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Volumn , Issue JANUARY, 2012, Pages

Intracerebral transplantation for neurological disorders. Lessons from developmental, experimental, and clinical studies

Author keywords

Brain plasticity; Embryonic stem cells; Induced pluripotent stem cells; Neurogenesis; Transplantation

Indexed keywords

CELL CULTURE; CELL MATURATION; CELL POPULATION; CELL TYPE; CELLULAR DISTRIBUTION; EMBRYO DEVELOPMENT; ENGRAFTMENT; EXPERIMENTAL STUDY; HUMAN; HUNTINGTON CHOREA; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; PARKINSON DISEASE; PLURIPOTENT STEM CELL; REVIEW; RISK ASSESSMENT; SPINAL CORD MOTONEURON; STEM CELL NICHE; STEM CELL TRANSPLANTATION;

EID: 84857016901     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2012.00002     Document Type: Review
Times cited : (2)

References (148)
  • 2
    • 0001159822 scopus 로고
    • Are new neurons formed in the brains of adult mammals?
    • Altman, J. (1962). Are new neurons formed in the brains of adult mammals? Science 135, 1127-1128.
    • (1962) Science , vol.135 , pp. 1127-1128
    • Altman, J.1
  • 4
    • 55949130712 scopus 로고    scopus 로고
    • Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats
    • Aubry, L., Bugi, A., Lefort, N., Rousseau, F., Peschanski, M., and Perrier, A. L. (2008). Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats. Proc. Natl. Acad. Sci. U.S.A. 105, 16707-16712.
    • (2008) Proc. Natl. Acad. Sci. U.S.A , vol.105 , pp. 16707-16712
    • Aubry, L.1    Bugi, A.2    Lefort, N.3    Rousseau, F.4    Peschanski, M.5    Perrier, A.L.6
  • 6
    • 33846977750 scopus 로고    scopus 로고
    • Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord
    • Battiste, J., Helms, A. W., Kim, E. J., Savage, T. K., Lagace, D. C., Mandyam, C. D., Eisch, A. J., Miyoshi, G., and Johnson, J. E. (2007). Ascl1 defines sequentially generated lineage-restricted neuronal and oligodendrocyte precursor cells in the spinal cord. Development 134, 285-293.
    • (2007) Development , vol.134 , pp. 285-293
    • Battiste, J.1    Helms, A.W.2    Kim, E.J.3    Savage, T.K.4    Lagace, D.C.5    Mandyam, C.D.6    Eisch, A.J.7    Miyoshi, G.8    Johnson, J.E.9
  • 7
    • 0036862406 scopus 로고    scopus 로고
    • Initiating Hox gene expression: In the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups
    • Bel-Vialar, S., Itasaki, N., and Krumlauf, R. (2002). Initiating Hox gene expression: in the early chick neural tube differential sensitivity to FGF and RA signaling subdivides the HoxB genes in two distinct groups. Development 129, 5103-5115.
    • (2002) Development , vol.129 , pp. 5103-5115
    • Bel-Vialar, S.1    Itasaki, N.2    Krumlauf, R.3
  • 8
    • 0037386102 scopus 로고    scopus 로고
    • Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor
    • Bell, E., Munoz-Sanjuan, I., Altmann, C. R., Vonica, A., and Brivanlou, A. H. (2003). Cell fate specification and competence by Coco, a maternal BMP, TGFbeta and Wnt inhibitor. Development 130, 1381-1389.
    • (2003) Development , vol.130 , pp. 1381-1389
    • Bell, E.1    Munoz-Sanjuan, I.2    Altmann, C.R.3    Vonica, A.4    Brivanlou, A.H.5
  • 9
    • 10444252732 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
    • Ben-Hur, T., Idelson, M., Khaner, H., Pera, M., Reinhartz, E., Itzik, A., and Reubinoff, B. E. (2004). Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 22, 1246-1255.
    • (2004) Stem Cells , vol.22 , pp. 1246-1255
    • Ben-Hur, T.1    Idelson, M.2    Khaner, H.3    Pera, M.4    Reinhartz, E.5    Itzik, A.6    Reubinoff, B.E.7
  • 10
    • 0037106657 scopus 로고    scopus 로고
    • Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells
    • Billon, N., Jolicoeur, C., Ying, Q. L., Smith, A., and Raff, M. (2002). Normal timing of oligodendrocyte development from genetically engineered, lineage-selectable mouse ES cells. J. Cell Sci. 115, 3657-3665.
    • (2002) J. Cell Sci , vol.115 , pp. 3657-3665
    • Billon, N.1    Jolicoeur, C.2    Ying, Q.L.3    Smith, A.4    Raff, M.5
  • 12
    • 33744536299 scopus 로고    scopus 로고
    • Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
    • Blaess, S., Corrales, J. D., and Joyner, A. L. (2006). Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region. Development 133, 1799-1809.
    • (2006) Development , vol.133 , pp. 1799-1809
    • Blaess, S.1    Corrales, J.D.2    Joyner, A.L.3
  • 14
    • 0029775569 scopus 로고    scopus 로고
    • Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
    • Bouwmeester, T., Kim, S., Sasai, Y., Lu, B., and De Robertis, E. M. (1996). Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
    • (1996) Nature , vol.382 , pp. 595-601
    • Bouwmeester, T.1    Kim, S.2    Sasai, Y.3    Lu, B.4    de Robertis, E.M.5
  • 15
    • 0035499454 scopus 로고    scopus 로고
    • Ten years of protein kinase B signalling: A hard Akt to follow
    • Brazil, D. P., and Hemmings, B. A. (2001). Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26, 657-664.
    • (2001) Trends Biochem. Sci , vol.26 , pp. 657-664
    • Brazil, D.P.1    Hemmings, B.A.2
  • 17
    • 52449117926 scopus 로고    scopus 로고
    • Research in motion: The enigma of Parkinson's disease pathology spread
    • Brundin, P., Li, J. Y., Holton, J. L., Lindvall, O., and Revesz, T. (2008). Research in motion: the enigma of Parkinson's disease pathology spread. Nat. Rev. Neurosci. 9, 741-745.
    • (2008) Nat. Rev. Neurosci , vol.9 , pp. 741-745
    • Brundin, P.1    Li, J.Y.2    Holton, J.L.3    Lindvall, O.4    Revesz, T.5
  • 18
    • 33845325474 scopus 로고    scopus 로고
    • Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats
    • Bühnemann, C., Scholz, A., Bernreuther, C., Malik, C. Y., Braun, H., Schachner, M., Reymann, K. G., and Dihné, M. (2006). Neuronal differentiation of transplanted embryonic stem cell-derived precursors in stroke lesions of adult rats. Brain 129, 3238-3248.
