Chronic treatment with escitalopram but not R-citalopram translocates Gαs from lipid raft domains and potentiates adenylyl cyclase: A 5-hydroxytryptamine transporter-independent action of this antidepressant compound

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 3, 2010, Pages 977-984

  Zhang, Lanqiu ^a,b   Rasenick, Mark M ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CITALOPRAM; CYCLIC AMP; ESCITALOPRAM; FLUOXETINE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; SEROTONIN TRANSPORTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LYSATE; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS COUPLING REACTION; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME ACTIVITY; GLIOMA CELL; LIPID RAFT; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN LOCALIZATION; RAT; WHOLE CELL;

ADENYLATE CYCLASE; ANIMALS; ANTIDEPRESSIVE AGENTS; CELL LINE, TUMOR; CITALOPRAM; CYCLIC AMP; ENZYME ACTIVATION; FORSKOLIN; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; ISOPROTERENOL; MEMBRANE MICRODOMAINS; PROTEIN TRANSPORT; RATS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77249094706     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.162644     Document Type: Article

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