Leptin and the immune system: How nutritional status influences the immune response

European Cytokine Network

Volumn 11, Issue 1, 2000, Pages 7-13

  Matarese, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Immune response; Inflammation; Leptin; Nutritional status; T lymphocytes

Indexed keywords

CYTOKINE RECEPTOR; GAMMA INTERFERON; GROWTH HORMONE; INTERLEUKIN 12; INTERLEUKIN 2; LEPTIN;

ADIPOSE TISSUE; ATROPHY; BODY TEMPERATURE; DELAYED HYPERSENSITIVITY; HYPERPHAGIA; IMMUNE SYSTEM; INFERTILITY; LYMPHOID ORGAN; MEMORY CELL; MOUSE; NONHUMAN; NUTRITIONAL STATUS; OBESITY; REVIEW; STARVATION; THYMUS;

ANIMALS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNE SYSTEM; LEPTIN; MICE; MICE, OBESE; NUTRITIONAL STATUS; STARVATION; T-LYMPHOCYTES;

EID: 0034097825     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. 1. Moore S E, Cole T J, Poskitt E M E, Sonko B J, Whitehead R G, McGregor I A, Prentice A M. 1997. Season of birth predicts mortality in rural Gambia. Nature 338: 434.
2. 2. Chandra R K. 1996. Nutrition, immunity and infection: from basic knowledge of dietary manipulation of immune responses to practical application of amelorating suffering and improving survival. Proc. Natl Acad. Sci. USA 93: 14304.
3. 3. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J M. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425.
4. 4. Halaas J L, Gajiwala K S, Maffei M. 1995. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543.
5. 5. Friedman J M, Halaas J L. 1998. Leptin and the regulation of body weight in mammals. (Review) Nature 395: 763.
6. 6. Pelleymounter M A, Cullen M J, Baker M B, Hecht R, Winters D, Boone T, Collins F. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540.
7. 7. Campfield L A, Smith F J, Guisez Y, Devos R, Burn P. 1995. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546.
8. 8. Sierra-Honigmann M R, Nath A K, Murakami C. 1998. Biological action of leptin as an angiogenic factor. Science 281: 1683.
9. 9. Bouloumie A, Drexler H C, Lafontan M, Busse R. 1998. Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res. 83: 1059.
10. 10. Bennet B D, Solar G P, Yuan J O, Mathias J, Thomas G R, Matthews W. 1996. A role for leptin and its cognate receptor in hematopoiesis. Curr. Biol. 9: 1170.
11. 11. Lord G M, Matarese G, Howard J K, Baker R J, Bloom S R, Lechler R I. 1998. Leptin modulates the T cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897.
12. 12. Cohen S L, Halaas J L, Friedman J M, Chait B T, Bennett L, Chang D, Hecht R, Collins F. 1996. Characterization of endogenous human leptin. Nature 382: 589.
13. 13. Zhang F, Basinski M B, Beals J M, Briggs S L, Churgay L M, Clawson D K, DiMarchi R D, Furman T C, Hale J E, Hsiung H M, Schoner B E, Smith D P, Zhang X Y, Wery J P, Schevitz R W. 1997. Crystal structure of the obese protein leptin-E100. Nature 387: 206.
14. 14. Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau J P, Bortoluzzi M N, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin M J. 1998. The stomach is a source of leptin. Nature 395: 790.
15. 15. Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, Nakao K. 1997. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3: 1029.
16. 16. Elmquist J K, Maratos-Flier E, Saper C B, Flier J S. 1998. Unraveling the central nervous system pathways underlying responses to leptin. (Review) Nat. Neurosci. 6: 445.
17. 17. Unger R H, Zhou Y T, Orci L. 1999. Regulation of fatty acid homeostasis in cells: novel role for leptin. Proc. Natl. Acad. Sci. USA 96: 2327.
18. 18. Casabiell X, Piñeiro V, Peino R. 1998. Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J. Clin. Endocr. Metab. 83: 2149.
19. 19. Zumbach M S, Boheme M W J, Wahal P, Stremmel W, Ziegler R, Nawroth P P. 1997. Tumor necrosis factor increases serum leptin levels in humans. J. Clin. Endocrinol. Metab. 82: 4080.
20. 20. Mantzoros C S, Moschos S, Avramopoulos I, Kaklamani V, Liolios A, Doulgerakis D E, Griveas I, Katsilambros N, Flier J S. 1997. Leptin concentrations in relation to body mass index and the tumor necrosis factor-α system in humans. J. Clin. Endocrinol. Metab. 82: 3408.
