Fetal neocortical tissue blocks implanted in brain infarcts of adult rats interconnect with the host brain

Experimental Neurology

Volumn 138, Issue 2, 1996, Pages 227-235

  Sørensen, Jens Christian ^a   Grabowski, Martin ^b   Zimmer, Jens ^c   Johansson, Barbro B ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; CONTROLLED STUDY; HISTOCHEMISTRY; MALE; NEOCORTEX; NERVE TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0029867899     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.0061     Document Type: Article

References (39)

1. BRUNDIN, P., O. ISACSON, F. H. GAGE, U. STENEVI, AND A. BJÖRKLUND. 1985. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res. 331: 251-259.
2. CASTRO, A. J., J. ZIMMER, N. A. SUNDE, AND E. L. BOLD. 1985. Transplantation of fetal cortex to the brain of newborn rats: A retrograde fluorescent analysis of callosal and thalamic projections from transplantation to host. Neurosci. Lett. 60: 283-288.
3. CASTRO, A. J., N. TONDER, N. A. SUNDE, AND J. ZIMMER. 1987. Fetal cortical transplants in the cerebral hemisphere of newborn rats: A retrograde fluorescent analysis of connections. Exp. Brain Res. 66: 533-542.
4. CASTRO, A. J., N. TONDER, N. A. SUNDE, AND J. ZIMMER. 1988. Fetal neocortical transplants grafted to the cerebral cortex of newborn rats receive afferents from the basal forebrain, locus coeruleus and midline raphe. Exp. Brain Res. 69: 613-622.
5. CASTRO, A. J., T. P. HOGAN, J. C. SORENSEN, B. S. KLAUSEN, E. H. DANIELSEN, J. ZIMMER, AND E. J. NEAFSEY. 1991. Heterotopic neocortical transplants. An anatomical and electrophysiological analysis of host projections to occipital cortical grafts placed into sensorimotor cortical lesions made in newborn rats. Brain Res. Dev. Brain Res. 58: 231-236.
6. CICIRATA, F., M. F. SERAPIDE, G. NICOTRA, AND R. RAFFAELE. 1992. Homotopic transplant of fetal cortex to lesioned motor cortex of adult rats. A compartmental and anatomical study. Arch. Ital. Biol. 130: 101-111.
7. COYLE, P. 1982. Middle cerebral artery occlusion in the young rat. Stroke 13: 855-859.
8. FONSECA, M., J. DEFELIPE, AND A. FARIEN. 1988. Local connections in transplanted and normal cerebral cortex of rats. Exp. Brain Res. 69: 387-398.
9. GONZALEZ, M. F., F. SHARP, AND J. E. LOKEN. 1988. Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats: Reciprocal connections with host thalamus demonstrated with WGA-HRP. Exp. Neurol. 99: 154-165.
10. GRABOWSKI, M. 1993. Neuronal Grafting in Stroke. An Experimental Study on Fetal Cortical Transplants in the Infarcted Brain. Thesis, Lund University, Sweden.
11. GRABOWSKI, M., P. BRUNDIN, AND B. B. JOHANSSON. 1992. Fetal neocortical grafts implanted in hypertensive rats with cortical infarcts following a middle cerebral artery occlusion: Ingrowth of afferent fibers from the host brain. Exp. Neurol. 116: 105-121.
12. GRABOWSKI, M., B. B. JOHANSSON, AND P. BRUNDIN. 1994. Survival of fetal neocortical grafts implanted in brain infarcts of adult rats: The influence of postlesion time and age of donor tissue. Exp. Neurol. 127: 126-136.
13. GRABOWSKI, M., B. B. JOHANSSON, AND P. BRUNDIN. 1995. Neocortical grafts placed in the infarcted brain of adult rats: Few or no efferent fibers grow from transplant to host. Submitted for publication.
14. GRABOWSKI, M., J. C. SØRENSEN, B. MATTSSON, J. ZIMMER, AND B. B. JOHANSSON. 1995. Influence of an enriched environment and cortical grafting on functional outcome in brain infarcts of adult rats. Exp. Neurol. 133: 96-102.
15. HEDREEN, J. C., S. J. BACON, AND D. L. PRICE. 1985. A modified histochemical technique to visualize acetylcholinesterase containing axons. J. Histochem. Cytochem. 33: 134-140.
16. ISACSON, O., K. WICTORIN, W. FISCHER, M. V. SOFRONIEW, AND A. BJORKLUND. 1988. Fetal cortical cell suspension grafts to the excitotoxically lesioned neocortex: Anatomical and neurochemical studies of trophic interactions. Prog. Brain Res. 78: 13-26.
17. ISACSON, O., AND M. V. SOFRONIEW. 1988. Neuronal loss or replacement in the injured adult cerebral neocortex induces extensive remodeling of intrinsic and afferent neural systems. Exp. Neurol. 117: 151-175.
18. KELCHE, C., J. C. DALRYMPLE-ALFORD, AND B. WILL. 1988. Housing conditions modulate the effects of intracerebral grafts in rats with brain lesions. Behav. Brain Res. 28: 287-295.
