Unbalanced serum leptin and ghrelin dynamics prolong postprandial satiety and inhibit hunger in healthy elderly: Another reason for the "anorexia of aging"

American Journal of Clinical Nutrition

Volumn 83, Issue 5, 2006, Pages 1149-1152

  Di Francesco, Vincenzo ^a,e   Zamboni, Mauro ^a   Zoico, Elena ^a   Mazzali, Gloria ^a   Dioli, Andrea ^a   Omizzolo, Francesca ^a   Bissoli, Luisa ^a   Fantin, Francesco ^a   Rizzotti, Paolo ^b   Solerte, Sebastiano B ^c   Micciolo, Rocco ^d   Bosello, Ottavio ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b UNIVERSITY HOSPITAL OF VERONA   (Italy)

^c UNIVERSITY OF PAVIA   (Italy)

^d UNIVERSITY OF TRENTO   (Italy)

^e MAGGIORE HOSPITAL   (Italy)

Author keywords

Aging; Ghrelin; Leptin; Malnutrition

Indexed keywords

GHRELIN; INSULIN; LEPTIN; PEPTIDE HORMONE;

AGED; AGING; ANOREXIA; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; FOOD INTAKE; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HUNGER; MALE; POSTPRANDIAL STATE; SATIETY; VISUAL ANALOG SCALE; ADULT; BLOOD; COMPARATIVE STUDY; DIET RESTRICTION; FOOD; PHYSIOLOGY;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANOREXIA; FASTING; FEMALE; FOOD; HUMANS; HUNGER; INSULIN; LEPTIN; MALE; PEPTIDE HORMONES; SATIATION;

EID: 33745176610     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/83.5.1149     Document Type: Article

References (27)

1. Mowé M, Bohmer T, Kindt E. Reduced nutritional status in an elderly population (> 70 y) is probable before disease and possibly contributes to the development of disease. Am J Clin Nutr 1994;59:317-24.
2. Morley JE. Anorexia of aging: physiologic and pathologic. Am J Clin Nutr 1997;66:760-73.
3. MacIntosh GC, Andrews JM, Jones KL, et al. Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1 and peptide YY and their relation to appetite and pyloric motility. Am J Clin Nutr 1999;69:999-1006.
4. Di Francesco V, Zamboni M, Dioli A, et al. Delayed postprandial gastric emptying and impaired gallbladder contraction together with elevated cholecystokinin and peptide YY serum levels sustain satiety and inhibit hunger in healthy Elderly persons. J Gerontol A Biol Sci Med Sci 2005;60:1581-5.
5. Havel PJ. Update on adipocyte hormones: regulation of energy balance and carbohydrate/lipid metabolism Diabetes 2004;53(suppl):S143-51.
6. Gomez JM, Maravall FJ, Gomez N, Navarro MA, Casamitjana R, Soler J. Interactions between serum leptin, the insulin-like growth factor-1 system, and age, anthropometric and body composition variables in a healthy population randomly selected. Clin Endocrinol 2003;58:213-9.
7. Ruhl CE, Everhart JE. Leptin concentrations in the United States: relations with demographic and anthropometric measures. Am J Clin Nutr 2001;74:295-301.
8. Zamboni M, Zoico E, Fantin F, et al. Relation between leptin and the metabolic syndrome in elderly women. J Gerontol A Biol Sci Med Sci 2004;59:396-400.
9. Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337-45.
10. Cummings DE, Purnell JQ, Frayo RS, Schmidova K, Wisse BE, Weigle DS. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001;50:1714-9.
11. Tolle V, Bassant MH, Zizzari P, et al. Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 2002;143:1353-61.
12. Rigamonti AE, Pincelli AI, Corra B, et al. Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients. J Endocrinol 2002;175:R1-5.
13. de Graaf C, Blom WA, Smeets PA, Stafleu A, Hendriks HF. Biomarkers of satiation and satiety. Am J Clin Nutr 2004;79:946-61.
14. Joannic JL, Oppert JM, Lahlou N, et al. Plasma leptin and hunger ratings in healthy humans. Appetite 1998;30:129-38.
15. Romon M, Lebel P, Velly C, Marecaux N, Fruchart JC, Dallongeville J. Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake. Am J Physiol 1999;277:E855-61.
16. Blom WA, Stafleu A, de Graaf C, Kok FJ, Schaafsma G, Hendriks HF. Ghrelin response to carbohydrate-enriched breakfast is related to insulin. Am J Clin Nutr 2005;81:367-75.
17. Wynne K, Stanley S, McGowan B, Bloom S. Appetite control. J Endocrinol 2005;184:291-318.
18. MacIntosch GC, Morley JE, Wishart J, et al. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 2001;86:830-7.
19. Barrachina MD, Martinez V, Wang L, Wei JY, Tache Y. Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci U S A 1997;94:10455-60.
20. Doucet E, St-Pierre S, Alméras N, et al. Fasting insulin levels influence plasma leptin levels ndependently from the contribution of adiposity: Evidence from both a cross-sectional and an intervention study. J Clin Endocrinol Metab 2000;85:4231-7.
21. Murdolo G, Lucidi P, Di Loreto C, et al. Insulin is required for prandial ghrelin suppression in humans. Diabetes 2003;52:2923-7.
22. Strader AD, Woods SC. Gastrointestinal hormones and food intake. Gastroenterology 2005;128:175-91.
23. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004;25:426-57.
24. Hosoda H, Kojima M, Matsuo H, et al. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000;279:909-13.
25. Asakawa A, Inui A, Fujimiya M, et al. Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 2005;54:18-24.
26. Sih R, Morley JE, Kaiser FE, Perry HM III, Patrick P, Ross C. Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J Clin Endocrinol Metab 1997;82:1661-7.
27. Parker BA, Ludher AK, Loon TK, Horowitz M, Chapman IM. Relationships of ratings of appetite to food intake in healthy older men and women. Appetite 2004;43:227-33.