21. 21. Janik J E, Curti B D, Considine R V, Rager H C, Powers G C, Alvord W G, Smith J W 2nd, Gause B L, Kopp W C. 1997. Interleukin-1 increases serum leptin levels in humans. J. Clin. Endocrinol. Metab. 82: 3084.
22. 22. Landt M, Parvin C A, Dagogo-Jack S, Bryant B, Coyne D W. 1999. Leptin elimination in hyperleptinaemic peritoneal dialysis patients. Nephrol. Dial. Transpl. 14: 732.
23. 23. Nordfors L, Linnqvist F, Heimburger O, Danielsson A, Schalling M, Stenvinkel P. 1998. Low leptin gene expression and hyperleptinemia in chronic renal failure. Kidney Int. 54: 1267.
24. 24. Torpy D J, Bornstein S R, Chrousos G P. 1998. Leptin and interleukin-6 in sepsis. Horm. Metab. Res. 30: 726.
25. 25. Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, Feingold K R. 1996. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. A role for leptin in the anorexia of infection. J. Clin. Invest. 97: 2152.
26. 26. Sarraf P, Frederich R C, Turner E M, Ma G, Jaskowiak N T, Rivet D J 3rd, Flier J S, Lowell B B, Fraker D L, Alexander H R. 1997. Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J. Exp. Med. 185: 171.
27. 27. Tartaglia L A, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards G J, Campfield L A, Clark F T, Deeds J. 1995. Identification and expression cloning of a leptin receptor, OB-R. Cell 83: 1263.
28. 28. Tartaglia L A. 1997. The leptin receptor. (Review) J. Biol. Chem. 272: 6093.
29. 29. Baumann H, Morella K K, White D W, Dembski M, Bailon P S, Kim H, Lai C F, Tartaglia L A. 1996. The full-lenght leptin receptor has signaling capabilities of IL-6-type cytokine receptor. Proc. Natl. Acad. Sci. USA 93: 8374.
30. 30. Vaisse C, Halaas J L, Horvath C M, Darnell J E Jr, Stoffel M, Friedman J M. 1996. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat. Genet. 14: 95.
31. 31. Zhao A Z, Bornfeldt K E, Beavo J A. 1998. Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J. Clin. Invest. 102: 869.
32. 32. Moon B C, Friedman J M. 1997. The molecular basis of the obese mutation in ob2j mice. Genomics 42: 152.
33. 33. Chen H, Charlat O, Tartaglia L A, Woolf E A, Weng X, Ellis S J, Lakey N D, Culpepper J, Moore K J, Breitbart R E, Duyk G M, Tepper R I, Morgenstern J P. 1996. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491.
34. 34. Chandra R K. 1980. Cell-mediated immunity in genetically obese (C57BL/6J ob/ob) mice. Am. J. Clin. Nutri. 33: 13.
35. 35. Mandel M A, Mahmoud A A. 1978. Impairment of cell-mediated immunity in mutation diabetic mice (db/db). J. Immunol. 120: 1375.
36. 36. Fernandes G, Handwerger B S, Yunis E J, Brown D M. 1978. Immune response in the mutant diabetic C57BL/Ks-db mouse. Discrepancies between in vitro and in vivo immunological assays. J. Clin. Invest. 61: 243.
37. 37. Dong Z M, Gutierrez-Ramos J C, Coxon A, Mayadas T N, Wagner D D. 1997. A new class of obesity genes encodes leukocyte adhesion receptors. Proc. Natl. Acad. Sci. USA 94: 7526.
38. 38. Ahima R S, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos Flier E, Flier J S. 1996. Role of leptin in the neuroendocrine response to fasting. Nature 382: 250.
39. 39. Boden G, Chen X, Mozzoli M, Ryan I. 1996. Effect of fasting on serum leptin in normal human subjects. J. Clin. Endocrinol. Metab. 81: 3419.
40. 40. Shoeller D A, Cella L K, Sinha M K, Caro J F. 1997. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J. Clin. Invest. 100: 1882.
41. 41. Flier J S. 1998. Lowered leptin slims immune response. Nat. Med. 10: 1124.
42. 42. Rolland V, Clement K, Dugail I, Guy-Grand B, Basdevant A, Froguel P, Lavau M. 1998. Leptin receptor gene in a large cohort of massively obese subjects: no indication of the fa/fa rat mutation. Detection of an intronic variant with no association with obesity. Obes. Res. 6: 122.
43. 43. Considine R V, Sinha M K, Heiman M L, Kriauciunas A, Stephens T W, Nyce M R, Ohannesian J P, Marco C C, McKee L J, Bauer T L. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334: 292.