    • (2006) Brain , vol.129 , pp. 3238-3248
    • Bühnemann, C.1    Scholz, A.2    Bernreuther, C.3    Malik, C.Y.4    Braun, H.5    Schachner, M.6    Reymann, K.G.7    Dihné, M.8
  • 19
    • 11344277387 scopus 로고    scopus 로고
    • Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling
    • Cai, J., Qi, Y., Hu, X., Tan, M., Liu, Z., Zhang, J., Li, Q., Sander, M., and Qiu, M. (2005). Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling. Neuron 45, 41-53.
    • (2005) Neuron , vol.45 , pp. 41-53
    • Cai, J.1    Qi, Y.2    Hu, X.3    Tan, M.4    Liu, Z.5    Zhang, J.6    Li, Q.7    Sander, M.8    Qiu, M.9
  • 20
    • 62149125434 scopus 로고    scopus 로고
    • Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
    • Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M., Sadelain, M., and Studer, L. (2009). Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 27, 275-280.
    • (2009) Nat. Biotechnol , vol.27 , pp. 275-280
    • Chambers, S.M.1    Fasano, C.A.2    Papapetrou, E.P.3    Tomishima, M.4    Sadelain, M.5    Studer, L.6
  • 21
    • 36549057057 scopus 로고    scopus 로고
    • Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation
    • Chang, C., and Harland, R. M. (2007). Neural induction requires continued suppression of both Smad1 and Smad2 signals during gastrulation. Development 134, 3861-3872.
    • (2007) Development , vol.134 , pp. 3861-3872
    • Chang, C.1    Harland, R.M.2
  • 22
    • 33646576842 scopus 로고    scopus 로고
    • Genetic selection of SOX1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation
    • Chung, S., Shin, B. S., Hedlund, E., Pruszak, J., Ferree, A., Kang, U. J., Isacson, O., and Kim, K. S. (2006). Genetic selection of SOX1GFP-expressing neural precursors removes residual tumorigenic pluripotent stem cells and attenuates tumor formation after transplantation. J. Neurochem. 97, 1467-1480.
    • (2006) J. Neurochem , vol.97 , pp. 1467-1480
    • Chung, S.1    Shin, B.S.2    Hedlund, E.3    Pruszak, J.4    Ferree, A.5    Kang, U.J.6    Isacson, O.7    Kim, K.S.8
  • 24
    • 45749113333 scopus 로고    scopus 로고
    • Adherent self-renewable human embryonic stem cell-derived neural stem cell line: Functional engraft-ment in experimental stroke model
    • doi: 10.1371/journal.pone.0001644
    • Daadi, M., Maag, A. L., and Steinberg, G. K. (2008). Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraft-ment in experimental stroke model. PLoS One 3, e1644. doi: 10.1371/journal.pone.0001644
    • (2008) PLoS One , vol.3
    • Daadi, M.1    Maag, A.L.2    Steinberg, G.K.3
  • 25
    • 33747593039 scopus 로고    scopus 로고
    • Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brain
    • Dihné, M., Bernreuther, C., Hagel, C., Wesche, K. O., and Schachner, M. (2006). Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brain. Stem Cells 24, 1458-1466.
    • (2006) Stem Cells , vol.24 , pp. 1458-1466
    • Dihné, M.1    Bernreuther, C.2    Hagel, C.3    Wesche, K.O.4    Schachner, M.5
  • 27
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard, Y., Epstein, D. J., St-Jacques, B., Shen, L., Mohler, J., Mcmahon, J. A., and Mcmahon, A. P. (1993). Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75, 1417-1430.
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 30
    • 77949892562 scopus 로고    scopus 로고
    • Efficient derivation of functional floor plate tissue from human embryonic stem cells
    • Fasano, C. A., Chambers, S. M., Lee, G., Tomishima, M. J., and Studer, L. (2010). Efficient derivation of functional floor plate tissue from human embryonic stem cells. Cell Stem Cell 6, 336-347.
    • (2010) Cell Stem Cell , vol.6 , pp. 336-347
    • Fasano, C.A.1    Chambers, S.M.2    Lee, G.3    Tomishima, M.J.4    Studer, L.5
  • 32
    • 33745001244 scopus 로고    scopus 로고
    • Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation
    • Fukuda, H., Takahashi, J., Watanabe, K., Hayashi, H., Morizane, A., Koyanagi, M., Sasai, Y., and Hashimoto, N. (2006). Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation. Stem Cells 24, 763-771.
    • (2006) Stem Cells , vol.24 , pp. 763-771
    • Fukuda, H.1    Takahashi, J.2    Watanabe, K.3    Hayashi, H.4    Morizane, A.5    Koyanagi, M.6    Sasai, Y.7    Hashimoto, N.8
  • 33
    • 34748861854 scopus 로고    scopus 로고
    • Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons
    • Gaillard, A., Prestoz, L., Dumartin, B., Cantereau, A., Morel, F., Roger, M., and Jaber, M. (2007). Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons. Nat. Neurosci. 10, 1294-1299.
    • (2007) Nat. Neurosci , vol.10 , pp. 1294-1299
    • Gaillard, A.1    Prestoz, L.2    Dumartin, B.3    Cantereau, A.4    Morel, F.5    Roger, M.6    Jaber, M.7
  • 34
    • 11244351576 scopus 로고    scopus 로고
    • Generation of purified oligodendrocyte progenitors from embryonic stem cells
    • Glaser, T., Perez-Bouza, A., Klein, K., and Brüstle, O. (2005). Generation of purified oligodendrocyte progenitors from embryonic stem cells. FASEB J. 19, 112-114.
    • (2005) FASEB J , vol.19 , pp. 112-114
    • Glaser, T.1    Perez-Bouza, A.2    Klein, K.3    Brüstle, O.4
  • 35
    • 0023865298 scopus 로고
    • Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats: Reciprocal connections with host thalamus demonstrated with WGA-HRP
    • Gonzalez, M. F., Sharp, F. R., and Loken, J. E. (1988). Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats: reciprocal connections with host thalamus demonstrated with WGA-HRP. Exp. Neurol. 99, 154-165.
    • (1988) Exp. Neurol , vol.99 , pp. 154-165
    • Gonzalez, M.F.1    Sharp, F.R.2    Loken, J.E.3
  • 37
    • 33750452294 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain
    • Guillaume, D. J., Johnson, M. A., Li, X. J., and Zhang, S. C. (2006). Human embryonic stem cell-derived neural precursors develop into neurons and integrate into the host brain. J. Neurosci. Res. 84, 1165-1176.
