Dependence of 6β-acetoxy-7α-hydroxyroyleanone block of Kv1.2 channels on C-type inactivation

Cellular and Molecular Life Sciences

Volumn 67, Issue 1, 2010, Pages 147-156

  Leung, Yuk Man ^a   Wong, Kar Lok ^a   Lin, Chia Huei ^a   Chao, Chia Chia ^a   Chou, Chun Hsiao ^a   Chang, Li Yun ^a   Chen, Siao Wei ^a   Cheng, Tzu Hurng ^a   Kuo, Yueh Hsiung ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

6 acetoxy 7 hydroxy royleanone; Block; C type inactivation; Voltage gated K+ channels

Indexed keywords

6BETA ACETOXY 7ALPHA HYDROXYROYLEANONE; DITERPENOID; GLYCINE; POTASSIUM CHANNEL KV1.2; POTASSIUM CHANNEL KV1.2 C TYPE; UNCLASSIFIED DRUG; VALINE; 7 ACYLOXY 6 HYDROXYROYLEANONE; 7-ACYLOXY-6-HYDROXYROYLEANONE; DITERPENE; POTASSIUM CHANNEL BLOCKING AGENT;

AMINO ACID SUBSTITUTION; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DEPOLARIZATION; ELECTRIC POTENTIAL; HUMAN; HUMAN CELL; IC 50; KINETICS; MUTANT; POTASSIUM CELL LEVEL; POTASSIUM CURRENT; REGULATORY MECHANISM; STEADY STATE; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROPHYSIOLOGY; METABOLISM; SITE DIRECTED MUTAGENESIS;

TAIWANIA CRYPTOMERIOIDES;

AMINO ACID SUBSTITUTION; CELL LINE; DITERPENES; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; KV1.2 POTASSIUM CHANNEL; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNEL BLOCKERS;

EID: 73749083014     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-009-0178-0     Document Type: Article

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