Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice

Diabetes

Volumn 49, Issue 3, 2000, Pages 436-444

  Nakagawa, Tsutomu ^a   Tsuchida, Atsushi ^a   Itakura, Yasushi ^a   Nonomura, Takeshi ^a   Ono, Michiko ^a   Hirota, Fumiyo ^a   Inoue, Tadashi ^a   Nakayama, Chikao ^a   Taiji, Mutsuo ^a   Noguchi, Hiroshi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; GLUCAGON; GLUCOSE; INSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DIABETES MELLITUS; ENERGY BALANCE; ENERGY METABOLISM; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HORMONE ACTION; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 18144435678     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.3.436     Document Type: Article

References (40)

1. Korsching S: The neurotrophic factor concept: a reexamination. J Neurosci 13:2739-2748, 1993
2. Yuen EC, Howe CL, Li Y, Holtzman DM, Mobley WC: Nerve growth factor and the neurotrophic factor hypothesis. Brain Dev 18:362-368, 1996
3. Lindsay RM, Wiegand SJ, Altar CA, DiStefano PS: Neurotrophic factors: from molecule to man. Trends Neurosci 17:182-190, 1994
4. Skup MH: BDNF and NT-3 widen the scope of neurotrophin activity: pharmacological implications. Acta Neurobiol Exp 54:81-94, 1994
5. Barbacid M: Neurotrophic factors and their receptors. Curr Opin Cell Biol 7:148-155, 1995
6. Lewin GR, Barde YA: Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317, 1996
7. Hofer M, Pagliusi SR, Hohn A, Leibrock J, Barde YA: Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J 9:2459-2464, 1990
8. Schecterson LC, Bothwell M: Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron 9:449-463, 1992
9. Merlio JP, Ernfors P, Jaber M, Persson H: Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system. Neuroscience 51:513-532, 1992
10. Barbacid M: The trk family of neurotrophin receptors. J Neurobiol 25:1386-1403, 1994
11. Yuen EC, Mobley WC: Therapeutic potential of neurotrophic factors for neurological disorders. Ann Neurol 40:346-354, 1996
12. Connor B, Dragunow M: The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Res Brain Res Rev 27:1-39, 1998
13. Ono M, Ichihara J, Nonomura T, Itakura Y, Taiji M, Nakayama C, Noguchi H: Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238:633-637, 1997
14. db mice. Diabetes 48: 588-594, 1999
15. Coleman DL: Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14:141-148, 1978
16. Like AA, Chick WL: Studies in the diabetic mutant mouse. I. Light microscopy and radioautography of pancreatic islets. Diabetologia 6:207-215, 1970
17. Swenne I, Andersson A: Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27:464-467, 1984
18. Chick WL, Like AA: Studies in the diabetic mutant mouse. III. Physiological factors associated with alteration in beta cell proliferation. Diabetologia 6:243-251, 1970
19. Roesler WJ, Khandelwal RL: Age-related changes in hepatic glycogen metabolism in the genetically diabetic (db/db) mouse. Diabetes 34:395-402, 1985
20. Iwatsuka H, Shino A: Studies on diabetogenic action of obesity in mice: congenital insulin resistance of KK mice. Endocrinologia Japonica 17:535-540, 1970
21. Tabata H, Kubo M, Suzuki H, Matsuzawa T: Rapid determination of haemoglobin A1c and glucose in mice: strain difference, glucose tolerance tests and the neonatal streptozotocin-induced diabetic model. Comp Haematol Int 8:53-57, 1998
22. Gomori G: Aldehyde-fuchsin: a new stain for elastic tissue. Am J Clin Pathol 20:665-666, 1950
23. Mayer J, Russell RE, Bates MW, Dickie MM: Basal oxygen consumption of hereditarily obese and diabetic mice. Endocrinology 50:318-323, 1952
24. Joosten HFP, van der Kroon PHW: Role of the thyroid in the development of the obese-hyperglycemic syndrome in mice (ob/ob). Metabolism 23:425-436, 1974
25. 2 consumption, and early detection of ob/ob genotype in mice. Am J Physiol 227:912-915, 1974
26. Himms-Hagen J: Brown adipose tissue metabolism and thermogenesis. Annu Rev Nutr 5:69-94, 1985
27. Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM: Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci U S A 94:7001-7005, 1997
28. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98:1101-1106, 1996
29. Elmquist JK, Ahima RS, Maratos-Flier E, Flier JS, Saper CB: Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138: 839-842, 1997
30. Hetherington AW, Ranson SW: The spontaneous activity and food intake of rats with hypothalamic lesions. Am J Physiol 130:609-617, 1942
31. Hallakou S, Doare L, Foufelle F, Kergoat M, Guerre-Millo M, Berthault MF, Dugail I, Morin J, Auwerx J, Ferre P: Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. Diabetes 46:1393-1399, 1997
32. Okuno A, Tamemoto H, Tobe K, Ueki K, Mori Y, Iwamoto K, Umesono K, Akanuma Y, Fujiwara T, Horikoshi H, Yazaki Y, Kadowaki T: Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101:1354-1361, 1998
33. Fujiwara T, Yoshioka S, Yoshioka T, Ushiyama I, Horikoshi H: Characterization of new oral antidiabetic agent CS-045: studies in KK and ob/ob mice and Zucker fatty rats. Diabetes 37:1549-1558, 1988
34. Suter SL, Nolan JJ, Wallace P, Gumbiner B, Olefsky JM: Metabolic effects of new oral hypoglycemic agent CS-045 in NIDDM subjects. Diabetes Care 15:193-203, 1992
35. Ikeda H, Taketomi S, Sugiyama Y, Shimura Y, Sohda T, Meguro K, Fujita T: Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneimittelforschung 40:156-162, 1990
36. Tominaga M, Igarashi M, Daimon M, Eguchi H, Matsumoto M, Sekikawa A, Yamatani K, Sasaki H: Thiazolidinediones (AD-4833 and CS-045) improve hepatic insulin resistance in streptozotocin-induced diabetic rats. Endocr J 40:343-349, 1993
37. Lehmann JM, Moore LB, Smith-Oliver TA, Wilkinson WO, Willson TM, Kliewer SA: An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 270: 12953-12956, 1995
38. Shibayama E, Koizumi H: Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am J Pathol 148:1807-1818, 1996
39. Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M: Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 28:103-117, 1995
40. Shichiri M: Symposium on treatment of diabetic complications. V. Strict glycemic control and diabetic microvascular complications. Intern Med 36: 144-147, 1997