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Volumn 8, Issue 1, 2012, Pages 63-75

Obesity as a model of premature immunosenescence

Author keywords

Immune function; Immunosenescence; Obesity; Oxi inflamm aging; Premature aging

Indexed keywords

ADIPONECTIN; GHRELIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LEPTIN; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

EID: 84856456222     PISSN: 15733955     EISSN: 1875631X     Source Type: Journal    
DOI: 10.2174/157339512798991290     Document Type: Article
Times cited : (21)

References (106)
  • 1
    • 70449431387 scopus 로고    scopus 로고
    • An update of the oxidationinflammation theory of aging: The involvement of the immune system in oxi-inflamm-aging
    • De la Fuente M, Miquel J. An update of the oxidationinflammation theory of aging:the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des 2009; 15: 3003-26.
    • (2009) Curr Pharm Des , vol.15 , pp. 3003-3026
    • de la Fuente, M.1    Miquel, J.2
  • 2
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 2: 298-300.
    • (1956) J Gerontol , vol.2 , pp. 298-300
    • Harman, D.1
  • 5
    • 4544322045 scopus 로고    scopus 로고
    • Free radicals and aging
    • Barja G. Free radicals and aging. Trends Neurosci 2004; 27: 595-600.
    • (2004) Trends Neurosci , vol.27 , pp. 595-600
    • Barja, G.1
  • 6
    • 0031964919 scopus 로고    scopus 로고
    • An update on the oxygen stress-mitochondrial mutation theory of aging: Genetic and evolutionary implications
    • Miquel J. An update on the oxygen stress-mitochondrial mutation theory of aging: genetic and evolutionary implications. Exp Gerontol 1998; 33: 113-26.
    • (1998) Exp Gerontol , vol.33 , pp. 113-126
    • Miquel, J.1
  • 7
    • 84985570313 scopus 로고
    • Biochemistry of oxidative stress
    • Sies H. Biochemistry of oxidative stress. Angewandte Chem 1986; 25: 1058-71.
    • (1986) Angewandte Chem , vol.25 , pp. 1058-1071
    • Sies, H.1
  • 8
    • 0034050669 scopus 로고    scopus 로고
    • Review: Free Radicals, Antioxidants, and Immune System
    • Knight JA. Review: Free Radicals, Antioxidants, and Immune System. Ann Clin Lab Sci 2000; 30: 145-58.
    • (2000) Ann Clin Lab Sci , vol.30 , pp. 145-158
    • Knight, J.A.1
  • 9
    • 62749186719 scopus 로고    scopus 로고
    • Dose effect of oxidative stress on signal transduction in aging
    • Yoon SO, Yun ChH, Cheng AS. Dose effect of oxidative stress on signal transduction in aging. Mech Ageing Develop 2002; 50: 1-8.
    • (2002) Mech Ageing Develop , vol.50 , pp. 1-8
    • Yoon, S.O.1    Yun, C.H.2    Cheng, A.S.3
  • 10
    • 0000055057 scopus 로고
    • Pleiotropy, natural selection and the evolution of senescence
    • Williams GC. Pleiotropy, natural selection and the evolution of senescence. Evolution 1957; 2: 397-411.
    • (1957) Evolution , vol.2 , pp. 397-411
    • Williams, G.C.1
  • 12
    • 0018861356 scopus 로고
    • Asessment of biological age using a profile of physical parameters
    • Borkan A, Norris AH. Asessment of biological age using a profile of physical parameters. J Gerontol 1980; 35: 177-84.
    • (1980) J Gerontol , vol.35 , pp. 177-184
    • Borkan, A.1    Norris, A.H.2
  • 13
    • 0021883226 scopus 로고
    • Biological and social predictors of health in an aging cohort
    • Benfante R, Reed D, Brody J. Biological and social predictors of health in an aging cohort. J Chronic Dis 1985; 38: 385-95.
    • (1985) J Chronic Dis , vol.38 , pp. 385-395
    • Benfante, R.1    Reed, D.2    Brody, J.3
  • 14
    • 47549102739 scopus 로고    scopus 로고
    • Development of models for predicting biological age (BA) with physical, biochemical, and hormonal parameters
    • Bae CY, Kang YG, Kim S, et al. Development of models for predicting biological age (BA) with physical, biochemical, and hormonal parameters. Arch Gerontol Geriatr 2008; 47: 253-65.
