Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter-a review of current understanding of its mechanism of action

Psychopharmacology

Volumn 219, Issue 1, 2012, Pages 1-13

  Zhong, Huailing ^a   Haddjeri, Nasser ^b   Sánchez, Connie ^c  

^a U Pharm Laboratories LLC   (United States)

^b UNIVERSITÉ LYON 1   (France)

^c LUNDBECK RESEARCH USA   (United States)

Author keywords

Allosteric; Escitalopram (S citalopram); Selective serotonin reuptake inhibitor (SSRI); Serotonin (5 HT); Serotonin transporter (SERT)

Indexed keywords

AMFEBUTAMONE; BRAIN DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; ESCITALOPRAM; FLUOXETINE; IMIPRAMINE; PAROXETINE; SEROTONIN TRANSPORTER;

ADAPTATION; BINDING SITE; DRUG ANTAGONISM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG MECHANISM; DRUG METABOLISM; DRUG PROTEIN BINDING; GENETIC VARIABILITY; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TRANSPORT; PSYCHOPHARMACOTHERAPY; REVIEW; SYNAPTIC TRANSMISSION;

ALLOSTERIC REGULATION; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CITALOPRAM; DEPRESSIVE DISORDER; HUMANS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS;

EID: 84856639838     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2463-5     Document Type: Review

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