19. MAMPALAM, T. J., M. F. GONZALEZ, P. WEINSTEIN, AND F. R. SHARP. 1988. Neuronal changes in fetal cortex transplanted to ischemic adult rat cortex. J. Neurosurg. 69: 904-912.
20. MUFSON, E. J., R. LABBE, AND D. G. STEIN. 1987. Morphologic features of embryonic neocortex grafts in adult rats following frontal cortical ablation. Brain Res. 401: 162-167.
21. NIETO-SAMPEDRO, M., E. R. LEWIS, C. W. COTMAN, M. MANTHORPE, S. D. SKAPER, G. R. BARBIN, F. M. LONGO, AND S. VARON. 1982. Brain-injury causes a time dependent increase in neuronotrophic activity in the lesion site. Science 217: 860-861.
22. NIETO-SAMPEDRO, M., S. R. WHITTEMORE, D. L. NEEDLES, J. L. LARSON, AND C. W. COTMAN. 1984. The survival of brain transplants is enhanced by extracts from injured brain. Proc. Natl. Acad. Sci. USA 81: 6250-6254.
23. NORDBORG, C., T. E. O. SOKRAB, AND B. B. JOHANSSON. 1991. The relationship between plasma protein extravasation and remote tissue changes after experimental brain infarction. Acta Neuropathol. 82: 118-126.
24. OBUKHOVA, G. P., KH.K. GOGELIYA, V. V. SENATOROV, AND Z. FYULEUP. 1992. Afferent and efferent connections of cortical transplants implanted into the damaged sensorimotor area of the cerebral cortex of adult rats. Neurosci. Behav. Physiol. 22: 1-6.
25. OHLSSON, A.-L., AND B. B. JOHANSSON. 1995. The environment influences functional outcome of cerebral infarction in rats. Stroke 26: 644-649.
26. PLUMET, J., A. EBRAHIMI, J. GUITET, AND M. ROGER. 1993. Partial recovery of skilled forelimb reaching after transplantation of fetal cortical tissue in adult rats with motor cortex lesion -Anatomical and functional aspects. Restor. Neurol. Neurosci. 6: 9-27.
27. ROSE, F. D. 1988. Environmental enrichment and recovery of function following brain damage in the rat. Med. Sci. Res. 16: 257-263.
28. SCHMUED, L. C., AND J. H. FALLON. 1986. Fluoro-Gold: A new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res. 377: 147-154.
29. SCHULZ, M., T. P. HOGAN, AND A. J. CASTRO. 1993. Connectivity of fetal neocortical block transplants in the excitotoxically ablated cortex of adult rats. Exp. Brain Res. 96: 480-486.
30. SENATOROV, V. V., C. NYAKAS, AND Z. FÜLÖP. 1993. Visualization of outgrowing axons of grafted neurons by anterograde labeling with phaseolus-vulgaris leucoagglutinin in the motor cortex of the rat. Restor. Neurol. Neurosci. 5: 337-345.
31. SHARP, F. R., AND M. F. GONZALEZ. 1986. Fetal cortical transplants ameliorate thalamic atrophy ipsilateral to neonatal frontal cortex lesions. Neurosci. Lett. 71: 247-251.
32. SHARP, F. R., M. F. GONZALEZ, D. M. FERRIERO, AND S. M. SAGAR. 1986. Injured adult neocortical neurons sprout fibers into surviving fetal frontal cortex transplants: Evidence using NADPH-diaphorase staining. Neurosci. Lett. 65: 204-208.
33. SOFRONIEW, M. V., S. B. DUNNETT, AND O. ISACSON. 1990. Remodelling of intrinsic and afferent systems in neocortex with cortical transplants. Prog. Brain Res. 82: 313-320.
34. SOFRONIEW, M. V., O. ISACSON, AND A. BJORKLUND. 1986. Cortical grafts prevent atrophy of cholinergic basal nucleus neurons induced by excitotoxic cortical damage. Brain Res. 378: 409-415.
35. STEIN, D. G., C. PALATUCCI, D. KAHN, AND R. LABBE. 1988. Temporal factors influence recovery of function after embryonic brain tissue transplants in adult rats with frontal cortex lesions. Behav. Neurosci. 102: 260-267.
36. SØRENSEN, J. C., J. ZIMMER, AND A. J. CASTRO. 1989. Fetal cortical transplants reduce the thalamic atrophy induced by frontal cortical lesions in newborn rats. Neurosci. Lett. 98: 33-38.
37. SØRENSEN, J. C., H. WANNER-OLSEN, N. TØNDER, E. DANIELSEN, A. J. CASTRO, AND J. ZIMMER. 1990. Axotomized adult basal forebrain neurons can innervate fetal frontal cortex grafts: A double fluorescent tracer study in the rat. Exp. Brain Res. 81: 545-551.
38. VEENMAN, C. L., A. REINER, AND M. G. HONIG. 1992. Biotinylated Dextran amine as an anterograde tracer for single- and double-labeling studies. J. Neurosci. Methods 41: 239-254.
39. WILL, B., AND C. KELCHE. 1992. Environmental approaches to recovery of function from brain damage: A review of animal studies (1981-1991). In F. D. Rose and D. A. Johnson, Eds., Recovery from Brain Damage. Plenum, New York.