    • (2008) Arch Gerontol Geriatr , vol.47 , pp. 253-265
    • Bae, C.Y.1    Kang, Y.G.2    Kim, S.3
  • 16
    • 0031240062 scopus 로고    scopus 로고
    • Natural killer cells in the later decades of human life
    • Ogata K, Yokose N, Tamura H, et al. Natural killer cells in the later decades of human life. Clin Immunol Immunopathol 1997; 84: 269-75.
    • (1997) Clin Immunol Immunopathol , vol.84 , pp. 269-275
    • Ogata, K.1    Yokose, N.2    Tamura, H.3
  • 17
    • 0037012047 scopus 로고    scopus 로고
    • Leukocyte function and life span in a murine model of premature immunosenescence
    • Guayerbas N, Puerto M, Victor VM, Miquel J, De la Fuente M. Leukocyte function and life span in a murine model of premature immunosenescence. Exp Gerontol 2002; 37: 249-56.
    • (2002) Exp Gerontol , vol.37 , pp. 249-256
    • Guayerbas, N.1    Puerto, M.2    Victor, V.M.3    Miquel, J.4    de la Fuente, M.5
  • 18
    • 0037151259 scopus 로고    scopus 로고
    • Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence
    • Guayerbas N, Catalan M, Victor VM, Miquel J, De la Fuente M. Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence. Behav Brain Res 2002; 134: 41-8.
    • (2002) Behav Brain Res , vol.134 , pp. 41-48
    • Guayerbas, N.1    Catalan, M.2    Victor, V.M.3    Miquel, J.4    de la Fuente, M.5
  • 19
    • 0037393466 scopus 로고    scopus 로고
    • An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice
    • Guayerbas N, De La Fuente M. An impairment of phagocytic function is linked to a shorter life span in two strains of prematurely aging mice. Dev Comp Immunol 2003; 27: 339-50.
    • (2003) Dev Comp Immunol , vol.27 , pp. 339-350
    • Guayerbas, N.1    de la Fuente, M.2
  • 20
    • 24144436152 scopus 로고    scopus 로고
    • The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise
    • De la Fuente M, Hernanz A, Vallejo, MC. The immune system in the oxidation stress conditions of aging and hypertension. Favorable effects of antioxidants and physical exercise. Antioxid Redox Signal 2005; 7: 1356-66.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 1356-1366
    • de la Fuente, M.1    Hernanz, A.2    Vallejo, M.C.3
  • 21
    • 0025213974 scopus 로고
    • Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60
    • Wayne SJ, Rhyne RL, Garry PJ, Goodwin JS. Cell-mediated immunity as a predictor of morbidity and mortality in subjects over 60. J Gerontol 1990;45: M45-8.
    • (1990) J Gerontol , vol.45
    • Wayne, S.J.1    Rhyne, R.L.2    Garry, P.J.3    Goodwin, J.S.4
  • 22
    • 0343488802 scopus 로고    scopus 로고
    • Physiological basis for long life span
    • Ma YX, Yue Z, Wang ZS, et al. Physiological basis for long life span. Mech Ageing Dev 1997; 98: 47-55.
    • (1997) Mech Ageing Dev , vol.98 , pp. 47-55
    • Ma, Y.X.1    Yue, Z.2    Wang, Z.S.3
  • 24
    • 33847640493 scopus 로고    scopus 로고
    • Immunosenescence: Emerging challenges for an ageing population
    • Aw D, Silva AB, Palmer DB. Immunosenescence: emerging challenges for an ageing population. Immunology 2007; 120: 435-46.
    • (2007) Immunology , vol.120 , pp. 435-446
    • Aw, D.1    Silva, A.B.2    Palmer, D.B.3
  • 25
    • 0842324563 scopus 로고    scopus 로고
    • Infection as a cause of age-related morbidity and mortality
    • High KP. Infection as a cause of age-related morbidity and mortality. Ageing Res Rev 2004; 3: 1-14.
    • (2004) Ageing Res Rev , vol.3 , pp. 1-14
    • High, K.P.1
  • 27
    • 0029124510 scopus 로고
    • Immunosenescence in humans: Deterioration or remodelling?