44. 44. Ozata M, Ozdemir I C, Licinio J. 1998. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicates new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J. Clin. Endocrinol. Metab. 84: 3686.
45. 45. Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte J M, Basdevant A, Bougneres P, Lebouc Y, Froguel P, Guy-Grand B. 1998. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392: 398.
46. 46. Christadoss P, Talal N, Lindstrom J, Fernandes G. 1984. Suppression of cellular and humoral immunity to T-dependent antigens by caloric restriction. Cell. Imunol. 88: 1.
47. 47. Marcos A, Varela P, Toro O, Lopez-Vidriero I, Nova E, Madruga D, Casas J, Morande G. 1997. Interactions between nutrition and immunity in anorexia nervosa: a 1-year follow up study. Am. J. Clin. Nutr. 66: 485S.
48. 48. Chan J, Tian Y, Tanaka K E, Tsang M S, Yu K, Salgame P, Carroll D, Kress Y, Teitelbaum R, Bloom B R. 1996. Effects of protein caloric malnutrition on tubercolosis mice. Proc. Natl. Acad. Sci. USA 93: 14857.
49. 49. Matzoros C S, Prasad A S, Beck F W, Grabowski S, Kaplan J, Adair C, Brewer G J. 1998. Zinc may regulate serum leptin concentrations in humans. J. Am. Coll. Nutr. 17: 270.
50. 50. McKenzie R, Rafferty T S, Beckett G J. 1998. Selenium: an essential element for immune function. Immunol. Today 19: 342.
51. 51. Semba R D, Ward M B J, Griffin D E, Scott A L, Natadisastra G, West K P, Sommer A. 1993. Abnormal T cell subset proportions in vitamin-A deficient children. Lancet 341: 5.
52. 52. Varvarigou A, Mantzoros C S, Beratis N G. 1999. Cord blood leptin concentrations in relation to intrauterine growth. Clin. Endocrinol. (Oxf). 50: 177.
53. 53. Simon J. 1845. A physiological assay on the thymus gland. Renshaw, London.
54. 54. Watts T. 1969. Thymus weights in malnourished children. J. Trop. Pediatr. 15: 155.
55. 55. Chevalier P. 1997. Thymic ultrasonography in children, a non-invasive assessment of nutritional immune deficiency. Nutrition Research 17: 1271.
56. 56. Howard J K, Lord G M, Matarese G, Vendetti S, Ghatei M A, Ritter M A, Lechler R I, Bloom S R. 1999. Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice. J. Clin. Invest. 104: 1051.
57. 57. Dhurandhar N V, Kulkarni P R, Ajinkya S M, Sherikar A A, Atkinson R L. 1997. Association of adenovirus infection with human obesity. Obes. Res. 5: 464.
58. 58. Astrup A, Lundsgaard C, Stock M J. 1998. Is obesity contagious? Int. J. Obes. 22: 375.
59. + lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation. Clin. Rheumatol. 18: 394.
60. 60. Komaki G, Kanazawa F, Sogawa H, Mine K, Tamai H, Okamura S, Kubo C. 1997. Alteration in lymphocyte subsets and pituitary-adrenal gland related hormones during fasting. Am. J. Clin. Nutr. 66: 147.
61. 61. Barone K S, O'Brien P C, Stevenson J R. 1993. Characterization and mechanisms of thymic athrophy in protein-malnourished mice: role of corticosterone. Cell. Immunol. 148: 226.
62. 62. Heymsfield S B, Greenberg A S, Fujioka K, Dixon R M, Kushner R, Hunt T, Lubina J A, Patane J, Self B, Hunt P, McCamish M. 1999. Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial. JAMA 282: 1568.
63. 63. Gura T. 1999. Obesity research. Leptin not impressive in clinical trial. Science 286: 881.
64. 64. Farooqi I S, Jebb S A, Langmack G, Lawrence E, Cheetham C H, Prentice A M, Hughes I A, McCamish M A, O'Rahilly S. 1999. Effects of recombinant leptin therapy in a child with congenital leptin deficiency. N. Engl. J. Med. 341: 879.
65. 65. Schols A M, Creutzberg E C, Buurman W A, Campfield L A, Saris W H, Wouters E F. 1999. Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 160: 1220.
66. 66. Loffreda S, Yang S Q, Lin H Z, Karp C L, Brengman M L, Wang D J, Klein A S, et al. 1998. Leptin regulates proinflammatory immune responses. FASEB J. 12: 57.
67. 67. Santos-Alvarez J, Goberna R, Sanchez-Margalet V. 1999. Human leptin stimulates proliferation and activation of human circulating monocytes. Cell. Immunol. 194: 6.
68. 68. Carro E, Senaris R, Considine R V, Casanueva F F, Dieguez C. 1997. Regulation of in vivo growth hormone secretion by leptin. Endocrinology 138: 2203.