Involvement of C-type inactivation gating in the actions of voltage-gated K + channel inhibitors

Pharmacology and Therapeutics

Volumn 133, Issue 2, 2012, Pages 151-158

  Leung, Yuk Man ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Blockers; C type inactivation; Gating; Voltage gated K + channels

Indexed keywords

2' (4 METHOXYPHENYLACETAMIDOMETHYL) N [2 (3 PYRIDYL)ETHYL] 2 BIPHENYLCARBOXAMIDE; 4 AMINOPYRIDINE; ARGININE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CASPASE; DENDROTOXIN; DOFETILIDE; GLUTAMIC ACID; LYSINE; POTASSIUM CHANNEL KV1.2; QUATERNARY AMMONIUM DERIVATIVE; QUINIDINE; RHYNCHOPHYLLINE; SCORPION VENOM; SHAB POTASSIUM CHANNEL; SHAKER POTASSIUM CHANNEL; TETRYLAMMONIUM; TITYUS TOXIN; VALINE; VERAPAMIL;

APOPTOSIS; CHANNEL GATING; DEPOLARIZATION; EPILEPSY; HUMAN; MEMBRANE STABILIZATION; MEMBRANE TRANSPORT; MUTAGENESIS; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; POTASSIUM TRANSPORT; PRIORITY JOURNAL; REVIEW; STEADY STATE;

ANIMALS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED;

EID: 84856501465     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.10.005     Document Type: Review

References (68)