    • Franceschi C, Monti D, Barbieri D, et al. Immunosenescence in humans: deterioration or remodelling? Int Rev Immunol 1995; 12: 57-74.
    • (1995) Int Rev Immunol , vol.12 , pp. 57-74
    • Franceschi, C.1    Monti, D.2    Barbieri, D.3
  • 30
    • 33646397029 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impacto of immunosenescence
    • Trzonkowski P, Szmit E, Mysliwska J, Mysliwski A. CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impacto of immunosenescence. Clin Immunol 2006; 119: 307-16.
    • (2006) Clin Immunol , vol.119 , pp. 307-316
    • Trzonkowski, P.1    Szmit, E.2    Mysliwska, J.3    Mysliwski, A.4
  • 31
    • 21744437451 scopus 로고    scopus 로고
    • Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence
    • De la Fuente M, Hernanz A, Guayerbas N, Álvarez P, Alvarado C. Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence. Cell Mol Biol 2004, 50: 683-90.
    • (2004) Cell Mol Biol , vol.50 , pp. 683-690
    • de la Fuente, M.1    Hernanz, A.2    Guayerbas, N.3    Álvarez, P.4    Alvarado, C.5
  • 33
    • 57149096659 scopus 로고    scopus 로고
    • Role of neuroimmunomodulation in aging
    • De la Fuente M. Role of neuroimmunomodulation in aging. Neuroimmunomodulation 2008; 15: 213-23.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 213-223
    • de la Fuente, M.1
  • 36
    • 0021871082 scopus 로고
    • Changes in the macrophage function with aging
    • De la Fuente M. Changes in the macrophage function with aging. Comp Biochem Physiol 1985; 81: 935-8.
    • (1985) Comp Biochem Physiol , vol.81 , pp. 935-938
    • de la Fuente, M.1
  • 37
    • 0041345879 scopus 로고    scopus 로고
    • Immune disfunction in the elderly and its reversal by antihistaminas
    • Rafi A, Castle SC, Uyemura K, Makinodan T. Immune disfunction in the elderly and its reversal by antihistaminas. Biomed Pharmacother 2003; 57: 246-50.
    • (2003) Biomed Pharmacother , vol.57 , pp. 246-250
    • Rafi, A.1    Castle, S.C.2    Uyemura, K.3    Makinodan, T.4
  • 38
    • 33646550890 scopus 로고    scopus 로고
    • Age-dependent modifications of type 1 and type 2 cytokines within virgen and memory CD4+ T cells in humans
    • Alberti S, Cevenini E, Ostan R, et al. Age-dependent modifications of type 1 and type 2 cytokines within virgen and memory CD4+ T cells in humans. Mech Ageing Dev 2006; 127: 560-6.
    • (2006) Mech Ageing Dev , vol.127 , pp. 560-566
    • Alberti, S.1    Cevenini, E.2    Ostan, R.3
  • 39
    • 70349412916 scopus 로고    scopus 로고
    • A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people
    • Colonna-Romano G, Bulati M, Aquino A, et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev 2009; 130: 681-90.
    • (2009) Mech Ageing Dev , vol.130 , pp. 681-690
    • Colonna-Romano, G.1    Bulati, M.2    Aquino, A.3
  • 40
    • 33244457799 scopus 로고    scopus 로고
    • Neural-immune interactions: An integrative view of bidirectional relationship between the brain and immune systems
    • Wrona D. Neural-immune interactions: An integrative view of bidirectional relationship between the brain and immune systems. J Neuroimmunol 2006; 172: 38-58.
    • (2006) J Neuroimmunol , vol.172 , pp. 38-58
    • Wrona, D.1
  • 41
    • 33845186911 scopus 로고    scopus 로고
    • Physiology of psychoneuroimmunology: A personal view
    • Besedovsky HO, Del Rey A. Physiology of psychoneuroimmunology: a personal view. Brain Behav Immun 2007; 21: 34-44.
    • (2007) Brain Behav Immun , vol.21 , pp. 34-44
    • Besedovsky, H.O.1    del Rey, A.2
  • 42
    • 0025417859 scopus 로고
    • A neuroendocrine-immune theory of aging
    • Fabris N. A neuroendocrine-immune theory of aging. Int J Neurosci 1990; 51: 373-5.
