Acquired dendritic channelopathy in temporal lobe epilepsy

Science

Volumn 305, Issue 5683, 2004, Pages 532-535

  Bernard, Christophe ^a,b   Anderson, Anne ^a   Becker, Albert ^c   Poolos, Nicholas P ^a,d   Deck, Heinz ^c   Johnston, Daniel ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b INSERM   (France)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; DISEASES; ENZYME INHIBITION; ENZYMES;

CHANNELOPATHY; EPILEPSY; NEURONS;

NEUROLOGY;

MITOGEN ACTIVATED PROTEIN KINASE; POTASSIUM CHANNEL;

MEDICINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITE; ENZYME INHIBITION; GENETIC TRANSCRIPTION; NERVE CELL EXCITABILITY; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RAT; SEIZURE; SIGNAL TRANSDUCTION; TEMPORAL LOBE EPILEPSY;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; BUTADIENES; DENDRITES; ENZYME INHIBITORS; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; MALE; MEMBRANE POTENTIALS; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; PHOSPHORYLATION; PILOCARPINE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN KINASE C; PYRAMIDAL CELLS; RATS; RATS, SPRAGUE-DAWLEY; SHAL POTASSIUM CHANNELS;

ANIMALIA;

EID: 3242743584     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1097065     Document Type: Article

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30. This work was supported by INSERM; NIH grants NS39943, NS37444, MH44754, and MH48432; Ligue Française Contre l'Epilepsie; Sanofi Synthélabo; and Fondation Simone et Cino Del Duca. H.B. was supported by SFB-TR3 subproject C2 and Heisenberg stipend of the Deutsche Forschungs gemeinschaft. We thank M. Esclapez for helping to set up morphology, R. Gray for computer help, and P. Bregestovski for helpful comments on the manuscript. C.B. also thanks Y. Liang and other members of the lab for help with animal dissections.