study in the rat. J Comp Neurol 348: 41-79, 1994.
7. Danielsen EH, Magnuson DJ, and Gray TS. The central amygdaloid nucleus innervation of the dorsal vagal complex in rat: a Phaseolus vulgaris leucoagglutinin lectin anterograde tracing study. Brain Res Bull 22: 705-715, 1989.
8. Davis JD. A model for the control of ingestion-20 years later. In: Progress in Psychobiology and Physiological Psychology, edited by Morrison AR and Fluharty SJ. San Diego, CA: Academic, 1998, p. 127-173.
9. Deckner ML, Frisen J, Verge VM, Hokfelt T, and Risling M. Localization of neurotrophin receptors in olfactory epithelium and bulb. Neuroreport 5: 301-304, 1993.
10. Dong HW and Swanson LW. Projections from the rhomboid nucleus of the bed nuclei of the stria terminalis: implications for cerebral hemisphere regulation of ingestive behaviors. J Comp Neurol 463: 434-472, 2003.
11. Drewnowski A and Popkin BM. The nutrition transition: new trends in the global diet. Nutr Rev 55: 31-43, 1997.
12. Duan W, Guo Z, Jiang H, Ware M, and Mattson MP. Reversal of behavioral and metabolic abnormalities, and insulin resistance syndrome, by dietary restriction in mice deficient in brain-derived neurotrophic factor. Endocrinology 144: 2446-2453, 2003.
13. Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos G, and Katz DM. Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. J Neurosci 16: 5361-5371, 1996.
14. Erlanson-Albertsson C and York D. Enterostatin-a peptide regulating fat intake. Obes Res 5: 360-372, 1997.
15. Farley C, Cook JA, Spar BD, Austin TM, and Kowalski TJ. Meal pattern analysis of diet-induced obesity in susceptible and resistant rats. Obes Res 11: 845-851, 2003.
16. Ferdinandis TG, Dissanayake AS, and De Silva HJ. Effects of carbohydrate meals of varying consistency on gastric myoelectrical activity. Singapore Med J 43: 579-582, 2002.
17. Foster LA, Boeshore K, and Norgren R. Intestinal fat suppressed intake of fat longer than intestinal sucrose. Physiol Behav 64: 451-455, 1998.
18. Fox EA, Phillips RJ, Baronowsky EA, Byerly MS, Jones S, and Powley TL. Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety. J Neurosci 21: 8602-8615, 2001.
19. Gorski JA, Balogh SA, Wehner JM, and Jones KR. Learning deficits in forebrain-restricted brain-derived neurotrophic factor mutant mice. Neuroscience 121: 341-354, 2003.
20. Hajnal A, Takenouchi K, and Norgren R. Effect of intraduodenal lipid on parabrachial gustatory coding in awake rats. J Neurosci 19: 7182-7190, 1999.
21. Kaplan JM, Baird JP, and Grill HJ. Dissociation of licking and volume intake controls in rats ingesting glucose and maltodextrin. Behav Neurosci 115: 188-195, 2001.
22. Kerlin P and Phillips S. Differential transit of liquids and solid residue through the human ileum. Am J Physiol Gastrointest Liver Physiol 245: G38-G43, 1983.
23. Kernie SG, Liebl DJ, and Parada LF. BDNF regulates eating behavior and locomotor activity in mice. EMBO J 19: 1290-1300, 2000.
24. Kissileff HR, Nakashima RK, and Stunkard AJ. Effects of jejunoileal bypass on meal patterns in genetically obese and lean rats. Am J Physiol Regul Integr Comp Physiol 237: R217-R224, 1979.
25. Kuhlbusch R, Zacchi-Deutschbein P, Frieling T, Lubke HJ, and Enck P. Postprandial changes of electrical activity of the stomach after different meals. Z Gastroenterol 36: 885-886, 889-891, 1998.
26. Lommatzsch M, Braun A, Mannsfeldt A, Botchkarev VA, Botchkareva NV, Paus R, Fischer A, Lewin GR, and Renz H. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions. Am J Pathol 155: 1183-1193, 1999.