    • (1990) Int J Neurosci , vol.51 , pp. 373-375
    • Fabris, N.1
  • 43
    • 34547253128 scopus 로고    scopus 로고
    • Biochemical aspects of inflammation
    • Kulinsky VI. Biochemical aspects of inflammation. Biochemistry 2007; 72: 595-607.
    • (2007) Biochemistry , vol.72 , pp. 595-607
    • Kulinsky, V.I.1
  • 44
    • 55449136486 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction during aging: Role of NF-kappaB
    • Csiszar A, Wang M, Lakatia EG, Ungvari Z. Inflammation and endothelial dysfunction during aging: role of NF-kappaB. J Appl Physiol 2008; 105: 1333-41.
    • (2008) J Appl Physiol , vol.105 , pp. 1333-1341
    • Csiszar, A.1    Wang, M.2    Lakatia, E.G.3    Ungvari, Z.4
  • 45
    • 33747172229 scopus 로고    scopus 로고
    • Inlamm-aging, cytokines and aging: State of the art, new hypotheses on the role of mitochondria and new perspectivas from systems biology
    • Salvioli S, Capri M, Valensin S, et al. Inlamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectivas from systems biology. Curr Pharm Design 2006; 12: 3161-71.
    • (2006) Curr Pharm Design , vol.12 , pp. 3161-3171
    • Salvioli, S.1    Capri, M.2    Valensin, S.3
  • 46
    • 77950213263 scopus 로고    scopus 로고
    • Low grade inflammation as a common pathogenetic denominador in agerelated diseases: Novel drug targets for anti-ageing strategies and successful ageing achievement
    • Candore G, Caruso C, Jirillo E, Magrote T, Vasto S. Low grade inflammation as a common pathogenetic denominador in agerelated diseases: novel drug targets for anti-ageing strategies and successful ageing achievement. Current Pharm Des 2010, 16: 584-596.
    • (2010) Current Pharm Des , vol.16 , pp. 584-596
    • Candore, G.1    Caruso, C.2    Jirillo, E.3    Magrote, T.4    Vasto, S.5
  • 47
    • 57149086454 scopus 로고    scopus 로고
    • Immunosenescence and immunogenetic of human longevity
    • Ostan R, Bucci L, Capri M, et al. Immunosenescence and immunogenetic of human longevity. Neuroimmunomodulation 2008; 15: 224-43.
    • (2008) Neuroimmunomodulation , vol.15 , pp. 224-243
    • Ostan, R.1    Bucci, L.2    Capri, M.3
  • 48
    • 37049027109 scopus 로고    scopus 로고
    • A model of premature ageing in mice based on altered stress-related behavioural response and immunosenescence
    • Viveros MP, Arranz L, Hernanz A, Miquel J, De la Fuente M. A model of premature ageing in mice based on altered stress-related behavioural response and immunosenescence. Neuroimmunomodulation 2007; 14: 157-62.
    • (2007) Neuroimmunomodulation , vol.14 , pp. 157-162
    • Viveros, M.P.1    Arranz, L.2    Hernanz, A.3    Miquel, J.4    de la Fuente, M.5
  • 50
    • 79954522117 scopus 로고    scopus 로고
    • Role of the immune system in aging and longevity
    • Alonso-Fernandez P, De la Fuente M. Role of the immune system in aging and longevity. Curr Aging Sci 2011; 4(2): 78-100.
    • (2011) Curr Aging Sci , vol.4 , Issue.2 , pp. 78-100
    • Alonso-Fernandez, P.1    de la Fuente, M.2
  • 51
    • 22144481264 scopus 로고    scopus 로고
    • Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice
    • Puerto M, Guayerbas N, Alvarez, P, De la Fuente M. Modulation of neuropeptide Y and norepinephrine on several leucocyte functions in adult, old and very old mice. J Neuroimmunol 2005; 165: 33-40.
    • (2005) J Neuroimmunol , vol.165 , pp. 33-40
    • Puerto, M.1    Guayerbas, N.2    Alvarez, P.3    de la Fuente, M.4
  • 52
    • 77955863405 scopus 로고    scopus 로고
    • Preserved immune functions and controlled leukocyte oxidative stress in long-lived mice: Possible role of nuclear factor-kappaB
    • Arranz L, Caamano J, Lord JM, De la Fuente M. Preserved immune functions and controlled leukocyte oxidative stress in long-lived mice: Possible role of nuclear factor-kappaB. J Gerontol A Biol Sci Med Sci 2010; 65(9): 941-50.
