Rhynchophylline from Uncaria rhynchophylla functionally turns delayed rectifiers into A-type K+ channels

Journal of Natural Products

Volumn 72, Issue 5, 2009, Pages 830-834

  Chou, Chun Hsiao ^a   Gong, Chi Li ^a   Chao, Chia Chia ^a   Lin, Chia Huei ^a   Kwan, Chiu Yin ^a   Hsieh, Ching Liang ^a   Leung, Yuk Man ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL KV1.2; RHYNCHOPHYLLINE; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; POTASSIUM CELL LEVEL; POTASSIUM CURRENT; UNCARIA; UNCARIA RHYNCHOPHYLLA;

ANIMALS; DRUGS, CHINESE HERBAL; HUMANS; INDOLE ALKALOIDS; KV1.2 POTASSIUM CHANNEL; MICE; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; UNCARIA;

UNCARIA RHYNCHOPHYLLA;

EID: 66449090965     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np800729q     Document Type: Article

References (30)

1. Sutter, M. C.; Wang, Y. X. Cardiovasc. Res. 1993, 27, 1891-1901.
2. Shi, J. S.; Yu, J. X.; Chen, X. P.; Xu, R. X. Acta Pharmacol. Sin. 2003, 24, 97-101.
3. Endo, K.; Oshima, Y.; Kikuchi, H.; Koshihara, Y.; Hikino, H. Planta Med. 1983, 49, 188-190.
4. Zhang, W. B.; Chen, C. X.; Sim, S. M.; Kwan, C. Y. Naunyn- Schmiedebergs Arch. Pharmacol. 2004, 369, 232-238.
5. Kang, T. H.; Murakami, Y.; Takayama, H.; Kitajima, M.; Aimi, N.; Watanabe, H. Life Sci. 2004, 76, 331-343.
6. Shimada, Y.; Goto, H.; Itoh, T.; Sakakibara, I.; Kubo, M.; Sasaki, H. J. Pharm. Pharmacol. 1999, 51, 715-722.
7. Mohamed, A. F.; Matsumoto, K.; Tabata, K.; Takayama, H.; Kitajima, M.; Watanabe, H. J. Pharm. Pharmacol. 2000, 52, 1553-1561.
8. Hu, C. L.; Liu, Z.; Zeng, X. M.; Liu, Z. Q.; Chen, X. H.; Zhang, Z. H. Neuropharmacology 2006, 51, 737-746.
9. Sun, H. S.; Feng, Z. P.; Barber, P. A.; Buchan, A. M.; French, R. J. Neuroscience 2007, 144, 1509-1515.
10. Hille, B. Ion Channels of Excitable Membranes, 3rd ed.; Sinauer Press: Sunderland, MA, 2001; pp 131-143.
11. Yu, S. P. Prog. Neurobiol. 2003, 70, 363-386.
12. Choe, S.; Kreusch, A.; Pfaffinger, P. J. Trends Biochem. Sci. 1999, 24, 345-349.
13. Choe, S. Nat. Rev. Neurosci. 2002, 3, 115-121.
14. Yellen, G. Nature (London) 2002, 419, 35-42.
15. Kukuljan, M.; Labarca, P.; Latorre, R. Am. J. Physiol. 1995, 268, 535-556.
16. Kurata, H. T.; Soon, G. S.; Fedida, D. Gen. Physiol. 2001, 118, 315-332.
17. Andalib, P.; Consiglio, J. F.; Trapani, J. G.; Korn, S. J. Biophys. J. 2004, 87, 3148-3161.
18. Kurata, H. T.; Fedida, D. Prog. Biophys. Mol. Biol. 2006, 92, 185-208.
19. Chao, C. C.; Shieh, J.; Kuo, S. C.; Wu, B. T.; Hour, M. J.; Leung, Y. M. Neuropharmacology 2008, 54, 1128-1135.
20. Chung, Y. H.; Shin, C. M.; Kim, M. J.; Lee, B. K.; Cha, C. I. Brain Res. 2001, 897, 193-198.
21. Black, J. A.; Waxman, S. G.; Smith, K. J. Brain 2006, 129, 1319-1329.
22. Leung, Y. M.; Kang, Y.; Gao, X.; Xia, F.; Xie, H.; Sheu, L. J. Biol. Chem. 2003, 278, 17532-17538.
23. Wang, X. L.; Zhang, L. M.; Hua, Z. Yao Xue Xue Bao 1994, 29, 9-14.
24. Gui, L.; Li, Z. W.; Du, R.; Yuan, G. H.; Li, W.; Ren, F. X. Sheng Li Xue Bao 2005, 57, 648-652.
25. Cordero-Morales, J. F.; Jogini, V.; Lewis, A.; Vásquez, V.; Cortes, D. M.; Roux, B. Nat. Struct. Mol. Biol. 2007, 14, 1062-1069.
26. Ledoux, J.; Chartier, D.; Leblanc, N. J. Pharmacol. Exp. Ther. 1999, 290, 1165-1174.
27. Rezazadeh, S.; Claydon, T. W.; Fedida, D. K. J. Pharmacol. Exp. Ther. 2006, 317, 292-299.
28. McKay, M. C.; Worley, J. F. Am. J. Physiol. Cell Physiol. 2001, 281, 1277-1284.
29. Oliver, D.; Lien, C. C.; Soom, M.; Baukrowitz, T.; Jonas, P.; Fakler, B. Science 2004, 304, 265-270.
30. Gubitosi-Klug, R. A.; Gross, R. W. J. Biol. Chem. 1996, 271, 32519-32522.