Neural induction

Current Opinion in Genetics and Development

Volumn 10, Issue 4, 2000, Pages 357-362

  Harland, Richard ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; MESSENGER RNA;

AMPHIBIA; CHICKEN; ECTODERM; EMBRYOLOGY; MODEL; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW; ZEBRA FISH;

EID: 0033924331     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00096-4     Document Type: Review

References (85)

1. Bier E. Anti-neural-inhibition: a conserved mechanism for neural induction. Cell. 89:1997;681-684.
2. Graff J.M. Embryonic patterning: to BMP or not to BMP, that is the question. Cell. 89:1997;171-174.
3. Harland R., Gerhart J. Formation and function of Spemann's organizer. Annu Rev Cell Dev Biol. 13:1997;611-667.
4. Sasai Y., De Robertis E.M. Ectodermal patterning in vertebrate embryos. Dev Biol. 182:1997;5-20.
5. Wilson P.A., Hemmati-Brivanlou A. Vertebrate neural induction: inducers, inhibitors, and a new synthesis. Neuron. 18:1997;699-710.
6. Streit A., Stern C.D. Neural induction. A bird's eye view. Trends Genet. 15:1999;20-24.
7. Weinstein D.C., Hemmati-Brivanlou A. Neural induction. Annu Rev Cell Dev Biol. 15:1999;411-433.
8. Smith J.L., Schoenwolf G.C. Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation. J Exp Zool. 250:1989;49-62.
9. Sater A.K., Jacobson A.G. The role of the dorsal lip in the induction of heart mesoderm in Xenopus laevis. Development. 108:1990;461-470.
10. Shih J., Fraser S.E. Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage. Development. 122:1996;1313-1322.
11. Davidson B.P., Kinder S.J., Steiner K., Schoenwolf G.C., Tam P.P. Impact of node ablation on the morphogenesis of the body axis and the lateral asymmetry of the mouse embryo during early organogenesis. Dev Biol. 211:1999;11-26.
12. Ang S.L., Rossant J. HNF-3 beta is essential for node and notochord formation in mouse development. Cell. 78:1994;561-574.
13. Weinstein D.C., Ruiz i Altaba A., Chen W.S., Hoodless P., Prezioso V.R., Jessell T.M., Darnell J.E. Jr. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell. 78:1994;575-588.
14. Klingensmith J., Ang S.L., Bachiller D., Rossant J. Neural induction and patterning in the mouse in the absence of the node and its derivatives. Dev Biol. 216:1999;535-549. The authors demonstrate the absence of node signaling activities from mice lacking HNF3β yet the presence of neural inducing activity.
15. Yuan S., Darnell D.K., Schoenwolf G.C. Mesodermal patterning during avian gastrulation and neurulation: experimental induction of notochord from non-notochordal precursor cells. Dev Genet. 17:1995;38-54.
16. Psychoyos D., Stern C.D. Restoration of the organizer after radical ablation of Hensen's node and the anterior primitive streak in the chick embryo. Development. 122:1996;3263-3273.
17. Joubin K., Stern C.D. Molecular interactions continuously define the organizer during the cell movements of gastrulation. Cell. 98:1999;559-571.
18. Jones E.A., Woodland H.R. Spatial aspects of neural induction in Xenopus laevis. Development. 107:1989;785-791.
19. Hemmati-Brivanlou A., Stewart R.M., Harland R.M. Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus. Science. 250:1990;800-802.
20. Stewart R.M., Gerhart J.C. The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula. Development. 109:1990;363-372.
21. Harland R.M. Neural induction in Xenopus. Curr Opin Genet Dev. 4:1994;543-549.
22. Smith W.C., Harland R.M. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. Cell. 70:1992;829-840.
23. Lamb T.M., Knecht A.K., Smith W.C., Stachel S.E., Economides A.N., Stahl N., Yancopolous G.D., Harland R.M. Neural induction by the secreted polypeptide noggin. Science. 262:1993;713-718.