    • (2010) J Gerontol A Biol Sci Med Sci , vol.65 , Issue.9 , pp. 941-950
    • Arranz, L.1    Caamano, J.2    Lord, J.M.3    de la Fuente, M.4
  • 53
    • 76949096175 scopus 로고    scopus 로고
    • Models of Aging of Neuroimmunomodulation. Strategies for its Improvement
    • De la Fuente M, Gimenez-Llort L. Models of Aging of Neuroimmunomodulation. Strategies for its Improvement. Neuroimmunomodulation. 2010; 17: 213-6.
    • (2010) Neuroimmunomodulation. , vol.17 , pp. 213-216
    • de la Fuente, M.1    Gimenez-Llort, L.2
  • 54
    • 77956110851 scopus 로고    scopus 로고
    • Environmental enrichment improves age-related immune system impairment. Long exposure since adulthood increases life span in mice
    • Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M. Environmental enrichment improves age-related immune system impairment. Long exposure since adulthood increases life span in mice. Rejuvenation Res 2010; 13(4): 415-28.
    • (2010) Rejuvenation Res , vol.13 , Issue.4 , pp. 415-428
    • Arranz, L.1    de Castro, N.M.2    Baeza, I.3    Maté, I.4    Viveros, M.P.5    de la Fuente, M.6
  • 55
    • 11244353176 scopus 로고    scopus 로고
    • Changes with aging in several leukocyte functions of male and female rats
    • De la Fuente M, Baeza I, Guayerbas N,. et al. Changes with aging in several leukocyte functions of male and female rats. Biogerontol 2004; 5: 389-400.
    • (2004) Biogerontol , vol.5 , pp. 389-400
    • de la Fuente, M.1    Baeza, I.2    Guayerbas, N.3
  • 56
    • 77249105928 scopus 로고    scopus 로고
    • Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems
    • Baeza I, De Castro NM, Gimenez-Llort L, De la Fuente M. Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems. J Neuroimmunol 2010; 219: 90-9.
    • (2010) J Neuroimmunol , vol.219 , pp. 90-99
    • Baeza, I.1    de Castro, N.M.2    Gimenez-Llort, L.3    de la Fuente, M.4
  • 57
    • 44849116310 scopus 로고    scopus 로고
    • The perfect storm: Obesity, adipocyte dysfunction, and metabolic consequences
    • De Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 2008; 54: 945-55.
    • (2008) Clin Chem , vol.54 , pp. 945-955
    • de Ferranti, S.1    Mozaffarian, D.2
  • 58
    • 33745896155 scopus 로고    scopus 로고
    • Recent advances in the relationship between obesity, inflammation, and insulin resistance
    • Bastard JP, Maachi M, Lagathu C, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17: 4-12.
    • (2006) Eur Cytokine Netw , vol.17 , pp. 4-12
    • Bastard, J.P.1    Maachi, M.2    Lagathu, C.3
  • 59
  • 61
    • 27844545767 scopus 로고    scopus 로고
    • Signalling role of adipose tissue: Adipokines and inflammation in obesity
    • Trayhurn P, Wood IS. Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans 2005; 33: 1078-81.
    • (2005) Biochem Soc Trans , vol.33 , pp. 1078-1081
    • Trayhurn, P.1    Wood, I.S.2
  • 62
    • 33748992313 scopus 로고    scopus 로고
    • Adipocytokines: Mediators linking adipose tissue, inflammation and immunity
    • Tilg H, Moschen AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 2006; 6: 772-83.
    • (2006) Nat Rev Immunol , vol.6 , pp. 772-783
    • Tilg, H.1    Moschen, A.R.2
  • 63
    • 35148886659 scopus 로고    scopus 로고
    • Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity
    • Gil A, María Aguilera C, Gil-Campos M, Cañete R. Altered signalling and gene expression associated with the immune system and the inflammatory response in obesity. Br J Nutr 2007; 98: S121-6.
    • (2007) Br J Nutr , vol.98
    • Gil, A.1    María Aguilera, C.2    Gil-Campos, M.3    Cañete, R.4
  • 64
    • 34548639473 scopus 로고    scopus 로고
    • Obesity-induced inflammation: A metabolic dialogue in the language of inflammation
    • Ferrante AW Jr. Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 2007; 262: 408-14.