1. C.A. Ahern, A.L. Eastwood, D.A. Dougherty, and R. Horn An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels J Gen Physiol 134 2009 461 469
2. C.M. Armstrong Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons J Gen Physiol 58 1971 413 437
3. +: a tale of two inactivation mechanisms Neuron 15 1995 951 960
4. + channel Science 271 1996 653 656 (Pubitemid 26052911)
5. C. Bernard, A. Anderson, A. Becker, N.P. Poolos, H. Beck, and D. Johnston Acquired dendritic channelopathy in temporal lobe epilepsy Science 305 2004 532 535 (Pubitemid 38971346)
6. + channel inactivation Cell Biochem Biophys 41 2004 25 40
7. + structure of the KcsA potassium channel Structure 19 1 2011 70 79
8. D.L. Browne, S.T. Gancher, J.G. Nutt, E.R. Brunt, E.A. Smith, and P. Kramer Episodic ataxia/myokymia syndrome is associated with point mutations in the human potassium channel gene, KCNA1 Nat Genet 8 1994 136 140 (Pubitemid 24308360)
9. C.C. Chao, C.C. Huang, C.S. Kuo, and Y.M. Leung Control of ionic selectivity by a pore helix residue in the Kv1.2 channel J Physiol Sci 60 2010 441 446
10. + channels in mouse neuroblastoma N2A cells Neuropharmacology 54 2008 1128 1135
11. W.W. Cheng, J.G. McCoy, A.N. Thompson, C.G. Nichols, and C.M. Nimigean Mechanism for selectivity-inactivation coupling in KcsA potassium channels Proc Natl Acad Sci U S A 108 2011 5272 5277
12. S. Choe, A. Kreusch, and P.J. Pfaffinger Towards the three-dimensional structure of voltage-gated potassium channels Trends Biochem Sci 24 1999 345 349 (Pubitemid 29421809)
13. + channels J Nat Prod 72 2009 830 834
14. T.W. Claydon, M. Vaid, S. Rezazadeh, S.J. Kehl, and D. Fedida 4-aminopyridine prevents the conformational changes associated with p/c-type inactivation in shaker channels J Pharmacol Exp Ther 320 2007 162 172 (Pubitemid 46025731)
15. J.F. Cordero-Morales, V. Jogini, S. Chakrapani, and E. Perozo A multipoint hydrogen-bond network underlying KcsA C-type inactivation Biophys J 100 2011 2387 2393
16. J.F. Cordero-Morales, V. Jogini, A. Lewis, V. Vasquez, D.M. Cortes, and B. Roux Molecular driving forces determining potassium channel slow inactivation Nat Struct Mol Biol 14 2007 1062 1069 (Pubitemid 350060332)
17. + channels Nature 466 2010 203 208
18. N. Decher, P. Kumar, T. Gonzalez, B. Pirard, and M.C. Sanguinetti Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation Mol Pharmacol 70 2006 1204 1211 (Pubitemid 44435971)
19. + conduction and selectivity Science 280 1998 69 77 (Pubitemid 28169082)
20. D. Fedida, N.D. Maruoka, and S. Lin Modulation of slow inactivation in human cardiac Kv1.5 channels by extra- and intracellular permeant cations J Physiol 515 Pt 2 1999 315 329 (Pubitemid 29129204)
21. + channels Circ Res 82 1998 386 395 (Pubitemid 28101196)
22. A.L. Harvey, and B. Robertson Dendrotoxins: structure-activity relationships and effects on potassium ion channels Curr Med Chem 11 2004 3065 3072 (Pubitemid 39545575)
23. L. Heginbotham, and R. MacKinnon The aromatic binding site for tetraethylammonium ion on potassium channels Neuron 8 1992 483 491
24. B. Hille Potassium channels and chloride channels Ion Channels of Excitable Membranes 3rd ed. 2001 Sinauer Press Sunderland, MA 134 141
25. G. Hollerer-Beitz, R. Schonherr, M. Koenen, and S.H. Heinemann N-Terminal deletions of rKv1.4 channels affect the voltage dependence of channel availability Pflugers Arch 438 1999 141 146 (Pubitemid 29291304)
26. T. Hoshi, W.N. Zagotta, and R.W. Aldrich Biophysical and molecular mechanisms of Shaker potassium channel inactivation Science 250 1990 533 538 (Pubitemid 120031778)
27. + channels: effects of alterations in the carboxy-terminal region Neuron 7 1991 547 556
28. M.J. Hour, and L.J. Hung Synthesis and antiplatelet activity of alkoxy derivatives of 2-phenylquinazolines Chin Pharm J 52 2000 167 177
29. C.L. Hsieh, T.Y. Ho, S.Y. Su, W.Y. Lo, C.H. Liu, and N.Y. Tang Uncaria rhynchophylla and Rhynchophylline inhibit c-Jun N-terminal kinase phosphorylation and nuclear factor-kappaB activity in kainic acid-treated rats Am J Chin Med 37 2009 351 360
30. C.L. Hu, Z. Liu, X.M. Zeng, Z.Q. Liu, X.H. Chen, and Z.H. Zhang 4-aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons Neuropharmacology 51 2006 737 746 (Pubitemid 44286928)
31. + suppresses the activation of apoptosis in lymphocytes J Biol Chem 272 1997 30567 30576 (Pubitemid 27512272)
32. F.M. Hughes Jr., and J.A. Cidlowski Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo Adv Enzyme Regul 39 1999 157 171
33. S. Imai, M. Osawa, K. Takeuchi, and I. Shimada Structural basis underlying the dual gate properties of KcsA Proc Natl Acad Sci U S A 107 14 2010 6216 6221
34. + channels expressed in Xenopus oocytes J Physiol 549 2003 683 695 (Pubitemid 36889762)
35. S.I. Judge, and C.T. Bever Jr. Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment Pharmacol Ther 111 2006 224 259 (Pubitemid 43765538)
36. T.H. Kang, Y. Murakami, H. Takayama, M. Kitajima, N. Aimi, and H. Watanabe Protective effect of rhynchophylline and isorhynchophylline on in vitro ischemia-induced neuronal damage in the hippocampus: putative neurotransmitter receptors involved in their action Life Sci 76 2004 331 343 (Pubitemid 39452914)