    • (2006) J. Neurosci. Res , vol.84 , pp. 1165-1176
    • Guillaume, D.J.1    Johnson, M.A.2    Li, X.J.3    Zhang, S.C.4
  • 38
    • 0028149562 scopus 로고
    • Efferents of frontal or occipital cortex grafted into adult rat's motor cortex
    • Guitet, J., Garnier, C., Ebrahimi-Gaillard, A., and Roger, M. (1994). Efferents of frontal or occipital cortex grafted into adult rat's motor cortex. Neurosci. Lett. 180, 265-268.
    • (1994) Neurosci. Lett , vol.180 , pp. 265-268
    • Guitet, J.1    Garnier, C.2    Ebrahimi-Gaillard, A.3    Roger, M.4
  • 41
    • 84855574943 scopus 로고    scopus 로고
    • Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis
    • Harris, V. K., Yan, Q. J., Vyshkina, T., Sahabi, S., Liu, X., and Sadiq, S. A. (2012). Clinical and pathological effects of intrathecal injection of mesenchymal stem cell-derived neural progenitors in an experimental model of multiple sclerosis. J. Neurol. Sci. 313, 167-177.
    • (2012) J. Neurol. Sci , vol.313 , pp. 167-177
    • Harris, V.K.1    Yan, Q.J.2    Vyshkina, T.3    Sahabi, S.4    Liu, X.5    Sadiq, S.A.6
  • 42
    • 0028270311 scopus 로고
    • Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity
    • Hemmati-Brivanlou, A., Kelly, O. G., and Melton, D. A. (1994). Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell 77, 283-295.
    • (1994) Cell , vol.77 , pp. 283-295
    • Hemmati-Brivanlou, A.1    Kelly, O.G.2    Melton, D.A.3
  • 43
    • 70349564337 scopus 로고    scopus 로고
    • The 5-HT7 receptor and disorders of the nervous system: An overview
    • Hedlund, P. B. (2009). The 5-HT7 receptor and disorders of the nervous system: an overview. Psychopharmacology (Berl) 206, 345-354.
    • (2009) Psychopharmacology (Berl) , vol.206 , pp. 345-354
    • Hedlund, P.B.1
  • 45
    • 0347753249 scopus 로고    scopus 로고
    • IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
    • Hsieh, J., Aimone, J. B., Kaspar, B. K., Kuwabara, T., Nakashima, K., and Gage, F. H. (2004). IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes. J. Cell Biol. 164, 111-122.
    • (2004) J. Cell Biol , vol.164 , pp. 111-122
    • Hsieh, J.1    Aimone, J.B.2    Kaspar, B.K.3    Kuwabara, T.4    Nakashima, K.5    Gage, F.H.6
  • 46
    • 67649212160 scopus 로고    scopus 로고
    • Human oligodendrocytes from embryonic stem cells: Conserved SHH signaling networks and divergent FGF effects
    • Hu, B. Y., Du, Z. W., Li, X. J., Ayala, M., and Zhang, S. C. (2009). Human oligodendrocytes from embryonic stem cells: conserved SHH signaling networks and divergent FGF effects. Development 136, 1443-1452.
    • (2009) Development , vol.136 , pp. 1443-1452
    • Hu, B.Y.1    Du, Z.W.2    Li, X.J.3    Ayala, M.4    Zhang, S.C.5
  • 47
    • 77749279749 scopus 로고    scopus 로고
    • Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    • Hu, B. Y., Weick, J. P., Yu, J., Ma, L. X., Zhang, X. Q., Thomson, J. A., and Zhang, S. C. (2010). Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc. Natl. Acad. Sci. U.S.A. 107, 4335-4340.
    • (2010) Proc. Natl. Acad. Sci. U.S.A , vol.107 , pp. 4335-4340
    • Hu, B.Y.1    Weick, J.P.2    Yu, J.3    Ma, L.X.4    Zhang, X.Q.5    Thomson, J.A.6    Zhang, S.C.7
  • 48
    • 58149201611 scopus 로고    scopus 로고
    • Effects of direct transplantation of multi-potent mesenchymal stromal/stem cells into the demyelinated spinal cord
    • Hunt, D. P., Irvine, K. A., Webber, D. J., Compston, D. A., Blakemore, W. F., and Chandran, S. (2008). Effects of direct transplantation of multi-potent mesenchymal stromal/stem cells into the demyelinated spinal cord. Cell Transplant. 17, 865-873.
    • (2008) Cell Transplant , vol.17 , pp. 865-873
    • Hunt, D.P.1    Irvine, K.A.2    Webber, D.J.3    Compston, D.A.4    Blakemore, W.F.5    Chandran, S.6
  • 49
    • 0030795109 scopus 로고    scopus 로고
    • Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1
    • Hynes, M., Stone, D. M., Dowd, M., Pitts-Meek, S., Goddard, A., Gurney, A., and Rosenthal, A. (1997). Control of cell pattern in the neural tube by the zinc finger transcription factor and oncogene Gli-1. Neuron 19, 15-26.
    • (1997) Neuron , vol.19 , pp. 15-26
    • Hynes, M.1    Stone, D.M.2    Dowd, M.3    Pitts-Meek, S.4    Goddard, A.5    Gurney, A.6    Rosenthal, A.7
  • 50
  • 51
    • 0024271727 scopus 로고
    • Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: Anatomical and neuro-chemical studies of trophic interactions
    • Isacson, O., Wictorin, K., Fischer, W., Sofroniew, M. V., and Bjorklund, A. (1988). Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: anatomical and neuro-chemical studies of trophic interactions. Prog. Brain Res. 78, 13-26.
    • (1988) Prog. Brain Res , vol.78 , pp. 13-26
    • Isacson, O.1    Wictorin, K.2    Fischer, W.3    Sofroniew, M.V.4    Bjorklund, A.5
  • 54
    • 33846909499 scopus 로고    scopus 로고
    • Efficient induction of oligodendrocytes from human embryonic stem cells
    • Kang, S. M., Cho, M. S., Seo, H., Yoon, C. J., Oh, S. K., Choi, Y. M., and Kim, D. W. (2007). Efficient induction of oligodendrocytes from human embryonic stem cells. Stem Cells 25, 419-424.
    • (2007) Stem Cells , vol.25 , pp. 419-424
    • Kang, S.M.1    Cho, M.S.2    Seo, H.3    Yoon, C.J.4    Oh, S.K.5    Choi, Y.M.6    Kim, D.W.7
  • 58
    • 18644384444 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived oligo-dendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury
    • Keirstead, H. S., Nistor, G., Bernal, G., Totoiu, M., Cloutier, F., Sharp, K., and Steward, O. (2005). Human embryonic stem cell-derived oligo-dendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J. Neurosci. 25, 4694-4705.