    • (2007) J Intern Med , vol.262 , pp. 408-414
    • Ferrante Jr., A.W.1
  • 65
    • 33748742519 scopus 로고    scopus 로고
    • Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue
    • Cancello R, Clément K. Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue. BJOG 2006; 113: 1141-7.
    • (2006) BJOG , vol.113 , pp. 1141-1147
    • Cancello, R.1    Clément, K.2
  • 66
    • 0037469177 scopus 로고    scopus 로고
    • Clinical application of C-reactive protein for cardiovascular disease detection and prevention
    • Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation 2003; 107: 363-9.
    • (2003) Circulation , vol.107 , pp. 363-369
    • Ridker, P.M.1
  • 67
    • 34547670845 scopus 로고    scopus 로고
    • Biomarkers of obesity and subsequent cardiovascular events
    • Mussad S, Haynes EN. Biomarkers of obesity and subsequent cardiovascular events. Epidemiol Rev 2007; 29: 98-114.
    • (2007) Epidemiol Rev , vol.29 , pp. 98-114
    • Mussad, S.1    Haynes, E.N.2
  • 68
    • 16244381893 scopus 로고    scopus 로고
    • The inflammatory syndrome: The role of adipose tissue cytokines in metabolic disorders linked to obesity
    • Wisse BE. The inflammatory syndrome: the role of adipose tissue cytokines in metabolic disorders linked to obesity. J Am Soc Nephrol 2004; 15: 2792-800.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 2792-2800
    • Wisse, B.E.1
  • 69
    • 33746234763 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome
    • Picchi A, Gao X, Belmadani S, et al. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 2006; 99: 69-77.
    • (2006) Circ Res , vol.99 , pp. 69-77
    • Picchi, A.1    Gao, X.2    Belmadani, S.3
  • 70
    • 33846263404 scopus 로고    scopus 로고
    • Adipocytokines-novel link between inflammation and vascular function?
    • Guzik TJ, Mangalat D, Korbut R. Adipocytokines-novel link between inflammation and vascular function? J Physiol Pharmacol 2006; 57: 505-28.
    • (2006) J Physiol Pharmacol , vol.57 , pp. 505-528
    • Guzik, T.J.1    Mangalat, D.2    Korbut, R.3
  • 72
    • 0034097825 scopus 로고    scopus 로고
    • Leptin and the immune system: How nutritional status influences the immune response
    • Matarese G. Leptin and the immune system: how nutritional status influences the immune response. Eur Cytokine Netw 2000; 11: 7-14.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 7-14
    • Matarese, G.1
  • 73
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, an adipocytederived plasma protein, inhibits endothelial KF-kappaB signalling through a camp-dependent pathway
    • Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocytederived plasma protein, inhibits endothelial KF-kappaB signalling through a camp-dependent pathway. Circulation 2000; 102: 1296-301.
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 74
    • 35648993484 scopus 로고    scopus 로고
    • Novel connections between the neuroendocrine and immune systems: The ghrelin immunoregulatory network
    • Taub DD. Novel connections between the neuroendocrine and immune systems: the ghrelin immunoregulatory network. Vitam Horm 2008; 77: 325-46.
    • (2008) Vitam Horm , vol.77 , pp. 325-346
    • Taub, D.D.1
  • 78
    • 77949493588 scopus 로고    scopus 로고
    • Leptin and adiponectin: From energy and metabolic dysbalance to inflammation and autoimmunity
    • Stofkova A. Leptin and adiponectin: from energy and metabolic dysbalance to inflammation and autoimmunity. Endocr Regul 2009; 43: 157-68.
    • (2009) Endocr Regul , vol.43 , pp. 157-168
    • Stofkova, A.1
  • 79
    • 33750812250 scopus 로고    scopus 로고
    • The role of leptin in innate and adaptive immune responses
    • Bernotiene E, Palmer G, Gabay C. The role of leptin in innate and adaptive immune responses. Arthritis Res Ther 2006; 8: 217.
    • (2006) Arthritis Res Ther , vol.8 , pp. 217
    • Bernotiene, E.1    Palmer, G.2    Gabay, C.3
  • 80
    • 0033782028 scopus 로고    scopus 로고
    • Leptin in the regulation of immunity, inflammation, and hematopoiesis
    • Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol 2000; 68: 437-46.