24. Hemmati-Brivanlou A., Kelly O.G., Melton D.A. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell. 77:1994;283-295.
25. Sasai Y., Lu B., Steinbeisser H., Geissert D., Gont L.K., De Robertis E.M. Xenopus chordin: a novel dorsalizing factor activated by orgaizer-specific homeobox genes. Cell. 79:1994;779-790.
26. Sasai Y., Lu B., Steinbeisser H., De Robertis E.M. Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus. Nature. 376:1995;333-336.
27. Smith W.C., McKendry R., Ribisi S. Jr., Harland R.M. A nodal-related gene defines a physical and functional domain within the Spemann organizer. Cell. 82:1995;37-46.
28. Hansen C.S., Marion C.D., Steele K., George S., Smith W.C. Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3. Development. 124:1997;483-492.
29. Bouwmeester T., Kim S., Sasai Y., Lu B., De Robertis E.M. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature. 382:1996;595-601.
30. Hemmati-Brivanlou A., Melton D.A. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 359:1992;609-614.
31. Harland R.M. Commentary: the transforming growth factor beta family and induction of the vertebrate mesoderm: bone morphogenetic proteins are ventral inducers. Proc Natl Acad Sci USA. 91:1994;10 243-10 246.
32. Wilson P.A., Hemmati-Brivanlou A. Induction of epidermis and inhibition of neural fate by Bmp-4. Nature. 376:1995;331-333.
33. Piccolo S., Sasai Y., Lu B., De Robertis E.M. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4. Cell. 86:1996;589-598.
34. Zimmerman L.B., De Jesus-Escobar J.M., Harland R.M. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Cell. 86:1996;599-606.
35. Hsu D.R., Economides A.N., Wang X., Eimon P.M., Harland R.M. The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell. 1:1998;673-683.
36. Piccolo S., Agius E., Leyns L., Bhattacharya S., Grunz H., Bouwmeister T., De Robertis E. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature. 397:1999;707-710.
37. Fainsod A., Deissler K., Yelin R., Marom K., Epstein M., Pillemer G., Steinbeisser H., Blum M. The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4. Mech Dev. 63:1997;39-50.
38. Iemura S., Yamamoto T.S., Takagi C., Uchiyama H., Natsume T., Shimasaki S., Sugino H., Ueno N. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc Natl Acad Sci USA. 95:1998;9337-9342.
39. Liem K.F. Jr., Tremml G., Jessell T.M. A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord. Cell. 91:1997;127-138.
40. Meno C., Gritsman K., Ohishi S., Ohfuji Y., Heckscher E., Mochida K., Shimono A., Kondoh H., Talbot W.S., Robertson E.J.et al. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell. 4:1999;287-298.
41. Matzuk M.M., Lu N., Vogel H., Sellheyer K., Roop D.R., Bradley A. Multiple defects and perinatal death in mice deficient in follistatin. Nature. 374:1995;360-363.
42. McMahon J.A., Takada S., Zimmerman L.B., Fan C.M., Harland R.M., McMahon A.P. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 12:1998;1438-1452.
43. Simpson E.H., Johnson D.K., Hunsicker P., Suffolk R., Jordan S.A., Jackson I.J. The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation. Dev Biol. 213:1999;202-206.
44. Bachiller D., Klingensmith J., Kemp C., Belo J.A., Anderson R.M., May S.R., McMahon J.A., McMahon A.P., Harland R.M., Rossant J., De Robertis E.M. The organizer factors Chordin and Noggin are required for mouse forebrain development. Nature. 403:2000;658-661. Even a double mutant in BMP antagonists makes a neural plate, though a poorly patterned one.
45. Hammerschmidt M., Pelegri F., Mullins M.C., Kane D.A., van Eeden F.J., Granato M., Brand M., Furutani-Seiki M., Haffter P., Heisenberg C.P.et al. dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development. 123:1996;95-102.