    • (2005) J. Neurosci , vol.25 , pp. 4694-4705
    • Keirstead, H.S.1    Nistor, G.2    Bernal, G.3    Totoiu, M.4    Cloutier, F.5    Sharp, K.6    Steward, O.7
  • 59
    • 0038701738 scopus 로고    scopus 로고
    • The effects of various concentrations of FGF-2 on the proliferation and neu-ronal yield of murine embryonic neural precursor cells in vitro
    • Kelly, C. M., Zietlow, R., Dunnett, S. B., and Rosser, A. E. (2003). The effects of various concentrations of FGF-2 on the proliferation and neu-ronal yield of murine embryonic neural precursor cells in vitro. Cell Transplant. 12, 215-223.
    • (2003) Cell Transplant , vol.12 , pp. 215-223
    • Kelly, C.M.1    Zietlow, R.2    Dunnett, S.B.3    Rosser, A.E.4
  • 60
    • 31544442467 scopus 로고    scopus 로고
    • Competing waves of oligodendro-cytes in the forebrain and postnatal elimination of an embryonic lineage
    • Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., and Richardson, W. D. (2006). Competing waves of oligodendro-cytes in the forebrain and postnatal elimination of an embryonic lineage. Nat. Neurosci. 9, 173-179.
    • (2006) Nat. Neurosci , vol.9 , pp. 173-179
    • Kessaris, N.1    Fogarty, M.2    Iannarelli, P.3    Grist, M.4    Wegner, M.5    Richardson, W.D.6
  • 61
    • 1842454960 scopus 로고    scopus 로고
    • Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors
    • Kessaris, N., Jamen, F., Rubin, L. L., and Richardson, W. D. (2004). Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors. Development 131, 1289-1298.
    • (2004) Development , vol.131 , pp. 1289-1298
    • Kessaris, N.1    Jamen, F.2    Rubin, L.L.3    Richardson, W.D.4
  • 63
    • 55049100009 scopus 로고    scopus 로고
    • The incredible elastic brain: How neural stem cells expand our minds
    • Kokovay, E., Shin, Q., and Temple, S. (2008). The incredible elastic brain: how neural stem cells expand our minds. Neuron 60, 420-429.
    • (2008) Neuron , vol.60 , pp. 420-429
    • Kokovay, E.1    Shin, Q.2    Temple, S.3
  • 67
    • 55249107197 scopus 로고    scopus 로고
    • Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease
    • doi: 10.1371/journal. pone.0000166
    • Krystkowiak, P., Gaura, V., Labalette, M., Rialland, A., Remy, P., Peschanski, M., and Bachoud-Lévi, A. C. (2007). Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease. PLoS One 2, e166. doi: 10.1371/journal. pone.0000166
    • (2007) PLoS One , vol.2
    • Krystkowiak, P.1    Gaura, V.2    Labalette, M.3    Rialland, A.4    Remy, P.5    Peschanski, M.6    Bachoud-Lévi, A.C.7
  • 68
    • 0036351133 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor AB (PDGF AB) promote adult SVZ-derived oligodendrogenesis in vivo
    • Lachapelle, F., Avellana-Adalid, V., Nait-Oumesmar, B., and Baron-Van Evercooren, A. (2002). Fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor AB (PDGF AB) promote adult SVZ-derived oligodendrogenesis in vivo. Mol. Cell. Neurosci. 20, 390-403.
    • (2002) Mol. Cell. Neurosci , vol.20 , pp. 390-403
    • Lachapelle, F.1    Avellana-Adalid, V.2    Nait-Oumesmar, B.3    Baron-Van, E.A.4
  • 70
    • 77956222795 scopus 로고    scopus 로고
    • Clinical and pathological topics of multiple sclerosis
    • Lassmann, H. (2009). Clinical and pathological topics of multiple sclerosis. Rinsho Shinkeigaku 49, 715-718.
    • (2009) Rinsho Shinkeigaku , vol.49 , pp. 715-718
    • Lassmann, H.1
  • 72
    • 0026783674 scopus 로고
    • Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog
    • Lee, J. J., Von Kessler, D. P., Parks, S., and Beachy, P. A. (1992). Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell 71, 33-50.
    • (1992) Cell , vol.71 , pp. 33-50
    • Lee, J.J.1    von Kessler, D.P.2    Parks, S.3    Beachy, P.A.4
  • 73
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of mid-brain and hindbrain neurons from mouse embryonic stem cells
    • Lee, S. H., Lumelsky, N., Studer, L., Auerbach, J. M., and McKay, R. D. (2000). Efficient generation of mid-brain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 18, 675-679.
    • (2000) Nat. Biotechnol , vol.18 , pp. 675-679
    • Lee, S.H.1    Lumelsky, N.2    Studer, L.3    Auerbach, J.M.4    McKay, R.D.5
  • 74
    • 0037030677 scopus 로고    scopus 로고
    • Origin of GABAergic neurons in the human neocortex
    • Letinic, K., Zoncu, R., and Rakic, P. (2002). Origin of GABAergic neurons in the human neocortex. Nature 417, 645-649.
    • (2002) Nature , vol.417 , pp. 645-649
    • Letinic, K.1    Zoncu, R.2    Rakic, P.3
  • 75
    • 45849146018 scopus 로고    scopus 로고
    • Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules
    • Li, X. J., Hu, B. Y., Jones, S. A., Zhang, Y. S., Lavaute, T., Du, Z. W., and Zhang, S. C. (2008). Directed differentiation of ventral spinal progenitors and motor neurons from human embryonic stem cells by small molecules. Stem Cells 26, 886-893.
    • (2008) Stem Cells , vol.26 , pp. 886-893
    • Li, X.J.1    Hu, B.Y.2    Jones, S.A.3    Zhang, Y.S.4    Lavaute, T.5    Du, Z.W.6    Zhang, S.C.7
  • 76
    • 70450159769 scopus 로고    scopus 로고
    • Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telen-cephalic neuron types from human embryonic stem cells
    • Li, X. J., Zhang, X., Johnson, M. A., Wang, Z. B., Lavaute, T., and Zhang, S. C. (2009). Coordination of sonic hedgehog and Wnt signaling determines ventral and dorsal telen-cephalic neuron types from human embryonic stem cells. Development 136, 4055-4063.
    • (2009) Development , vol.136 , pp. 4055-4063
    • Li, X.J.1    Zhang, X.2    Johnson, M.A.3    Wang, Z.B.4    Lavaute, T.5    Zhang, S.C.6
  • 77
    • 68849091654 scopus 로고    scopus 로고
    • Characterization of the functional properties of the neu-roectoderm in mouse Cripto(-/-) embryos showing severe gastrula-tion defects
    • Liguori, G. L., Echevarria, D., Bonilla, S., D'Andrea, D., Liguoro, A., Persico, M. G., and Martinez, S. (2009). Characterization of the functional properties of the neu-roectoderm in mouse Cripto(-/-) embryos showing severe gastrula-tion defects. Int. J. Dev. Biol. 53, 549-557.