27. Lyons WE, Mamounas LA, Ricaurte GA, Coppola V, Reid SW, Bora SH, Wihler C, Koliatsos VE, and Tessarollo L. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc Natl Acad Sci USA 96: 15239-15244, 1999.
28. Mistretta CM, Goosens KA, Farinas I, and Reichardt LF. Alterations in size, number, and morphology of gustatory papillae and taste buds in BDNF null mutant mice demonstrate neural dependence of developing taste organs. J Comp Neurol 409: 13-24, 1999.
29. Moga MM, Herbert H, Hurley KM, Yasui Y, Gray TS, and Saper CB. Organization of cortical, basal forebrain, and hypothalamic afferents to the parabrachial nucleus in the rat. J Comp Neurol 295: 624-661, 1990.
30. Mojaverian P, Ferguson RK, Vlasses PH, Rocci ML Jr, Oren A, Fix JA, Caldwell LJ, and Gardner C. Estimation of gastric residence time of the Heidelberg capsule in humans: effect of varying food composition. Gastroenterology 89: 392-397, 1985.
31. Montague MC. The physiology of obesity. ABNF J 14: 56-60, 2003.
32. Nakagawa T, Ogawa Y, Ebihara K, Yamanaka M, Tsuchida A, Taiji M, Noguchi H, and Nakao K. Anti-obesity and anti-diabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance. Int J Obes Relat Metab Disord 27: 557-565, 2003.
33. Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, Hirota F, Inoue T, Nakayama C, Taiji M, and Noguchi H. Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49: 436-444, 2000.
34. Nonomura T, Tsuchida A, Ono-Kishino M, Nakagawa T, Taiji M, and Noguchi H. Brain-derived neurotrophic factor regulates energy expenditure through the central nervous system in obese diabetic mice. Int J Exp Diabetes Res 2: 201-209, 2001.
35. Nosrat CA, Ebendal T, and Olson L. Differential expression of brain-derived neurotrophic factor and neurotrophin 3 mRNA in lingual papillae and taste buds indicates roles in gustatory and somatosensory innervation. J Comp Neurol 376: 587-602, 1996.
36. Prentice AM. Obesity and its potential mechanistic basis. Br Med Bull 60: 51-67, 2001.
37. Rios M, Fan G, Fekete C, Kelly J, Bates B, Kuehn R, Lechan RM, and Jaenisch R. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15: 1748-1757, 2001.
38. Sclafani A and Ackroff K. Deprivation alters rats' flavor preferences for carbohydrates and fats. Physiol Behav 53: 1091-1099, 1993.
39. Smith BK, York DA, and Bray GA. Activation of hypothalamic serotonin receptors reduced intake of dietary fat and protein but not carbohydrate. Am J Physiol Regul Integr Comp Physiol 277: R802-R811, 1999.
40. Smith GP. The controls of eating: a shift from nutritional homeostasis to behavioral neuroscience. Nutrition 16: 814-820, 2000.
41. Strohmayer AJ and Smith GP. The meal pattern of genetically obese (ob/ob) mice. Appetite 8: 111-123, 1987.
42. Tecott LH and Abdallah L. Mouse genetic approaches to feeding regulation: serotonin 5-HT2C receptor mutant mice. CNS Spectr 8: 584-588, 2003.
43. Timmusk T, Belluardo N, Metsis M, and Persson H. Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues. Eur J Neurosci 5: 605-613, 1993.
44. Tonra JR, Ono M, Liu X, Garcia K, Jackson C, Yancopoulos GD, Wiegand SJ, and Wong V. Brain-derived neurotrophic factor improves blood glucose control and alleviates fasting hyperglycemia in C57BLKS-Lepr(db)/lepr(db) mice. Diabetes 48: 588-594, 1999.
45. Warwick ZS and Synowski SJ. Effect of food deprivation and maintenance diet composition on fat preference and acceptance in rats. Physiol Behav 68: 235-239, 1999.
46. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, and Reichardt LF. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 736-742, 2003.
47. Zhang C, Brandemihl A, Lau D, Lawton A, and Oakley B. BDNF is required for the normal development of taste neurons in vivo. Neuroreport 8: 1013-1017, 1997.