46. Schulte-Merker S., Lee K.J., McMahon A.P., Hammerschmidt M. The zebrafish organizer requires chordino. Nature. 387:1997;862-863.
47. Piccolo S., Agius E., Lu B., Goodman S., Dale L., De Robertis E.M. Cleavage of Chordin by Xolloid metalloprotease suggests a role for proteolytic processing in the regulation of Spemann organizer activity. Cell. 91:1997;407-416.
48. Miller-Bertoglio V., Carmany-Rampey A., Furthauer M., Gonzalez E.M., Thisse C., Thisse B., Halpern M.E., Solnica-Krezel L. Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signalling. Dev Biol. 214:1999;72-86.
49. Kishimoto Y., Lee K.H., Zon L., Hammerschmidt M., Schulte-Merker S. The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning. Development. 124:1997;4457-4466.
50. Dick A., Hild M., Bauer H., Imai Y., Maifeld H., Schier A.F., Talbot W.S., Bouwmeester T., Hammerschmidt M. Essential role of Bmp7 (snailhouse) and its prodomain in dorsoventral patterning of the zebrafish embryo. Development. 127:2000;343-354.
51. Hild M., Dick A., Rauch G.J., Meier A., Bouwmeester T., Haffter P., Hammerschmidt M. The smad5 mutation somitabun blocks Bmp2b signaling during early dorsoventral patterning of the zebrafish embryo. Development. 126:1999;2149-2159.
52. Feldman B., Gates M.A., Egan E.S., Dougan S.T., Rennebeck G., Sirotkin H.I., Schier A.F., Talbot W.S. Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature. 395:1998;181-185.
53. Gritsman K., Zhang J., Cheng S., Heckscher E., Talbot W.S., Schier A.F. The EGF-CFC protein one-eyed pinhead is essential for nodal signalling. Cell. 97:1999;121-132.
54. Sirotkin H.I., Dougan S.T., Schier A.F., Talbot W. bozozok and squint act in parallel to specify dorsal mesoderm and anterior neurectoderm in zebrafish. Development. 127:2000;2583-2592. A combination of mutations in mesoderm inducers and Wnt/β-catenin target genes; these animals still make a neural plate.
55. Sagerstrom C.G., Grinbalt Y., Sive H. Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions. Development. 122:1996;1873-1883.
56. Woo K., Fraser S.E. Specification of the zebrafish nervous system by nonaxial signals. Science. 277:1997;254-257.
57. Schneider S., Steinbeisser H., Warga R.M., Hausen P. Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mech Dev. 57:1996;191-198.
58. Feldman B., Dougan S.T., Schier A.F., Talbot W.S. Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish. Curr Biol. 10:2000;531-534. In the absence of mesoderm inducers, the dorsal mesodermal territory becomes neural plate.
59. Koos D.S., Ho R.K. The nieuwkoid/dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula. Dev Biol. 215:1999;190-207. Transcriptional repression of bmp2 transcripts by a β-catenin target gene.
60. Fekany-Lee K., Gonzalez E., Miller-Bertoglio V., Solnica-Krezel L. The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways. Development. 127:2000;2333-2345. More on transcriptional repression of bmp genes.
61. Larabell C.A., Torres M., Rowning B.A., Yost C., Miller J.R., Wu M., Kimelman D., Moon R.T. Establishment of the dorso-ventral axis in Xenopus is presaged by early asymmetries in beta-catenin that are modulated by the Wnt signaling pathway. J Cell Biol. 136:1997;1123-1136.
62. Rowning B.A., Wells J., Wu M., Gerhart J.C., Moon R.T., Larabell C.A. Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs. Proc Natl Acad Sci USA. 94:1997;1224-1229.
63. Baker J.C., Beddington R.S., Harland R.M. Wnt signaling in Xenopus embryos inhibits bmp4 expression and activates neural development. Genes Dev. 13:1999;3149-3159. Demonstrates that Wnt signals are sufficient for neural induction of ectoderm, and that this is accompanied by an early repression of bmp transcripts.