    • (2009) Int. J. Dev. Biol , vol.53 , pp. 549-557
    • Liguori, G.L.1    Echevarria, D.2    Bonilla, S.3    D'andrea, D.4    Liguoro, A.5    Persico, M.G.6    Martinez, S.7
  • 78
    • 80955142155 scopus 로고    scopus 로고
    • Cell therapeutics in Parkinson's disease
    • Lindvall, O., and Björklund, A. (2011). Cell therapeutics in Parkinson's disease. Neurotherapeutics 8, 539-548.
    • (2011) Neurotherapeutics , vol.8 , pp. 539-548
    • Lindvall, O.1    Björklund, A.2
  • 79
    • 10344233654 scopus 로고    scopus 로고
    • Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists
    • Linker, C., and Stern, C. D. (2004). Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists. Development 131, 5671-5681.
    • (2004) Development , vol.131 , pp. 5671-5681
    • Linker, C.1    Stern, C.D.2
  • 80
    • 82255175070 scopus 로고    scopus 로고
    • Specification of neuronal and glial subtypes from human pluripotent stem cells
    • Liu, H., and Zhang, S. C. (2010). Specification of neuronal and glial subtypes from human pluripotent stem cells. Cell. Mol. Life Sci. 68, 3995-4008.
    • (2010) Cell. Mol. Life Sci , vol.68 , pp. 3995-4008
    • Liu, H.1    Zhang, S.C.2
  • 81
    • 0034705056 scopus 로고    scopus 로고
    • Embryonic stem cells differentiate into oligodendrocytes and myeli-nate in culture and after spinal cord transplantation
    • Liu, S., Qu, Y., Stewart, T. J., Howard, M. J., Chakrabortty, S., Holekamp, T. F., and Mcdonald, J. W. (2000). Embryonic stem cells differentiate into oligodendrocytes and myeli-nate in culture and after spinal cord transplantation. Proc. Natl. Acad. Sci. U.S.A. 97, 6126-6131.
    • (2000) Proc. Natl. Acad. Sci. U.S.A , vol.97 , pp. 6126-6131
    • Liu, S.1    Qu, Y.2    Stewart, T.J.3    Howard, M.J.4    Chakrabortty, S.5    Holekamp, T.F.6    McDonald, J.W.7
  • 82
    • 33646726733 scopus 로고    scopus 로고
    • Notch promotes neural lineage entry by pluripotent embryonic stem cells
    • doi: 10.1371/journal.pbio.0040121
    • Lowell, S., Benchoua, A., Heavey, B., and Smith, A. G. (2006). Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol. 4, e121. doi: 10.1371/journal.pbio.0040121
    • (2006) PLoS Biol , vol.4
    • Lowell, S.1    Benchoua, A.2    Heavey, B.3    Smith, A.G.4
  • 83
    • 31444436983 scopus 로고    scopus 로고
    • Mechanisms of ventral patterning in the vertebrate nervous system
    • Lupo, G., Harris, W. A., and Lewis, K. E. (2006). Mechanisms of ventral patterning in the vertebrate nervous system. Nat. Rev. Neurosci. 7, 103-114.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 103-114
    • Lupo, G.1    Harris, W.A.2    Lewis, K.E.3
  • 88
    • 12344263973 scopus 로고    scopus 로고
    • Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation
    • Molotkova, N., Molotkov, A., Sirbu, I. O., and Duester, G. (2005). Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation. Mech. Dev. 122, 145-155.
    • (2005) Mech. Dev , vol.122 , pp. 145-155
    • Molotkova, N.1    Molotkov, A.2    Sirbu, I.O.3    Duester, G.4
  • 89
    • 52749094901 scopus 로고    scopus 로고
    • Microenvironmental determinants of adult neural stem cell proliferation and lienage commitment on the healthy and injured central nervous system
    • Moyse, E., Segura, S., Liard, O., Mahaut, S., and Mechawar, N. (2008). Microenvironmental determinants of adult neural stem cell proliferation and lienage commitment on the healthy and injured central nervous system. Curr. Stem Cell Res. Ther. 3, 163-184.
    • (2008) Curr. Stem Cell Res. Ther , vol.3 , pp. 163-184
    • Moyse, E.1    Segura, S.2    Liard, O.3    Mahaut, S.4    Mechawar, N.5
  • 90
    • 67449083632 scopus 로고    scopus 로고
    • Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease
    • Muramatsu, S., Okuno, T., Suzuki, Y., Nakayama, T., Kakiuchi, T., Takino, N., Iida, A., Ono, F., Terao, K., Inoue, N., Nakano, I., Kondo, Y., and Tsukada, H. (2009). Multitracer assessment of dopamine function after transplantation of embryonic stem cell-derived neural stem cells in a primate model of Parkinson's disease. Synapse 63, 541-548.
    • (2009) Synapse , vol.63 , pp. 541-548
    • Muramatsu, S.1    Okuno, T.2    Suzuki, Y.3    Nakayama, T.4    Kakiuchi, T.5    Takino, N.6    Iida, A.7    Ono, F.8    Terao, K.9    Inoue, N.10    Nakano, I.11    Kondo, Y.12    Tsukada, H.13
  • 91
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase B
    • Navé, B. T., Ouwens, M., Withers, D. J., Alessi, D. R., and Shepherd, P. R. (1999). Mammalian target of rapamycin is a direct target for protein kinase B. J. Neurosci. 2, 427-431.
    • (1999) J. Neurosci , vol.2 , pp. 427-431
    • Navé, B.T.1    Ouwens, M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 93
    • 34548204310 scopus 로고    scopus 로고
    • Transcrip-tional control of oligodendrogene-sis
    • Nicolay, D. J., Doucette, J. R., and Nazarali, A. J. (2007). Transcrip-tional control of oligodendrogene-sis. Glia 55, 1287-1299.
    • (2007) Glia , vol.55 , pp. 1287-1299
    • Nicolay, D.J.1    Doucette, J.R.2    Nazarali, A.J.3
  • 94
    • 80955143534 scopus 로고    scopus 로고
    • Human pluripotent stem cell therapy for Huntington's disease: Technical, immunological, and safety challenges
    • Nicoleau, C., Viegas, P., Perrier, A., and Peschanski, M. (2011). Human pluripotent stem cell therapy for Huntington's disease: technical, immunological, and safety challenges. Neurotherapeutics 8, 562-576.
