Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 32, 2005, Pages 11545-11550

  Prasad, Harish C ^a   Zhu, Chong Bin ^a   McCauley, Jacob L ^a   Samuvel, Devadoss J ^c   Ramamoorthy, Sammanda ^c   Shelton, Richard C ^a   Hewlett, William A ^a   Sutcliffe, James S ^a,b   Blakely, Randy D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Antidepressant; Autism; Polymorphism; Regulation; Transport

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; 8 BROMO CYCLIC GMP; COMPLEMENTARY DNA; CYCLIC GMP DEPENDENT PROTEIN KINASE; IODINE 125; MITOGEN ACTIVATED PROTEIN KINASE P38; SEROTONIN; SEROTONIN TRANSPORTER; TRITIUM; TRYPTAMINE;

ARTICLE; AUTISM; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENETIC POLYMORPHISM; GENOTYPE; HELA CELL; HUMAN; HUMAN CELL; LYMPHOCYTE; MENTAL DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION;

CYCLIC GMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION; HELA CELLS; HERPESVIRUS 4, HUMAN; HUMANS; LYMPHOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; SEROTONIN; SIGNAL TRANSDUCTION; TRANSFECTION; VARIATION (GENETICS);

HUMAN HERPESVIRUS 4;

EID: 23844454012     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0501432102     Document Type: Article

References (54)