64. Re'em-Kalma Y., Lamb T., Frank D. Competition between noggin and bone morphogenetic prein 4 activities may regulate dorsalization during Xenopus development. Proc Natl Acad Sci USA. 92:1995;12 141-12 145.
65. Hammerschmidt M., Serbedzija G.N., McMahon A.P. Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev. 10:1996;2452-2461.
66. Nguyen V.H., Schmid B., Trout J., Connors S.A., Ekker M., Mullins M.C. Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes. Dev Biol. 199:1998;93-110.
67. Fan M.J., Sokol S.Y. A role for Siamois in Spemann organizer formation. Development. 124:1997;2581-2589.
68. Kessler D.S. Siamois is required for formation of Spemann's organizer. Proc Natl Acad Sci USA. 94:1997;13 017-13 022.
69. Steinbeisser H., De Robertis E.M., Ku M., Kessler D.S., Melton D.A. Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs. Development. 118:1993;499-507.
70. Watabe T., Kim S., Candia A., Rothbacher U., Hashimoto C., Inoue K., Cho K.W. Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse. Genes Dev. 9:1995;3038-3050.
71. Kroll K.L., Salic A.N., Evans L.M., Kirschner M.W. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 125:1998;3247-3258.
72. Mariani F.V., Harland R.M. XBF-2 is a transcriptional repressor that converts ectoderm into neural tissue. Development. 125:1998;5019-5031.
73. Sasai Y. Identifying the missing links: genes that connect neural induction and primary neurogenesis in vertebrate embryos. Neuron. 21:1998;455-458.
74. Psychoyos D., Stern C.D. Fates and migratory routes of primitive streak cells in the chick embryo. Development. 122:1996;1523-1534.
75. Selleck M.A., Stern C.D. Fate mapping and cell lineage analysis of Hensen's node in the chick embryo. Development. 112:1991;615-626.
76. Streit A., Lee K.J., Woo I., Roberts C., Jessell T.M., Stern C.D. Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo. Development. 125:1998;507-519.
77. Streit A., Stern C.D. Establishment and maintenance of the border of the neural plate in the chick: involvement of FGF and BMP activity. Mech Dev. 82:1999;51-66.
78. Streit A., Stern C.D. Mesoderm patterning and somite formation during node regression: differential effects of chordin and noggin. Mech Dev. 85:1999;85-96.
79. Wilson S.I., Graziano E., Harland R.M., Jessel T.M., Edlund T. An early requirement for FGF signalling in the acquisition of neural cell fate in the chick embryo. Curr Biol. 10:2000;421-429. Shows that the epiblast of the chick embryo is specified to become neural, and that FGF signaling inhibits bmp expression. When FGF signaling is suppressed, and bmp transcripts are present, Noggin can induce neural tissue.
80. Jones C.M., Kuehn M.R., Hogan B.L., Smith J.C., Wright C.V. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. Development. 121:1995;3651-3662.
81. Erter C.E., Solnica-Krezel L., Wright C.V. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Dev Biol. 204:1998;361-372.
82. Waldrip W.R., Bikoff E.K., Hoodless P.A., Wrana J.L., Robertson E.J. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell. 92:1998;797-808.
83. Conlon F.L., Lyons K.M., Takaesu N., Barth K.S., Kispert A., Herrmann B., Robertson E.J. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse. Development. 120:1994;1919-1928.
84. Belo J.A., Bouwmeester T., Leyns L., Kertesz N., Gallo M., Follettie M., De Robertis E.M. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech Dev. 68:1997;45-57.
85. Servetnick M., Grainger R.M. Homeogenetic neural induction in Xenopus. Dev Biol. 147:1991;73-82.