    • (2011) Neurotherapeutics , vol.8 , pp. 562-576
    • Nicoleau, C.1    Viegas, P.2    Perrier, A.3    Peschanski, M.4
  • 95
    • 13544264789 scopus 로고    scopus 로고
    • Human embryonic stem cells differentiate into oligodendro-cytes in high purity and myelinate after spinal cord transplantation
    • Nistor, G. I., Totoiu, M. O., Haque, N., Carpenter, M. K., and Keirstead, H. S. (2005). Human embryonic stem cells differentiate into oligodendro-cytes in high purity and myelinate after spinal cord transplantation. Glia 49, 385-396.
    • (2005) Glia , vol.49 , pp. 385-396
    • Nistor, G.I.1    Totoiu, M.O.2    Haque, N.3    Carpenter, M.K.4    Keirstead, H.S.5
  • 97
    • 0028830691 scopus 로고
    • A retinoic acid-triggered cascade of HOXB1 gene activation
    • Ogura, T., and Evans, R. M. (1995). A retinoic acid-triggered cascade of HOXB1 gene activation. Proc. Natl. Acad. Sci. U.S.A. 92, 387-391.
    • (1995) Proc. Natl. Acad. Sci. U.S.A , vol.92 , pp. 387-391
    • Ogura, T.1    Evans, R.M.2
  • 98
    • 0032562172 scopus 로고    scopus 로고
    • Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence
    • Olsson, M., Bjorklund, A., and Campbell, K. (1998). Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence. Neuroscience 84, 867-876.
    • (1998) Neuroscience , vol.84 , pp. 867-876
    • Olsson, M.1    Bjorklund, A.2    Campbell, K.3
  • 99
    • 34848896595 scopus 로고    scopus 로고
    • Differences in neurogenic potential in floor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic floor plate cells
    • Ono, Y., Nakatani, T., Sakamoto, Y., Mizuhara, E., Minaki, Y., Kumai, M., Hamaguchi, A., Nishimura, M., Inoue, Y., Hayashi, H., Takahashi, J., and Imai, T. (2007). Differences in neurogenic potential in floor plate cells along an anteroposterior location: midbrain dopaminergic neurons originate from mesencephalic floor plate cells. Development 134, 3213-3225.
    • (2007) Development , vol.134 , pp. 3213-3225
    • Ono, Y.1    Nakatani, T.2    Sakamoto, Y.3    Mizuhara, E.4    Minaki, Y.5    Kumai, M.6    Hamaguchi, A.7    Nishimura, M.8    Inoue, Y.9    Hayashi, H.10    Takahashi, J.11    Imai, T.12
  • 100
    • 79953771723 scopus 로고    scopus 로고
    • Regenerative medicine for stroke - are we there yet?
    • Onteniente, B., and Polentes, J. (2011). Regenerative medicine for stroke - are we there yet? Cerebrovasc. Dis. 31, 544-551.
    • (2011) Cerebrovasc. Dis , vol.31 , pp. 544-551
    • Onteniente, B.1    Polentes, J.2
  • 101
    • 0031196773 scopus 로고    scopus 로고
    • Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve
    • Owada, Y., Utsunomiya, A., Yoshimoto, T., and Kondo, H. (1997). Expression of mRNA for Akt, serine-threonine protein kinase, in the brain during development and its transient enhancement following axotomy of hypoglossal nerve. J. Mol. Neurosci. 9, 27-33.
    • (1997) J. Mol. Neurosci , vol.9 , pp. 27-33
    • Owada, Y.1    Utsunomiya, A.2    Yoshimoto, T.3    Kondo, H.4
  • 102
    • 0026322250 scopus 로고
    • Retinoic acid causes abnormal development and segmental patterning of the anterior hindbrain in Xenopus embryos
    • Papalopulu, N., Clarke, J. D., Bradley, L., Wilkinson, D., Krumlauf, R., and Holder, N. (1991). Retinoic acid causes abnormal development and segmental patterning of the anterior hindbrain in Xenopus embryos. Development 113, 1145-1158.
    • (1991) Development , vol.113 , pp. 1145-1158
    • Papalopulu, N.1    Clarke, J.D.2    Bradley, L.3    Wilkinson, D.4    Krumlauf, R.5    Holder, N.6
  • 105
    • 59649113863 scopus 로고    scopus 로고
    • Telencephalic morphogenesis during the process of neurulation: An experimental study using quail-chick chimeras
    • Pombero, A., and Martinez, S. (2009). Telencephalic morphogenesis during the process of neurulation: an experimental study using quail-chick chimeras. J. Comp. Neurol. 512, 784-797.
    • (2009) J. Comp. Neurol , vol.512 , pp. 784-797
    • Pombero, A.1    Martinez, S.2
  • 106
    • 34248581586 scopus 로고    scopus 로고
    • The human subventricular zone: A source of new cells and a potential source of brain tumors
    • Quinones-Hinojosa, A., and Chaichana, K. (2007). The human subventricular zone: a source of new cells and a potential source of brain tumors. Exp. Neurol. 205, 313-324.
    • (2007) Exp. Neurol , vol.205 , pp. 313-324
    • Quinones-Hinojosa, A.1    Chaichana, K.2
  • 108
    • 0031011861 scopus 로고    scopus 로고
    • A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neural progenitor cells
    • Ray, J., Baird, A., and Gage, F. H. (1997). A 10-amino acid sequence of fibroblast growth factor 2 is sufficient for its mitogenic activity on neural progenitor cells. Proc. Natl. Acad. Sci. U.S.A. 94, 7047-7070.
    • (1997) Proc. Natl. Acad. Sci. U.S.A , vol.94 , pp. 7047-7070
    • Ray, J.1    Baird, A.2    Gage, F.H.3
  • 110
    • 0036581270 scopus 로고    scopus 로고
    • Opinion: Neural stem cell therapy for neurological diseases: Dreams and reality
    • Rossi, F., and Cattaneo, E. (2002). Opinion: neural stem cell therapy for neurological diseases: dreams and reality. Nat. Rev. Neurosci. 3, 401-409.
    • (2002) Nat. Rev. Neurosci , vol.3 , pp. 401-409
    • Rossi, F.1    Cattaneo, E.2
  • 111
    • 0034941567 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothe-lial cells
    • Rossig, L., Jadidi, A. S., Urbich, C., Badorff, C., Zeiher, A. M., and Dimmeler, S. (2001). Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothe-lial cells. Mol. Cell. Biol. 21, 5644-5657.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 5644-5657
    • Rossig, L.1    Jadidi, A.S.2    Urbich, C.3    Badorff, C.4    Zeiher, A.M.5    Dimmeler, S.6
  • 112
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopamin-ergic neurons enriched by cocul-ture with telomerase-immortalized midbrain astrocytes
    • Roy, N. S., Cleren, C., Singh, S. K., Yang, L., Beal, M. F., and Goldman, S. A. (2006). Functional engraftment of human ES cell-derived dopamin-ergic neurons enriched by cocul-ture with telomerase-immortalized midbrain astrocytes. Nat. Med. 12, 1259-1268.
