Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans

Chirality

Volumn 9, Issue 7, 1997, Pages 686-692

  Sidhu, Jagdev ^a   Priskorn, Morten ^a   Poulsen, Mette ^a   Segonzac, Alain ^b   Grollier, Gilles ^c   Larsen, Frank ^a  

^a H LUNDBECK A S   (Denmark)

^b Group for Pharmacological Research   (France)

^c CAEN UNIVERSITY HOSPITAL   (France)

Author keywords

Citalopram; DCT; DDCT; Enantiomer pharmacokinetics; Metabolites; Stereospecific HPLC analysis

Indexed keywords

CITALOPRAM; NORCITALOPRAM;

ADULT; ARTICLE; BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG URINE LEVEL; ENANTIOMER; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SEROTONINERGIC TRANSMISSION; SEX DIFFERENCE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ADULT; ANTIDEPRESSIVE AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITALOPRAM; FEMALE; HUMANS; MALE; STEREOISOMERISM;

EID: 0030682236     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:7<686::AID-CHIR9>3.0.CO;2-5     Document Type: Article

References (16)

1. Hyttel, J., Larsen, J.J. Serotonin-selective antidepressants. Acta Pharmacol. Toxicol. 56 (Suppl 1):146-153, 1985.
2. Øyehaug, E., Østensen, E.T., Salvesen, B. High-performance liquid chromatography determination of citalopram and four of its metabolites in plasma and urine samples from psychiatric patients. J. Chromatogr. 308:199-208, 1984.
3. Baumann, P., Larsen, F. The pharmacokinetics of citalopram. Rev. Contemp. Pharmacother. 6:287-295, 1995.
4. Hyttel, J., Bøgesø, K.P., Perregaard, J., Sanchez, C. The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer. J. Neural. Transm. 88:157-160, 1992.
5. Chung, M. Computation of model-independent pharmacokinetic parameters during multiple dosing. J. Pharm. Sci. 73:570-571, 1984.
6. Rochat, B., Amey, M., Baumann, P. Analysis of the enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse phase liquid chromatography. Ther. Drug Monitor. 17:273-279, 1995.
7. Williams, K.M. Molecular asymmetry and its pharmacological consequences. Adv. Pharmacol. 22:57-135, 1991.
8. Rochat, B., Amey, M., van Gelderen, H., Testa, B., Baumann, P. Determination of the enantiomers of citalopram, its demethylated and propionic acid metabolites in human plasma by chiral HPLC. Chirality 7:389-395, 1995.
9. Nakamura, Y., Yamaguchi, T., Takahashi, S., Hashimoto, S., Iwatani, K., Nakagawa, Y. Optical isomerization mechanism of R(-)-hydratropic acid derivatives. J. Pharmacobiodyn. 4:S-1, 1981.
10. Reist, M., Testa, B., Carrupt, P.-A., Jung, M., Schurig, V. Racemization, enantiomerization, diastereomerization, and epimerization: Their meaning and pharmacological significance. Chirality 7:396-400, 1995.
11. Sindrup, S.H., Brøsen, K., Hansen, M.G.J., Aaes-Jørgensen, T., Overø, K.F., Gram, L.F. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther. Drug Monitor. 15:11-17, 1993.
12. Kobayashi, K. Identification of CYP P450 isoforms involved in citalopram N-demethylation by human liver microsomes. J Pharmacol Exp Ther 280:927-933, 1997.
13. Bondolfi, G., Chautems, C., Rochat, B., Bertschy, G., Baumann, P. Non-response to citalopram in depressive patients: Pharmacokinetic and clinical consequences of a fluvoxamine augmentation. Psychopharmacology 128:421-425, 1996.
14. van Crugten, J., Bochner, F., Keal, J., Somogyi, A. Selectivity of the cimetidine-induced alterations in the renal handling of organic substrates in humans. Studies with anionic, cationic and zwitterionic drugs. J. Pharmacol. Exp. Ther. 236:481-487, 1986.
15. Priskorn, M., Larsen, F., Segonzac, A., Moulin, M. Pharmacokinetic interaction study of citalopram and cimetidine in healthy subjects. Eur. J. Clin. Pharmacol. 52:241-242, 1997.
16. Leinonen, E., Lepola, U., Koponen, H., Kinnunen, I. The effect of age and concomitant treatment with other psychoactive drugs on serum concentrations of citalopram measured with a nonenantioselective method. Ther. Drug Monitor. 18:111-117, 1996.