    • (2000) J Leukoc Biol , vol.68 , pp. 437-446
    • Fantuzzi, G.1    Faggioni, R.2
  • 82
    • 33645069631 scopus 로고    scopus 로고
    • Therapeutic action of ghrelin in a mouse model of colitis
    • Gonzalez-Rey E, Chorny A, Delgado M. Therapeutic action of ghrelin in a mouse model of colitis. Gastroenterology 2006; 130: 1707-20.
    • (2006) Gastroenterology , vol.130 , pp. 1707-1720
    • Gonzalez-Rey, E.1    Chorny, A.2    Delgado, M.3
  • 84
    • 0035975710 scopus 로고    scopus 로고
    • Leptin signaling and aging: Insight from caloric restriction
    • Shimokawa I, Higami Y. Leptin signaling and aging: insight from caloric restriction. Mech Ageing Dev 2001: 122: 1511-9.
    • (2001) Mech Ageing Dev , vol.122 , pp. 1511-1519
    • Shimokawa, I.1    Higami, Y.2
  • 85
    • 27544497632 scopus 로고    scopus 로고
    • Ghrelin and immunity: A young player in an old field
    • Dixit VD, Taub DD. Ghrelin and immunity: a young player in an old field. Exp Gerontol 2005; 40: 900-10.
    • (2005) Exp Gerontol , vol.40 , pp. 900-910
    • Dixit, V.D.1    Taub, D.D.2
  • 86
    • 3242749843 scopus 로고    scopus 로고
    • Ghrelin inhibits leptin-and activation-induced pro-inflammatory cytokine expression by human monocytes and T cells
    • Dixit VD, Schaffer EM, Pyle RS, et al. Ghrelin inhibits leptin-and activation-induced pro-inflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004; 114: 57-66.
    • (2004) J Clin Invest , vol.114 , pp. 57-66
    • Dixit, V.D.1    Schaffer, E.M.2    Pyle, R.S.3
  • 87
    • 33845642664 scopus 로고    scopus 로고
    • The role of leptin and ghrelin in the regulation of food intake and body weight in humans: A review
    • Klok MD, Jakobsdottir S, Drent ML. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 2007; 8: 21-34.
    • (2007) Obes Rev , vol.8 , pp. 21-34
    • Klok, M.D.1    Jakobsdottir, S.2    Drent, M.L.3
  • 88
    • 33745176610 scopus 로고    scopus 로고
    • Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: Another reason for the "anorexia of aging"
    • Di Francesco V, Zamboni M, Zoico E, et al. Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: another reason for the "anorexia of aging". Am J Clin Nutr 2006; 83: 1149-52.
    • (2006) Am J Clin Nutr , vol.83 , pp. 1149-1152
    • di Francesco, V.1    Zamboni, M.2    Zoico, E.3
  • 90
    • 75149135340 scopus 로고    scopus 로고
    • Immunosenescence and vaccination of the elderly II. New strategies to restore age-related immune impairment
    • Ongrádi J, Stercz B, Kövesdi V, Vértes L. Immunosenescence and vaccination of the elderly II. New strategies to restore age-related immune impairment. Acta Microbiol Immunol Hung 2009; 56: 301-12.
    • (2009) Acta Microbiol Immunol Hung , vol.56 , pp. 301-312
    • Ongrádi, J.1    Stercz, B.2    Kövesdi, V.3    Vértes, L.4
  • 91
    • 74149086079 scopus 로고    scopus 로고
    • Maintenance of naivë CD8 T cells in nonagenarians by leptin, IGFBP3 and T3
    • Chen J, Li J, Lim FC, et al. Maintenance of naivë CD8 T cells in nonagenarians by leptin, IGFBP3 and T3. Mech Ageing Dev 2010; 131: 29-37.
    • (2010) Mech Ageing Dev , vol.131 , pp. 29-37
    • Chen, J.1    Li, J.2    Lim, F.C.3
  • 92
    • 34948853362 scopus 로고    scopus 로고
    • Ghrelin promotes thymopoiesis during aging
    • Dixit VD, Yang H, Sun Y, et al. Ghrelin promotes thymopoiesis during aging. J Clin Invest 2007; 117: 2778-90.