    • (2006) Nat. Med , vol.12 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 113
    • 0031820135 scopus 로고    scopus 로고
    • Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog
    • Ruizi Altaba, A. (1998). Combinatorial Gli gene function in floor plate and neuronal inductions by Sonic hedgehog. Development 125, 2203-2212.
    • (1998) Development , vol.125 , pp. 2203-2212
    • Ruizi, A.A.1
  • 116
    • 0032839336 scopus 로고    scopus 로고
    • Neural precursor differentiation following transplantation into neocortex is dependent on intrinsic developmental state and receptor competence
    • Sheen, V. L., Arnold, M. W., Wang, Y., and Macklis, J. D. (1999). Neural precursor differentiation following transplantation into neocortex is dependent on intrinsic developmental state and receptor competence. Exp. Neurol. 158, 47-62.
    • (1999) Exp. Neurol , vol.158 , pp. 47-62
    • Sheen, V.L.1    Arnold, M.W.2    Wang, Y.3    Macklis, J.D.4
  • 117
    • 21244485072 scopus 로고    scopus 로고
    • Human motor neuron differentiation from human embryonic stem cells
    • Shin, S., Dalton, S., and Stice, S. L. (2005). Human motor neuron differentiation from human embryonic stem cells. Stem Cells Dev. 14, 266-269.
    • (2005) Stem Cells Dev , vol.14 , pp. 266-269
    • Shin, S.1    Dalton, S.2    Stice, S.L.3
  • 118
    • 77957346211 scopus 로고    scopus 로고
    • A consensus statement addressing mes-enchymal stem cell transplantation for multiple sclerosis: It's time!
    • Siatskas, C., Payne, N. L., Short, M. A., and Bernard, C. C. (2010). A consensus statement addressing mes-enchymal stem cell transplantation for multiple sclerosis: it's time! Stem Cell Rev. 6, 500-506.
    • (2010) Stem Cell Rev , vol.6 , pp. 500-506
    • Siatskas, C.1    Payne, N.L.2    Short, M.A.3    Bernard, C.C.4
  • 119
    • 80052992052 scopus 로고    scopus 로고
    • Adult human neurogenesis: From microscopy to magnetic resonance imaging
    • doi: 10.3389/fnins.2011.00047
    • Sierra, A., Encinas, J. M., and Maletic-Savatic, M. (2011). Adult human neurogenesis: from microscopy to magnetic resonance imaging. Front. Neurosci. 4, 47. doi: 10.3389/fnins.2011.00047
    • (2011) Front. Neurosci , vol.4 , pp. 47
    • Sierra, A.1    Encinas, J.M.2    Maletic-Savatic, M.3
  • 120
    • 4744355621 scopus 로고    scopus 로고
    • Akt-1 expression level regulates CNS precursors
    • Sinor, A. D., and Lillien, L. (2004). Akt-1 expression level regulates CNS precursors. J. Neurosci. 24, 8531-8541.
    • (2004) J. Neurosci , vol.24 , pp. 8531-8541
    • Sinor, A.D.1    Lillien, L.2
  • 121
    • 0026646326 scopus 로고
    • Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
    • Smith, W. C., and Harland, R. M. (1992). Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell 70, 829-840.
    • (1992) Cell , vol.70 , pp. 829-840
    • Smith, W.C.1    Harland, R.M.2
  • 122
    • 33846904764 scopus 로고    scopus 로고
    • Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin
    • Sonntag, K. C, Pruszak, J., Yoshizaki, T., van Arensbergen, J., Sanchez-Pernaute, R., and Isacson, O. (2007). Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein antagonist noggin. Stem Cells 25, 411-418.
    • (2007) Stem Cells , vol.25 , pp. 411-418
    • Sonntag, K.C.1    Pruszak, J.2    Yoshizaki, T.3    van Arensbergen, J.4    Sanchez-Pernaute, R.5    Isacson, O.6
  • 123
    • 0029867899 scopus 로고    scopus 로고
    • Fetal neocortical tissue blocks implanted in brain infarcts of adult rats interconnect with the host brain
    • Sorensen, J. C., Grabowski, M., Zimmer, J., and Johansson, B. B. (1996). Fetal neocortical tissue blocks implanted in brain infarcts of adult rats interconnect with the host brain. Exp. Neurol. 138, 227-235.
    • (1996) Exp. Neurol , vol.138 , pp. 227-235
    • Sorensen, J.C.1    Grabowski, M.2    Zimmer, J.3    Johansson, B.B.4
  • 124
    • 0035041063 scopus 로고    scopus 로고
    • Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: Oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism
    • Soula, C., Danesin, C., Kan, P., Grob, M., Poncet, C., and Cochard, P. (2001). Distinct sites of origin of oligodendrocytes and somatic motoneurons in the chick spinal cord: oligodendrocytes arise from Nkx2.2-expressing progenitors by a Shh-dependent mechanism. Development 128, 1369-1379.
    • (2001) Development , vol.128 , pp. 1369-1379
    • Soula, C.1    Danesin, C.2    Kan, P.3    Grob, M.4    Poncet, C.5    Cochard, P.6
  • 125
    • 33645219877 scopus 로고    scopus 로고
    • Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons
    • Soundararajan, P., Miles, G. B., Rubin, L. L., Brownstone, R. M., and Rafuse, V. F. (2006). Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J. Neurosci. 26, 3256-3268.
    • (2006) J. Neurosci , vol.26 , pp. 3256-3268
    • Soundararajan, P.1    Miles, G.B.2    Rubin, L.L.3    Brownstone, R.M.4    Rafuse, V.F.5
  • 126
    • 14644401158 scopus 로고    scopus 로고
    • A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
    • Stamataki, D., Ulloa, F., Tsoni, S. V., Mynett, A., and Briscoe, J. (2005). A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube. Genes Dev. 19, 626-641.
    • (2005) Genes Dev , vol.19 , pp. 626-641
    • Stamataki, D.1    Ulloa, F.2    Tsoni, S.V.3    Mynett, A.4    Briscoe, J.5
  • 127
    • 77955843135 scopus 로고    scopus 로고
    • Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium
    • Sundberg, M., Skottman, H., Suuronen, R., and Narkilahti, S. (2011). Production and isolation of NG2+ oligodendrocyte precursors from human embryonic stem cells in defined serum-free medium. Stem Cell Res. 5, 91-103.