37. + channels are mutually exclusive Biophys J 86 2004 191 209 (Pubitemid 38067448)
38. + channel, hKv1.3: implications for a second open state? Br J Pharmacol 157 2009 757 768
39. H.T. Kurata, and D. Fedida A structural interpretation of voltage-gated potassium channel inactivation Prog Biophys Mol Biol 92 2006 185 208
40. + channels in vascular myocytes J Pharmacol Exp Ther 290 1999 1165 1174 (Pubitemid 29400257)
41. J.H. Lee, S.H. Choi, B.H. Lee, T.J. Shin, M.K. Pyo, and S.H. Hwang The effects of ginsenoside Rg(3) on human Kv1.4 channel currents without the N-terminal rapid inactivation domain Biol Pharm Bull 32 2009 614 618
42. J.H. Lee, S.H. Choi, T.J. Shin, B.H. Lee, S.H. Hwang, and H.C. Kim Effect of dextromethorphan on human K(v)1.3 channel activity: involvement of C-type inactivation Eur J Pharmacol 651 2011 122 127
43. + channel modulators as neuroprotective agents Life Sci 86 2010 775 780
44. + channels play a role in cAMP-stimulated neuritogenesis in mouse neuroblastoma N2A cells J Cell Physiol 226 2011 1090 1098
45. Y.M. Leung, K.L. Wong, C.H. Lin, C.C. Chao, C.H. Chou, and L.Y. Chang Dependence of 6beta-acetoxy-7alpha-hydroxyroyleanone block of Kv1.2 channels on C-type inactivation Cell Mol Life Sci 67 2010 147 156
46. J. Liu, M. Zhang, M. Jiang, and G.N. Tseng Structural and functional role of the extracellular s5-p linker in the HERG potassium channel J Gen Physiol 120 2002 723 737 (Pubitemid 35332590)
47. J. Lopez-Barneo, T. Hoshi, S.H. Heinemann, and R.W. Aldrich Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels Receptors Channels 1 1993 61 71
48. S. Maljevic, T.V. Wuttke, and H. Lerche Nervous system KV7 disorders: breakdown of a subthreshold brake J Physiol 586 2008 1791 1801 (Pubitemid 351997508)
49. S. McFarlane, and N.S. Pollock A role for voltage-gated potassium channels in the outgrowth of retinal axons in the developing visual system J Neurosci 20 2000 1020 1029 (Pubitemid 30220459)
50. F. Miceli, M.V. Soldovieri, M. Martire, and M. Taglialatela Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs Curr Opin Pharmacol 8 2008 65 74 (Pubitemid 351168693)
51. S. Mouhat, N. Andreotti, B. Jouirou, and J.M. Sabatier Animal toxins acting on voltage-gated potassium channels Curr Pharm Des 14 2008 2503 2518
52. R. Olcese It's spring-time for slow inactivation J Gen Physiol 134 2009 457 459
53. J.M. Pascual, C.C. Shieh, G.E. Kirsch, and A.M. Brown Multiple residues specify external tetraethylammonium blockade in voltage-gated potassium channels Biophys J 69 1995 428 434
54. N.S. Pollock, K. Atkinson-Leadbeater, J. Johnston, M. Larouche, W.C. Wildering, and S. McFarlane Voltage-gated potassium channels regulate the response of retinal growth cones to axon extension and guidance cues Eur J Neurosci 22 2005 569 578 (Pubitemid 41192267)
55. + channel (Kv1.4) expressed in Xenopus oocytes J Physiol 489 Pt 3 1995 709 721 (Pubitemid 26015842)
56. H. Rauer, and S. Grissmer Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3 Mol Pharmacol 50 1996 1625 1634 (Pubitemid 26425120)
57. S. Rezazadeh, T.W. Claydon, and D. Fedida KN-93 (2-[N-(2-hydroxyethyl)]- N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinn amyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels J Pharmacol Exp Ther 317 2006 292 299
58. A.R. Rodrigues, E.C. Arantes, F. Monje, W. Stuhmer, and W.A. Varanda Tityustoxin-K(alpha) blockade of the voltage-gated potassium channel Kv1.3 Br J Pharmacol 139 2003 1180 1186 (Pubitemid 36920681)
59. + current expressed in Xenopus oocytes J Physiol 481 Pt 3 1994 571 584
60. T. Sacco, A. De Luca, and F. Tempia Properties and expression of Kv3 channels in cerebellar Purkinje cells Mol Cell Neurosci 33 2006 170 179 (Pubitemid 44415491)
61. Y.S. Shiau, P.T. Huang, H.H. Liou, Y.C. Liaw, Y.Y. Shiau, and K.L. Lou Structural basis of binding and inhibition of novel tarantula toxins in mammalian voltage-dependent potassium channels Chem Res Toxicol 16 2003 1217 1225
62. S. Wang, M.J. Morales, Y.J. Qu, G.C. Bett, H.C. Strauss, and R.L. Rasmusson Kv1.4 channel block by quinidine: evidence for a drug-induced allosteric effect J Physiol 546 2003 387 401 (Pubitemid 36175975)
63. S.Y. Wang, and J.B. Wu Antioxidant activity of abietane-type diterpenes from heartwood of Taiwania cryptomerioides Hayata Holzforschung 56 2002 487 492
64. B.F. Yang, D.H. Xu, C.Q. Xu, Z. Li, Z.M. Du, and H.Z. Wang Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels Acta Pharmacol Sin 25 2004 554 560
65. G. Yellen The voltage-gated potassium channels and their relatives Nature 419 2002 35 42 (Pubitemid 34987863)
66. S.P. Yu Regulation and critical role of potassium homeostasis in apoptosis Prog Neurobiol 70 2003 363 386 (Pubitemid 37101137)
67. S.P. Yu, C.H. Yeh, S.L. Sensi, B.J. Gwag, L.M. Canzoniero, and Z.S. Farhangrazi Mediation of neuronal apoptosis by enhancement of outward potassium current Science 278 1997 114 117 (Pubitemid 27446288)
68. W.N. Zagotta, T. Hoshi, and R.W. Aldrich Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB Science 250 1990 568 571 (Pubitemid 120031789)