    • (2007) J Clin Invest , vol.117 , pp. 2778-2790
    • Dixit, V.D.1    Yang, H.2    Sun, Y.3
  • 95
    • 34249799917 scopus 로고    scopus 로고
    • The physiology of obese-hyperglycemic mice [ob/ob mice]
    • Lindström P. The physiology of obese-hyperglycemic mice [ob/ob mice]. ScientificWorldJournal 2007; 7: 666-85.
    • (2007) ScientificWorldJournal , vol.7 , pp. 666-685
    • Lindström, P.1
  • 96
    • 33846890411 scopus 로고    scopus 로고
    • Obesity and asthma: Lessons from animal models
    • Shore SA. Obesity and asthma: lessons from animal models. J Appl Physiol 2007; 102: 516-28.
    • (2007) J Appl Physiol , vol.102 , pp. 516-528
    • Shore, S.A.1
  • 98
    • 33747799996 scopus 로고    scopus 로고
    • Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice
    • Palmer G, Aurrand-Lions M, Contassot E, et al. Indirect effects of leptin receptor deficiency on lymphocyte populations and immune response in db/db mice. J Immunol 2006; 177: 2899-907.
    • (2006) J Immunol , vol.177 , pp. 2899-2907
    • Palmer, G.1    Aurrand-Lions, M.2    Contassot, E.3
  • 99
    • 34249279490 scopus 로고    scopus 로고
    • Animal models in type 2 diabetes research: An overview
    • Srinivasan K, Ramarao P. Animal models in type 2 diabetes research: an overview. Indian J Med Res 2007; 125: 451-72.
    • (2007) Indian J Med Res , vol.125 , pp. 451-472
    • Srinivasan, K.1    Ramarao, P.2
  • 100
    • 0017347635 scopus 로고
    • The Zucker-fatty rat: A review
    • Bray GA. The Zucker-fatty rat: a review. Fed Proc 1977; 36: 148-53.
    • (1977) Fed Proc , vol.36 , pp. 148-153
    • Bray, G.A.1
  • 101
    • 0030977881 scopus 로고    scopus 로고
    • Evidence for a central mechanism of obesity in the Zucker rat: Role of neuropeptide Y and leptin
    • White BD, Martin RJ. Evidence for a central mechanism of obesity in the Zucker rat: role of neuropeptide Y and leptin. Proc Soc Exp Biol Med 1997; 214: 222-32.
    • (1997) Proc Soc Exp Biol Med , vol.214 , pp. 222-232
    • White, B.D.1    Martin, R.J.2
  • 102
    • 73349118496 scopus 로고    scopus 로고
    • Experimental rat models to study the metabolic syndrome
    • Aleixandre de Artiñano A, Miguel Castro M. Experimental rat models to study the metabolic syndrome. Br J Nutr 2009; 102: 1246-53.
    • (2009) Br J Nutr , vol.102 , pp. 1246-1253
    • Aleixandre de Artiñano, A.1    Miguel Castro, M.2
  • 103
    • 15844372440 scopus 로고    scopus 로고
    • Identification and characterization of the mouse obesity gene tubby: A member of a novel gene family
    • Kleyn PW, Fan W, Kovats SG, et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 1996; 85: 281-90.
    • (1996) Cell , vol.85 , pp. 281-290
    • Kleyn, P.W.1    Fan, W.2    Kovats, S.G.3
  • 105
    • 0030459456 scopus 로고    scopus 로고
    • High-fat diet-induced hyperglycemia and obesity in mice: Differential effects of dietary oils
    • Ikemoto S, Takahashi M, Tsunoda N, Maruyama K, Itakura H, Ezaki O. High-fat diet-induced hyperglycemia and obesity in mice: differential effects of dietary oils. Metabolism 1996; 45: 1539-46.
    • (1996) Metabolism , vol.45 , pp. 1539-1546
    • Ikemoto, S.1    Takahashi, M.2    Tsunoda, N.3    Maruyama, K.4    Itakura, H.5    Ezaki, O.6
  • 106
    • 0030807358 scopus 로고    scopus 로고
    • Diet-induced obese mice develop peripheral, but not central, resistance to leptin
    • Van Heek M, Compton DS, France CF, et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest 1997; 99: 385-90.
    • (1997) J Clin Invest , vol.99 , pp. 385-390
    • van Heek, M.1    Compton, D.S.2    France, C.F.3


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