    • (2011) Stem Cell Res , vol.5 , pp. 91-103
    • Sundberg, M.1    Skottman, H.2    Suuronen, R.3    Narkilahti, S.4
  • 128
    • 78149302874 scopus 로고    scopus 로고
    • Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions
    • Swistowski, A., Peng, J., Liu, Q., Mali, P., Rao, M. S., Cheng, L., and Zeng, X. (2011). Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells 28, 1893-1904.
    • (2011) Stem Cells , vol.28 , pp. 1893-1904
    • Swistowski, A.1    Peng, J.2    Liu, Q.3    Mali, P.4    Rao, M.S.5    Cheng, L.6    Zeng, X.7
  • 129
    • 22444449591 scopus 로고    scopus 로고
    • Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain
    • Tabar, V., Panagiotakos, G., Greenberg, E. D., Chan, B. K., Sadelain, M., Gutin, P. H., and Studer, L. (2005). Migration and differentiation of neural precursors derived from human embryonic stem cells in the rat brain. Nat. Biotechnol. 23, 601-606.
    • (2005) Nat. Biotechnol , vol.23 , pp. 601-606
    • Tabar, V.1    Panagiotakos, G.2    Greenberg, E.D.3    Chan, B.K.4    Sadelain, M.5    Gutin, P.H.6    Studer, L.7
  • 130
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., and Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 131
    • 0027474898 scopus 로고
    • Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication
    • Tashiro, S., Michiue, T., Higashijima, S., Zenno, S., Ishimaru, S., Takahashi, F., Orihara, M., Kojima, T., and Saigo, K. (1993). Structure and expression of hedgehog, a Drosophila segment-polarity gene required for cell-cell communication. Gene 124, 183-189.
    • (1993) Gene , vol.124 , pp. 183-189
    • Tashiro, S.1    Michiue, T.2    Higashijima, S.3    Zenno, S.4    Ishimaru, S.5    Takahashi, F.6    Orihara, M.7    Kojima, T.8    Saigo, K.9
  • 134
    • 11344261775 scopus 로고    scopus 로고
    • Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain
    • Vallstedt, A., Klos, J. M., and Ericson, J. (2005). Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain. Neuron 45, 55-67.
    • (2005) Neuron , vol.45 , pp. 55-67
    • Vallstedt, A.1    Klos, J.M.2    Ericson, J.3
  • 135
    • 74249116918 scopus 로고    scopus 로고
    • Molecular mechanisms controlling brain development: An overview of neu-roepithelial secondary organizers
    • Vieira, C., Pombero, A., Garcia-Lopez, R., Gimeno, L., Echevarria, D., and Martinez, S. (2010). Molecular mechanisms controlling brain development: an overview of neu-roepithelial secondary organizers. Int. J. Dev. Biol. 54, 7-20.
    • (2010) Int. J. Dev. Biol , vol.54 , pp. 7-20
    • Vieira, C.1    Pombero, A.2    Garcia-Lopez, R.3    Gimeno, L.4    Echevarria, D.5    Martinez, S.6
  • 138
    • 0024398330 scopus 로고
    • Intrinsic organization and connectivity of intrastriatal striatal transplants in rats as revealed by DARPP-32 immunohistochemistry: Specificity of connections with the lesioned host brain
    • Wictorin, K., Ouimet, C. C., and Bjorklund, A. (1989). Intrinsic organization and connectivity of intrastriatal striatal transplants in rats as revealed by DARPP-32 immunohistochemistry: specificity of connections with the lesioned host brain. Eur. J. Neurosci. 1, 690-701.
    • (1989) Eur. J. Neurosci , vol.1 , pp. 690-701
    • Wictorin, K.1    Ouimet, C.C.2    Bjorklund, A.3
  • 141
    • 0032577445 scopus 로고    scopus 로고
    • FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
    • Ye, W., Shimamura, K., Rubenstein, J. L., Hynes, M. A., and Rosenthal, A. (1998). FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766.
    • (1998) Cell , vol.93 , pp. 755-766
    • Ye, W.1    Shimamura, K.2    Rubenstein, J.L.3    Hynes, M.A.4    Rosenthal, A.5
  • 142
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
    • Ying, Q. L., Stavridis, M., Griffiths, D., Li, M., and Smith, A. (2003). Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotechnol. 21, 183-186.
    • (2003) Nat. Biotechnol , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 144
    • 4043064327 scopus 로고    scopus 로고
    • Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1
    • Zervas, M., Millet, S., Ahn, S., and Joyner, A. L. (2004). Cell behaviors and genetic lineages of the mesencephalon and rhombomere 1. Neuron 43, 345-357.
    • (2004) Neuron , vol.43 , pp. 345-357
    • Zervas, M.1    Millet, S.2    Ahn, S.3    Joyner, A.L.4
  • 145
    • 0033616730 scopus 로고    scopus 로고
    • Adult brain retains the potential to generate oligoden-droglial progenitors with extensive myelination capacity
    • Zhang, S. C., Ge, B., and Duncan, I. D. (1999). Adult brain retains the potential to generate oligoden-droglial progenitors with extensive myelination capacity. Proc. Natl. Acad. Sci. U.S.A. 96, 4089-4094.
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 4089-4094
    • Zhang, S.C.1    Ge, B.2    Duncan, I.D.3
  • 146
    • 0035200623 scopus 로고    scopus 로고
    • In vitro differentiation of transplantable neural precursors from human embryonic stem cells
    • Zhang, S. C., Wernig, M., Duncan, I. D., Brüstle, O., and Thomson, J. A. (2001). In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol. 19, 1129-1133.
    • (2001) Nat. Biotechnol , vol.19 , pp. 1129-1133
    • Zhang, S.C.1    Wernig, M.2    Duncan, I.D.3    Brüstle, O.4    Thomson, J.A.5
  • 147
    • 39149107803 scopus 로고    scopus 로고
    • Mechanisms and functional implications of adult neurogenesis
    • Zhao, C., Deng, W., and Gage, F. H. (2008). Mechanisms and functional implications of adult neurogenesis. Cell 132, 645-660.
    • (2008) Cell , vol.132 , pp. 645-660
    • Zhao, C.1    Deng, W.2    Gage, F.H.3
  • 148
    • 0030598829 scopus 로고    scopus 로고
    • The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4
    • Zimmerman, L. B., De Jesus-Escobar, J. M., and Harland, R. M. (1996). The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell 86, 599-606.
    • (1996) Cell , vol.86 , pp. 599-606
    • Zimmerman, L.B.1    De Jesus-Escobar, J.M.2    Harland, R.M.3


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