1. Jacobs, B. & Azmitia, E. C. (1992) Physiol Rev. 72, 165-229.
2. Fozzard, J. E. (1989) Peripheral Actions of 5-Hydroxytryptamine (Oxford Univ. Press, New York).
3. Insel, T. R., Zohar, J., Benkelfat, C. & Murphy, D. L. (1990) Ann. N.Y. Acad. Sci., 574-586.
4. Meltzer, H. Y. (1990) Ann. N.Y. Acad. Sci., 486-499.
5. Gershon, M. D. (1999) Aliment. Pharmacol. Ther. 13, Suppl. 2, 15-30.
6. Cook, E. H., Jr., & Leventhal, B. L. (1996) Curr. Opin. Pediatr. 8, 348-354.
7. Ramamoorthy, S., Bauman, A. L., Moore, K. R., Han, H., Yang-Feng, T., Chang, A. S., Ganapathy, V. & Blakely, R. D. (1993) Proc. Natl. Acad Sci. USA 90, 2542-2546.
8. Bradley, C. C. & Blakely, R. D. (1997) J. Neurochem. 69, 1356-1367.
9. Ozsarac, N., Santha, E. & Hoffman, B. J. (2002) J. Neurochem. 82, 336-344.
10. Hoffman, B. J., Mezey, E. & Brownstein, M. J. (1991) Science 254, 579-580.
11. Chen, J. G., Liu-Chen, S. & Rudnick, G. (1998) J. Biol. Chem. 273, 12675-12681.
12. Miner, L. H., Schroeter, S., Blakely, R. D. & Sesack, S. R. (2000) J. Comp. Neurol. 427, 220-234.
13. Ramamoorthy, S., Giovanetti, E., Qian, Y. & Blakely, R. D. (1998) J. Biol. Chem. 273, 2458-2466.
14. Ramamoorthy, S. & Blakely, R. D. (1999) Science 285, 763-766.
15. Zhu, C. B., Hewlett, W. A., Feoktistov, I., Biaggioni, I. & Blakely, R. D. (2004) Mol. Pharmacol. 65, 1462-1474.
16. Samuvel, D. J., Jayanthi, L. D., Bhat, N. R. & Ramamoorthy, S. (2005) J. Neurosci. 5, 29-41.
17. Zhu, C.-B., Carneiro, A. M., Dostmann, W. R., Hewlett, W. A. & Blakely, R. D. (2005) J. Biol. Chem. 280, 15649-15658.
18. Murphy, D. L., Lerner, A., Rudnick, G. & Lesch, K. P. (2004) Mol. Interv. 4, 109-123.
19. Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H. & Murphy, D. L. (1996) Science 274, 1527-1531.
20. MacKenzie, A. & Quinn, J. (1999) Proc. Natl. Acad. Sci. USA 96, 15251-15255.
21. Glatt, C. E., DeYoung, J. A., Delgado, S., Service, S. K., Giacomini, K. M., Edwards, R. H., Risch, N. & Freimer, N. B. (2001) Nat. Genet. 27, 435-438.
22. Di Bella, D., Catalano, M., Balling, U., Smeraldi, E. & Lesch, K. P. (1996) Am. J. Med. Genet. 67, 541-545.
23. Kilic, F., Murphy, D. L. & Rudnick, G. (2003) Mol. Pharmacol. 64, 440-446.
24. Ozaki, N., Goldman, D., Kaye, W. H., Plotnicov, K., Greenberg, B. D., Lappalainen, J., Rudnick, G. & Murphy, D. L. (2003) Mol. Psychiatry 8, 895, 933-936.
25. Pritchard, J. K. (2001) Am. J. Hum. Genet. 69, 124-137.
26. Cohen, J. C., Kiss, R. S., Pertsemlidis, A., Marcel, Y. L., McPherson, R. & Hobbs, H. H. (2004) Science 305, 869-872.
27. Qian, Y., Galli, A., Ramamoorthy, S., Risso, S., DeFelice, L. J. & Blakely, R. D. (1997) J. Neurosci. 17, 45-47.
28. Miller, K. J. & Hoffman, B. J. (1994) J. Biol. Chem. 269, 27351-27356.
29. Launay, J., Bondoux, D., Oset-Gasque, M., Emami, S., Mutel, V., Haimart, M. & Gespach, C. (1994) Am. J. Physiol. 266, 526-536.
30. Zhu, C. B., Hewlett, W. A., Francis, S. H., Corbin, J. D. & Blakely, R. D. (2004) Eur. J. Pharmacol. 504, 1-6.
31. McCauley, J. L., Olson, L. M., Dowd, M., Amin, T., Steele, A., Blakely, R. D., Holstein, S. E., Haines, J. L. & Sutcliffe, J. S. (2004) Am. J. Med. Genet. B Neuropsychiatr. Genet. 127, 104-112.
32. Hahn, M. K. & Blakely, R. D. (2002) Pharmacogenomics J. 2, 217-235.
33. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A. & Poulton, R. (2003) Science 301, 386-389.
34. Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Lane, C. R., Lim, E. P., Kalayanaraman, N., Nemesh, J., et al. (1999) Nat. Genet. 22, 231-238.
35. Shannon, J. R., Flattem, N. L., Jordan, J., Jacob, G., Black, B. K., Biaggioni, I., Blakely, R. D. & Robertson, D. (2000) N. Engl. J. Med. 342, 541-549.
36. Shu, Y., Leabman, M. K., Feng, B., Mangravite, L. M., Huang, C. C., Stryke, D., Kawamoto, M., Johns, S. J., DeYoung, J., Carlson, E., et al. (2003) Proc. Natl. Acad. Sci. USA 100, 5902-5907.
37. Hastrup, H., Karlin, A. & Javitch, J. A. (2001) Proc. Natl. Acad. Sci. USA 98, 10055-10060.
38. Haase, J., Killian, A. M., Magnani, F. & Williams, C. (2001) Biochem. Soc. Trans. 29, 722-728.
39. Bauman, A. L., Apparsundaram, S., Ramamoorthy, S., Wadzinski, B. E., Vaughan, R. A. & Blakely, R. D. (2000) J. Neurosci. 20, 7571-7578.
40. Carneiro, A., Ingram, S. L., Beaulieu, J.-M., Sweeney, A., Amara, S. G., Thomas, S. M., Caron, M. G. & Torres, G. E. (2002) J. Neurosci. 22, 7045-7054.
41. Jess, U., El Far, O., Kirsch, J. & Betz, H. (2002) Biochem. Biophys. Res. Commun. 294, 272-279.
42. Chen, J. G., Sachpatzidis, A. & Rudnick, G. (1997) J. Biol. Chem. 272, 28321-28327.
43. Norregaard, L., Frederiksen, D., Nielsen, E. O. & Gether, U. (1998) EMBO J. 17, 4266-4273.
44. Melikian, H. E. (2004) Pharmacol. Ther. 104, 17-27.
45. Jayanthi, L. D., Samuvel, D. J., Blakely, R. D. & Ramamoorthy, S. (2005) Mol. Pharmacol. 67, 2077-2087.
46. Lebrand, C., Cases, O., Wehrle, R., Blakely, R. D., Edwards, R. H. & Caspar, P. (1998) J. Comp. Neurol. 401, 506-524.
47. Persico, A. M., Mengual, E., Moessner, R., Hall, F. S., Revay, R. S., Sora, I., Arellano, J., DeFelipe, J., Gimenez-Amaya, J. M., Conciatori, M., et al. (2001) J. Neurosci. 21, 6862-6873.
48. Ansorge, M. S., Zhou, M., Lira, A., Hen, R. & Gingrich, J. A. (2004) Science 306, 879-881.
49. Ciaranello, R. D. (1982) N. Engl. J. Med. 307, 181-183.
50. Piven, J., Tsai, G. C., Nehme, E., Coyle, J. T., Chase, G. A. & Folstein, S. E. (1991) J. Autism Dev. Disord. 21, 51-59.
51. Chugani, D. C., Muzik, O., Behen, M., Rothermel, R., Janisse, J. J., Lee, J. & Chugani, H. T. (1999) Ann. Neurol. 45, 287-295.
52. Yonan, A. L., Alarcon, M., Cheng, R., Magnusson, P. K., Spence, S. J., Palmer, A. A., Grunn, A., Hank Juo, S. H., Terwilliger, J. D., Liu, J., et al. (2003) Am. J. Hum. Genet. 73, 886-897.
53. International Molecular Genetic Study of Autism Consortium (2001) Am. J. Hum. Genet. 69, 570-581.
54. Stone, J. L., Merriman, B., Cantor, R. M., Yonan, A. L., Gilliam, T. C., Geschwind, D. H. & Nelson, S. F. (2004) Am. J. Hum. Genet. 75, 1117-1123.